9543 results
Cited 44 times since 2006 (2.3 per year)
source: EuropePMC
Vascular pharmacology,
Volume 45, Issue 5, 22 4 2006, Pages 281-301
Murine models of myocardial and limb ischemia: diagnostic end-points and relevance to clinical problems.
Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V, Eefting D, Quax PH, Hu Y, Xu Q, Hemdahl AL, van Golde J, Huijberts M, de Lussanet Q, Struijker Boudier H, Couffinhal T, Duplaa C, Chimenti S, Staszewsky L, Latini R, Baumans V, Levy BI
Ischemic disease represents the new epidemic worldwide. Animal models of ischemic disease are useful because they can help us to understand the underlying pathogenetic mechanisms and develop new therapies. The present review article summarizes the results of a consensus conference on the status and future development of experimentation in the field of cardiovascular medicine using murine models of peripheral and myocardial ischemia. The starting point was to recognize the limits of the approach,...
Abstract
Cited 138 times since 2006 (7.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 48, Issue 5, 17 3 2006, Pages 964-969
Should major vascular surgery be delayed because of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate control?
Poldermans D, Bax JJ, Schouten O, Neskovic AN, Paelinck B, Rocci G, van Dortmont L, Durazzo AE, van de Ven LL, van Sambeek MR, Kertai MD, Boersma E, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echo Study Group
Objectives: The purpose of this study was to assess the value of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate (HR) control scheduled for major vascular surgery. Background: Treatment guidelines of the American College of Cardiology/American Heart Association recommend cardiac testing in these patients to identify subjects at increased risk. This policy delays surgery, even though test results might be redundant and beta-blockers...
Abstract
Cited 53 times since 2006 (2.7 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 93, Issue 2, 16 3 2006, Pages 226-231
Plasma N-terminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery.
Feringa HH, Schouten O, Dunkelgrun M, Bax JJ, Boersma E, Elhendy A, de Jonge R, Karagiannis SE, Vidakovic R, Poldermans D
Objective: To assess the long-term prognostic value of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) after major vascular surgery. Design: A single-centre prospective cohort study. Patients: 335 patients who underwent abdominal aortic aneurysm repair or lower extremity bypass surgery. Interventions: Prior to surgery, baseline NT-proBNP level was measured. Patients were also evaluated for cardiac risk factors according to the Revised Cardiac Risk Index. Dobutamine stress echocardio...
Abstract
Cited 39 times since 2006 (2 per year)
source: EuropePMC
Heart rhythm,
Volume 3, Issue 12, 10 2 2006, Pages 1397-1403
Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patients.
Smit MD, Van Dessel PF, Nieuwland W, Wiesfeld AC, Tan ES, Anthonio RL, Van Erven L, Van Veldhuisen DJ, Van Gelder IC
Background: Right ventricular (RV) pacing in implantable cardioverter-defibrillator (ICD) patients may have detrimental effects on morbidity and mortality, in particular by inducing heart failure (HF). Objective: We investigated whether RV pacing increases the risk of HF in an asymptomatic ICD population. Methods: We evaluated all patients without symptomatic HF who received an ICD. The primary endpoint was the occurrence of HF, which was defined as new HF, hospitalization for HF, or death due t...
Abstract
Cited 41 times since 2006 (2.1 per year)
source: EuropePMC
Journal of human evolution,
Volume 52, Issue 1, 8 2 2006, Pages 59-71
Variation in brain size and ecology in Pongo.
Taylor AB, van Schaik CP
Numerous hypotheses have been advanced to explain relative increases in brain size in primates and other mammals. However, notably less attention has been directed towards addressing the biological limits to increasing brain size. Here we explore variation in brain size in orangutans. We evaluated both raw and size-adjusted cranial capacity (CC) in adult Pongo pygmaeus pygmaeus (n=147), P. p. wurmbii (n=24), P. p. morio (n=14), and P. abelii (n=36). Results demonstrate significant variation in C...
Abstract
Cited 5 times since 2006 (0.3 per year)
source: EuropePMC
Journal of pediatric gastroenterology and nutrition,
Volume 43, Issue 2, 1 1 2006, Pages 265-266
Rhamnose and rhamnitol in dual sugar permeability tests.
Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG
Rhamnose is one of the sugars regularly used to conduct the dual sugar permeability test. For more than 30 years, it has been assumed that rhamnose is an inert sugar not metabolized by the human body and only fermented by some colonic bacteria into rhamnulose. While conducting an investigation on gut permeability in children undergoing cardiac surgery, increased concentrations of rhamnitol were found in the urine samples. The present report suggests that rhamnose is not an inert sugar and it is...
Abstract
Cited 3 times since 2006 (0.2 per year)
source: EuropePMC
Virus genes,
Volume 33, Issue 1, 1 1 2006, Pages 59-68
The intraleader AUG nucleotide sequence context is important for equine arteritis virus replication.
Archambault D, Kheyar A, de Vries AA, Rottier PJ
The 5(-terminal leader sequence of the equine arteritis virus (EAV) genome contains an open reading frame (ORF) with an AUG codon in a suboptimal context for initiation of protein synthesis. To investigate the significance of this intraleader ORF (ILO), an expression plasmid was generated carrying a DNA copy of the subgenomic mRNA7 behind a T7 promoter. Capped RNA transcribed from this construct was shown to direct, in an in vitro translation system, the synthesis of leader peptide as well as N...
Abstract
Cited 7 times since 2006 (0.4 per year)
source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 13, Issue 4, 1 1 2006, Pages 468-475
Roentgen stereophotogrammetric analysis: an accurate tool to assess stent-graft migration.
Koning OH, Oudegeest OR, Valstar ER, Garling EH, van der Linden E, Hinnen JW, Hamming JF, Vossepoel AM, van Bockel JH
Purpose: To evaluate in an in vitro model the feasibility and accuracy of Roentgen stereophotogrammetric analysis (RSA) versus computed tomography (CT) for the ability to detect stent-graft migration. Methods: An aortic model was constructed from a 22-mm-diameter Plexiglas tube with 6-mm polytetrafluoroethylene inlays to mimic the renal arteries. Six tantalum markers were placed in the wall of the aortic tube proximal to the renal arteries. Another 6 markers were added to a Gianturco stent, whic...
Abstract
Cited 10 times since 2006 (0.5 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 47, Issue 8, 1 1 2006, Pages 1307-1311
Nitrate administration increases blood flow in dysfunctional but viable myocardium, leading to improved assessment of myocardial viability: A PET study.
Slart RH, Agool A, van Veldhuisen DJ, Dierckx RA, Bax JJ
Unlabelled: SPECT with 99mTc-labeled agents is better able to detect viability after nitrate administration. Nitrates induce vasodilation and may increase blood flow to severely hypoperfused but viable myocardium, thereby enhancing tracer delivery and improving the detection of viability. Quantitative data on the changes in blood flow are lacking in SPECT but can be provided by PET. The aim of the present study was to use PET to evaluate whether nitrate administration increases blood flow to chr...
Abstract
Cited 31 times since 2006 (1.6 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 44, Issue 2, 1 1 2006, Pages 419-424
Statins for the prevention of perioperative cardiovascular complications in vascular surgery.
Schouten O, Bax JJ, Dunkelgrun M, Feringa HH, van Urk H, Poldermans D
Perioperative cardiovascular complications in vascular surgery remain a significant problem despite recent advancements in perioperative care. This clinical update summarizes the results of recent studies on the effectiveness and safety of perioperative statin use for the prevention of these perioperative cardiovascular complications. Five studies in patients undergoing major noncardiac vascular surgery and two studies in patients undergoing carotid endarterectomy are described. All studies repo...
Abstract
Cited 9 times since 2006 (0.5 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 47, Issue 8, 1 1 2006, Pages 1302-1306
Prognostic stratification of obese patients by stress 99mTc-tetrofosmin myocardial perfusion imaging.
Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Biagini E, Poldermans D
Unlabelled: Obesity is a major heath problem associated with increased cardiovascular mortality. There are currently no data to support a role for stress imaging techniques in the risk stratification of obese patients. The aim of this study was to assess the independent value of stress 99mTc-tetrofosmin SPECT in predicting mortality and hard cardiac events in obese patients. Methods: We studied 265 patients with a body mass index greater than 30 kg/m2 by exercise or dobutamine stress 99mTc-tetro...
Abstract
Cited 1 times since 2006 (0.1 per year)
source: EuropePMC
Coronary artery disease,
Volume 17, Issue 5, 1 1 2006, Pages 447-453
Hemodynamic responses and long-term follow-up results in patients using chronic beta 1-selective and nonselective beta-blockers during dobutamine stress echocardiography.
Feringa HH, Bax JJ, Elhendy A, van Domburg RT, Schouten O, Krenning B, Poldermans D
Objective: This study was undertaken to determine to what extent hemodynamic responses to dobutamine infusion between patients using concomitant beta1-selective or nonselective beta-blockers differ and whether this difference affects the long-term prognostic value of dobutamine stress echocardiography with respect to cardiac events. Design: Single center, observational study. Methods: A total of 1234 patients using chronic beta-blockers underwent dobutamine stress echocardiography and were prosp...
Abstract
Cited 4 times since 2006 (0.2 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 33, Issue 8, 1 1 2006, Pages 862-865
Will innervation imaging predict ventricular arrhythmias in ischaemic cardiomyopathy?
Henneman MM, Bengel FM, Bax JJ
Abstract
Cited 62 times since 2006 (3.2 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 17, Issue 8, 1 1 2006, Pages 899-901
Postero-lateral scar tissue resulting in non-response to cardiac resynchronization therapy.
Bleeker GB, Schalij MJ, Van Der Wall EE, Bax JJ
In large cardiac resynchronization therapy (CRT) trials, approximately 20-30% of patients did not respond to CRT. Recent studies indicated that left ventricular (LV) dyssynchrony is needed for response to CRT. However, the presence of LV dyssynchrony may not be the only determinant of response, because some patients with LV dyssynchrony do not benefit from CRT. In the current case report, we present a patient with ischemic cardiomyopathy, NYHA class III heart failure symptoms, and substantial LV...
Abstract
Journal of internal medicine,
Volume 260, Issue 2, 1 1 2006, Pages 183-185
Lipoprotein (a) and risk of cardiovascular disease in patients with metabolic syndrome in a population of familial hypercholesterolaemia.
Rana JS, Jansen AC, Zwinderman AH, van Aalst-Cohen ES, Jukema JW, Trip MD, Kastelein JJ
Abstract
Cited 38 times since 2006 (2 per year)
source: EuropePMC
European journal of neurology,
Volume 13, Issue 8, 1 1 2006, Pages 809-818
European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society.
European Federation of Neurological Societies, Peripheral Nerve Society, Hadden RD, Nobile-Orazio E, Sommer C, Hahn A, Illa I, Morra E, Pollard J, Hughes RA, Bouche P, Cornblath D, Evers E, Koski CL, Léger JM, Van den Bergh P, van Doorn P, van Schaik IN
Background: Paraprotein-associated neuropathies have heterogeneous clinical, neurophysiological, neuropathological and haematological features. Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic demyelinating neuropathy, PDN). Methods: Search of MEDLINE and the Cochrane library, review of evidence and consensus agreement of an expert panel. Recommendations: In the absence o...
Abstract
Cited 51 times since 2006 (2.6 per year)
source: EuropePMC
European journal of neurology,
Volume 13, Issue 8, 1 1 2006, Pages 802-808
European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy.
European Federation of Neurological Societies, Peripheral Nerve Society, van Schaik IN, Bouche P, Illa I, Léger JM, Van den Bergh P, Cornblath DR, Evers EM, Hadden RD, Hughes RA, Koski CL, Nobile-Orazio E, Pollard J, Sommer C, van Doorn PA
Several diagnostic criteria for multifocal motor neuropathy have been proposed in recent years and a beneficial effect of intravenous immunoglobulin (IVIg) and various other immunomodulatory drugs has been suggested in several trials and uncontrolled studies. The objectives were to prepare consensus guidelines on the definition, investigation and treatment of multifocal motor neuropathy. Disease experts and a patient representative considered references retrieved from MEDLINE and the Cochrane Li...
Abstract
Cited 95 times since 2006 (4.9 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 80, Issue 2, 1 1 2006, Pages 192-201
Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib.
Gardner ER, Burger H, van Schaik RH, van Oosterom AT, de Bruijn EA, Guetens G, Prenen H, de Jong FA, Baker SD, Bates SE, Figg WD, Verweij J, Sparreboom A, Nooter K
Objective: Our objective was to explore the relationships between imatinib pharmacokinetics and 9 allelic variants in 7 genes coding for adenosine triphosphate-binding cassette transporters (ABCB1 and ABCG2) and enzymes (cytochrome P450 [CYP] 2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) of putative relevance for imatinib. Methods: Imatinib transport in vitro was studied by use of human embryonic kidney 293 cells transfected with wild-type ABCG2 and an ABCG2 Q141K clone. Steady-state pharmacokinetic...
Abstract
Cited 23 times since 2006 (1.2 per year)
source: EuropePMC
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Volume 43, Issue 5, 31 5 2006, Pages 616-623
Potential confounding in evaluating infection-control interventions in hospital settings: changing antibiotic prescription.
Nijssen S, Bootsma M, Bonten M
The colonization dynamics of antibiotic-resistant pathogens in hospital settings are complex, with multiple and continuously interacting variables (e.g., introduction of resistance, infection-control practices, antibiotic use). Quantification of these variables is indispensable in the evaluation of intervention studies, because these variables represent potential confounders. In this article, the complexity of colonization dynamics is described. Through a systematic review, we identified studies...
Abstract
Cited 48 times since 2006 (2.5 per year)
source: EuropePMC
Cardiovascular research,
Volume 72, Issue 2, 29 5 2006, Pages 282-291
Progressive increase in conduction velocity across human mesenchymal stem cells is mediated by enhanced electrical coupling.
Pijnappels DA, Schalij MJ, van Tuyn J, Ypey DL, de Vries AA, van der Wall EE, van der Laarse A, Atsma DE
Objective: The purpose of the study was to investigate the development of electrical transmission across human adult bone marrow-derived mesenchymal stem cells (hMSCs) during long-term co-incubation with cardiomyocytes (CMCs). Methods: Neonatal rat CMCs were cultured in multi-electrode array dishes. A conduction block was induced by creating a central acellular channel, yielding two asynchronously beating CMC fields. Enhanced green fluorescent protein (eGFP)-labeled hMSCs from ischemic heart dis...
Abstract
