Research

Publications

Below you can find a list of our published research.

7365 results

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2 1 2025 Development and Validation of a Prognostic Model for Persistent Hypoparathyroidism After Total or Completion Thyroidectomy. van Dijk SPJ, Maas CCHM, Alshangi A, van Driel MHE, Feitsma EA, van Kinschot CMJ, Lončar I, van Noord C, Koppert LB, Kruijff S, van Klaveren D, Verhoef C, Peeters RP, van Ginhoven TM, Hypoparathyroidism Study Group of the Thyroid Network

Background: The aim of this study was to develop and validate a clinical prediction model to predict the occurrence of persistent hypoparathyroidism after total or completion thyroidectomy. Methods: This multicentre retrospective cohort study included patients who underwent total or completion thyroidectomy between January 2010 and June 2021 in 12 Dutch hospitals. Results: Of the 366 patients included, 44 (12.0%) patients developed persistent hypoparathyroidism in the first year follow-up after... Abstract

Microbial genomics, Volume 11, Issue 10, 1 1 2025 The Kocurious case of Noodlococcus: genomic insights into Kocuria rhizophila from characterisation of a laboratory contaminant. McCallum GE, Ho SFS, Cummins EA, Wildsmith AJ, McInnes RS, Weigel C, Tong LYS, Quick J, van Schaik W, Moran RA

The laboratory contaminant strain Noodlococcus was named for its coccoid cells and unusual colony morphology, which resembled a pile of noodles. Along with laboratory characterisation and electron microscopy, we generated a complete Noodlococcus genome sequence using Illumina and Oxford Nanopore data. The genome consisted of a single, circular, 2,732,108 bp chromosome that shared 97.5% average nucleotide identity (ANI) with the Kocuria rhizophila type strain TA68. We identified genomic features... Abstract

The New England journal of medicine, Volume 393, Issue 17, 1 1 2025, Pages 1669-1680 European Study of Prostate Cancer Screening - 23-Year Follow-up. Roobol MJ, de Vos II, Månsson M, Godtman RA, Talala KM, den Hond E, Nelen V, Villers A, Poinas G, Kwiatkowski M, Wyler S, Recker F, Puliti D, Gorini G, Zappa M, Paez A, Lujan M, Bangma CH, Tammela T, Schröder FH, Remmers S, Hugosson J, Auvinen A, ERSPC Investigators

Background: The European Randomized Study of Screening for Prostate Cancer (ERSPC) was initiated in 1993 to assess the effect of prostate-specific antigen (PSA) testing on prostate cancer mortality. Because deaths from prostate cancer are expected to rise worldwide owing to increased life expectancy and population growth, a final analysis of the long-term outcomes of prostate cancer screening is essential to understanding the benefits and harms of PSA testing. Methods: We updated the findings fr... Abstract

Global change biology, Volume 31, Issue 10, 1 1 2025, Pages e70531 One Species Hibernates Shorter, the Other Longer: Rapid but Opposing Responses to Warming Climate in Two Sympatric Bat Species. Krivek G, Meier F, Grosche L, Kerth G, van Schaik J

The timing of hibernation represents a key seasonal transition in the annual cycle of hibernators, directly impacting their survival and reproductive success. Ongoing climate change affects many of the factors that influence hibernation phenology, such as weather patterns, food availability and the timing of mating and reproduction. The extent to which individuals should adjust their hibernation phenology in response is likely to vary between species, sexes and age classes. Consequently, long-te... Abstract

Frontiers in digital health, Volume 7, 1 1 2025, Pages 1528860 Content evaluation of the inclusive eHealth guide: how to develop interventions for people with a lower socioeconomic position? Al-Dhahir I, Breeman LD, Faber JS, Wentzel J, van den Berg-Emons RJG, Kraal JJ, Janssen VR, Kraaijenhagen RA, Visch VT, Chavannes NH, Evers AWM

Objectives: eHealth interventions favor those with higher socio-economic positions (SEPs). This can widen disparities, as people with lower SEPs may lack resources and face digital or financial barriers, making tailored solutions necessary. This study evaluates professionals' perceptions of the Inclusive eHealth Guide (IeG) regarding its content. The aim was to ensure it meets the needs of professionals and the targeted lower SEP demographic, thereby enhancing the effectiveness of eHealth i... Abstract

Therapeutic advances in medical oncology, Volume 17, 1 1 2025, Pages 17588359251379665 Predicting response and survival to first-line treatment with baseline [18F]FDG-PET-CT in patients with small-cell lung cancer: an integrated diagnostic approach. Ventura D, Schindler P, Kies P, Bleckmann A, Mohr M, Lenz G, Schäfers M, Roll W, Evers G

Background: Small-cell lung cancer (SCLC) is a highly malignant disease with a propensity for early progression and high mortality. The prognostic value of treatment response and survival has been verified for solely established imaging, clinical, and biochemical markers. There is a lack of evidence for the combination of those parameters with machine learning and integrated models, particularly in the context of molecular imaging. Objectives: The aim of this study was to predict early disease p... Abstract

Cited 9 times since 2025 (72.2 per year) source: EuropePMC

European heart journal, Volume 46, Issue 40, 1 1 2025, Pages 3952-4041 2025 ESC Guidelines for the management of myocarditis and pericarditis. Schulz-Menger J, Collini V, Gröschel J, Adler Y, Brucato A, Christian V, Ferreira VM, Gandjbakhch E, Heidecker B, Kerneis M, Klein AL, Klingel K, Lazaros G, Lorusso R, Nesukay EG, Rahimi K, Ristić AD, Rucinski M, Sade LE, Schaubroeck H, Semb AG, Sinagra G, Thune JJ, Imazio M, ESC Scientific Document Group

Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 11, 1 1 2025, Pages euaf214 Prediction of ventricular arrhythmias and sudden cardiac death by quantification and location of late gadolinium enhancement on cardiac magnetic resonance: a systematic review and meta-analysis. Jensen TN, Omara S, Nielsen JC, Samuel M, van der Geest RJ, Kim WY, Zeppenfeld K

Aims: In non-ischaemic cardiomyopathy (NICM), late gadolinium enhancement (LGE) detected by cardiovascular magnetic resonance is related to ventricular arrhythmia (VA) and sudden cardiac death (SCD) risk. The incremental prognostic value of quantifying LGE volume or mass beyond its mere presence, however, remains unresolved. The aim was to evaluate whether LGE quantification improves the prediction of SCD. Methods and results: PubMed, Embase, and Web of Science were searched on 20 November 2024... Abstract

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 27, Issue 10, 1 1 2025, Pages euaf240 Evolution of implantable cardioverter-defibrillator shock therapy in children in the era of optimized ICD programming and remote monitoring. Bertels RA, Boersma E, Zeggelaar MD, van Dongen SAF, Ten Harkel ADJ, van Erven L, Smeding C, Bartelds B, van den Berg G, Boesaard EP, Bhagwandien RE, Yap SC, Knops RE, Blom NA, Kammeraad JAE

Aims: Implantable cardioverter defibrillator (ICD) therapy is effective in preventing sudden cardiac death in children. Unnecessary shocks should be avoided. ICD programming strategies and remote monitoring have been proven to be effective in preventing ICD shock therapy in adults; the present study evaluates the effectiveness in children. Methods and results: Retrospective multi-centre study, including children with transvenous or epicardial ICD implantation. During follow-up data on ICD shocks... Abstract

Interdisciplinary cardiovascular and thoracic surgery, 30 5 2025, Pages ivaf231 A European survey on non-technical skills in robotic thoracic surgery for lung resections. Shahin GMM, Verhagen MJ, Hutteman M, Wink J, Stamenkovic SA, Durand M, Baste JM, Melfi F, Braun J

Objectives: In robotic surgery, interaction between team-members differs from that in open surgery, which impacts the team-members' tasks and responsibilities. Training for robot-assisted thoracic surgery (RATS) is primarily focused on technical skills. However, non-technical skills (NOTECHS) are equally important for safe and high-quality surgery. There is debate whether NOTECHS require adjustments to meet specific needs of RATS. The aim of this study is to evaluate how NOTECHS-domains are... Abstract

BJA open, Volume 16, 29 5 2025, Pages 100485 The association between postoperative myocardial injury of unexplained aetiology after noncardiac surgery and sex and cancer on 1-yr survival: a retrospective, single-centre, observational cohort study. van Schaik EPC, Vernooij LM, Haddou Y, Grobben RB, van Klei WA, van Waes JAR

Background: The aetiology of postoperative myocardial injury (PMI) is often unexplained, and the effect of sex and cancer surgery on prognosis in patients with PMI is unknown. We aimed to estimate the proportion of patients developing PMI of unknown aetiology and compare their prognosis with those with explained PMI, and to investigate the interaction with sex and cancer surgery. Methods: This retrospective, single-centre, observational cohort study included patients aged ≥60 yr undergoing nonca... Abstract

Scientific reports, Volume 15, Issue 1, 26 4 2025, Pages 33000 Green synthesis of antimicrobial alginate/hydroxyethyl cellulose hydrogels crosslinked by Ca2+ and dual Ca2+/Mg2. Jahir Hussain FS, Ghosh S, Al Saadi HSO, Al-Sibani M, Al Amri IS, Al Harrasi A, Al Abri AM, Al-Hinai A, Al-Housni SK, Al-Hatmi AMS

Eco-friendly antimicrobial hydrogels derived from carbohydrate polymers are receiving significant attention for their sustainable and cost-effective properties. This study focuses on developing antimicrobial hydrogels based on alginate and hydroxyethyl cellulose (SA/HEC) using a green chemistry approach. The impact of bivalent metal ions on cross-linking efficiency and the hydrogels' physicochemical properties were analyzed, with hydrogels produced in various forms, such as beads, sponges,... Abstract

PLoS pathogens, Volume 21, Issue 9, 26 4 2025, Pages e1013535 Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Khan I, MacDonald SJ, Markússon S, Kies PJ, Kraemer-Zimpel C, Robson C, Parker JL, Newstead S, Boucher D, Hammer ND, Van Der Woude M, Thomas GH

Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of peptides by S. aureus involves at least two transport systems: the di/tripeptide permease DtpT and the oligopeptide ABC transporter Opp3. Here we study the individual and combined functions of DtpT and Opp3 in enabling utilisation of diverse di-/tripeptides via a high-throughput phenotypic screen. We re... Abstract

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 11, 25 4 2025, Pages 2111-2123 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Journal of vascular surgery, 24 4 2025, Pages S0741-5214(25)01771-9 Five-year outcomes of the IceBERG study, an international, prospective, multicenter registry on the GORE EXCLUDER Iliac Branch Endoprosthesis for aortoiliac aneurysms. van der Veen D, Holewijn S, Bellosta R, Attisani L, van Sterkenburg SMM, Heyligers JMM, Ficarelli I, Gómez Palonés FJ, Mangialardi N, Mosquera NJ, Holden A, Reijnen MMPJ, IceBERG Study collaboration

Objective: This study aimed to provide insight in the long-term outcomes of patients treated with the GORE EXCLUDER Iliac Branch Endoprosthesis (IBE) for aneurysms involving the common iliac artery. Technical, clinical, and patient-reported outcomes were evaluated. Methods: This is an investigator-initiated, international, real-world, postmarket, multicenter, prospective cohort study, enrolling patients with an indication for elective treatment of an (aorto)iliac aneurysm using the GORE EXCLUDER... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

The Canadian journal of cardiology, 23 4 2025, Pages S0828-282X(25)01178-X New Cardiovascular Damage Staging Classification for Chronic Significant Aortic Regurgitation. Bergeron A, Lopez Santi P, Bernard J, Hecht S, Fleury MA, Jacob S, Marchand C, Clavel MA, Côté N, Bax JJ, Marsan NA, Pibarot P

Background: Current recommendations for management of chronic aortic regurgitation (AR) are based on AR severity, symptoms and repercussions on the left ventricle (LV), only providing modest risk stratification value in patients with AR. The objective was to assess the prognostic value of a new staging classification characterizing the extent of cardiovascular damage for risk stratification in patients with chronic AR. Methods: According to cardiovascular damages at echocardiography, 619 patient... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract

Clinical oral investigations, Volume 29, Issue 10, 20 3 2025, Pages 468 The effect of dry mouth on the pressure/pain sensitivity of the oral mucosa of patients using mandibular implant-supported overdenture prosthesis. Eraslan R, Kılıç D, Bayyıldız S, Yılmaz DD, Sert H

Abstract

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 32618 (Cardiac) complexity needs interaction. De Coster T

The heart exemplifies a complex system where electrical, mechanical, and biochemical processes interact dynamically. Understanding cardiac complexity requires exploring these interactions across multiple levels, from cellular dynamics to organ-wide behavior. This collection examines key interactions in cardiology, including excitation-contraction coupling, arrhythmia quantification, electromechanical modeling, and imaging advances. By integrating mathematical, computational, and clinical perspec... Abstract