Research

Publications

Below you can find a list of our published research.

9543 results

Cited 20 times since 2014 (1.8 per year) source: EuropePMC

BMC cardiovascular disorders, Volume 14, 18 3 2014, Pages 87 Scarcity of atrial fibrillation in a traditional African population: a community-based study. Koopman JJ, van Bodegom D, Westendorp RG, Jukema JW

Background: In western societies, atrial fibrillation is an increasingly common finding among the elderly. Established risk factors of atrial fibrillation include obesity, diabetes, hypertension, and cardiovascular disease. Atrial fibrillation has almost exclusively been studied in western populations where these risk factors are widely present. Therefore, we studied the epidemiology of atrial fibrillation in a traditional African community. Methods: In rural Ghana, among 924 individuals aged 50... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Clinical and experimental rheumatology, Volume 32, Issue 6 Suppl 86, 17 3 2014, Pages S-60-7 Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures. Ninaber MK, Hamersma WB, Schouffoer AA, Kovacs G, Olschewski H, Holman ER, Ajmone Marsan N, Stolk J

Objectives: During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates to systolic PAP at rest. Methods: In a prospective design we evaluated V'O₂/HR slopes for breakpoints. To understand its physiologi... Abstract

Cited 132 times since 2014 (11.6 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 17, 17 3 2014, Pages 1373-1381 Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG, ZAHARA-II investigators

Objectives: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. Methods: In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPR... Abstract

Cited 18 times since 2014 (1.6 per year) source: EuropePMC

Journal of the neurological sciences, Volume 345, Issue 1-2, 16 3 2014, Pages 15-25 Muscle and nerve inflammation in intensive care unit-acquired weakness: a systematic translational review. Witteveen E, Wieske L, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Background: Intensive care unit-acquired weakness (ICU-AW) is an important complication of critical illness. The main risk factors, sepsis and the systemic inflammatory response syndrome, suggest an inflammatory pathogenesis. In this systematic translational review we summarize current knowledge on inflammation in muscle and nerve tissue in animal models of ICU-AW and in critically ill patients with ICU-AW. Methods: We conducted a systematic search in the databases of MEDLINE, EMBASE and Web of... Abstract

Cited 87 times since 2014 (7.7 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 7, Issue 8, 16 3 2014, Pages 774-784 CMR-based identification of critical isthmus sites of ischemic and nonischemic ventricular tachycardia. Piers SR, Tao Q, de Riva Silva M, Siebelink HM, Schalij MJ, van der Geest RJ, Zeppenfeld K

Objectives: This study evaluates whether contrast-enhanced (CE) cardiac magnetic resonance (CMR) can be used to identify critical isthmus sites for ventricular tachycardia (VT) in ischemic and nonischemic heart disease. Background: Fibrosis interspersed with viable myocytes may cause re-entrant VT. CE-CMR has the ability to accurately delineate fibrosis. Methods: Patients who underwent VT ablation with CE-CMR integration were included. After the procedure, critical isthmus sites (defined as site... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

PloS one, Volume 9, Issue 7, 16 3 2014, Pages e102433 Development of a lentivirus vector-based assay for non-destructive monitoring of cell fusion activity. Neshati Z, Liu J, Zhou G, Schalij MJ, de Vries AA

Cell-to-cell fusion can be quantified by endowing acceptor and donor cells with latent reporter genes/proteins and activators of these genes/proteins, respectively. One way to accomplish this goal is by using a bipartite lentivirus vector (LV)-based cell fusion assay system in which the cellular fusion partners are transduced with a flippase-activatable Photinus pyralis luciferase (PpLuc) expression unit (acceptor cells) or with a recombinant gene encoding FLPeNLS+, a nuclear-targeted and molecu... Abstract

Cited 457 times since 2014 (40.2 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 349, 10 2 2014, Pages g4164 Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A, Trompet S, Wong A, Cavadino A, Drogan D, Padmanabhan S, Li S, Yesupriya A, Leusink M, Sundstrom J, Hubacek JA, Pikhart H, Swerdlow DI, Panayiotou AG, Borinskaya SA, Finan C, Shah S, Kuchenbaecker KB, Shah T, Engmann J, Folkersen L, Eriksson P, Ricceri F, Melander O, Sacerdote C, Gamble DM, Rayaprolu S, Ross OA, McLachlan S, Vikhireva O, Sluijs I, Scott RA, Adamkova V, Flicker L, Bockxmeer FM, Power C, Marques-Vidal P, Meade T, Marmot MG, Ferro JM, Paulos-Pinheiro S, Humphries SE, Talmud PJ, Mateo Leach I, Verweij N, Linneberg A, Skaaby T, Doevendans PA, Cramer MJ, van der Harst P, Klungel OH, Dowling NF, Dominiczak AF, Kumari M, Nicolaides AN, Weikert C, Boeing H, Ebrahim S, Gaunt TR, Price JF, Lannfelt L, Peasey A, Kubinova R, Pajak A, Malyutina S, Voevoda MI, Tamosiunas A, Maitland-van der Zee AH, Norman PE, Hankey GJ, Bergmann MM, Hofman A, Franco OH, Cooper J, Palmen J, Spiering W, de Jong PA, Kuh D, Hardy R, Uitterlind

Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odd... Abstract

Cited 15 times since 2014 (1.3 per year) source: EuropePMC

Annals of neurology, Volume 76, Issue 2, 9 2 2014, Pages 213-222 N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk. Wijsman LW, Sabayan B, van Vliet P, Trompet S, de Ruijter W, Poortvliet RK, van Peet PG, Gussekloo J, Jukema JW, Stott DJ, Sattar N, Ford I, Westendorp RG, de Craen AJ, Mooijaart SP

Objective: Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with cognitive impairment, which might be explained by cardiovascular diseases or risk factors. The aim of this study was to investigate the association of NT-proBNP with cognitive function and decline in older adults at high risk of cardiovascular disease. Methods: We studied 5,205 men and women (mean age = 75 years) who were recruited into the PROspective Study of Pravastatin in the Elderly at Ris... Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Neuro-oncology, Volume 17, Issue 1, 3 1 2014, Pages 145-150 A prospective open-label study of sirolimus for the treatment of anti-Hu associated paraneoplastic neurological syndromes. de Jongste AH, van Gelder T, Bromberg JE, de Graaf MT, Gratama JW, Schreurs MW, Hooijkaas H, Sillevis Smitt PA

Background: Several lines of evidence suggest a T cell-mediated immune response in paraneoplastic neurological syndromes with anti-Hu antibodies (Hu-PNS). In order to investigate whether suppression of T cell-mediated immune responses in Hu-PNS patients improved their neurological outcome, we performed a prospective open-label, single-arm study on sirolimus. Methods: Seventeen progressive Hu-PNS patients were treated with sirolimus with an intended treatment duration of 8 weeks. Primary outcome... Abstract

Cited 12 times since 2014 (1.1 per year) source: EuropePMC

Research in veterinary science, Volume 97, Issue 2, 2 1 2014, Pages 226-229 Associations between the decrease in bovine clinical mastitis and changes in dairy farmers' attitude, knowledge, and behavior in the Netherlands. van den Borne BH, Jansen J, Lam TJ, van Schaik G

The aim of this study was to associate changes in dairy farmers' self-reported attitude, knowledge, and behavior with the decrease in incidence rate of clinical mastitis (IRCM). Farmer-diagnosed clinical mastitis cases were obtained from two surveys conducted before (July 2004-June 2005) and at the end (2009) of a mastitis control program in the Netherlands. Information on farmers' attitude, knowledge, and behavior was also obtained by sending the farmers the same questionnaire during... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

International journal of cardiology, Volume 175, Issue 3, 2 1 2014, Pages 539-544 Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. Rodrigo SF, van Ramshorst J, Mann I, Leong DP, Cannegieter SC, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Bax JJ, Schalij MJ, Beeres SL, Atsma DE

Background: We previously showed that intramyocardial bone marrow cell (BMC) injection in patients with refractory angina and chronic myocardial ischemia improves myocardial perfusion, cardiac function and disease-related complaints. Treatment effect varied between patients, but the predictors of response remain to be identified. Therefore, the aim of the present study was to assess whether patient characteristics, procedural data and baseline measurements influence the response to intramyocardi... Abstract

Cited 23 times since 2014 (2 per year) source: EuropePMC

Asian journal of andrology, Volume 16, Issue 4, 1 1 2014, Pages 607-610 The 5-HT2C receptor gene Cys23Ser polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation. Janssen PK, Schaik Rv, Olivier B, Waldinger MD

It has been postulated that the persistent short intravaginal ejaculation latency time (IELT) of men with lifelong premature ejaculation (LPE) is related to 5-hydroxytryptamine (HT)2C receptor functioning. The aim of this study was to investigate the relationship of Cys23Ser 5-HT2C receptor gene polymorphism and the duration of IELT in men with LPE. Therefore, a prospective study was conducted in 64 Dutch Caucasian men with LPE. Baseline IELT during coitus was assessed by stopwatch over a 1-mont... Abstract

Cited 26 times since 2014 (2.3 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 10, 1 1 2014, Pages 1287-1295 Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. Matic M, Simons SH, van Lingen RA, van Rosmalen J, Elens L, de Wildt SN, Tibboel D, van Schaik RH

Aim: Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. Materials & methods: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who received placebo infusion and for whom need and dose for rescue morphine was documented. Results: For OPRM1 and COMT separately, the ex... Abstract

Cited 5 times since 2014 (0.4 per year) source: EuropePMC

The Turkish journal of pediatrics, Volume 56, Issue 4, 1 1 2014, Pages 458-461 Development of end-stage renal disease at a young age in two cases with Joubert syndrome. Sönmez F, Güzünler-Şen M, Yılmaz D, Cömertpay G, Heise M, Çırak S, Uyanık G

Joubert syndrome (JS) is an autosomal recessive genetic disorder. To date, mutations in 20 genes of the genetically heterogeneous JS and JS-related disorders (JSRD) have been reported. Renal involvement occurs in 2-20% of JS cases. Identified renal abnormalities are cystic dysplasia and nephronophthisis. Here we report the clinical course and management of renal failure in early childhood. We present two cases diagnosed with JS that developed end-stage renal disease at young ages. In the genetic... Abstract

Cited 15 times since 2014 (1.3 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 10, Issue 3, 1 1 2014, Pages 364-371 Geometry of left atrial appendage assessed with multidetector-row computed tomography: implications for transcatheter closure devices. van Rosendael PJ, Katsanos S, van den Brink OW, Scholte AJ, Trines SA, Bax JJ, Schalij MJ, Marsan NA, Delgado V

Aims: To assess the left atrial appendage (LAA) geometry with multidetector-row computed tomography (MDCT) and its implications for selection of closure devices. Methods and results: One hundred and ninety-seven patients who underwent MDCT prior to catheter ablation for atrial fibrillation were evaluated. Feasibility for Watchman and Amplatzer Cardiac Plug (ACP) devices was assessed based on the maximal cross-sectional diameter and perimeter of the ostium and at 10 mm depth and on the LAA diamet... Abstract

Cited 51 times since 2014 (4.5 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 18, Issue 8, 1 1 2014, Pages 1509-1518 Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes. Dambrot C, Braam SR, Tertoolen LG, Birket M, Atsma DE, Mummery CL

It has been known for over 20 years that foetal calf serum can induce hypertrophy in cultured cardiomyocytes but this is rarely considered when examining cardiomyocytes derived from pluripotent stem cells (PSC). Here, we determined how serum affected cardiomyocytes from human embryonic- (hESC) and induced pluripotent stem cells (hiPSC) and hiPSC from patients with hypertrophic cardiomyopathy linked to a mutation in the MYBPC3 gene. We first confirmed previously published hypertrophic effects of... Abstract

Michigan medicine, Volume 113, Issue 4, 1 1 2014, Pages 12-13 Voice of medicine heard in state budget process. Schepers AR

Abstract

Cited 18 times since 2014 (1.6 per year) source: EuropePMC

World journal of surgery, Volume 38, Issue 7, 1 1 2014, Pages 1713-1718 Incidence and epidemiology of casualties treated at the Dutch role 2 enhanced medical treatment facility at multi national base Tarin Kowt, Afghanistan in the period 2006-2010. Hoencamp R, Idenburg FJ, Hamming JF, Tan EC

Background: To improve care for the injured service member, we have analyzed battle casualty patterns and mechanisms. This study is the first documented report of wounding patterns and mechanisms of battle casualties treated at the Dutch role 2 enhanced medical treatment facility at the multi-national base Tarin Kowt, Uruzgan, Afghanistan. Methods: Participants were selected from the trauma registry at the Dutch role 2 enhanced medical treatment facility if they fitted the criteria 'battle... Abstract

Cited 514 times since 2014 (45.1 per year) source: EuropePMC

Nature genetics, Volume 46, Issue 8, 29 5 2014, Pages 818-825 Whole-genome sequence variation, population structure and demographic history of the Dutch population. Genome of the Netherlands Consortium

Whole-genome sequencing enables complete characterization of genetic variation, but geographic clustering of rare alleles demands many diverse populations be studied. Here we describe the Genome of the Netherlands (GoNL) Project, in which we sequenced the whole genomes of 250 Dutch parent-offspring families and constructed a haplotype map of 20.4 million single-nucleotide variants and 1.2 million insertions and deletions. The intermediate coverage (∼13×) and trio design enabled extensive charact... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 1, 28 4 2014, Pages 40-47 Beneficial effect of high dose statins on the vascular wall in patients with repaired aortic coarctation? Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Konings TC, Stroes ES, Zwinderman AH, Mulder BJ

Background: Carotid intima-media thickness (CIMT) is a marker for atherosclerosis. Adult post-coarctectomy patients (CoA) demonstrate an increased cardiovascular risk and increased CIMT compared to controls. This study evaluates the effect of high dose statins on the change in CIMT and cardiovascular risk. Methods: We designed a multicenter, prospective, randomized, open label trial with blinded endpoint (PROBE design) to evaluate the effect of three year treatment with atorvastatin 80 mg on CIM... Abstract