Research

Publications

Below you can find a list of our published research.

9543 results

Cited 27 times since 2015 (2.5 per year) source: EuropePMC

Pharmacogenomics, Volume 16, Issue 2, 1 1 2015, Pages 137-148 Economic evaluation of pharmacogenomic-guided warfarin treatment for elderly Croatian atrial fibrillation patients with ischemic stroke. Mitropoulou C, Fragoulakis V, Bozina N, Vozikis A, Supe S, Bozina T, Poljakovic Z, van Schaik RH, Patrinos GP

Background & methods: Economic evaluation in genomic medicine is an emerging discipline to assess the cost-effectiveness of genome-guided treatment. Here, we developed a pharmaco-economic model to assess whether pharmacogenomic (PGx)-guided warfarin treatment of elderly ischemic stroke patients with atrial fibrillation in Croatia is cost effective compared with non-PGx therapy. The time horizon of the model was set at 1 year. Results: Our primary analysis indicates that 97.07% (95% CI: 94.08... Abstract

Cited 31 times since 2015 (2.8 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 1, 1 1 2015, Pages 20-25 High survival rate of 43% in out-of-hospital cardiac arrest patients in an optimised chain of survival. Boyce LW, Vliet Vlieland TP, Bosch J, Wolterbeek R, Volker G, van Exel HJ, Heringhaus C, Schalij MJ, Goossens PH

Aims: Survival to hospital discharge after out-of-hospital cardiac arrest (OHCA) varies widely. This study describes short-term survival after OHCA in a region with an extensive care path and a follow-up of 1 year. Methods: Consecutive patients ≥16 years admitted to the emergency department between April 2011 and December 2012 were included. In July 2014 a follow-up took place. Socio-demographic data, characteristics of the OHCA and interventions were described and associations with survival wer... Abstract

Cited 22 times since 2015 (2 per year) source: EuropePMC

Education for health (Abingdon, England), Volume 28, Issue 1, 1 1 2015, Pages 52-57 Challenges of interprofessional team training: a qualitative analysis of residents' perceptions. van Schaik S, Plant J, O'Brien B

Background: Simulation-based interprofessional team training is thought to improve patient care. Participating teams often consist of both experienced providers and trainees, which likely impacts team dynamics, particularly when a resident leads the team. Although similar team composition is found in real-life, debriefing after simulations puts a spotlight on team interactions and in particular on residents in the role of team leader. The goal of the current study was to explore residents'... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

PloS one, Volume 9, Issue 12, 31 5 2015, Pages e111156 No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A, Tang W, Rudnicka AR, Mälarstig A, Hottenga JJ, Kavousi M, Lahti J, Tanaka T, Hayward C, Huffman JE, Morange PE, Rose LM, Basu S, Rumley A, Stott DJ, Buckley BM, de Craen AJ, Sanna S, Masala M, Biffar R, Homuth G, Silveira A, Sennblad B, Goel A, Watkins H, Müller-Nurasyid M, Rückerl R, Taylor K, Chen MH, de Geus EJ, Hofman A, Witteman JC, de Maat MP, Palotie A, Davies G, Siscovick DS, Kolcic I, Wild SH, Song J, McArdle WL, Ford I, Sattar N, Schlessinger D, Grotevendt A, Franzosi MG, Illig T, Waldenberger M, Lumley T, Tofler GH, Willemsen G, Uitterlinden AG, Rivadeneira F, Räikkönen K, Chasman DI, Folsom AR, Lowe GD, Westendorp RG, Slagboom PE, Cucca F, Wallaschofski H, Strawbridge RJ, Seedorf U, Koenig W, Bis JC, Mukamal KJ, van Dongen J, Widen E, Franco OH, Starr JM, Liu K, Ferrucci L, Polasek O, Wilson JF, Oudot-Mellakh T, Campbell H, Navarro P, Bandinelli S, Eriksson J, Boomsma DI, Dehghan A, Clarke R

Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-sc... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

Clinical genitourinary cancer, Volume 13, Issue 3, 31 5 2015, Pages 204-9.e2 Pharmacokinetic, Pharmacodynamic, and Activity Evaluation of TMX-101 in a Multicenter Phase 1 Study in Patients With Papillary Non-Muscle-Invasive Bladder Cancer. Arends TJ, Lammers RJ, Falke J, van der Heijden AG, Rustighini I, Pozzi R, Ravic M, Eisenhardt A, Vergunst H, Witjes JA

Introduction/background: Non-muscle-invasive bladder cancer (NMIBC) has a strong tendency to recur despite adjuvant instillations. TMX-101 is a new liquid form of imiquimod for intravesical instillation and has activity in vitro against urothelial carcinoma. The purpose was to analyze the activity of TMX-101 in low-grade NMIBC. Furthermore, pharmacokinetic and pharmacodynamic characteristics and adverse events were evaluated. Patients and methods: A multicenter, prospective phase 1 trial in 7 pa... Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

BMJ open, Volume 4, Issue 12, 31 5 2015, Pages e007065 A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol. Boss HM, Van Schaik SM, Deijle IA, de Melker EC, van den Berg BT, Scherder EJ, Bosboom WM, Weinstein HC, Van den Berg-Vos RM

Introduction: Patients with transient ischaemic attack (TIA) or stroke are at risk for cognitive impairment and dementia. Currently, there is no known effective strategy to prevent this cognitive decline. Increasing evidence exists that physical exercise is beneficial for cognitive function. However, in patients with TIA or stroke who are at risk of cognitive impairment and dementia, only a few trials have been conducted. In this study, we aim to investigate whether a physical exercise programme... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 22, Issue 3, 30 5 2015, Pages 408-418 Clinical topic: Nuclear imaging in hypertrophic cardiomyopathy. Delgado V, Bax JJ

Non-invasive cardiac imaging plays a central role in the diagnosis and management of patients with hypertrophic cardiomyopathy. Transthoracic echocardiography is the imaging technique of first choice to evaluate wall thickness, left ventricular systolic and diastolic function, presence of left ventricular outflow tract obstruction, and abnormal mitral anatomy, whereas cardiac magnetic resonance provides additional information on tissue characterization (replacement fibrosis) using late gadoliniu... Abstract

Cited 25 times since 2014 (2.3 per year) source: EuropePMC

The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 70, Issue 8, 24 4 2014, Pages 982-988 Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study. Loeffen R, Winckers K, Ford I, Jukema JW, Robertson M, Stott DJ, Spronk HM, ten Cate H, Lowe GD, PROSPER Study Group

Background: Hypercoagulability may be an important contributor to the pathophysiology of atherosclerosis and atherothrombosis. As thrombin fulfills a central role in coagulation and links to several cellular mechanisms involved in arterial disease, we hypothesized that thrombin generation is associated with cardiovascular events in elderly patients. Methods: We studied the relationship between plasma thrombin generation and incident coronary heart disease (CHD) and stroke in the PROspective Stud... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, Volume 24, Issue 3, 24 4 2014, Pages 566-572 Practice variation in long-term secondary stroke prevention in The Netherlands. van Schaik SM, de Vries BS, Weinstein HC, Visser MC, Van den Berg-Vos RM

Background: Stroke guidelines emphasize the importance of adequate vascular risk factor assessment and management in transient ischemic attack (TIA) and ischemic stroke patients, but it is not clear how these guidelines are applied in routine clinical practice. The limited data that are available indicate that TIA and ischemic stroke patients often do not receive the recommended interventions. The aim of this study was to investigate practice variations in long-term secondary stroke prevention i... Abstract

Cited 10 times since 2014 (0.9 per year) source: EuropePMC

International journal of cardiology, Volume 181, 23 4 2014, Pages 362-368 The prognostic impact of diastolic dysfunction in patients with chronic heart failure and post-acute myocardial infarction: Can age-stratified E/A ratio alone predict survival? Rigolli M, Rossi A, Quintana M, Klein AL, Yu CM, Ghio S, Dini FL, Prior D, Troughton RW, Temporelli PL, Poppe KK, Doughty RN, Whalley GA, MeRGE Collaborators

Objective: To determine the prognostic implications of diastolic filling grades and identify whether age-stratified E/A ratio alone can identify patients at high risk of death post-AMI and HF. We hypothesized that in response to ageing and pathology, a normal E/A (>1) could be considered abnormal in patients post-AMI older than 65years, and that in patients with symptomatic HF, a normal E/A always represents advanced diastolic dysfunction. Methods and results: This is a sub-analysis of the Me... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Biometrical journal. Biometrische Zeitschrift, Volume 57, Issue 4, 20 3 2014, Pages 592-613 Covariate-adjusted measures of discrimination for survival data. White IR, Rapsomaniki E, Emerging Risk Factors Collaboration

Motivation: Discrimination statistics describe the ability of a survival model to assign higher risks to individuals who experience earlier events: examples are Harrell's C-index and Royston and Sauerbrei's D, which we call the D-index. Prognostic covariates whose distributions are controlled by the study design (e.g. age and sex) influence discrimination and can make it difficult to compare model discrimination between studies. Although covariate adjustment is a standard procedure for... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Frontiers in neuroscience, Volume 8, 19 3 2014, Pages 424 Research topic: neuromorphic engineering systems and applications. A snapshot of neuromorphic systems engineering. Delbruck T, van Schaik A, Hasler J

Abstract

Cited 12 times since 2014 (1.1 per year) source: Scopus

The American journal of cardiology, Volume 115, Issue 5, 18 3 2014, Pages 664-669 Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. Ewe SH, Muratori M, van der Kley F, Pepi M, Delgado V, Tamborini G, Fusini L, de Weger A, Gripari P, Bartorelli A, Bax JJ, Marsan NA

The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months.... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 149, Issue 4, 18 3 2014, Pages 968 Long-term follow-up after the arterial switch operation: Not as perfect as we would have hoped? Hazekamp MG

Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Vascular, Volume 23, Issue 6, 18 3 2014, Pages 661-662 Late onset acute occlusion of the subclavian artery after clavicle fracture. van Schaik PM, de Borst GJ, Moll FL, Toorop RJ

Vascular injuries after a clavicle fracture are rare. The treatment remains, if possible, conservative. In case of life-threatening bleeding or limb ischemia, endovascular treatment is the treatment of choice. In this case report, we describe a patient who suffered a clavicle fracture five years before and now presented with acute invalidating claudication caused by an acute occlusion superimposed on a brachial artery stenosis. After unsuccessful thrombolytic therapy a surgical exploration of th... Abstract

Cited 239 times since 2014 (21.9 per year) source: EuropePMC

PLoS genetics, Volume 10, Issue 12, 18 3 2014, Pages e1004776 Dissemination of cephalosporin resistance genes between Escherichia coli strains from farm animals and humans by specific plasmid lineages. de Been M, Lanza VF, de Toro M, Scharringa J, Dohmen W, Du Y, Hu J, Lei Y, Li N, Tooming-Klunderud A, Heederik DJ, Fluit AC, Bonten MJ, Willems RJ, de la Cruz F, van Schaik W

Third-generation cephalosporins are a class of β-lactam antibiotics that are often used for the treatment of human infections caused by Gram-negative bacteria, especially Escherichia coli. Worryingly, the incidence of human infections caused by third-generation cephalosporin-resistant E. coli is increasing worldwide. Recent studies have suggested that these E. coli strains, and their antibiotic resistance genes, can spread from food-producing animals, via the food-chain, to humans. However, thes... Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

Veterinary research, Volume 45, 17 3 2014, Pages 129 Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype. Benedictus L, Otten HG, van Schaik G, van Ginkel WG, Heuven HC, Nielen M, Rutten VP, Koets AP

Bovine Neonatal Pancytopenia (BNP), a bleeding syndrome of neonatal calves, is caused by alloantibodies absorbed from the colostrum of particular cows. A commercial BVD vaccine is the likely source of alloantigens eliciting BNP associated alloantibodies. We hypothesized that the rare occurrence of BNP in calves born to vaccinated dams could be associated with genetic differences within dams and calves. We found that the development of BNP within calves was a heritable trait for dams, not for cal... Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

Behavior modification, Volume 39, Issue 3, 16 3 2014, Pages 390-412 Cognitive behavior therapy for anxiety in people with dementia: a clinician guideline for a person-centered approach. Charlesworth G, Sadek S, Schepers A, Spector A

This article describes a 10-session cognitive-behavioral therapy (CBT) used in a randomized controlled trial with people with anxiety and mild-to-moderate dementia. The aim of the therapy is to reduce symptoms of anxiety by increasing a sense of safety and self-efficacy. The therapy is characterized by a person-centered approach to CBT, using individual tailoring to accommodate for cognitive deficits and other challenges. Three phases of therapy are described: (a) socialization to model (includi... Abstract

Cited 5 times since 2014 (0.5 per year) source: EuropePMC

Injury, Volume 46, Issue 5, 16 3 2014, Pages 863-869 Impact of combat events on first responders: experiences of the armed conflict in Uruzgan, Afghanistan. Hoencamp R, Idenburg FJ, Vermetten E, Tan E, Plat MC, Hoencamp E, Leenen LP, Hamming JF

Introduction: Care for battle casualties demands special skills from medics, nurses, and tactical commanders. To date, no inventory has been performed evaluating the first responders (medics, nurses and tactical commanders) around battle casualties. Method: This observational cohort study was conducted amongst the first responders (n=195) who were deployed to Southern Afghanistan (2009-2010) in three Marine companies. The survey focused on four main topics: (1) participants general background, (... Abstract

Cited 65 times since 2014 (5.9 per year) source: EuropePMC

Frontiers in immunology, Volume 5, 12 2 2014, Pages 629 Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in europe. Kerr J, Quinti I, Eibl M, Chapel H, Späth PJ, Sewell WA, Salama A, van Schaik IN, Kuijpers TW, Peter HH

The consumption of immunoglobulins (Ig) is increasing due to better recognition of antibody deficiencies, an aging population, and new indications. This review aims to examine the various dosing regimens and research developments in the established and in some of the relevant off-label indications in Europe. The background to the current regulatory settings in Europe is provided as a backdrop for the latest developments in primary and secondary immunodeficiencies and in immunomodulatory indicati... Abstract