Research

Publications

Below you can find a list of our published research.

9543 results

Cited 97 times since 2007 (5.2 per year) source: EuropePMC

The American journal of clinical nutrition, Volume 85, Issue 4, 1 1 2007, Pages 989-995 Is higher dairy consumption associated with lower body weight and fewer metabolic disturbances? The Hoorn Study. Snijder MB, van der Heijden AA, van Dam RM, Stehouwer CD, Hiddink GJ, Nijpels G, Heine RJ, Bouter LM, Dekker JM

Background: Dairy consumption has been postulated to reduce the risk of obesity and metabolic disturbances. Objective: The aim of this study was to evaluate the associations of dairy consumption with body weight and other components of the metabolic syndrome. Design: We used cross-sectional data for 2064 men and women aged 50-75 y who participated in the Hoorn Study. The metabolic syndrome was defined according to the National Cholesterol Education Program Expert Panel. Dairy consumption was ass... Abstract

Cited 82 times since 2007 (4.4 per year) source: EuropePMC

The Journal of pharmacology and experimental therapeutics, Volume 322, Issue 1, 28 4 2007, Pages 141-147 Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. van Vliet EA, van Schaik R, Edelbroek PM, Voskuyl RA, Redeker S, Aronica E, Wadman WJ, Gorter JA

Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to pharmacoresistance that occurs in a subset of epileptic patients. Whether P-gp expression and function is affected in other brain regions and in organs that are involved in drug metabolism is less studied. Therefore, we investigated P-gp expression in different brain regions and liver of chronic epilepti... Abstract

Cited 4 times since 2007 (0.2 per year) source: EuropePMC

International journal of pediatric otorhinolaryngology, Volume 71, Issue 6, 26 4 2007, Pages 857-861 Immunohistochemical assesment of heat shock protein 70 in adenoid tissue. Aktepe F, Sahin O, Dilek H, Yilmaz D, Kahveci O, Derekoy S

Objectives: To evaluate the expression of heat shock protein 70 (HSP70) and its relation to histopathologic parameters in adenoid hypertrophy and hyperplasia. In addition, HSP70 expression in adenoid tissue was compared with in adult and childhood. Methods: Paraffin-embedded adenoid tissue sections were obtained from 19 childhood and 15 adult patients. Expression of HSP70 was evaluated by immunohistochemical staining using anti-HSP70 monoclonal antibody and correlated with histopathologic parame... Abstract

Cited 82 times since 2007 (4.4 per year) source: EuropePMC

American journal of respiratory and critical care medicine, Volume 176, Issue 2, 22 4 2007, Pages 121-128 Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Slats AM, Janssen K, van Schadewijk A, van der Plas DT, Schot R, van den Aardweg JG, de Jongste JC, Hiemstra PS, Mauad T, Rabe KF, Sterk PJ

Rationale: Deep inspirations provide physiologic protection against airway narrowing in healthy subjects, which is impaired in asthma and chronic obstructive pulmonary disease (COPD). Airway inflammation has been suggested to alter airway mechanics during deep inspiration. Objectives: We tested the hypothesis that the number of bronchial inflammatory cells is related to deep inspiration-induced bronchodilation in asthma and COPD. Methods: In a cross-sectional study, three modified methacholine c... Abstract

Cited 16 times since 2007 (0.9 per year) source: EuropePMC

The American journal of cardiology, Volume 99, Issue 9, 15 3 2007, Pages 1193-1195 Prognostic significance of myocardial ischemia during dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus and no prior history of coronary events. Sozzi FB, Elhendy A, Rizzello V, Biagini E, van Domburg RT, Schinkel AF, Bax JJ, Vourvouri E, Danzi GB, Poldermans D

The prognostic significance of myocardial ischemia assessed by dobutamine stress echocardiography in asymptomatic patients with diabetes mellitus who have no previous coronary artery disease remains unclear. We assessed the value of dobutamine stress echocardiography for risk stratification in 161 asymptomatic patients with type 2 diabetes (mean 62 +/- 12 years of age; 96 men) who had no previous myocardial infarction or revascularization. End point during follow-up was hard cardiac events (card... Abstract

Cited 70 times since 2007 (3.7 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 27, Issue 6, 15 3 2007, Pages 1426-1432 Expression of vascular endothelial growth factor, stromal cell-derived factor-1, and CXCR4 in human limb muscle with acute and chronic ischemia. van Weel V, Seghers L, de Vries MR, Kuiper EJ, Schlingemann RO, Bajema IM, Lindeman JH, Delis-van Diemen PM, van Hinsbergh VW, van Bockel JH, Quax PH

Objective: Vascular endothelial growth factor (VEGF)-induced stromal cell-derived factor-1 (SDF-1) has been implicated in angiogenesis in ischemic tissues by recruitment of CXCR4-positive bone marrow-derived circulating cells with paracrine functions in preclinical models. Here, evidence for this is provided in patients with peripheral artery disease. Methods and results: Expression patterns of VEGF, SDF-1, and CXCR4 were studied in amputated limbs of 16 patients. VEGF-A was expressed in vascula... Abstract

Cited 69 times since 2007 (3.7 per year) source: EuropePMC

Journal of vascular surgery, Volume 45, Issue 5, 13 2 2007, Pages 936-943 The effect of intensified lipid-lowering therapy on long-term prognosis in patients with peripheral arterial disease. Feringa HH, Karagiannis SE, van Waning VH, Boersma E, Schouten O, Bax JJ, Poldermans D

Background: The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) are associated with improved outcome in patients with peripheral arterial disease. Statins may also have beneficial properties beyond their lipid-lowering effect. Methods: A prospective, observational cohort study was conducted at a university hospital from 1990 to 2005 to examine whether higher doses of statins and lower low-density lipoprotein (LDL) cholesterol levels are both independently associated with imp... Abstract

Cited 111 times since 2007 (5.9 per year) source: EuropePMC

Circulation, Volume 115, Issue 11, 12 2 2007, Pages 1426-1432 Noninvasive evaluation of coronary sinus anatomy and its relation to the mitral valve annulus: implications for percutaneous mitral annuloplasty. Tops LF, Van de Veire NR, Schuijf JD, de Roos A, van der Wall EE, Schalij MJ, Bax JJ

Background: Percutaneous mitral annuloplasty has been proposed as an alternative to surgical annuloplasty. In this respect, evaluation of the coronary sinus (CS) and its relation with the mitral valve annulus (MVA) and the coronary arteries is relevant. The feasibility of evaluating these issues noninvasively with multislice computed tomography was determined. Methods and results: In 105 patients (72 men, age 59+/-11 years), 64-slice multislice computed tomography was performed for noninvasive e... Abstract

Cited 13 times since 2007 (0.7 per year) source: EuropePMC

BMC geriatrics, Volume 7, 8 2 2007, Pages 6 Depression and anxiety, an indicated prevention (DIP) protocol in homes for the elderly: feasibility and (cost) effectiveness of a stepped care programme. Dozeman E, van Schaik DJ, Beekman AT, Stalman WA, Bosmans JE, van Marwijk HW

Background: Depressive and anxiety disorders are a very common, serious and underdetected problem in homes for the elderly. Elderly persons in residential homes are at high risk for developing major depressive and anxiety disorders, and, therefore, deserve attention with regard to prevention. Methods/design: This protocol describes a randomised trial on the feasibility and (cost) effectiveness of a stepped-care programme for prevention of depressive and anxiety disorders in homes for the elderly... Abstract

Cited 188 times since 2007 (10 per year) source: EuropePMC

The American journal of cardiology, Volume 99, Issue 8, 6 1 2007, Pages 1072-1081 Cyphering the complexity of coronary artery disease using the syntax score to predict clinical outcome in patients with three-vessel lumen obstruction undergoing percutaneous coronary intervention. Valgimigli M, Serruys PW, Tsuchida K, Vaina S, Morel MA, van den Brand MJ, Colombo A, Morice MC, Dawkins K, de Bruyne B, Kornowski R, de Servi S, Guagliumi G, Jukema JW, Mohr FW, Kappetein AP, Wittebols K, Stoll HP, Boersma E, Parrinello G, ARTS II

The Syntax score (SXscore) was recently developed as a comprehensive angiographic scoring system aiming to assist in patient selection and risk stratification of patients with extensive coronary artery disease undergoing contemporary revascularization. A validation of this angiographic classification scheme is lacking. We assessed its predictive value in patients who underwent percutaneous intervention (PCI) for 3-vessel disease and explored its performance in comparison with the modified lesion... Abstract

Cited 96 times since 2007 (5.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 49, Issue 11, 6 1 2007, Pages 1137-1148 Role of imaging in cardiac stem cell therapy. Beeres SL, Bengel FM, Bartunek J, Atsma DE, Hill JM, Vanderheyden M, Penicka M, Schalij MJ, Wijns W, Bax JJ

Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for... Abstract

Turkish journal of haematology : official journal of Turkish Society of Haematology, Volume 24, Issue 1, 1 1 2007, Pages 32-35 Intense myelofibrosis in a child: unusual result of EBV-associated hemophagocytic lymphohistiocytosis. Karapınar B, Yılmaz D, Aydınok Y, Türkoğlu E, Hekimgil M, Kavaklı K

A previously healthy 12-year-old girl was admitted to the intensive care unit with severe pulmonary bleeding. Her history revealed that she had suffered from high fever, fatigue, sore throat, myalgia and generalized rash for two weeks. Physical examination revealed hepatosplenomegaly. Laboratory investigation showed pancytopenia associated with unusual high levels of serum ferritin, triglyceride and lactate dehydrogenase (LDH) and low fibrinogen levels. Apparent hemophagocytosis was seen in bone... Abstract

Cited 17 times since 2007 (0.9 per year) source: EuropePMC

Stroke, Volume 38, Issue 4, 1 1 2007, Pages 1374-1376 Pravastatin decreases wall shear stress and blood velocity in the internal carotid artery without affecting flow volume: results from the PROSPER MRI study. Box FM, van der Grond J, de Craen AJ, Palm-Meinders IH, van der Geest RJ, Jukema JW, Reiber JH, van Buchem MA, Blauw GJ, PROSPER Study Group

Background and purpose: Despite speculations, it is unknown whether statins affect wall shear stress (WSS). Therefore, the effect of pravastatin on WSS was investigated. Methods: In 355 elderly individuals participating in the PROSPER study (follow up after 3 years), the effect of 40 mg pravastatin on WSS was assessed in the internal carotid artery using magnetic resonance imaging. Results: WSS and blood velocity decreased both in the pravastatin group and in the placebo group but decreased fast... Abstract

Cited 59 times since 2007 (3.1 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 83, Issue 3, 1 1 2007, Pages 907-911 Predicting outcome of pulmonary valve replacement in adult tetralogy of Fallot patients. Henkens IR, van Straten A, Schalij MJ, Hazekamp MG, de Roos A, van der Wall EE, Vliegen HW

Background: Predicting changes in right ventricular (RV) size and function after pulmonary valve replacement (PVR) is important for timely reintervention in adult tetralogy of Fallot patients. Methods: We analyzed the influence of pulmonary regurgitation severity and RV size and function before PVR on the outcome of RV size and function after PVR in 27 adult Fallot patients who had cardiac magnetic resonance imaging before and after PVR. RV dimensions were indexed for body surface area. Results:... Abstract

Cited 1 times since 2007 (0.1 per year) source: EuropePMC

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 8, Issue 2, 1 1 2007, Pages 174-176 Do pediatric patients with septic shock benefit from steroid therapy? A critical appraisal of "Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock" by Oppert et al. (Crit Care Med 2005; 33:2457-2464). van Schaik SM

Objective: To review the findings and discuss the implications of studies on the use of low-dose corticosteroids in septic shock. Design: A critical appraisal of "Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock" by Oppert et al. (Crit Care Med 2005; 33:2457-2464) with literature review. Findings: Previous studies have shown that low-dose corticosteroids shorten duration of shock in adults with sepsis, which is confirmed by... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 20, Issue 3, 1 1 2007, Pages 257-261 Prognostic significance of akinesis becoming dyskinesis during dobutamine stress echocardiography. Sozzi FB, Elhendy A, Rizzello V, Biagini E, van Domburg RT, Vourvouri EC, Schinkel AF, Danzi GB, Bax JJ, Poldermans D

Background: Akinesis becoming dyskinesis (AKBD) at high-dose dobutamine stress echocardiography (DSE) has been disregarded as a marker of myocardial ischemia. However, its prognostic significance is unknown. Objectives: We sought to assess the long-term outcome of patients with AKBD during DSE. Methods: A total of 731 patients (age 62 +/- 15 years, 628 men) with two or more akinetic left ventricular segments at rest underwent DSE and were followed up for a mean period of 5 +/- 2.7 years. The end... Abstract

Cited 14 times since 2007 (0.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 93, Issue 3, 1 1 2007, Pages 375-376 Scar tissue on contrast-enhanced MRI predicts left ventricular remodelling after acute infarction. Kaandorp TA, Lamb HJ, Viergever EP, Poldermans D, Boersma E, van der Wall EE, de Roos A, Bax JJ

Abstract

Cited 12 times since 2007 (0.6 per year) source: EuropePMC

Journal of agricultural and food chemistry, Volume 55, Issue 6, 23 4 2007, Pages 2459-2466 Porosity and the effect of structural changes on the mechanical glass transition temperature. Kasapis S, Sablani SS, Rahman MS, Al-Marhoobi IM, Al-Amri IS

Continuing an investigation on the fundamentals and applications of a recently proposed concept, i.e., the mechanical or network glass transition temperature, we now report data on the macrostructural changes in dehydrated apple tissue in relation to apparent porosity. Care was taken to keep the moisture content of the matrix constant (approximately 81%) while the volume fraction of total pores ranged from 0.38 to 0.79. Reproducible mechanical profiles identified the first derivative of shear st... Abstract

Cited 5 times since 2007 (0.3 per year) source: EuropePMC

BMC gastroenterology, Volume 7, 23 4 2007, Pages 7 Oxidised- and total non-protein bound glutathione and related thiols in gallbladder bile of patients with various gastrointestinal disorders. Peters WH, van Schaik A, Peters JH, van Goor H

Background: Glutathione is a tripeptide composed of glutamate, cysteine and glycine, accomplishing a broad range of vital functions. Synthesis of glutathione and cysteine is performed mainly in the liver, whereas most other tissues are supplied with these thiols via sinusoidal efflux into the blood. Since canalicular efflux also occurs, thiols may be present in human bile. However, thiol composition of human gallbladder bile is largely unknown, which makes it difficult to speculate on the exact... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

European heart journal, Volume 28, Issue 5, 22 4 2007, Pages 519-521 Indications of prophylactic coronary revascularization in patients undergoing major vascular surgery: the saga continues. Hoeks SE, Bax JJ, Poldermans D

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