Research

Publications

Below you can find a list of our published research.

9618 results

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 6 Suppl G, 1 1 2010, Pages G28-37 Non-invasive imaging in percutaneous mitral valve procedures. Marsan NA, Bax JJ

Novel percutaneous techniques for the treatment of mitral valve (MV) disease have recently been developed and provide an alternative to surgery in patients with high operative risk. However, the complexity of MV anatomy and the variety of mitral regurgitation mechanisms require sophisticated procedures and accurate patient selection. Non-invasive imaging (echocardiography, multislice computed tomography) provides crucial anatomical details and exact characterisation of the mechanism underlying m... Abstract

Cited 18 times since 2010 (1.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 9, 1 1 2010, Pages 661 Edwards SAPIEN transcatheter heart valve in native pulmonary valve position. Bertels RA, Blom NA, Schalij MJ

Abstract

Cited 541 times since 2010 (35.3 per year) source: EuropePMC

The New England journal of medicine, Volume 362, Issue 20, 1 1 2010, Pages 1881-1889 Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. De Bruin JL, Baas AF, Buth J, Prinssen M, Verhoeven EL, Cuypers PW, van Sambeek MR, Balm R, Grobbee DE, Blankensteijn JD, DREAM Study Group

Background: For patients with large abdominal aortic aneurysms, randomized trials have shown an initial overall survival benefit for elective endovascular repair over conventional open repair. This survival difference, however, was no longer significant in the second year after the procedure. Information regarding the comparative outcome more than 2 years after surgery is important for clinical decision making. Methods: We conducted a long-term, multicenter, randomized, controlled trial comparin... Abstract

Cited 48 times since 2010 (3.1 per year) source: EuropePMC

Journal of innate immunity, Volume 2, Issue 4, 30 5 2010, Pages 307-315 Endogenous inflammatory molecules engage Toll-like receptors in cardiovascular disease. Ionita MG, Arslan F, de Kleijn DP, Pasterkamp G

Innate immunity is important in the pathogenesis and progression of cardiovascular disease. Innate immune cells express various pattern-recognition receptors, among which also Toll-like receptors (TLRs). TLRs occur in atherosclerotic lesions where they are triggered by both exogenous (bacterial and viral pathogens) and endogenous (tissue damage-associated) molecules. Several endogenous TLR activators are described in relation to atherosclerotic disease or ischemia-induced cardiac injury. Experim... Abstract

Cited 45 times since 2010 (2.9 per year) source: EuropePMC

Clinical journal of the American Society of Nephrology : CJASN, Volume 5, Issue 7, 29 5 2010, Pages 1198-1204 Temporary perioperative decline of renal function is an independent predictor for chronic kidney disease. van Kuijk JP, Flu WJ, Chonchol M, Hoeks SE, Winkel TA, Verhagen HJ, Bax JJ, Poldermans D

Background and objectives: Acute kidney injury is an independent predictor of short- and long-term survival; however, data on the relationship between reversible transitory decline of kidney function and chronic kidney disease (CKD) are lacking. We assessed the prognostic value of temporary renal function decline on the development of long-term CKD. Design, setting, participants, & measurements: The study included 1308 patients who were undergoing major vascular surgery (aortic aneurysm repa... Abstract

Cited 165 times since 2010 (10.8 per year) source: EuropePMC

Neurology, Volume 74, Issue 21, 28 4 2010, Pages 1680-1686 Distinguishing acute-onset CIDP from fluctuating Guillain-Barre syndrome: a prospective study. Ruts L, Drenthen J, Jacobs BC, van Doorn PA, Dutch GBS Study Group

Objective: The aim of the study was to provide criteria that can help to distinguish between GBS-TRF and A-CIDP in the early phase of disease. Background: The distinction between Guillain-Barré syndrome (GBS) with fluctuations shortly after start of treatment (treatment-related fluctuations, or GBS-TRF) and chronic inflammatory demyelinating polyneuropathy with acute onset (A-CIDP) is difficult but important because prognosis and treatment strategy largely differ. Methods: Patients with GBS (n =... Abstract

Cited 10 times since 2010 (0.7 per year) source: EuropePMC

European journal of neurology, Volume 17, Issue 8, 27 4 2010, Pages 1098-1104 Age-related changes in motor unit number estimates in adult patients with Charcot-Marie-Tooth type 1A. van Dijk JP, Verhamme C, van Schaik IN, Schelhaas HJ, Mans E, Bour LJ, Stegeman DF, Zwarts MJ

Background: Charcot-Marie-Tooth disease type 1A (CMT1A) is known as a demyelinating hereditary neuropathy. Secondary axonal dysfunction is the most important determinant of disease severity. In adult patients, clinical progression may be because of further axonal deterioration as was shown with compound muscle action potential (CMAP) amplitude reductions over time. The motor unit number estimation (MUNE) technique may be more accurate to determine the number of axons as it is not disturbed by th... Abstract

Cited 137 times since 2010 (8.9 per year) source: EuropePMC

European heart journal, Volume 31, Issue 13, 27 4 2010, Pages 1640-1647 Prognostic importance of strain and strain rate after acute myocardial infarction. Antoni ML, Mollema SA, Delgado V, Atary JZ, Borleffs CJ, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Aims: Recently, strain and strain rate have been introduced as novel parameters reflecting left ventricular (LV) function. The purpose of the current study was to assess the prognostic importance of strain and strain rate after acute myocardial infarction (AMI). Methods and results: A total of 659 patients after AMI were evaluated. Baseline echocardiography was performed to assess LV function with traditional parameters and strain and strain rate. During follow-up, 51 patients (8%) reached the p... Abstract

Cited 56 times since 2010 (3.7 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 33, Issue 8, 27 4 2010, Pages 1013-1019 Recurrent implantable cardioverter-defibrillator replacement is associated with an increasing risk of pocket-related complications. Borleffs CJ, Thijssen J, de Bie MK, van Rees JB, van Welsenes GH, van Erven L, Bax JJ, Cannegieter SC, Schalij MJ

Background: Despite beneficial effects of implantable cardioverter-defibrillator (ICD) therapy, limited service life results in replacement within the majority of patients. Data concerning the effect of replacement procedures on the occurrence of pocket-related adverse events are scarce. In this study, the requirement for pocket-related surgical re-interventions following ICD treatment and the effect of device replacement were evaluated. Methods: From 1992 to 2008, 2,415 patients receiving an IC... Abstract

Cited 84 times since 2010 (5.5 per year) source: EuropePMC

Molecular and cellular biology, Volume 30, Issue 13, 26 4 2010, Pages 3286-3298 PHF8 targets histone methylation and RNA polymerase II to activate transcription. Fortschegger K, de Graaf P, Outchkourov NS, van Schaik FM, Timmers HT, Shiekhattar R

Mutations in PHF8 are associated with X-linked mental retardation and cleft lip/cleft palate. PHF8 contains a plant homeodomain (PHD) in its N terminus and is a member of a family of JmjC domain-containing proteins. While PHDs can act as methyl lysine recognition motifs, JmjC domains can catalyze lysine demethylation. Here, we show that PHF8 is a histone demethylase that removes repressive histone H3 dimethyl lysine 9 marks. Our biochemical analysis revealed specific association of the PHF8 PHD... Abstract

Cited 34 times since 2010 (2.2 per year) source: EuropePMC

Journal of electrocardiology, Volume 43, Issue 4, 24 4 2010, Pages 294-301 The spatial QRS-T angle in the Frank vectorcardiogram: accuracy of estimates derived from the 12-lead electrocardiogram. Schreurs CA, Algra AM, Man SC, Cannegieter SC, van der Wall EE, Schalij MJ, Kors JA, Swenne CA

Background and purpose: The spatial QRS-T angle (SA), a predictor of sudden cardiac death, is a vectorcardiographic variable. Gold standard vertorcardiograms (VCGs) are recorded by using the Frank electrode positions. However, with the commonly available 12-lead ECG, VCGs must be synthesized by matrix multiplication (inverse Dower matrix/Kors matrix). Alternatively, Rautaharju proposed a method to calculate SA directly from the 12-lead ECG. Neither spatial angles computed by using the inverse Do... Abstract

Cited 25 times since 2010 (1.6 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 30, Issue 8, 22 4 2010, Pages 1591-1597 6-mercaptopurine inhibits atherosclerosis in apolipoprotein e*3-leiden transgenic mice through atheroprotective actions on monocytes and macrophages. Pols TW, Bonta PI, Pires NM, Otermin I, Vos M, de Vries MR, van Eijk M, Roelofsen J, Havekes LM, Quax PH, van Kuilenburg AB, de Waard V, Pannekoek H, de Vries CJ

Objective: 6-Mercaptopurine (6-MP), the active metabolite of the immunosuppressive prodrug azathioprine, is commonly used in autoimmune diseases and transplant recipients, who are at high risk for cardiovascular disease. Here, we aimed to gain knowledge on the action of 6-MP in atherosclerosis, with a focus on monocytes and macrophages. Methods and results: We demonstrate that 6-MP induces apoptosis of THP-1 monocytes, involving decreased expression of the intrinsic antiapoptotic factors B-cell... Abstract

Cited 24 times since 2010 (1.6 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 37, Issue 9, 22 4 2010, Pages 1698-1705 Cardiac autonomic neuropathy in patients with diabetes and no symptoms of coronary artery disease: comparison of 123I-metaiodobenzylguanidine myocardial scintigraphy and heart rate variability. Scholte AJ, Schuijf JD, Delgado V, Kok JA, Bus MT, Maan AC, Stokkel MP, Kharagitsingh AV, Dibbets-Schneider P, van der Wall EE, Bax JJ

Purpose: The purpose of this study was to evaluate the prevalence of cardiac autonomic neuropathy (CAN) in a cohort of patients with type 2 diabetes, truly asymptomatic for coronary artery disease (CAD), using heart rate variability (HRV) and (123)I-metaiodobenzylguanidine ((123)I-mIBG) myocardial scintigraphy. Methods: The study group comprised 88 patients with type 2 diabetes prospectively recruited from an outpatient diabetes clinic. In all patients myocardial perfusion scintigraphy, CAN by H... Abstract

Cited 104 times since 2010 (6.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 96, Issue 11, 20 3 2010, Pages 872-878 The emerging burden of hospital admissions of adults with congenital heart disease. Verheugt CL, Uiterwaal CS, van der Velde ET, Meijboom FJ, Pieper PG, Sieswerda GT, Plokker HW, Grobbee DE, Mulder BJ

Objective: To assess the extent and the characteristics of hospital admissions in registered adult patients with congenital heart disease. Design: Observational cohort study. Setting: The Netherlands. Patients: 5798 adult patients with congenital heart disease from the Dutch CONCOR national registry linked to the Dutch National Medical Registration (Prismant). Main outcome measures: All hospital admissions from the years 2001 up until 2006. Results: During 28 990 patient-years, 2908 patients (50... Abstract

Cited 53 times since 2010 (3.5 per year) source: EuropePMC

Circulation, Volume 121, Issue 17, 19 3 2010, Pages 1887-1895 Early reperfusion during acute myocardial infarction affects ventricular tachycardia characteristics and the chronic electroanatomic and histological substrate. Wijnmaalen AP, Schalij MJ, von der Thüsen JH, Klautz RJ, Zeppenfeld K

Background: Reperfusion therapy during acute myocardial infarction results in myocardial salvage and improved ventricular function but may also influence the arrhythmogenic substrate for ventricular tachycardia (VT). This study used electroanatomic mapping and infarct histology to assess the impact of reperfusion on the substrate and on VT characteristics late after acute myocardial infarction. Methods and results: The study population consisted of 36 patients (32 men; age, 63+/-15 years) referr... Abstract

Cited 296 times since 2010 (19.3 per year) source: EuropePMC

Circulation, Volume 121, Issue 17, 19 3 2010, Pages 1941-1950 Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study. Hellings WE, Peeters W, Moll FL, Piers SR, van Setten J, Van der Spek PJ, de Vries JP, Seldenrijk KA, De Bruin PC, Vink A, Velema E, de Kleijn DP, Pasterkamp G

Background: Identification of patients at risk for primary and secondary manifestations of atherosclerotic disease progression is based mainly on established risk factors. The atherosclerotic plaque composition is thought to be an important determinant of acute cardiovascular events, but no prospective studies have been performed. The objective of the present study was to investigate whether atherosclerotic plaque composition is associated with the occurrence of future vascular events. Methods a... Abstract

Cited 148 times since 2010 (9.6 per year) source: EuropePMC

BMC genomics, Volume 11, 14 2 2010, Pages 239 Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island. van Schaik W, Top J, Riley DR, Boekhorst J, Vrijenhoek JE, Schapendonk CM, Hendrickx AP, Nijman IJ, Bonten MJ, Tettelin H, Willems RJ

Background: The Gram-positive bacterium Enterococcus faecium is an important cause of nosocomial infections in immunocompromized patients. Results: We present a pyrosequencing-based comparative genome analysis of seven E. faecium strains that were isolated from various sources. In the genomes of clinical isolates several antibiotic resistance genes were identified, including the vanA transposon that confers resistance to vancomycin in two strains. A functional comparison between E. faecium and t... Abstract

Cited 21 times since 2010 (1.4 per year) source: EuropePMC

Leukemia research, Volume 34, Issue 10, 14 2 2010, Pages 1275-1281 DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, Arinç E

It is now well established that genetic polymorphisms impairing the DNA repair capacity can disrupt the genomic integrity and potentially modulate individual's susceptibility to various cancers. In this study, we investigated the possible association of X-ray repair cross-complimenting group 1 (XRCC1) Arg399Gln and Arg194Trp variants with the risk of incidence of childhood acute lymphoblastic leukemia (ALL) in Turkish population comprised of 190 healthy controls and 167 ALL patients. For Ar... Abstract

Cited 218 times since 2010 (14.2 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 24, Issue 9, 12 2 2010, Pages 3135-3144 Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. Talens RP, Boomsma DI, Tobi EW, Kremer D, Jukema JW, Willemsen G, Putter H, Slagboom PE, Heijmans BT

The prospect of finding epigenetic risk factors for complex diseases would be greatly enhanced if DNA from existing biobanks, which is generally extracted from whole blood, could be used to perform epigenetic association studies. We characterized features of DNA methylation at 16 candidate loci, 8 of which were imprinted, in DNA samples from the Netherlands Twin Register biobank. Except for unmethylated or fully methylated sites, CpG methylation varied considerably in a sample of 30 unrelated in... Abstract

Cited 14 times since 2010 (0.9 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 40, Issue 1, 10 2 2010, Pages 65-70 Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer. Bosman WM, Vlot J, van der Steenhoven TJ, van den Berg O, Hamming JF, de Vries AC, Brom HL, Jacobs MJ

Objective: This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model. Design: Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created. Material: The formulation used in the experiments consisted of a two-component addition-cure... Abstract