9543 results
Cited 11 times since 2015 (1 per year)
source: EuropePMC
Physics in medicine and biology,
Volume 60, Issue 4, 22 4 2015, Pages 1477-1496
Influence of vascular normalization on interstitial flow and delivery of liposomes in tumors.
Ozturk D, Yonucu S, Yilmaz D, Unlu MB
Elevated interstitial fluid pressure is one of the barriers of drug delivery in solid tumors. Recent studies have shown that normalization of tumor vasculature by anti-angiogenic factors may improve the delivery of conventional cytotoxic drugs, possibly by increasing blood flow, decreasing interstitial fluid pressure, and enhancing the convective transvascular transport of drug molecules. Delivery of large therapeutic agents such as nanoparticles and liposomes might also benefit from normalizati...
Abstract
Cited 40 times since 2015 (3.7 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 20, Issue 4, 22 4 2015, Pages 520-530
Mortality after cardiac surgery in patients with liver cirrhosis classified by the Child-Pugh score.
Jacob KA, Hjortnaes J, Kranenburg G, de Heer F, Kluin J
Liver cirrhosis is a known risk factor for postoperative mortality in patients undergoing cardiac surgery. Clinical assessment of liver cirrhosis using the widely accepted Child-Pugh (CP) score is thus vital for evaluation of surgical options and perioperative care. However, detailed mortality rates as a consequence of liver cirrhosis are unclear. This review aimed to stratify the risk of short-term (
Abstract
Cited 70 times since 2015 (6.5 per year)
source: EuropePMC
Circulation research,
Volume 116, Issue 5, 21 3 2015, Pages 836-845
Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling.
Qi XY, Huang H, Ordog B, Luo X, Naud P, Sun Y, Wu CT, Dawson K, Tadevosyan A, Chen Y, Harada M, Dobrev D, Nattel S
Rationale: Fibroblasts are involved in cardiac arrhythmogenesis and contribute to the atrial fibrillation substrate in congestive heart failure (CHF) by generating tissue fibrosis. Fibroblasts display robust ion currents, but their functional importance is poorly understood. Objective: To characterize atrial fibroblast inward-rectifier K(+) current (IK1) remodeling in CHF and its effects on fibroblast properties. Methods and results: Freshly isolated left atrial fibroblasts were obtained from co...
Abstract
Cited 66 times since 2015 (6.1 per year)
source: EuropePMC
Journal of virology,
Volume 89, Issue 7, 21 3 2015, Pages 3763-3775
Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses.
Koel BF, Mögling R, Chutinimitkul S, Fraaij PL, Burke DF, van der Vliet S, de Wit E, Bestebroer TM, Rimmelzwaan GF, Osterhaus AD, Smith DJ, Fouchier RA, de Graaf M
Unlabelled: The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from neutralizing antibodies, affect viral fitness, and change receptor preference. In this study, we constructed mutants with substitutions in the hemagglutinin of A/Netherlands/602/0...
Abstract
Cited 18 times since 2015 (1.7 per year)
source: EuropePMC
European journal of radiology,
Volume 84, Issue 5, 20 3 2015, Pages 856-861
Volumetric CT-images improve testing of radiological image interpretation skills.
Ravesloot CJ, van der Schaaf MF, van Schaik JP, ten Cate OT, van der Gijp A, Mol CP, Vincken KL
Rationale and objectives: Current radiology practice increasingly involves interpretation of volumetric data sets. In contrast, most radiology tests still contain only 2D images. We introduced a new testing tool that allows for stack viewing of volumetric images in our undergraduate radiology program. We hypothesized that tests with volumetric CT-images enhance test quality, in comparison with traditional completely 2D image-based tests, because they might better reflect required skills for clin...
Abstract
Cited 645 times since 2015 (59.5 per year)
source: EuropePMC
Nature communications,
Volume 6, 19 3 2015, Pages 5890
Biological interpretation of genome-wide association studies using predicted gene functions.
Pers TH, Karjalainen JM, Chan Y, Westra HJ, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, Frayling T, Speliotes EK, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
Renal failure,
Volume 37, Issue 3, 19 3 2015, Pages 387-391
Evaluation of children with steroid-sensitive nephrotic syndrome in terms of allergies.
Yılmaz D, Yenigün A, Sönmez F, Kurt Ömürlü İ
Background: The etiology of minimal-change disease is not fully known, it is believed to be mediated by the immune system. Minimal-change disease also reported as having association with atopy. In this study, atopy history, the levels of serum IgE, and skin prick test in children with steroid-sensitive nephrotic syndrome were investigated. Methods: A group of 30 children (mean age 7.7 ± 2.2 years, 56.6% male) diagnosed with steroid-sensitive nephrotic syndrome were included in the study. Serum i...
Abstract
Cited 25 times since 2015 (2.3 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 48, Issue 6, 18 3 2015, Pages 833-40; discussion 840-1
Comprehensive rhythm evaluation in a large contemporary Fontan population.
Bossers SS, Duppen N, Kapusta L, Maan AC, Duim AR, Bogers AJ, Hazekamp MG, van Iperen G, Helbing WA, Blom NA
Objectives: Rhythm disturbances are an important cause of morbidity in Fontan patients. Currently, the total cavopulmonary connection is performed by using the intra-atrial lateral tunnel (ILT) ('baffle ILT' or 'prosthetic ILT'), or the extracardiac conduit (ECC). The aim of the study was to evaluate rhythm abnormalities and compare the surgical techniques in a contemporary cohort. Methods: In a cross-sectional multicentre study, 115 patients (age 12.5 ± 3.1 years) underwent...
Abstract
Cited 3 times since 2015 (0.3 per year)
source: EuropePMC
Cardiorenal medicine,
Volume 5, Issue 1, 16 3 2015, Pages 69-78
Neuronal nitric oxide synthase-dependent amelioration of diastolic dysfunction in rats with chronic renocardiac syndrome.
Bongartz LG, Soni S, Cramer MJ, Steendijk P, Gaillard CA, Verhaar MC, Doevendans PA, van Veen TA, Joles JA, Braam B
We have recently described the chronic renocardiac syndrome (CRCS) in rats with renal failure, cardiac dysfunction and low nitric oxide (NO) availability by combining subtotal nephrectomy and transient low-dose NO synthase (NOS) inhibition. Cardiac gene expression of the neuronal isoform of NOS (nNOS) was induced. Hence, we studied the role of nNOS, in vivo cardiac function and β-adrenergic response in our CRCS model by micromanometer/conductance catheter. Left ventricular (LV) hemodynamics were...
Abstract
Cited 28 times since 2015 (2.6 per year)
source: EuropePMC
Journal of the American Academy of Dermatology,
Volume 72, Issue 3, 13 2 2015, Pages 465-472
Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas?: A cohort study.
Raphael MF, Breugem CC, Vlasveld FA, de Graaf M, Slieker MG, Pasmans SG, Breur JM
Background: Although consensus guidelines for pretreatment evaluation and monitoring of propranolol therapy in patients with infantile hemangiomas (IH) have been formulated, little is known about the cardiovascular side effects. Objectives: We sought to analyze cardiovascular evaluations in patients with IH at baseline and during treatment with an oral beta-blocker. Methods: Data from 109 patients with IH were retrospectively analyzed. Patient and family history, pretreatment electrocardiogram (...
Abstract
Cited 12 times since 2015 (1.1 per year)
source: EuropePMC
Acta physiologica (Oxford, England),
Volume 213, Issue 3, 9 2 2015, Pages 653-663
Mild hypothermia induces incomplete left ventricular relaxation despite spontaneous bradycardia in pigs.
Schwarzl M, Alogna A, Zirngast B, Steendijk P, Verderber J, Zweiker D, Huber S, Maechler H, Pieske BM, Post H
Aim: Mild hypothermia (MH) decreases left ventricular (LV) end-diastolic capacitance. We sought to clarify whether this results from incomplete relaxation. Methods: Ten anaesthetized pigs were cooled from normothermia (NT, 38 °C) to MH (33 °C). LV end-diastolic pressure (LVPed), volume (LVVed) and pressure-volume relationships (EDPVRs) were determined during stepwise right atrial pacing. LV capacitance (i.e. LVVed at LVPed of 10 mmHg, LV VPed10) was derived from the EDPVR. Pacing-induced changes...
Abstract
Cited 27 times since 2015 (2.5 per year)
source: EuropePMC
Molecular ecology,
Volume 24, Issue 2, 9 2 2015, Pages 310-327
Reconstructing the demographic history of orang-utans using Approximate Bayesian Computation.
Nater A, Greminger MP, Arora N, van Schaik CP, Goossens B, Singleton I, Verschoor EJ, Warren KS, Krützen M
Investigating how different evolutionary forces have shaped patterns of DNA variation within and among species requires detailed knowledge of their demographic history. Orang-utans, whose distribution is currently restricted to the South-East Asian islands of Borneo (Pongo pygmaeus) and Sumatra (Pongo abelii), have likely experienced a complex demographic history, influenced by recurrent changes in climate and sea levels, volcanic activities and anthropogenic pressures. Using the most extensive...
Abstract
Cited 7 times since 2015 (0.6 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 20, Issue 4, 6 1 2015, Pages 499-503
Hybrid branch pulmonary artery stent placement in adults with congenital heart disease.
Lynch W, Boekholdt SM, Hazekamp MG, de Winter RJ, Koolbergen DR
Objectives: Valuable treatment modalities for branch pulmonary artery (BPA) stenoses are surgical patch angioplasty, percutaneous BPA stenting and hybrid stent placement. The purpose of this study was to report our institutional experience with hybrid stent placement to relieve BPA stenoses. Methods: Between August 2007 and May 2014, 7 adults (5 females) with congenital heart disease (CHD) had elective intraoperative BPA stent placement. All 7 patients had undergone previous surgery [6 tetralogy...
Abstract
Cited 30 times since 2015 (2.8 per year)
source: EuropePMC
European heart journal. Acute cardiovascular care,
Volume 5, Issue 1, 5 1 2015, Pages 3-12
Opportunities for improvement in anti-thrombotic therapy and other strategies for the management of acute coronary syndromes: Insights from EPICOR, an international study of current practice patterns.
Bueno H, Sinnaeve P, Annemans L, Danchin N, Licour M, Medina J, Pocock S, Sánchez-Covisa J, Storey RF, Jukema JW, Zeymer U, Van de Werf F, EPICOR Investigators
Aims: To describe international patterns and opportunities for improvement of pre- and in-hospital care of patients hospitalized for acute coronary syndromes (ACS), with special focus on anti-thrombotic therapy. Methods and results: EPICOR (long-tErm follow-uP of anti-thrombotic management patterns In acute CORonary syndrome patients), an international, cohort study, which enrolled 10,568 consecutive ACS survivors from 555 hospitals in 20 countries across Europe and Latin America (September 2010...
Abstract
Cited 5 times since 2015 (0.5 per year)
source: EuropePMC
European heart journal,
Volume 36, Issue 4, 2 1 2015, Pages 206-213
The year in cardiology 2014: imaging.
Gaemperli O, Marsan NA, Delgado V, Bax JJ
Abstract
Cited 41 times since 2015 (3.8 per year)
source: EuropePMC
Kardiologia polska,
Volume 73, Issue 12, 1 1 2015, Pages 1207-1294
[2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation].
Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S
Abstract
Cited 112 times since 2015 (10.3 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 17 Suppl 1, 1 1 2015, Pages i1-75
Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association.
Raatikainen MJ, Arnar DO, Zeppenfeld K, Merino JL, Levya F, Hindriks G, Kuck KH
Aims: There has been large variations in the use of invasive electrophysiological therapies in the member countries of the European Society of Cardiology (ESC). The aim of this analysis was to provide comprehensive information on cardiac implantable electronic device (CIED) and catheter ablation therapy trends in the ESC countries over the last five years. Methods: The European Heart Rhythm Association (EHRA) has collected data on CIED and catheter ablation therapy since 2008. Last year 49 of th...
Abstract
Cited 99 times since 2015 (9.1 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 65, Issue 3, 1 1 2015, Pages 246-254
The risk for type B aortic dissection in Marfan syndrome.
den Hartog AW, Franken R, Zwinderman AH, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Pals G, Mulder BJ, Groenink M
Background: Aortic dissections involving the descending aorta are a major clinical problem in patients with Marfan syndrome. Objectives: The purpose of this study was to identify clinical parameters associated with type B aortic dissection and to develop a risk model to predict type B aortic dissection in patients with Marfan syndrome. Methods: Patients with the diagnosis of Marfan syndrome and magnetic resonance imaging or computed tomographic imaging of the aorta were followed for a median of...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference,
Volume 2015, 1 1 2015, Pages 7675-7678
Sleep apnoea episodes recognition by a committee of ELM classifiers from ECG signal.
Sadr N, de Chazal P, van Schaik A, Breen P
This paper describes a system for the recognition of sleep apnoea episodes from ECG signals using a committee of extreme learning machine (ELM) classifiers. RR-interval parameters (heart rate variability) have been used as the identifying features as they are directly affected by sleep apnoea. The MIT PhysioNet Apnea-ECG database was used. A committee of five ELM classifiers has been employed to classify one-minute epochs of ECG into normal or apnoeic epochs. Our results show that the classifica...
Abstract
Cited 2 times since 2015 (0.2 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 159, 1 1 2015, Pages A8909
[Estimating weight accurately for safe treatment: body weight estimation in patients with acute ischaemic stroke is frequently inaccurate].
van de Stadt SI, van Schaik SM, van den Berg-Vos RM
Patients with acute ischaemic stroke should receive intravenous thrombolysis with 0.9 mg/kg of recombinant tissue plasminogen activator as quickly as possible. In order to reduce the door-to-needle time, many physicians estimate the patient's body weight. However, these estimates are frequently inaccurate and inaccuracy can lead to dosage errors. According to a meta-analysis in a Cochrane study, the risk of developing intracranial haemorrhage is almost tripled for patients treated with high...
Abstract
