9543 results
Cited 39 times since 2014 (3.6 per year)
source: EuropePMC
BMC nephrology,
Volume 15, 11 2 2014, Pages 197
Soluble Klotho is not independently associated with cardiovascular disease in a population of dialysis patients.
Buiten MS, de Bie MK, Bouma-de Krijger A, van Dam B, Dekker FW, Jukema JW, Rabelink TJ, Rotmans JI
Background: Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, low levels of Klotho, a protein linked to aging, might constitute a key factor in this detrimental relationship. The purpose of the present study was to determine the relationship between serum Klotho (sKlotho) and the presence of CVD in dialysis patients. Methods: Plasma levels o...
Abstract
Cited 82 times since 2014 (7.5 per year)
source: EuropePMC
PLoS pathogens,
Volume 10, Issue 12, 11 2 2014, Pages e1004569
Apoplastic venom allergen-like proteins of cyst nematodes modulate the activation of basal plant innate immunity by cell surface receptors.
Lozano-Torres JL, Wilbers RH, Warmerdam S, Finkers-Tomczak A, Diaz-Granados A, van Schaik CC, Helder J, Bakker J, Goverse A, Schots A, Smant G
Despite causing considerable damage to host tissue during the onset of parasitism, nematodes establish remarkably persistent infections in both animals and plants. It is thought that an elaborate repertoire of effector proteins in nematode secretions suppresses damage-triggered immune responses of the host. However, the nature and mode of action of most immunomodulatory compounds in nematode secretions are not well understood. Here, we show that venom allergen-like proteins of plant-parasitic ne...
Abstract
Cited 8 times since 2014 (0.7 per year)
source: EuropePMC
World journal of urology,
Volume 33, Issue 10, 10 2 2014, Pages 1411-1417
Urinary cytokines in patients treated with intravesical mitomycin-C with and without hyperthermia.
Arends TJ, Falke J, Lammers RJ, Somford DM, Hendriks JC, de Weijert MC, Arentsen HC, van der Heijden AG, Oosterwijk E, Alfred Witjes J
Objectives: To explore whether urinary cytokine and chemokine (CK) levels differed between cold mitomycin-C (cold-MMC)-treated patients and chemohyperthermia (C-HT)-treated patients, to shed light on the possible molecular mechanisms that might explain the superior outcome of C-HT. Furthermore, CK-differences were explored between C-HT responders and C-HT non-responders. Methods: Twelve NMIBC patients were included. Nine received six-weekly C-HT, and three received four-weekly cold-MMC instillat...
Abstract
Cited 16 times since 2014 (1.5 per year)
source: EuropePMC
The International journal of social psychiatry,
Volume 61, Issue 6, 8 2 2014, Pages 530-538
The influence of acculturation on mental health and specialized mental healthcare for non-western migrants.
Nap A, van Loon A, Peen J, van Schaik DJ, Beekman AT, Dekker JJ
Background: The level of acculturation of migrants varies and is associated with variations in mental health. However, this association is complex and may differ among migrant groups. Aim: The aim of this study is to explore the association between acculturation, mental health and treatment effect. Methods: In a longitudinal cohort study of patients treated in specialized mental health facilities, different dimensions of acculturation (skills, social integration, traditions, norms/values and fee...
Abstract
Cited 14 times since 2014 (1.3 per year)
source: EuropePMC
Forensic science international,
Volume 248, 8 2 2014, Pages 101-112
Isotopic and elemental profiling of ammonium nitrate in forensic explosives investigations.
Brust H, Koeberg M, van der Heijden A, Wiarda W, Mügler I, Schrader M, Vivo-Truyols G, Schoenmakers P, van Asten A
Ammonium nitrate (AN) is frequently encountered in explosives in forensic casework. It is widely available as fertilizer and easy to implement in explosive devices, for example by mixing it with a fuel. Forensic profiling methods to determine whether material found on a crime scene and material retrieved from a suspect arise from the same source are becoming increasingly important. In this work, we have explored the possibility of using isotopic and elemental profiling to discriminate between di...
Abstract
Cited 32 times since 2014 (2.9 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 79, 5 1 2014, Pages 244-253
Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction.
Borgdorff MA, Koop AM, Bloks VW, Dickinson MG, Steendijk P, Sillje HH, van Wiechen MP, Berger RM, Bartelds B
Background: Right ventricular failure (RVF) due to pressure load is a major cause of death in congenital heart diseases and pulmonary hypertension. The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF. Methods and results: Wistar rats were subjected to a pulmonary artery banding (PAB n=12) or sham surgery (CON, n=7). After 52±5days, 5/12 PAB rats developed clinical symptoms of RVF...
Abstract
Cited 48 times since 2014 (4.4 per year)
source: Scopus
PloS one,
Volume 9, Issue 12, 4 1 2014, Pages e111952
ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm.
Kortekaas KE, Meijer CA, Hinnen JW, Dalman RL, Xu B, Hamming JF, Lindeman JH
Background: Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential of ACE inhibitors. Methods and results: Eleven patients scheduled for open AAA repair received ramipril (5 mg/day) dur...
Abstract
Cited 44 times since 2014 (4 per year)
source: EuropePMC
PLoS genetics,
Volume 10, Issue 12, 4 1 2014, Pages e1004799
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.
Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, Männistö S, Marques-Vidal P, Kaakinen M, Cavadino A, Postmus I, Husemoen LL, Skaaby T, Ahluwalia TS, Treur JL, Willemsen G, Dale C, Wannamethee SG, Lahti J, Palotie A, Räikkönen K, Kisialiou A, McConnachie A, Padmanabhan S, Wong A, Dalgård C, Paternoster L, Ben-Shlomo Y, Tyrrell J, Horwood J, Fergusson DM, Kennedy MA, Frayling T, Nohr EA, Christiansen L, Ohm Kyvik K, Kuh D, Watt G, Eriksson J, Whincup PH, Vink JM, Boomsma DI, Davey Smith G, Lawlor D, Linneberg A, Ford I, Jukema JW, Power C, Hyppönen E, Jarvelin MR, Preisig M, Borodulin K, Kaprio J, Kivimaki M, Smith BH, Smith BH, Hayward C, Romundstad PR, Sørensen TI, Munafò MR, Sattar N
We previously used a single nucleotide polymorphism (SNP) in the CHRNA5-A3-B4 gene cluster associated with heaviness of smoking within smokers to confirm the causal effect of smoking in reducing body mass index (BMI) in a Mendelian randomisation analysis. While seeking to extend these findings in a larger sample we found that this SNP is associated with 0.74% lower body mass index (BMI) per minor allele in current smokers (95% CI -0.97 to -0.51, P = 2.00 × 10(-10)), but also unexpectedly found t...
Abstract
Cited 50 times since 2014 (4.6 per year)
source: EuropePMC
BMJ open diabetes research & care,
Volume 2, Issue 1, 3 1 2014, Pages e000034
Inflammation increases plasma angiopoietin-like protein 4 in patients with the metabolic syndrome and type 2 diabetes.
Tjeerdema N, Georgiadi A, Jonker JT, van Glabbeek M, Alizadeh Dehnavi R, Tamsma JT, Smit JW, Kersten S, Rensen PC
Background: Angiopoietin-like protein 4 (ANGPTL4) inhibits lipoprotein lipase and associates with dyslipidemia. The expression of ANGPTL4 is regulated by free fatty acids (FFA) that activate lipid-sensing peroxisome proliferator-activated receptors (PPARs), but FFA can also activate pattern recognition receptors including Toll-like receptor 4 (TLR4) in macrophages. Objective: To assess whether systemic low-grade inflammation is a determinant for plasma ANGPTL4 levels in patients with the metabol...
Abstract
Cited 5 times since 2014 (0.5 per year)
source: EuropePMC
International journal of cardiology,
Volume 183, 3 1 2014, Pages 249-257
Abnormal sinoatrial node development resulting from disturbed vascular endothelial growth factor signaling.
Calkoen EE, Vicente-Steijn R, Hahurij ND, van Munsteren CJ, Roest AA, DeRuiter MC, Steendijk P, Schalij MJ, Gittenberger-de Groot AC, Blom NA, Jongbloed MR
Background: Sinus node dysfunction is frequently observed in patients with congenital heart disease (CHD). Variants in the Vascular Endothelial Growth Factor-A (VEGF) pathway are associated with CHD. In Vegf(120/120) mice, over-expressing VEGF120, a reduced sinoatrial node (SAN) volume was suggested. Aim of the study is to assess the effect of VEGF over-expression on SAN development and function. Methods: Heart rate was measured in Vegf(120/120) and wildtype (WT) embryos during high frequency ul...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 6, 1 1 2014, Pages 1245-1251
Multimodality imaging: bird's eye view from The European Society of Cardiology Congress 2014 Barcelona, August 30-September 3, 2014.
Bax JJ, Delgado V, Achenbach S, Sechtem U, Knuuti J
Abstract
Cited 133 times since 2014 (12.1 per year)
source: EuropePMC
Proceedings of the National Academy of Sciences of the United States of America,
Volume 111, Issue 50, 1 1 2014, Pages E5383-92
Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.
Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M
Jervell and Lange-Nielsen syndrome (JLNS) is one of the most severe life-threatening cardiac arrhythmias. Patients display delayed cardiac repolarization, associated high risk of sudden death due to ventricular tachycardia, and congenital bilateral deafness. In contrast to the autosomal dominant forms of long QT syndrome, JLNS is a recessive trait, resulting from homozygous (or compound heterozygous) mutations in KCNQ1 or KCNE1. These genes encode the α and β subunits, respectively, of the ion c...
Abstract
Cited 26 times since 2014 (2.4 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 48, 1 1 2014, Pages 3417-3425
Non-invasive cardiac imaging evaluation of patients with chronic systolic heart failure: a report from the European Association of Cardiovascular Imaging (EACVI).
Gimelli A, Lancellotti P, Badano LP, Lombardi M, Gerber B, Plein S, Neglia D, Edvardsen T, Kitsiou A, Scholte AJ, Schröder S, Cosyns B, Gargiulo P, Zamorano JL, Perrone-Filardi P
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Clinical and experimental immunology,
Volume 178 Suppl 1, 1 1 2014, Pages 1-2
7th International Immunoglobulin Conference: Foreword.
Jolles S, Jordan SC, Orange JS, van Schaik IN
Abstract
Cited 26 times since 2014 (2.4 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 12, 1 1 2014, Pages e113674
Prevalence of rotavirus genotypes in children younger than 5 years of age before the introduction of a universal rotavirus vaccination program: report of rotavirus surveillance in Turkey.
Durmaz R, Kalaycioglu AT, Acar S, Bakkaloglu Z, Karagoz A, Korukluoglu G, Ertek M, Torunoglu MA, Turkish Rotavirus Surveillance Network
Background: Group A rotaviruses are the most common causative agent of acute gastroenteritis among children less than 5 years of age throughout the world. This sentinel surveillance study was aimed to obtain baseline data on the rotavirus G and P genotypes across Turkey before the introduction of a universal rotavirus vaccination program. Methods: Rotavirus antigen-positive samples were collected from 2102 children less than 5 years of age who attended hospitals participating in the Turkish Rota...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Criminal behaviour and mental health : CBMH,
Volume 24, Issue 5, 1 1 2014, Pages 365-367
MAOA, COMT and 5-HTTLPR frequencies in convicted and never convicted Afro-Caribbeans in the Netherlands.
Vinkers DJ, Bogaerts S, Van Schaik RH
Abstract
Cited 44 times since 2014 (4 per year)
source: EuropePMC
Inflammatory bowel diseases,
Volume 20, Issue 12, 1 1 2014, Pages 2292-2298
Influence of combination therapy with immune modulators on anti-TNF trough levels and antibodies in patients with IBD.
van Schaik T, Maljaars JP, Roopram RK, Verwey MH, Ipenburg N, Hardwick JC, Veenendaal RA, van der Meulen-de Jong AE
Background: It is important to identify factors that can reduce the incidence of immunogenicity against anti-tumor necrosis factor medication in patients with inflammatory bowel disease. The objective of our study was to evaluate the influence of cotreatment with immune modulators (IMs) on trough levels (TLs) and antidrug antibodies. Methods: The records of all patients with inflammatory bowel disease at the Leiden University Medical Center who received either adalimumab or infliximab (IFX) in t...
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
Clinical and experimental immunology,
Volume 178 Suppl 1, 1 1 2014, Pages 163-168
Immunoglobulins: current understanding and future directions.
Jolles S, Jordan SC, Orange JS, van Schaik IN
Abstract
Cited 15 times since 2014 (1.4 per year)
source: EuropePMC
Pharmacogenomics,
Volume 15, Issue 16, 1 1 2014, Pages 1963-1972
POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia.
Drogari E, Ragia G, Mollaki V, Elens L, Van Schaik RH, Manolopoulos VG
Background: In children and adolescents with familial hypercholesterolemia (FH) pharmacotherapy with statins is the cornerstone in the current regimen to reduce low-density lipoprotein cholesterol (LDLc) and premature coronary heart disease risk. There is, however, a great interindividual variation in response to therapy, partially attributed to genetic factors. The polymorphic enzyme POR transfers electrons from NADPH to CYP450 enzymes including CYP3A, which metabolize atorvastatin. POR*28 poly...
Abstract
Cited 22 times since 2014 (2 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 87, Issue 2, 29 5 2014, Pages 201-203
Tumor flare after start of RAF inhibition in KRAS mutated NSCLC: a case report.
Mellema WW, Burgers SA, Smit EF
Here we describe a case of striking tumor flare after start of treatment with sorafenib and metformin as part of a phase II clinical trial. Previous reports have described a paradoxal activation of the MAPK pathway after treatment with a weak RAF inhibitor. This mechanism is based on inhibition of a negative feedback loop to upstream effectors of RAF and subsequently increased stimulation of the RAS-RAF-MEK-ERK (MAPK) pathway. We suggest that sorafenib may contribute to tumor progression through...
Abstract
