9543 results
Cited 50 times since 2009 (3.1 per year)
source: EuropePMC
Proceedings. Biological sciences,
Volume 276, Issue 1673, 5 1 2009, Pages 3689-3694
Tool use in wild orang-utans modifies sound production: A functionally deceptive innovation?
Hardus ME, Lameira AR, Van Schaik CP, Wich SA
Culture has long been assumed to be uniquely human but recent studies, in particular on great apes, have suggested that cultures also occur in non-human primates. The most apparent cultural behaviours in great apes involve tools in the subsistence context where they are clearly functional to obtain valued food. On the other hand, tool-use to modify acoustic communication has been reported only once and its function has not been investigated. Thus, the question whether this is an adaptive behavio...
Abstract
Cited 107 times since 2009 (6.6 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 2, Issue 5, 5 1 2009, Pages 548-554
Predicting ventricular arrhythmias in patients with ischemic heart disease: clinical application of the ECG-derived QRS-T angle.
Borleffs CJ, Scherptong RW, Man SC, van Welsenes GH, Bax JJ, van Erven L, Swenne CA, Schalij MJ
Background: In patients with primary prevention implantable cardioverter-defibrillators (ICDs), the incidence of life-threatening ventricular arrhythmias resulting in ICD therapy is relatively low, prompting for better risk stratification. The aim of this study was to assess the value of the QRS-T angle for prediction of ICD therapy and mortality in primary prevention patients with ischemic heart disease. Methods and results: ICD patients (n=412, 361 men; age, 63+/-11 years) with ischemic heart...
Abstract
Cited 168 times since 2009 (10.3 per year)
source: EuropePMC
Journal of neurology,
Volume 257, Issue 1, 4 1 2009, Pages 85-90
Pravastatin and cognitive function in the elderly. Results of the PROSPER study.
Trompet S, van Vliet P, de Craen AJ, Jolles J, Buckley BM, Murphy MB, Ford I, Macfarlane PW, Sattar N, Packard CJ, Stott DJ, Shepherd J, Bollen EL, Blauw GJ, Jukema JW, Westendorp RG
Observational studies have given conflicting results about the effect of statins in preventing dementia and cognitive decline. Moreover, observational studies are subject to prescription bias, making it hard to draw definite conclusions from them. Randomized controlled trials are therefore the preferred study design to investigate the association between statins and cognition. Here we present detailed cognitive outcomes from the randomized placebo-controlled PROspective Study of Pravastatin in t...
Abstract
Cited 69 times since 2009 (4.2 per year)
source: EuropePMC
Infection and immunity,
Volume 77, Issue 10, 3 1 2009, Pages 4437-4445
The global regulator CodY regulates toxin gene expression in Bacillus anthracis and is required for full virulence.
van Schaik W, Château A, Dillies MA, Coppée JY, Sonenshein AL, Fouet A
In gram-positive bacteria, CodY is an important regulator of genes whose expression changes upon nutrient limitation and acts as a repressor of virulence gene expression in some pathogenic species. Here, we report the role of CodY in Bacillus anthracis, the etiologic agent of anthrax. Disruption of codY completely abolished virulence in a toxinogenic, noncapsulated strain, indicating that the activity of CodY is required for full virulence of B. anthracis. Global transcriptome analysis of a codY...
Abstract
Cited 30 times since 2009 (1.8 per year)
source: EuropePMC
Nucleic acids research,
Volume 37, Issue 17, 3 1 2009, Pages 5725-5736
Stimulation of homology-directed gene targeting at an endogenous human locus by a nicking endonuclease.
van Nierop GP, de Vries AA, Holkers M, Vrijsen KR, Gonçalves MA
Homologous recombination (HR) is a highly accurate mechanism of DNA repair that can be exploited for homology-directed gene targeting. Since in most cell types HR occurs very infrequently (approximately 10(-6) to 10(-8)), its practical application has been largely restricted to specific experimental systems that allow selection of the few cells that become genetically modified. HR-mediated gene targeting has nonetheless revolutionized genetics by greatly facilitating the analysis of mammalian ge...
Abstract
Cited 19 times since 2009 (1.2 per year)
source: EuropePMC
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,
Volume 24, Issue 3-4, 3 1 2009, Pages 201-210
Pressure overload-induced right ventricular failure is associated with re-expression of myocardial tenascin-C and elevated plasma tenascin-C levels.
Hessel M, Steendijk P, den Adel B, Schutte C, van der Laarse A
Background: We investigated whether (1) monocrotaline(MCT)-induced right ventricular (RV) dilatation is associated with re-expression of myocardial tenascin-C (TNC), (2) elevated plasma TNC levels can be used as a marker of ventricular dilatation, and (3) MCT-induced RV dilatation is associated with alterations of other remodeling-related proteins. Methods: Rats were treated with MCT in low dose (30 mg/kg, MCT30, n=10) to induce compensated RV hypertrophy, in high dose (80 mg/kg, MCT80, n=11) to...
Abstract
Cited 11 times since 2009 (0.7 per year)
source: EuropePMC
British journal of clinical pharmacology,
Volume 68, Issue 2, 1 1 2009, Pages 221-225
Variation in the CYP2D6 gene is associated with a lower serum sodium concentration in patients on antidepressants.
Kwadijk-de Gijsel S, Bijl MJ, Visser LE, van Schaik RH, Hofman A, Vulto AG, van Gelder T, Ch Stricker BH
Aim: To study the effect of the CYP2D6*4 polymorphism on serum sodium concentration in users of antidepressants [selective serotonin reuptake inhibitors and tricyclic antidepressants (TCAs)]. Methods: In this population-based cohort study, all subjects in the Rotterdam Study were included who used an antidepressant at baseline and from whom a blood sample was available in which CYP2D6 genotype and serum sodium concentration could be determined (n= 76). Multivariate linear regression was used to...
Abstract
Cited 13 times since 2009 (0.8 per year)
source: EuropePMC
American heart journal,
Volume 158, Issue 2, 1 1 2009, Pages 202-208
Intima media thickness of the common carotid artery in vascular surgery patients: a predictor of postoperative cardiovascular events.
Flu WJ, van Kuijk JP, Hoeks SE, Kuiper R, Schouten O, Goei D, Winkel T, van Gestel YR, Verhagen HJ, Bax JJ, Poldermans D
Background: Cardiovascular (CV) complications are the leading cause of morbidity and mortality in vascular surgery patients. The Revised Cardiac Risk (RCR) index, identifying cardiac risk factors, is commonly used for preoperative risk stratification. However, a more direct marker of the underlying atherosclerotic disease, such as the common carotid artery intimamedia thickness (CCA-IMT) may be of predictive value as well. The current study evaluated the prognostic value of the CCA-IMT for posto...
Abstract
Cited 63 times since 2009 (3.9 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 19, Issue 8, 1 1 2009, Pages 626-634
Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism.
Sombogaard F, van Schaik RH, Mathot RA, Budde K, van der Werf M, Vulto AG, Weimar W, Glander P, Essioux L, van Gelder T
Objectives: The active metabolite of mycophenolate mofetil (MMF), mycophenolic acid, inhibits the activity of the target enzyme inosine monophosphate dehydrogenase (IMPDH). The aim of this study was to correlate eight different single nucleotide polymorphisms of the IMPDH type II gene to the activity of the IMPDH enzyme to explain between-patient differences in IMPDH activity. Methods and results: In a prospective study, we measured IMPDH activity, mycophenolic acid plasma concentrations, and ei...
Abstract
Cited 194 times since 2009 (11.9 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 13, Issue 8A, 1 1 2009, Pages 1577-1585
Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis.
van Solingen C, Seghers L, Bijkerk R, Duijs JM, Roeten MK, van Oeveren-Rietdijk AM, Baelde HJ, Monge M, Vos JB, de Boer HC, Quax PH, Rabelink TJ, van Zonneveld AJ
MicroRNAs are negative regulators of gene expression that play a key role in cell-type specific differentiation and modulation of cell function and have been proposed to be involved in neovascularization. Previously, using an extensive cloning and sequencing approach, we identified miR-126 to be specifically and highly expressed in human endothelial cells (EC). Here, we demonstrate EC-specific expression of miR-126 in capillaries and the larger vessels in vivo. We therefore explored the potentia...
Abstract
Cited 281 times since 2009 (17.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 54, Issue 9, 1 1 2009, Pages 764-776
The effects of right ventricular apical pacing on ventricular function and dyssynchrony implications for therapy.
Tops LF, Schalij MJ, Bax JJ
Cardiac pacing is the only effective treatment for patients with sick sinus syndrome and atrioventricular conduction disorders. In cardiac pacing, the endocardial pacing lead is typically positioned at the right ventricular (RV) apex. At the same time, there is increasing indirect evidence, derived from large pacing mode selection trials and observational studies, that conventional RV apical pacing may have detrimental effects on cardiac structure and left ventricular function, which are associa...
Abstract
Cited 3 times since 2009 (0.2 per year)
source: EuropePMC
Minerva cardioangiologica,
Volume 57, Issue 4, 1 1 2009, Pages 415-441
Advanced applications of 3-dimensional echocardiography.
Ng AC, Delgado V, Bertini M, Nucifora G, Shanks M, Ajmone Marsan N, Holman E, Van De Veire NR, Leung DY, Bax JJ
Over the last few decades, advancements in ultrasound, electronic and computing technologies have permitted current second generation 3-dimensional (3D) echocardiography to display on-line 3D rendered images of the heart. Since various studies demonstrated its superiority over 2-dimensional echocardiography, there is growing enthusiasm to embrace this new 3D echocardiographic technology. With its increasing widespread clinical availability, 3D echocardiography is getting closer to routine clinic...
Abstract
Cited 51 times since 2009 (3.1 per year)
source: EuropePMC
Pacing and clinical electrophysiology : PACE,
Volume 32, Issue 8, 1 1 2009, Pages 1040-1049
Relevance of echocardiographic evaluation of right ventricular function in patients undergoing cardiac resynchronization therapy.
Scuteri L, Rordorf R, Marsan NA, Landolina M, Magrini G, Klersy C, Frattini F, Petracci B, Vicentini A, Campana C, Tavazzi L, Ghio S
Aims: Right ventricular (RV) dysfunction is a marker of poor prognosis in heart failure (HF) patients. It is still unclear whether RV function might influence response to cardiac resynchronization therapy (CRT). Methods: Forty-four consecutive patients with HF, large QRS, and either intraventricular or interventricular dyssynchrony underwent echocardiographic evaluation before, 1 month after, and 6 months after CRT. Response to CRT was considered in case of significant LV reverse remodeling, def...
Abstract
Journal of vascular surgery,
Volume 50, Issue 2, 1 1 2009, Pages 407-412
Fluoroscopic Roentgen stereophotogrammetric analysis (FRSA) to study three-dimensional stent graft dynamics.
Koning OH, Kaptein BL, van der Vijver R, Dias NV, Malina M, Schalij MJ, Valstar ER, van Bockel JH
We report the clinical feasibility of fluoroscopic Roentgen stereophotogrammetric analysis (FRSA), a validated method to quantify real time three-dimensional (3D) dynamic motion of stent grafts and the first clinical results after abdominal and thoracic endovascular repair (EVAR). Stent graft motion was measured at 30 (stereo) frames per second, during the cardiac cycle and in the patient after abdominal EVAR, due to respiratory action. Translational motions of the center of mass, diameter chang...
Abstract
Cited 28 times since 2009 (1.7 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 74, Issue 2, 1 1 2009, Pages 335-343
In-ambulance abciximab administration in STEMI patients prior to primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: results from the Leiden MISSION! acute myocardial infarction treatment optimization program.
Hassan AK, Liem SS, van der Kley F, Bergheanu SC, Wolterbeek R, Bosch J, Bootsma M, Zeppenfeld K, van der Laarse A, Atsma DE, Jukema JW, Schalij MJ
Objectives: Our aim was to evaluate the effects of early abciximab administration in the ambulance on immediate, short, and long term outcomes. Background: Early abciximab administration before primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is recommended in practice guidelines. However, optimal timing of administration remains indistinct. Methods: Within a fixed protocol for PPCI, December 2006 was the cut-off point for this prospective...
Abstract
Cited 26 times since 2009 (1.6 per year)
source: EuropePMC
Archives of surgery (Chicago, Ill. : 1960),
Volume 144, Issue 8, 1 1 2009, Pages 728-733
Type D personality and mortality in peripheral arterial disease: a pilot study.
Aquarius AE, Smolderen KG, Hamming JF, De Vries J, Vriens PW, Denollet J
Background: Type D personality refers to the tendency to experience negative emotions and to inhibit self-expression in social interaction and has been shown to be an independent predictor of mortality in cardiac disease. Information about the effects of psychological traits on prognosis is lacking in cases of peripheral arterial disease (PAD). Objective: To examine whether type D personality predicts all-cause mortality in PAD. Design: Pilot follow-up study. Setting: Vascular surgery department...
Abstract
Critical care medicine,
Volume 37, Issue 8, 1 1 2009, Pages 2482-2483
Optimizing the shape of defibrillation shocks.
Steendijk P
Abstract
Cited 73 times since 2009 (4.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 25, Issue 7, 30 5 2009, Pages 669-676
Right ventricular peak systolic longitudinal strain is a sensitive marker for right ventricular deterioration in adult patients with tetralogy of Fallot.
Scherptong RW, Mollema SA, Blom NA, Kroft LJ, de Roos A, Vliegen HW, van der Wall EE, Bax JJ, Holman ER
The aim of this study was to evaluate the feasibility of right ventricular (RV) longitudinal peak systolic strain (LPSS) assessment for the follow-up of adult patients with corrected tetralogy of Fallot (TOF). Adult patients (n = 18) with corrected TOF underwent echocardiography and CMR twice with a time interval of 4.2 +/- 1.7 years. RV performance was derived from CMR, and included RV volumes and ejection fraction (EF). LPSS was calculated globally (GLPSS) and in the RV free wall (LPSS FW), wi...
Abstract
Cited 107 times since 2009 (6.5 per year)
source: EuropePMC
Animal cognition,
Volume 13, Issue 1, 24 4 2009, Pages 1-19
Cognitive consequences of cooperative breeding in primates?
Burkart JM, van Schaik CP
Several hypotheses propose that cooperative breeding leads to increased cognitive performance, in both nonhuman and human primates, but systematic evidence for such a relationship is missing. A causal link might exist because motivational and cognitive processes necessary for the execution and coordination of helping behaviors could also favor cognitive performance in contexts not directly related to caregiving. In callitrichids, which among primates rely most strongly on cooperative breeding, t...
Abstract
Cited 5 times since 2009 (0.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 104, Issue 6, 21 3 2009, Pages 758-763
Relation between Framingham risk categories and the presence of functionally relevant coronary lesions as determined on multislice computed tomography and stress testing.
Nucifora G, Schuijf JD, van Werkhoven JM, Djaberi R, van der Wall EE, de Roos A, Scholte AJ, Schalij MJ, Jukema JW, Bax JJ
Noninvasive assessment of subclinical atherosclerosis by multislice computed tomographic (MSCT) coronary angiography and demonstration of significant, flow-limiting coronary artery disease (CAD) by stress testing may improve patients' risk stratification. However, data relating the complementary information provided by these noninvasive techniques to traditional risk assessment are scarce. In 255 subjects (45% women, mean age 54 +/- 12 years) without known CAD, 64-slice MSCT coronary angiog...
Abstract
