Research

Publications

Below you can find a list of our published research.

9543 results

Cited 80 times since 2007 (4.3 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 7, 15 3 2007, Pages 1135-1146 Assessment of myocardial viability in patients with heart failure. Schinkel AF, Poldermans D, Elhendy A, Bax JJ

The prognosis for patients with chronic ischemic left ventricular dysfunction is poor, despite advances in different therapies. Noninvasive assessment of myocardial viability may guide patient management. Multiple imaging techniques have been developed to assess viable and nonviable myocardium by evaluating perfusion, cell membrane integrity, mitochondria, glucose metabolism, scar tissue, and contractile reserve. PET, (201)Tl and (99m)Tc scintigraphy, and dobutamine stress echocardiography have... Abstract

Cited 18 times since 2007 (1 per year) source: EuropePMC

The American journal of cardiology, Volume 100, Issue 3, 14 2 2007, Pages 476-482 Usefulness of triplane tissue Doppler imaging to predict acute response to cardiac resynchronization therapy. Van de Veire NR, Bleeker GB, Ypenburg C, De Sutter J, Ajmone Marsan N, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

This study evaluated the value of triplane tissue Doppler imaging (TDI) to predict acute response after cardiac resynchronization therapy (CRT). Forty-nine patients scheduled for CRT underwent triplane echocardiography with simultaneous TDI acquisition before and 48 hours after implantation. A 3-dimensional left ventricular (LV) volume was generated and LV volumes and ejection fraction were calculated. A parametric imaging technique, tissue synchronization imaging, was applied to portray the are... Abstract

Cited 4 times since 2007 (0.2 per year) source: EuropePMC

Preventive veterinary medicine, Volume 81, Issue 4, 12 2 2007, Pages 265-273 Factors associated with variation in Neospora caninum bulk-milk S/P ratios in initially bulk-milk negative testing Dutch dairy herds. Bartels CJ, van Schaik G, van Maanen K, Wouda W, Dijkstra T

We conducted a study on 81 initially bulk-milk ELISA negative dairy herds taken from a random sample of Dutch dairy herds to evaluate variation in bulk-milk S/P ratios and to study reasons for bulk-milk conversion. These herds were repeatedly (3-month intervals) tested between April 2004 and August 2005 and serostatus of all animals had previously been established as negative (N), low-positive (LP) or high-positive (HP). Of these herds, herd- and test-related factors associated with variation in... Abstract

Cited 90 times since 2007 (4.9 per year) source: EuropePMC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 25, Issue 19, 11 2 2007, Pages 2719-2726 Cigarette smoking and irinotecan treatment: pharmacokinetic interaction and effects on neutropenia. van der Bol JM, Mathijssen RH, Loos WJ, Friberg LE, van Schaik RH, de Jonge MJ, Planting AS, Verweij J, Sparreboom A, de Jong FA

Purpose: Several constituents of cigarette smoke are known to interact with drug metabolizing enzymes and potentially affect treatment outcome with substrate drugs. The purpose of this study was to determine the effects of cigarette smoking on the pharmacokinetics and adverse effects of irinotecan. Patients and methods: A total of 190 patients (49 smokers, 141 nonsmokers) treated with irinotecan (90-minute intravenous administration on a 3-week schedule) were evaluated for pharmacokinetics. Comp... Abstract

Cited 313 times since 2007 (16.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 24, 4 1 2007, Pages 2303-2311 Outcome of pregnancy in women with congenital heart disease: a literature review. Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, van Dijk AP, Vliegen HW, Yap SC, Moons P, Ebels T, van Veldhuisen DJ, ZAHARA Investigators

A search of peer-reviewed literature was conducted to identify reports that provide data on complications associated with pregnancy in women with structural congenital heart disease (CHD). This review describes the outcome of 2,491 pregnancies, including 377 miscarriages (15%) and 114 elective abortions (5%). Important cardiac complications were seen in 11% of the pregnancies. Obstetric complications do not appear to be more prevalent. In complex CHD, premature delivery rates are high, and more... Abstract

Cited 21 times since 2007 (1.1 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 104, Issue 24, 4 1 2007, Pages 10000-10005 Global distribution of negative cofactor 2 subunit-alpha on human promoters. Albert TK, Grote K, Boeing S, Stelzer G, Schepers A, Meisterernst M

Negative cofactor 2 (NC2) forms a stable complex with TATA-binding protein (TBP) on promoters in vitro. Its association with TBP prevents the binding of TFIIB and leads to inhibition of preinitiation complex formation. Here, we investigate the association of NC2 subunit-alpha with human RNA polymerase II promoter regions by using gene-specific ChIP and genome-wide promoter ChIPchip analyses. We find NC2alpha associated with a large number of human promoters, where it peaks close to the core regi... Abstract

Cited 19 times since 2007 (1 per year) source: EuropePMC

Journal of the American Geriatrics Society, Volume 55, Issue 6, 1 1 2007, Pages 872-877 The routine electrocardiogram for cardiovascular risk stratification in old age: the Leiden 85-plus study. de Ruijter W, Westendorp RG, Macfarlane PW, Jukema JW, Assendelft WJ, Gussekloo J

Objectives: To explore the prognostic value of signs of prior myocardial infarction (MI) and atrial fibrillation (AF) on routine electrocardiograms (ECGs) at the age of 85 with respect to mortality and changes in functional status. Design: Observational, prospective cohort study with complete 6-year follow-up. Setting: General population. Participants: A population-based sample of 566 85-year-old participants (377 women, 189 men), without exclusion criteria. Measurements: Annual ECG recording an... Abstract

Cited 6 times since 2007 (0.3 per year) source: EuropePMC

Current opinion in anaesthesiology, Volume 20, Issue 3, 1 1 2007, Pages 254-260 Perioperative medical management of ischemic heart disease in patients undergoing noncardiac surgery. Feringa HH, Bax JJ, Poldermans D

Purpose of review: Cardiovascular disease is the leading cause of death after anesthesia and surgery. The preoperative identification of patients with underlying coronary artery disease is important to initiate appropriate treatment strategies in order to reduce the risk of perioperative complications. The current review will discuss new insights in the field of perioperative medicine that can be applied to clinical practice or stimulate further investigation. Recent findings: Recent findings in... Abstract

Cited 13 times since 2007 (0.7 per year) source: EuropePMC

Current opinion in anaesthesiology, Volume 20, Issue 3, 1 1 2007, Pages 274-278 Management of patients with cardiac stents undergoing noncardiac surgery. Schouten O, Bax JJ, Poldermans D

Purpose of review: Coronary stenting is performed in over 4 million patients annually. Approximately 5% of these patients undergo a noncardiac surgical procedure within 1 year after stenting. Surgery might induce hypercoagulability. This causes increased concern about the effects of previous coronary stenting on postoperative cardiac outcome, particularly in-stent thrombosis. On the other hand, patients with multiple cardiac risk factors are at high risk for postoperative adverse cardiac events... Abstract

Cited 4 times since 2007 (0.2 per year) source: EuropePMC

International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, Volume 30, Issue 2, 1 1 2007, Pages 163-165 Factors important in the design of information material for scoliosis. van Schaik P, Flynn D, van Wersch A, Ryan KA, Ferguson V

The aim of this study was to identify the most salient characteristics for designing written information for persons with idiopathic scoliosis and their families. A sample of 106 persons with idiopathic scoliosis (n=83) and family members of persons with idiopathic scoliosis (n=23) completed a postal questionnaire to assess perceived level of scoliosis-related knowledge, importance attached to generic design characteristics of information material and preferences for presentation of risk informa... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 151, Issue 24, 1 1 2007, Pages 1375; author reply 1375 [The metabolic syndrome]. van der Heijden AJ

Abstract

Cited 26 times since 2007 (1.4 per year) source: EuropePMC

Environmental science & technology, Volume 41, Issue 12, 1 1 2007, Pages 4286-4291 Copper(II) binding to dissolved organic matter fractions in municipal solid waste incinerator bottom ash leachate. Olsson S, Van Schaik JW, Gustafsson JP, Kleja DB, Van Hees PA

Information on Cu speciation in municipal solid waste incineration (MSWI) bottom ash leachate is needed for Cu leaching predictions and toxicity estimates. The complexation of Cu with dissolved organic matter (DOM) in leachates from a stored MSWI bottom ash was studied potentiometrically using a Cu-ion selective electrode. More than 95% of the copper was bound to DOM in the hydrophilic fraction of the leachate, indicating that the hydrophilic acids contribute to Cu complex formation. The hydroph... Abstract

Cited 26 times since 2007 (1.4 per year) source: EuropePMC

American journal of primatology, Volume 69, Issue 6, 1 1 2007, Pages 641-651 Demography and life history of Thomas langurs (Presbytis thomasi). Wich SA, Steenbeek R, Sterck EH, Korstjens AH, Willems EP, Van Schaik CP

Life history data from wild primate populations are necessary to explain variation in primate social systems and explain differences between primates and other mammals. Here we report life history data from a 12.5-year study on wild Thomas langurs. Mean age at first reproduction was 5.4 years and the sex ratio at birth was even. The mean interbirth interval (IBI) after a surviving infant was 26.8 mo, after nonsurviving infants 17.7 mo, and combined 22.0 mo. Mean annual birth rate of adult female... Abstract

Cited 8 times since 2007 (0.4 per year) source: EuropePMC

American journal of Alzheimer's disease and other dementias, Volume 22, Issue 3, 1 1 2007, Pages 167-175 The Closing Group: Therapeutic recreation for nursing home residents with dementia and accompanying agitation and/or anxiety. Putman L, Wang JT

Long-term care residents who have a dementia diagnosis could account for as much 50% of a nursing home's population. Often residents with dementia experience a distressing behavioral symptom that affects the resident experiencing the symptom(s), other nursing home residents, visitors, and staff. The Closing Group intervention was developed as a nonpharmacological alternative that aims to reduce agitation and anxiety, increase socialization, decrease restraint use, and decrease antipsychotic... Abstract

Cited 130 times since 2007 (7 per year) source: EuropePMC

Journal of immunology (Baltimore, Md. : 1950), Volume 178, Issue 12, 1 1 2007, Pages 7678-7685 Down-regulation of E-cadherin in human bronchial epithelial cells leads to epidermal growth factor receptor-dependent Th2 cell-promoting activity. Heijink IH, Kies PM, Kauffman HF, Postma DS, van Oosterhout AJ, Vellenga E

Airway epithelial cells are well-known producers of thymus- and activation-regulated chemokine (TARC), a Th2 cell-attracting chemokine that may play an important role in the development of allergic airway inflammation. However, the mechanism responsible for up-regulation of TARC in allergy is still unknown. In the asthmatic airways, loss of expression of the cell-cell contact molecule E-cadherin and reduced epithelial barrier function has been observed, which may be the result of an inadequate r... Abstract

Cited 41 times since 2007 (2.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 1, 31 5 2007, Pages 48-52 Gender influence on the diagnostic accuracy of 64-slice multislice computed tomography coronary angiography for detection of obstructive coronary artery disease. Pundziute G, Schuijf JD, Jukema JW, van Werkhoven JM, Boersma E, de Roos A, van der Wall EE, Bax JJ

Objective: To compare the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography between female and male patients using conventional coronary angiography as the reference standard. Design: Diagnostic accuracy study. Setting: University hospital. Patients: 103 consecutive patients (51 men, 52 women, mean (SD) age 60 (10) years) with known and suspected coronary artery disease underwent 64-slice MSCT. Main outcome measures: Diagnostic accuracy of 64-slice MSCT t... Abstract

Cited 8 times since 2007 (0.4 per year) source: EuropePMC

Translational research : the journal of laboratory and clinical medicine, Volume 150, Issue 3, 25 4 2007, Pages 147-149 Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot study. Berkhout M, Roelofs HM, Friederich P, van Schaik A, Gosens MJ, Marian B, Pool-Zobel BL, van Krieken JH, Peters WH, Nagengast FM

Abstract

Cited 12 times since 2007 (0.6 per year) source: EuropePMC

Heart rhythm, Volume 4, Issue 9, 24 4 2007, Pages 1144-1148 Does left ventricular dyssynchrony immediately after acute myocardial infarction result in left ventricular dilatation? Mollema SA, Bleeker GB, Liem SS, Boersma E, van der Hoeven BL, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Reverse remodeling of the left ventricle (LV) is one of the advantageous mechanisms of cardiac resynchronization therapy (CRT). Substantial LV dyssynchrony seems mandatory for echocardiographic response to CRT. Conversely, LV dyssynchrony early after acute myocardial infarction may result in LV dilatation during follow-up. Objective: The purpose of this study was to evaluate the relation between LV dyssynchrony early after acute myocardial infarction and the occurrence of long-term L... Abstract

Cited 79 times since 2007 (4.3 per year) source: EuropePMC

Journal of lipid research, Volume 48, Issue 8, 24 4 2007, Pages 1763-1771 Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression. van der Hoogt CC, de Haan W, Westerterp M, Hoekstra M, Dallinga-Thie GM, Romijn JA, Princen HM, Jukema JW, Havekes LM, Rensen PC

In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester transfer protein (CETP). To this end, APOE*3-Leiden (E3L) transgenic mice without and with the human CETP transgene, under the control of its natural regulatory flanking regions, were fed a Western-type diet with or without fenofibrate. Fenofibrate... Abstract

Cited 89 times since 2007 (4.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 22, 23 4 2007, Pages 2204-2210 Usefulness of 64-slice multislice computed tomography coronary angiography to assess in-stent restenosis. Cademartiri F, Schuijf JD, Pugliese F, Mollet NR, Jukema JW, Maffei E, Kroft LJ, Palumbo A, Ardissino D, Serruys PW, Krestin GP, Van der Wall EE, de Feyter PJ, Bax JJ

Objectives: This study sought to evaluate the diagnostic accuracy of 64-slice multislice computed tomography (MSCT) coronary angiography in the follow-up of patients with previous coronary stent implantation. Background: Recent investigations have shown increased image quality and diagnostic accuracy for noninvasive coronary angiography with 64-slice MSCT as compared with previous-generation MSCT scanners, but data on the evaluation of coronary stents are scarce. Methods: In 182 patients (152 [8... Abstract