Research

Publications

Below you can find a list of our published research.

9543 results

Cited 17 times since 2008 (1 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 295, Issue 2, 13 2 2008, Pages H755-60 Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex. Gademan MG, van Bommel RJ, Ypenburg C, Haest JC, Schalij MJ, van der Wall EE, Bax JJ, Swenne CA

Metabolic and mechanical stress in the failing heart activates the cardiac sympathetic afferent reflex (CSAR). It has been demonstrated that cardiac resynchronization therapy (CRT) acutely reduces MSNA in clinical responders. Mechanistically, this beneficial effect might be explained by acute deactivation of the CSAR. In addition to sympathoexcitation, CSAR inhibits the arterial baroreflex at the level of the nucleus tractus solitarii. Hence, in responders, CRT is likely to remove/reduce this in... Abstract

Cited 104 times since 2008 (6 per year) source: EuropePMC

Circulation research, Volume 103, Issue 2, 12 2 2008, Pages 167-176 Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integration with cardiomyocyte cultures. Pijnappels DA, Schalij MJ, Ramkisoensing AA, van Tuyn J, de Vries AA, van der Laarse A, Ypey DL, Atsma DE

Alignment of cardiomyocytes (CMCs) contributes to the anisotropic (direction-related) tissue structure of the heart, thereby facilitating efficient electrical and mechanical activation of the ventricles. This study aimed to investigate the effects of forced alignment of stem cells during cardiomyogenic differentiation on their functional integration with CMC cultures. Labeled neonatal rat (nr) mesenchymal stem cells (nrMSCs) were allowed to differentiate into functional heart muscle cells in dif... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

Clinical pediatrics, Volume 47, Issue 9, 10 2 2008, Pages 856-860 Attitudes of parents and physicians toward febrile seizures. Yilmaz D, Arhan E, Yuksel D, Ozçelik A, Senbil N, Serdaroglu A, Gurer YK

Objectives: Although febrile seizures are common in children, attitudes may change among parents. The management of a child may differ depending on the specialty of the attending physician. This study was carried out to analyze attitudes of Turkish parents and physicians toward febrile seizures. Material and methods: 308 children with febrile seizure who were admitted to the Department of Pediatric Neurology at Dr Sami Ulus Children's Hospital and Gazi University in Turkey between January 2... Abstract

Cited 37 times since 2008 (2.1 per year) source: EuropePMC

Vaccine, Volume 26, Issue 33, 6 1 2008, Pages 4224-4230 Immunogenicity and efficacy of two candidate human metapneumovirus vaccines in cynomolgus macaques. Herfst S, Schrauwen EJ, de Graaf M, van Amerongen G, van den Hoogen BG, de Swart RL, Osterhaus AD, Fouchier RA

Human metapneumovirus (HMPV) is an important cause of acute respiratory tract disease for which the development of vaccine candidates is warranted. We have previously described the generation of an iscom matrix-adjuvanted HMPV fusion protein subunit vaccine (Fsol) and a live-attenuated vaccine (HMPVM11). Here, we evaluate the immunogenicity and efficacy of these vaccines in cynomolgus macaques. Immunization with Fsol induced HMPV F-specific antibody responses, virus neutralizing antibody titers,... Abstract

Cited 51 times since 2008 (2.9 per year) source: EuropePMC

Current gene therapy, Volume 8, Issue 3, 1 1 2008, Pages 147-161 Episomal vectors for gene therapy. Ehrhardt A, Haase R, Schepers A, Deutsch MJ, Lipps HJ, Baiker A

The increasing knowledge of the molecular and genetic background of many different human diseases has led to the vision that genetic engineering might be used one day for their phenotypic correction. The main goal of gene therapy is to treat loss-of-function genetic disorders by delivering correcting therapeutic DNA sequences into the nucleus of a cell, allowing its long-term expression at physiologically relevant levels. Manifold different vector systems for the therapeutic gene delivery have b... Abstract

Cited 4 times since 2008 (0.2 per year) source: EuropePMC

Tijdschrift voor gerontologie en geriatrie, Volume 39, Issue 3, 1 1 2008, Pages 100-106 [Screening for depression and anxiety in residential homes for the elderly]. Dozeman E, van Schaik DJ, van Marwijk HW, de Wit AE, Beekman AT

Elderly persons in residential homes in the Netherlands are at high risk for developing major depressive and anxiety disorders. A stepped-care protocol being used in a study for vulnerable elderly in the community may also be feasible and effective for this group. A pilot study in a residential home in Amsterdam showed more problems than expected in screening and motivating the inhabitants for this intervention protocol. This article describes the problems in our screening procedure. A personal... Abstract

Cited 37 times since 2008 (2.1 per year) source: EuropePMC

Pediatric research, Volume 63, Issue 6, 1 1 2008, Pages 674-679 Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Allegaert K, van Schaik RH, Vermeersch S, Verbesselt R, Cossey V, Vanhole C, van Fessem M, de Hoon J, van den Anker JN

To document determinants of O-demethylation in critically ill (pre)term neonates and infants, tramadol (M) and O-demethyl tramadol (M1) concentrations were quantified in eighty-six 24 h urine collections and 168 plasma samples. A significant correlation of urine log M/M1 (0.98, SD 0.66) and plasma log M/M1 (0.78, SD 0.45) with postmenstrual age (PMA) (r = -0.69 and -0.65) was observed. One-way analysis of variance documented a significant decrease in urine log and plasma log M/M1 with increasing... Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

Pharmacogenomics, Volume 9, Issue 6, 1 1 2008, Pages 783-789 A drug transporter for all ages? ABCB1 and the developmental pharmacogenetics of cyclosporine. Hesselink DA, van Schaik RH, Nauta J, van Gelder T

Evaluation of: Fanta S, Niemi M, Jönsson S et al.: Pharmacogenetics of cyclosporine in children suggests an age-dependent influence of ABCB1polymorphisms. Pharmacogenet. Genomics 18(2), 77-90 (2008). The clinical use of the immunosuppressive agent cyclosporine is complicated by its toxicity, narrow therapeutic window and highly variable pharmacokinetics between individuals. In adults, genetic polymorphisms in the genes encoding the cyclosporine-metabolizing enzymes CYP3A4 and CYP3A5, as well as... Abstract

Cited 59 times since 2008 (3.4 per year) source: EuropePMC

American journal of primatology, Volume 70, Issue 6, 1 1 2008, Pages 533-541 Begging for information: mother-offspring food sharing among wild Bornean orangutans. Jaeggi AV, van Noordwijk MA, van Schaik CP

Transfer of solid food from mothers or other adults to dependent offspring is commonly observed in various primate species and both nutritional and informational benefits have been proposed to explain the function of such food sharing. Predictions from these hypotheses are tested using observational data on wild orangutans (Pongo pygmaeus wurmbii) at Tuanan, Central Borneo, Indonesia. In 1,145 hr of focal observation and 458 recorded food interactions between four pairs of females with offspring... Abstract

Cited 12 times since 2008 (0.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 135, Issue 6, 1 1 2008, Pages 1247-52; discussion 1252-3 Magnetic resonance imaging assessment of reverse left ventricular remodeling late after restrictive mitral annuloplasty in early stages of dilated cardiomyopathy. Westenberg JJ, Braun J, Van de Veire NR, Klautz RJ, Versteegh MI, Roes SD, van der Geest RJ, de Roos A, van der Wall EE, Reiber JH, Bax JJ, Dion RA

Objective: Magnetic resonance imaging was used to evaluate left ventricular reverse remodeling at long-term follow-up (3-4 years) after restrictive mitral annuloplasty in patients with early stages of nonischemic, dilated cardiomyopathy, and severe mitral regurgitation. Methods: Twenty-two selected patients (eligible to undergo magnetic resonance imaging) with mild to moderate heart failure (mean New York Heart Association class 2.2 +/- 0.4), dilated cardiomyopathy (left ventricular ejection fra... Abstract

Cited 12 times since 2008 (0.7 per year) source: EuropePMC

Pediatric hematology and oncology, Volume 25, Issue 4, 1 1 2008, Pages 301-311 Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder. Yilmaz D, Karapinar B, Balkan C, Akisü M, Kavakli K

Coagulopathy is an important cause of mortality in critically ill children. Traditional therapies to correct coagulopathy lead to great time delays and cause fluid overload in patients. The authors report the effectiveness and safety of the activated recombinant factor VII (rFVIIa) administration in a series of 13 nonhemophiliac children with acute, life-threatening bleeding. In this retrospective study, the records of the patients who were not diagnosed with congenital hemorrhagic disorder and... Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 2, 28 4 2008, Pages 135-139 Prognostic value of free plasma homocysteine levels in patients hospitalized with acute coronary syndrome. van Oijen MG, Claessen BE, Clappers N, van Schaik A, Laheij RJ, Jansen JB, Peters WH, Verheugt FW

Elevated total plasma homocysteine is an established risk factor for cardiovascular disease. Experimental evidence suggests that non-protein-bound free homocysteine is particularly hazardous to the vascular endothelium. This study evaluates the predictive role of free plasma homocysteine levels on cardiovascular endpoints in patients with acute coronary syndrome (ACS). In a cohort of 379 hospitalized patients with a diagnosis of myocardial infarction or unstable angina pectoris, total and free p... Abstract

Cited 122 times since 2008 (7 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 85, Issue 2, 28 4 2008, Pages 155-163 Pharmacogenetic pathway analysis of docetaxel elimination. Baker SD, Verweij J, Cusatis GA, van Schaik RH, Marsh S, Orwick SJ, Franke RM, Hu S, Schuetz EG, Lamba V, Messersmith WA, Wolff AC, Carducci MA, Sparreboom A

The purpose of this study was to evaluate the affinity of docetaxel for 14 transporter proteins and assess the functional significance of 17 variants in five genes involved in drug elimination. Among the transfected models investigated, OATP1B3 (SLCO1B3) was identified as the most efficient influx transporter for docetaxel. None of the observed genotypes (SLCO1B3, ABCB1, and ABCC2) was related with docetaxel clearance in 92 white patients (P > 0.17). However, the simultaneous presence of the... Abstract

Cited 35 times since 2008 (2 per year) source: EuropePMC

Circulation, Volume 117, Issue 22, 27 4 2008, Pages 2850-2858 Accessory atrioventricular myocardial connections in the developing human heart: relevance for perinatal supraventricular tachycardias. Hahurij ND, Gittenberger-De Groot AC, Kolditz DP, Bökenkamp R, Schalij MJ, Poelmann RE, Blom NA

Background: Fetal and neonatal atrioventricular (AV) reentrant tachycardias can be life-threatening but resolve in most cases during the first year of life. The transient presence of accessory AV myocardial connections during annulus fibrosus development may explain this phenomenon. Methods and results: A total of 45 human embryonic, fetal, and neonatal sectioned hearts (4 to 36 weeks of development) were studied immunohistochemically. Accessory myocardial AV connections were quantified and cate... Abstract

Cited 59 times since 2008 (3.4 per year) source: EuropePMC

Annals of vascular surgery, Volume 22, Issue 4, 27 4 2008, Pages 582-597 Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation. van Weel V, van Tongeren RB, van Hinsbergh VW, van Bockel JH, Quax PH

Stimulation of vascular growth to treat limb ischemia is promising, and early results obtained from uncontrolled clinical trials using angiogenic agents, e.g., vascular endothelial growth factor, led to high expectations. However, negative results from recent placebo-controlled trials warrant further research. Here, current insights into mechanisms of vascular growth in the adult, in particular the role of angiogenic factors, the immune system, and bone marrow, were reviewed, together with modes... Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Journal of vascular surgery, Volume 48, Issue 2, 23 4 2008, Pages 368-376 Treatment for peripheral arterial obstructive disease: An appraisal of the economic outcome of complications. Flu H, van der Hage JH, Knippenberg B, Merkus JW, Hamming JF, Lardenoye JW

Objective: This study determined the average estimated total costs after treatment for peripheral arterial occlusive disease (PAOD) and evaluated the effect of postoperative complications and their consequences for the total costs. Methods: Cost data on all admissions involving treatment for PAOD from January 2007 until July 2007 were collected. A prospective analysis was made using the patient-related risk factor and comorbidity (Society for Vascular Surgery/International Society of Cardiovascu... Abstract

Cited 314 times since 2008 (17.9 per year) source: EuropePMC

Lancet (London, England), Volume 371, Issue 9628, 22 4 2008, Pages 1927-1935 Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Sattar N, McConnachie A, Shaper AG, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Lennon L, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Whincup PH, Shepherd J, Wannamethee SG

Background: Clinical use of criteria for metabolic syndrome to simultaneously predict risk of cardiovascular disease and diabetes remains uncertain. We investigated to what extent metabolic syndrome and its individual components were related to risk for these two diseases in elderly populations. Methods: We related metabolic syndrome (defined on the basis of criteria from the Third Report of the National Cholesterol Education Program) and its five individual components to the risk of events of i... Abstract

Cited 30 times since 2008 (1.7 per year) source: EuropePMC

European journal of endocrinology, Volume 159, Issue 2, 21 3 2008, Pages 97-103 Increased aortic root diameters in patients with acromegaly. van der Klaauw AA, Bax JJ, Smit JW, Holman ER, Delgado V, Bleeker GB, Biermasz NR, Roelfsema F, Romijn JA, Pereira AM

Objective: The clinical manifestations of acromegalic cardiomyopathy include arrhythmias, valvular regurgitation, concentric left ventricular (LV) hypertrophy, and LV systolic and diastolic dysfunction. At present, it is unknown whether acromegaly also affects the aortic root. Design: Aortic root diameters were prospectively assessed in 37 acromegalic patients (18 patients with active disease and 19 with controlled disease) by conventional two-dimensional and Doppler echocardiography before, and... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

Journal of clinical pharmacology, Volume 48, Issue 7, 19 3 2008, Pages 837-848 Population pharmacokinetic modeling of epoetin delta in pediatric patients with chronic kidney disease. Knebel W, Palmen M, Dowell JA, Gastonguay M

This analysis quantifies the population pharmacokinetics of subcutaneous and intravenous epoetin delta, an epoetin produced in a human cell line, in pediatric patients with chronic kidney disease and estimates the effects of covariate factors on epoetin delta and epoetin alfa pharmacokinetic parameters. Erythropoietin serum concentration data, taken from a phase III study conducted in 60 patients aged 1 to 17 years, were best described by a 1-compartment model with first-order absorption and eli... Abstract

Cited 85 times since 2008 (4.9 per year) source: EuropePMC

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, Volume 11, Issue 3, 19 3 2008, Pages 77-98 CYP450 pharmacogenetics for personalizing cancer therapy. van Schaik RH

Today's drug therapy regimens rely on the anticipated relation between drug dose, acquired plasma level and desired effect. However, the capacity of individual patients to absorb and metabolise drugs may differ significantly, part of which is due to genetic factors. These genetic factors can be used to predict the drug metabolizing potential of patients before starting therapy. A major challenge is to identify the genetic polymorphisms which are relevant for a particular therapy and to dete... Abstract