Research

Publications

Below you can find a list of our published research.

9543 results

Cited 27 times since 2008 (1.6 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 9, 1 1 2008, Pages 1214-1226 Cell therapy for ischaemic heart disease. Beeres SL, Atsma DE, van Ramshorst J, Schalij MJ, Bax JJ

Abstract

Cited 40 times since 2008 (2.3 per year) source: EuropePMC

The Journal of bone and joint surgery. British volume, Volume 90, Issue 9, 1 1 2008, Pages 1205-1209 Early magnetic resonance imaging compared with bone scintigraphy in suspected scaphoid fractures. Beeres FJ, Rhemrev SJ, den Hollander P, Kingma LM, Meylaerts SA, le Cessie S, Bartlema KA, Hamming JF, Hogervorst M

We evaluated 100 consecutive patients with a suspected scaphoid fracture but without evidence of a fracture on plain radiographs using MRI within 24 hours of injury, and bone scintigraphy three to five days after injury. The reference standard for a true radiologically-occult scaphoid fracture was either a diagnosis of fracture on both MRI and bone scintigraphy, or, in the case of discrepancy, clinical and/or radiological evidence of a fracture. MRI revealed 16 scaphoid and 24 other fractures. B... Abstract

Cited 742 times since 2008 (43 per year) source: EuropePMC

Lancet (London, England), Volume 372, Issue 9645, 29 5 2008, Pages 1231-1239 Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, Tognoni G, Gissi-HF Investigators

Background: Large observational studies, small prospective studies and post-hoc analyses of randomised clinical trials have suggested that statins could be beneficial in patients with chronic heart failure. However, previous studies have been methodologically weak. We investigated the efficacy and safety of the statin rosuvastatin in patients with heart failure. Methods: We undertook a randomised, double-blind, placebo-controlled trial in 326 cardiology and 31 internal medicine centres in Italy.... Abstract

Cited 892 times since 2008 (51.7 per year) source: EuropePMC

Lancet (London, England), Volume 372, Issue 9645, 29 5 2008, Pages 1223-1230 Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, Tognoni G, Gissi-HF Investigators

Background: Several epidemiological and experimental studies suggest that n-3 polyunsaturated fatty acids (PUFA) can exert favourable effects on atherothrombotic cardiovascular disease, including arrhythmias. We investigated whether n-3 PUFA could improve morbidity and mortality in a large population of patients with symptomatic heart failure of any cause. Methods: We undertook a randomised, double-blind, placebo-controlled trial in 326 cardiology and 31 internal medicine centres in Italy. We en... Abstract

Cited 16 times since 2008 (0.9 per year) source: EuropePMC

PloS one, Volume 3, Issue 8, 29 5 2008, Pages e3084 Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system. Gonçalves MA, Holkers M, van Nierop GP, Wieringa R, Pau MG, de Vries AA

A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (Ad) vectors arguably represent the most efficient delivery systems of episomal DNA into eukaryotic cell nuclei. The most advanced recombinant Ads lack all adenoviral genes. This renders these so-called high-capacity (hc) Ad vectors less cytotoxic/imm... Abstract

Cited 196 times since 2008 (11.4 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 337, 29 5 2008, Pages a1331 Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis. Stettler C, Allemann S, Wandel S, Kastrati A, Morice MC, Schömig A, Pfisterer ME, Stone GW, Leon MB, de Lezo JS, Goy JJ, Park SJ, Sabaté M, Suttorp MJ, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen MT, Cervinka P, De Carlo M, Erglis A, Chechi T, Ortolani P, Schalij MJ, Diem P, Meier B, Windecker S, Jüni P

Objective: To compare the effectiveness and safety of three types of stents (sirolimus eluting, paclitaxel eluting, and bare metal) in people with and without diabetes mellitus. Design: Collaborative network meta-analysis. Data sources: Electronic databases (Medline, Embase, the Cochrane Central Register of Controlled Trials), relevant websites, reference lists, conference abstracts, reviews, book chapters, and proceedings of advisory panels for the US Food and Drug Administration. Manufacturers... Abstract

Cited 23 times since 2008 (1.3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 34, Issue 6, 28 4 2008, Pages 1149-1157 Early and late outcome of left ventricular reconstruction surgery in ischemic heart disease. Klein P, Bax JJ, Shaw LJ, Feringa HH, Versteegh MI, Dion RA, Klautz RJ

A systematic review of the literature was performed to determine early and late mortality associated with left ventricular (LV) reconstruction surgery and to assess the influence of different surgical techniques, concomitant surgical procedures, clinical and hemodynamic parameters on mortality. The MEDLINE database (January 1980-January 2005) was searched and from the pooled data, hospital mortality and survival were calculated. Summary estimates of relative risks (RR) were calculated for the te... Abstract

Cited 214 times since 2008 (12.4 per year) source: EuropePMC

European journal of heart failure, Volume 10, Issue 9, 28 4 2008, Pages 884-891 Long term vagal stimulation in patients with advanced heart failure: first experience in man. Schwartz PJ, De Ferrari GM, Sanzo A, Landolina M, Rordorf R, Raineri C, Campana C, Revera M, Ajmone-Marsan N, Tavazzi L, Odero A

Background: Experimentally, vagal stimulation (VS) is protective in chronic heart failure (HF). In man, VS is used in refractory epilepsy but has never been used in cardiovascular diseases. Increased sympathetic and reduced vagal activity predict increased mortality in HF. Aims: This pilot study assessed feasibility and safety and tested possible efficacy of chronic VS in HF patients. Methods: We studied 8 patients (mean age 54 years). CardioFit (BioControl Medical), a VS implantable system deli... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 9, 27 4 2008, Pages 1156-1158 Prognostic significance of myocardial ischemia by dobutamine stress echocardiography in patients without angina pectoris after coronary revascularization. Pedone C, Elhendy A, Biagini E, van Domburg RT, Schinkel AF, Di Pasquale G, Bax JJ, Poldermans D

The clinical utility of stress testing in patients without angina pectoris after revascularization has been questioned. Dobutamine stress echocardiography (DSE) is an established technique for detection of myocardial ischemia and cardiac risk stratification. We studied the prognostic value of DSE in 393 patients without typical angina pectoris after coronary revascularization. Ischemia was incremental to clinical data in predicting all-cause death (hazard ratio 3.5, 95% confidence interval 1.8 t... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 24, Issue 8, 12 2 2008, Pages 907-909 Coronary artery calcium screening: sufficient evidence for accurate risk assessment? van der Wall EE, Schuijf JD, Jukema JW, Bax JJ

Abstract

Cited 10 times since 2008 (0.6 per year) source: EuropePMC

Molecular and cellular biochemistry, Volume 320, Issue 1-2, 9 2 2008, Pages 75-84 Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent. Umar S, van der Valk EJ, Schalij MJ, van der Wall EE, Atsma DE, van der Laarse A

Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin stimulation induces cardiomyocyte hypertrophy. Integrins of neonatal rat cardiomyocytes (NRCMs) were stimulated with a peptide containing the Arg-Gly-Asp (RGD) sequence for 24 h. For comparison, alpha(1)-adrenergic stimulation by phenylephrine (PE) for 24 h was applied. Saline-treated NRCMs were used as control. The hypertrophic response was... Abstract

Cited 50 times since 2008 (2.9 per year) source: EuropePMC

Heart rhythm, Volume 5, Issue 9, 6 1 2008, Pages 1257-1264 Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, Van de Veire NR, Delgado V, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony... Abstract

Cited 171 times since 2008 (9.9 per year) source: EuropePMC

European heart journal, Volume 29, Issue 19, 5 1 2008, Pages 2373-2381 Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis. Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Boersma E, Reiber JH, Schalij MJ, Wijns W, Bax JJ

Aims: Atherosclerotic plaque characteristics play an important role in the development of coronary events. We investigated coronary plaque characteristics on multi-slice computed tomography (MSCT) and virtual histology intravascular ultrasound (VH IVUS) in patients with acute coronary syndromes (ACS) and stable coronary artery disease (CAD). Methods and results: Fifty patients (25 with ACS, 25 with stable CAD) underwent 64-slice MSCT followed by VH IVUS in 48 (96%) patients. In ACS patients, 32%... Abstract

Cited 45 times since 2008 (2.6 per year) source: EuropePMC

Experimental and molecular pathology, Volume 85, Issue 2, 5 1 2008, Pages 90-95 Release kinetics of intact and degraded troponin I and T after irreversible cell damage. Hessel MH, Michielsen EC, Atsma DE, Schalij MJ, van der Valk EJ, Bax WH, Hermens WT, van Dieijen-Visser MP, van der Laarse A

Purpose: We characterized the release kinetics of cardiac troponin I and T in relation to lactate dehydrogenase (LDH) from cardiomyocytes before and after the transition from reversible to irreversible cell damage. Methods: Cardiomyocytes were exposed to mild metabolic inhibition (1 mmol/L sodium azide) to induce a necrotic cell death process that is characterized by a reversible (0-12 h) and irreversible phase (12-30 h). At various time intervals cells and media were collected and analyzed for... Abstract

Cited 32 times since 2008 (1.8 per year) source: EuropePMC

Journal of leukocyte biology, Volume 84, Issue 6, 4 1 2008, Pages 1379-1391 Insights into mechanisms behind arteriogenesis: what does the future hold? van Oostrom MC, van Oostrom O, Quax PH, Verhaar MC, Hoefer IE

Arteriogenesis, the enlargement of collateral vessels, seems a promising new target to improve blood flow to ischemic regions in patients suffering from cardiovascular conditions. With the growing knowledge of the mechanisms involved in arteriogenesis and the factors that influence the process, an increasing number of clinical trials are being performed to stimulate arteriogenesis, providing more insight in therapeutic opportunities for arteriogenesis. The expression of growth factors and the co... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 8, 1 1 2008, Pages 973-975 Multislice CT: is it essential before atrial fibrillation ablation? Tops LF, Schalij MJ

Abstract

Cited 97 times since 2008 (5.6 per year) source: EuropePMC

Structure (London, England : 1993), Volume 16, Issue 8, 1 1 2008, Pages 1245-1256 Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. van Ingen H, van Schaik FM, Wienk H, Ballering J, Rehmann H, Dechesne AC, Kruijzer JA, Liskamp RM, Timmers HT, Boelens R

Trimethylation of lysine residue K4 of histone H3 (H3K4me3) strongly correlates with active promoters for RNA polymerase II-transcribed genes. Several reader proteins, including the basal transcription factor TFIID, for this nucleosomal mark have been identified. Its TAF3 subunit specifically binds the H3K4me3 mark via its conserved plant homeodomain (PHD) finger. Here, we report the solution structure of the TAF3-PHD finger and its complex with an H3K4me3 peptide. Using a combination of NMR, mu... Abstract

Cited 19 times since 2008 (1.1 per year) source: EuropePMC

Cyberpsychology & behavior : the impact of the Internet, multimedia and virtual reality on behavior and society, Volume 11, Issue 4, 1 1 2008, Pages 415-424 Involving persons with dementia in the evaluation of outdoor environments. Van Schaik P, Martyr A, Blackman T, Robinson J

Using virtual reality (VR), we examined the barriers to and facilitators of functioning outdoors in persons with dementia (PwD) and investigated the generalizability of findings in VR to the real world. An existing town center was modeled in VR. PwD took part in both real-world and VR walks. Based on the results, the model was redesigned and then tested again. Performance on the walks improved, and potentially beneficial adaptations to outdoor environments were identified, but limitations of VR... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 7-8, 1 1 2008, Pages 270-271 Atrial fibrillation: an unusual cause. Siebelink HJ, Willems TP, Götte MJ

Abstract

Cited 31 times since 2008 (1.8 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 30, Issue 4, 1 1 2008, Pages 439-444 AcylMPAG plasma concentrations and mycophenolic acid-related side effects in patients undergoing renal transplantation are not related to the UGT2B7-840G>A gene polymorphism. van Agteren M, Armstrong VW, van Schaik RH, de Fijter H, Hartmann A, Zeier M, Budde K, Kuypers D, Pisarski P, Le Meur Y, van der Werf M, Mamelok RD, Oellerich M, van Gelder T

Mycophenolic acid (MPA) is metabolized primarily by glucuronidation to form the biologically inactive 7-O-glucuronide conjugate (MPAG), which is the major urinary excretion product. MPA is also converted to acyl-glucuronide metabolite (AcylMPAG), which has been suggested to be involved in the generation of MPA-related adverse events such as diarrhea or leucopenia. This conversion of MPA to AcylMPAG is catalyzed by UDP-glucuronosyltransferase 2B7 (UGT2B7). We studied the impact of the -840G>A... Abstract