Publications
Below you can find a list of our published research.
Below you can find a list of our published research.
9543 results
Cited 14 times since 2009 (0.9 per year) source: EuropePMC
European heart journal, Volume 31, Issue 6, 23 4 2009, Pages 712-718 Mortality risk score in primary prevention implantable cardioverter defibrillator recipients with non-ischaemic or ischaemic heart disease. Borleffs CJ, van Welsenes GH, van Bommel RJ, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Rosendaal FR, Schalij MJ
Aims: To assess survival and to construct a baseline mortality risk score in primary prevention implantable cardioverter defibrillator (ICD) patients with non-ischaemic or ischaemic heart disease. Methods and results: Since 1996, data of all consecutive patients who received an ICD system in the Leiden University Medical Center were collected and assessed at implantation. For the current study, all 1036 patients [age 63 (SD 11) years, 81% male] with a primary indication for defibrillator implant... Abstract
Cited 182 times since 2009 (11.4 per year) source: EuropePMC
Journal of the American College of Cardiology, Volume 55, Issue 6, 20 3 2009, Pages 566-575 Optimizing hemodynamics in heart failure patients by systematic screening of left ventricular pacing sites: the lateral left ventricular wall and the coronary sinus are rarely the best sites. Derval N, Steendijk P, Gula LJ, Deplagne A, Laborderie J, Sacher F, Knecht S, Wright M, Nault I, Ploux S, Ritter P, Bordachar P, Lafitte S, Réant P, Klein GJ, Narayan SM, Garrigue S, Hocini M, Haissaguerre M, Clementy J, Jaïs P
Objectives: We sought to evaluate the impact of the left ventricular (LV) pacing site on hemodynamic response to cardiac resynchronization therapy (CRT). Background: CRT reduces morbidity and mortality in heart failure patients. However, 20% to 40% of eligible patients may not fully benefit from CRT device implantation. We hypothesized that selecting the optimal LV pacing site could be critical in this issue. Methods: Thirty-five patients with nonischemic dilated cardiomyopathy referred for CRT... Abstract
Cited 242 times since 2009 (15.1 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 3, Issue 1, 17 3 2009, Pages 94-102 Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography. Ng AC, Delgado V, van der Kley F, Shanks M, van de Veire NR, Bertini M, Nucifora G, van Bommel RJ, Tops LF, de Weger A, Tavilla G, de Roos A, Kroft LJ, Leung DY, Schuijf J, Schalij MJ, Bax JJ
Background: 3D transesophageal echocardiography (TEE) may provide more accurate aortic annular and left ventricular outflow tract (LVOT) dimensions and geometries compared with 2D TEE. We assessed agreements between 2D and 3D TEE measurements with multislice computed tomography (MSCT) and changes in annular/LVOT areas and geometries after transcatheter aortic valve implantations (TAVI). Methods and results: Two-dimensional circular (pixr(2)), 3D circular, and 3D planimetered annular and LVOT are... Abstract
Cited 12 times since 2009 (0.7 per year) source: EuropePMC
Circulation. Cardiovascular imaging, Volume 3, Issue 1, 17 3 2009, Pages 86-93 Prediction of cardiac resynchronization therapy response: value of calibrated integrated backscatter imaging. Bertini M, Delgado V, den Uijl DW, Nucifora G, Ng AC, van Bommel RJ, Borleffs CJ, Boriani G, Schalij MJ, Bax JJ
Background: Left ventricular (LV) fibrosis is important for the response to cardiac resynchronization therapy (CRT). Calibrated integrated backscatter derived by 2D echocardiography quantifies myocardial ultrasound reflectivity, which may provide a surrogate of LV fibrosis. The aim of the study was first, to investigate the relation of myocardial ultrasound reflectivity assessed with calibrated integrated backscatter on CRT response, and second, to explore the "myocardial ultrasound reflect... Abstract
Cited 8 times since 2009 (0.5 per year) source: EuropePMC
Diabetes care, Volume 33, Issue 2, 16 3 2009, Pages 372-374 Increased carotid intima-media thickness as a predictor of the presence and extent of abnormal myocardial perfusion in type 2 diabetes. Djaberi R, Schuijf JD, Jukema JW, Rabelink TJ, Stokkel MP, Smit JW, de Koning EJ, Bax JJ
Objective: Identification of asymptomatic patients with type 2 diabetes at increased risk for coronary artery disease (CAD) remains a challenge. We evaluated the potential of carotid intima-media thickness (CIMT) for prediction of abnormal myocardial perfusion in this population. Research design and methods: CIMT and SPECT myocardial perfusion imaging were assessed in 98 asymptomatic patients with type 2 diabetes. An increased CIMT was defined as > or =75th percentile of reference values. RES... Abstract
Cited 15 times since 2009 (0.9 per year) source: EuropePMC
The American journal of cardiology, Volume 105, Issue 1, 14 2 2009, Pages 43-47 Impact of prophylactic beta-blocker therapy to prevent stroke after noncardiac surgery. van Lier F, Schouten O, Hoeks SE, van de Ven L, Stolker RJ, Bax JJ, Poldermans D
beta Blockers are widely used to improve the postoperative cardiac outcome in patients with coronary artery disease scheduled for noncardiac surgery. However, recently serious concerns regarding the safety of perioperative beta blockers have emerged. To assess the incidence, risk factors, and beta-blocker use associated with postoperative stroke in the Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography (DECREASE) trials, we evaluated all 3,884 patients of the DECREA... Abstract
Cited 61 times since 2009 (3.8 per year) source: EuropePMC
BMC medicine, Volume 7, 12 2 2009, Pages 70 Oral high dose ascorbic acid treatment for one year in young CMT1A patients: a randomised, double-blind, placebo-controlled phase II trial. Verhamme C, de Haan RJ, Vermeulen M, Baas F, de Visser M, van Schaik IN
Background: High dose oral ascorbic acid substantially improved myelination and locomotor function in a Charcot-Marie-Tooth type 1A mouse model. A phase II study was warranted to investigate whether high dose ascorbic acid also has such a substantial effect on myelination in Charcot-Marie-Tooth type 1A patients and whether this treatment is safe. Methods: Patients below age 25 years were randomly assigned to receive placebo or ascorbic acid (one gram twice daily) in a double-blind fashion during... Abstract
Cited 10 times since 2009 (0.6 per year) source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 50, Issue 12, 12 2 2009, Pages 1980-1986 Endothelial dysfunction in diabetic patients with abnormal myocardial perfusion in the absence of epicardial obstructive coronary artery disease. Djaberi R, Roodt Jo, Schuijf JD, Rabelink TJ, de Koning EJ, Pereira AM, Stokkel MP, Smit JW, Bax JJ, Jukema JW
Unlabelled: In patients with diabetes mellitus, myocardial perfusion defects are often observed in the absence of obstructive epicardial coronary artery disease (CAD), thereby presenting a diagnostic problem. We hypothesized that these perfusion abnormalities may be explained by endothelial dysfunction or occult coronary atherosclerosis. Methods: Prospectively, 130 asymptomatic patients with diabetes mellitus underwent cardiovascular screening by coronary artery calcium (CAC) scoring, multislice... Abstract
Cited 97 times since 2009 (6 per year) source: EuropePMC
The Journal of clinical endocrinology and metabolism, Volume 95, Issue 1, 11 2 2009, Pages 93-99 Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach. Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N
Context: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. Objective: The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach. Methods: In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205)... Abstract
Cited 38 times since 2009 (2.4 per year) source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 39, Issue 1, 11 2 2009, Pages 70-86 A systematic review of implementation of established recommended secondary prevention measures in patients with PAOD. Flu HC, Tamsma JT, Lindeman JH, Hamming JF, Lardenoye JH
Objective: Since patients with peripheral arterial occlusive disease (PAOD) are at high-risk for cardiovascular morbidity and mortality, preventive measures aimed to reduce cardiovascular adverse events are advocated in the current guidelines. We conducted a systematic review to assess the implementation of secondary prevention (SP) measures in PAOD patients. Methods: PubMed, Cochrane Library, EMBASE and Web of Science databases were searched to perform a systematic review of the literature from... Abstract
Cited 15 times since 2009 (0.9 per year) source: EuropePMC
Atherosclerosis, Volume 210, Issue 1, 10 2 2009, Pages 28-34 Lipoprotein-associated phospholipase A(2), inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Caslake MJ, Packard CJ, Robertson M, Cooney J, Nelson JJ, Ford I, Gaw A, Jukema JW, Macfarlane PW, Stott DJ, Shepherd J, PROSPER Study Group
Objective: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an inflammatory biomarker that circulates mainly bound to LDL. We evaluated the association of Lp-PLA(2) with vascular events in the elderly where the importance of LDL is diminished as a risk factor for coronary disease. Methods: Mass and activity of Lp-PLA(2) were related to risk over 3.2 years for vascular events (definite or suspected death from CHD, non-fatal MI, fatal or non-fatal stroke) in the 2804 men and 3000 women age... Abstract
Cited 35 times since 2009 (2.2 per year) source: EuropePMC
Transplant infectious disease : an official journal of the Transplantation Society, Volume 12, Issue 2, 10 2 2009, Pages 98-105 Comparison of the QuantiFERON-TB Gold In-Tube test with the tuberculin skin test for detecting latent tuberculosis infection in hemodialysis patients. Seyhan EC, Sökücü S, Altin S, Günlüoğlu G, Trablus S, Yilmaz D, Koksalan OK, Issever H
Background and objectives: Hemodialysis (HD) patients are at increased risk of reactivation of latent tuberculosis (TB) infection (LTBI). LTBI screening of this population is recommended. The QuantiFERON-TB Gold assay (QFT-G) may be more accurate than the tuberculin skin test (TST) in the detection of LTBI. We prospectively compared the results of QFT-G to TST in HD patients. Methods: We examined 100 patients and performed TST and QFT-G tests. Data obtained from patients and medical records incl... Abstract
Cited 25 times since 2009 (1.6 per year) source: EuropePMC
Pediatric nephrology (Berlin, Germany), Volume 25, Issue 2, 7 1 2009, Pages 289-298 Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study. Geelhoed JJ, Taal HR, Steegers EA, Arends LR, Lequin M, Moll HA, Hofman A, van der Heijden AJ, Jaddoe VW
Information about growth of kidney structures in early life is limited. In a population-based prospective cohort study, from foetal life onwards, we constructed reference curves for kidney growth from the third trimester of pregnancy until early childhood, using data from 1,158 healthy children. Kidney size, defined as length, width, depth and volume, was measured in the third trimester of pregnancy and at the postnatal ages of 6 months and 24 months. Analyses were based on more than 2,500 kidne... Abstract
Cited 27 times since 2009 (1.7 per year) source: EuropePMC
Veterinary microbiology, Volume 142, Issue 3-4, 6 1 2009, Pages 268-275 The increase in seroprevalence of bluetongue virus (BTV) serotype 8 infections and associated risk factors in Dutch dairy herds, in 2007. Santman-Berends IM, Bartels CJ, van Schaik G, Stegeman JA, Vellema P
Bluetongue virus serotype 8 (BTV-8) emerged in the Netherlands in August 2006 for the first time. In the winter of 2006/2007, during the transmission free period, the government decided to establish a sentinel network to monitor the re-emergence of BTV-8 in 2007. Between June and December 2007, a sentinel network of 275 dairy herds with 8901 seronegative cows at start, was in place for BTV-8 testing in milk samples. Besides estimates of the monthly BTV-8 within-herd prevalence per region (south,... Abstract
Cited 44 times since 2009 (2.7 per year) source: EuropePMC
American journal of epidemiology, Volume 170, Issue 11, 4 1 2009, Pages 1415-1421 Apolipoprotein e genotype, plasma cholesterol, and cancer: a Mendelian randomization study. Trompet S, Jukema JW, Katan MB, Blauw GJ, Sattar N, Buckley B, Caslake M, Ford I, Shepherd J, Westendorp RG, de Craen AJ
Observational studies have shown an association between low plasma cholesterol levels and increased risk of cancer, whereas most randomized clinical trials involving cholesterol-lowering medications have not shown this association. Between 1997 and 2002, the authors assessed the association between plasma cholesterol levels and cancer risk, free from confounding and reverse causality, in a Mendelian randomization study using apolipoprotein E (ApoE) genotype. ApoE genotype, plasma cholesterol lev... Abstract
Cited 31 times since 2009 (1.9 per year) source: EuropePMC
The pharmacogenomics journal, Volume 10, Issue 3, 3 1 2009, Pages 219-225 The CYP2C19*17 genotype is associated with lower imipramine plasma concentrations in a large group of depressed patients. Schenk PW, van Vliet M, Mathot RA, van Gelder T, Vulto AG, van Fessem MA, Verploegh-Van Rij S, Lindemans J, Bruijn JA, van Schaik RH
CYP2C19 converts the tricyclic antidepressant imipramine to its active metabolite desipramine, which is subsequently inactivated by CYP2D6. The novel CYP2C19*17 allele causes ultrarapid metabolism of CYP2C19 substrates. We genotyped 178 depressed patients on imipramine for CYP2C19*17, and measured steady-state imipramine and desipramine plasma concentrations. Mean dose-corrected imipramine plasma concentration was significantly dependent on CYP2C19 genotype (Kruskal-Wallis test, P=0.01), with ci... Abstract
Cited 34 times since 2009 (2.1 per year) source: EuropePMC
JACC. Cardiovascular imaging, Volume 2, Issue 11, 1 1 2009, Pages 1271-1281 Integrated assessment of diastolic and systolic ventricular function using diagnostic cardiac magnetic resonance catheterization: validation in pigs and application in a clinical pilot study. Schmitt B, Steendijk P, Lunze K, Ovroutski S, Falkenberg J, Rahmanzadeh P, Maarouf N, Ewert P, Berger F, Kuehne T
Objectives: This study sought to develop and validate a method for the integrated analysis of systolic and diastolic ventricular function. Background: An integrated approach to assess ventricular pump function, myocontractility (end-systolic pressure-volume relationship [ESPVR]), and diastolic compliance (end-diastolic pressure-volume relation [EDPVR]) is of high clinical value. Cardiac magnetic resonance (CMR) is well established for measuring global pump function, and catheterization-combined... Abstract
Cited 8 times since 2009 (0.5 per year) source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 11 Suppl 5, 1 1 2009, Pages v32-9 The role of non-invasive imaging in patient selection. Van de Veire NR, Delgado V, Schuijf JD, van der Wall EE, Schalij MJ, Bax JJ
Cardiac resynchronization therapy (CRT) is an established therapy for patients with advanced heart failure, depressed left ventricular (LV) function and wide QRS complex. A substantial amount of patients do not respond to CRT. Recent studies suggest that assessment of mechanical dyssynchrony may allow identification of potential CRT responders. In addition, presence of scar tissue and venous anatomy may play a role in the selection of candidates. This article summarizes the role of non-invasive... Abstract
Cited 29 times since 2009 (1.8 per year) source: EuropePMC
Blood, Volume 114, Issue 20, 1 1 2009, Pages 4603-4; author reply 4604-5 Elevated fibrinogen gamma' ratio is associated with cardiovascular diseases and acute phase reaction but not with clinical outcome. Cheung EY, Vos HL, Kruip MJ, den Hertog HM, Jukema JW, de Maat MP
Cited 70 times since 2009 (4.4 per year) source: EuropePMC
Neurology, Volume 73, Issue 18, 1 1 2009, Pages 1457-1461 Somatosensory evoked potentials during mild hypothermia after cardiopulmonary resuscitation. Bouwes A, Binnekade JM, Zandstra DF, Koelman JH, van Schaik IN, Hijdra A, Horn J
Objective: In patients who remain in a coma after cardiopulmonary resuscitation (CPR), the bilateral absence of cortical N20 responses of median nerve somatosensory evoked potentials (SSEP) 24 hours after admission invariably correlates with a poor neurologic outcome. Nowadays, CPR patients are treated with mild hypothermia, with simultaneously administered sedative drugs, hampering clinical neurologic assessment. We investigated whether SSEP performed during hypothermia can reliably predict a p... Abstract