Research

Publications

Below you can find a list of our published research.

9543 results

Cited 71 times since 2005 (3.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 10, 21 3 2005, Pages 1943-1952 Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures. Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE, de Vries AA, Ypey DL, van der Wall EE, Schalij MJ

Objectives: We evaluated whether human adult bone marrow-derived mesenchymal stem cells (hMSCs) could repair an experimentally induced conduction block in cardiomyocyte cultures. Background: Autologous stem cell therapy is a novel treatment option for patients with heart disease. However, detailed electrophysiological characterization of hMSCs is still lacking. Methods: Neonatal rat cardiomyocytes were seeded on multi-electrode arrays. After 48 h, abrasion of a 200- to 450-microm-wide channel ca... Abstract

Cited 64 times since 2005 (3.2 per year) source: EuropePMC

European journal of heart failure, Volume 8, Issue 2, 7 1 2005, Pages 115-121 Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy. Westermann D, Knollmann BC, Steendijk P, Rutschow S, Riad A, Pauschinger M, Potter JD, Schultheiss HP, Tschöpe C

Background: The cardiac troponin T I79N mutation, linked to familial hypertrophic cardiomyopathy, carries a high risk of sudden cardiac death even in the absence of significant cardiac hypertrophy. The pathology underlying this mechanism has not yet been identified. Aims: To study the underlying mechanism of this phenomenon we characterized the left ventricular (LV) performance of transgenic mice carrying the human troponin T mutation I79N under basal and isoproterenol-induced stress conditions.... Abstract

Cited 5 times since 2005 (0.2 per year) source: EuropePMC

European heart journal, Volume 26, Issue 22, 4 1 2005, Pages 2358-2360 Should the ACC/AHA guidelines be changed in patients undergoing vascular surgery? Hoeks SE, Bax JJ, Poldermans D

Abstract

Cited 26 times since 2005 (1.3 per year) source: EuropePMC

The Journal of allergy and clinical immunology, Volume 116, Issue 5, 3 1 2005, Pages 1007-1013 Adding salmeterol to an inhaled corticosteroid reduces allergen-induced serum IL-5 and peripheral blood eosinophils. Koopmans JG, Lutter R, Jansen HM, van der Zee JS

Background: Adding a long-acting beta(2)-agonist to inhaled corticosteroids results in better symptomatic asthma control than increasing the dose of inhaled corticosteroids. Objective: Investigating whether adding the long-acting beta(2)-agonist salmeterol to the inhaled corticosteroid fluticasone propionate has an effect on allergen-induced allergic inflammation in asthma. Methods: Bronchial allergen challenges were performed in 26 patients with allergic asthma, pretreating them with a single d... Abstract

Cited 9 times since 2005 (0.4 per year) source: EuropePMC

Sexually transmitted diseases, Volume 32, Issue 10, 1 1 2005, Pages 625-629 Management of Chlamydia cases and their partners: results from a home-based screening program organized by municipal public health services with referral to regular health care. Götz HM, Hoebe CJ, Van Bergen JE, Veldhuijzen IK, Broer J, De Groot F, Verhooren MJ, Van Schaik DT, Coenen AJ, Richardus JH

Background: We evaluated the management of Chlamydia trachomatis cases and partners found in a systematic home-based chlamydia screening project in the Netherlands among 15- to 29-year-old women and men, organized by the Municipal Public Health Services (MHS). Methods: Infected participants (165/8339 = 2%) were referred to regular curative services. The treating physician provided feedback on treatment and partner notification. Results: Including the effect of a reminder, the treatment rate of a... Abstract

Cited 53 times since 2005 (2.6 per year) source: EuropePMC

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 11, Issue 20, 1 1 2005, Pages 7398-7404 Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients. Lepper ER, Baker SD, Permenter M, Ries N, van Schaik RH, Schenk PW, Price DK, Ahn D, Smith NF, Cusatis G, Ingersoll RG, Bates SE, Mathijssen RH, Verweij J, Figg WD, Sparreboom A

Purpose: To evaluate the effect of naturally occurring variants in genes encoding the cytochrome P450 (CYP) isoforms CYP3A4 and CYP3A5 in patients with cancer receiving midazolam as a phenotyping probe. Experimental design: Five variants in CYP3A4 and CYP3A5 were evaluated in 58 patients (21 women and 37 men) receiving a short i.v. bolus of midazolam (dose, 0.0145 or 0.025 mg/kg). Midazolam concentrations in plasma were determined using liquid chromatography-mass spectrometry, and pharmacokineti... Abstract

Cited 24 times since 2005 (1.2 per year) source: EuropePMC

Cardiovascular research, Volume 68, Issue 1, 1 1 2005, Pages 136-143 Involvement of furin-like proprotein convertases in the arterial response to injury. Sluijter JP, Verloop RE, Pulskens WP, Velema E, Grimbergen JM, Quax PH, Goumans MJ, Pasterkamp G, de Kleijn DP

Background: Furin-like proprotein convertases (PCs) are proteolytic activators of proproteins, like membrane type 1-matrix metalloproteinase (MT1-MMP) and transforming growth factor beta (TGF-beta), that are described in the arterial response to injury. However, the involvement of furin-like PCs in the arterial response to injury has not been studied yet. We studied furin, MT1-MMP, MMP levels and TGF-beta signaling after arterial injury. We also investigated the effect of an inhibitor of furin-l... Abstract

Cited 17 times since 2005 (0.8 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 16, Issue 10, 1 1 2005, Pages 1049-1056 Determinants of recurrent ventricular arrhythmia or death in 300 consecutive patients with ischemic heart disease who experienced aborted sudden death: data from the Leiden out-of-hospital cardiac arrest study. Kiès P, Boersma E, Bax JJ, van der Burg AE, Bootsma M, van Erven L, van der Wall EE, Schalij MJ

Objective: Evaluation of the relation between clinical characteristics and incidence of recurrent ventricular arrhythmias (VAs) or death during long-term follow-up in a cohort of 300 consecutive ischemic heart disease (IHD) patients who had survived an episode of sudden cardiac arrest (SCA). Background: Survivors of life-threatening VA are at high risk for recurrent events. Methods: A total of 300 consecutive survivors of SCA with IHD were included in a standardized screening and evaluation prot... Abstract

Cited 5 times since 2005 (0.2 per year) source: EuropePMC

World journal of gastroenterology, Volume 11, Issue 38, 1 1 2005, Pages 5997-6002 Effect of herpesvirus infection on pancreatic duct cell secretion. Hegyi P, Ordog B, Rakonczai Z, Takács T, Lonovics J, Szabolcs A, Sári R, Tóth A, Papp JG, Varró A, Kovács MK, Gray MA, Argent BE, Boldogköi Z

Aim: To examine the effect of acute infection caused by herpesvirus (pseudorabies virus, PRV) on pancreatic ductal secretion. Methods: The virulent Ba-DupGreen (BDG) and non-virulent Ka-RREp0lacgfp (KEG) genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein (GFP). Small intra/interlobular ducts were infected with BDG virus (10(7) PFU/mL for 6 h) or with KEG virus (10(10) PFU/mL for 6 h), while non-infected ducts were incubated... Abstract

Cited 124 times since 2005 (6.2 per year) source: EuropePMC

Heart rhythm, Volume 2, Issue 10, 1 1 2005, Pages 1076-1081 Fusion of multislice computed tomography imaging with three-dimensional electroanatomic mapping to guide radiofrequency catheter ablation procedures. Tops LF, Bax JJ, Zeppenfeld K, Jongbloed MR, Lamb HJ, van der Wall EE, Schalij MJ

Background: The outcome of catheter ablation procedures of cardiac arrhythmias depends on the ability to evaluate the underlying mechanism and to depict target sites for ablation. Fusion of different imaging modalities within one system may improve electroanatomic modeling and facilitate ablation procedures. Objectives: The purpose of this study was to study the feasibility of fusion of multislice computed tomography (MSCT) with electroanatomic mapping to guide radiofrequency catheter ablation o... Abstract

Cited 31 times since 2005 (1.5 per year) source: EuropePMC

Bone marrow transplantation, Volume 36, Issue 7, 1 1 2005, Pages 605-610 Long-term renal function after hemopoietic stem cell transplantation in children. Kist-van Holthe JE, Bresters D, Ahmed-Ousenkova YM, Goedvolk CA, Abbink FC, Wolterbeek R, Bredius RG, Pauwels EK, van der Heijden AJ

Glomerular function of all long-term survivors who underwent hemopoietic stem cell transplantation (HSCT) from 1991 to 1998 (study I, n=121) was studied retrospectively. In addition, we prospectively analyzed glomerular and tubular function of all long-term surviving children who received an HSCT between 1998 and 2000 (study II, n=41). We found a lower prevalence of children with chronic renal failure (CRF) post-HSCT in our more recent cohort (study II: 10%) as compared to the older cohort (stud... Abstract

Cited 41 times since 2005 (2 per year) source: EuropePMC

The American journal of cardiology, Volume 96, Issue 7, 1 1 2005, Pages 996-1001 Role of disease status and type D personality in outcomes in patients with peripheral arterial disease. Aquarius AE, Denollet J, Hamming JF, De Vries J

Patients with peripheral arterial disease (PAD) often experience diminishing quality of life (QOL) in many domains of their lives. However, factors associated with impaired QOL and perceived stress in these patients are not completely understood. The relative effects of disease status and type D ("distressed") personality (tendencies to experience negative emotions and be socially inhibited) on these patient-based outcomes were examined. It has been argued that type D personality might... Abstract

Cited 16 times since 2005 (0.8 per year) source: EuropePMC

The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 60, Issue 10, 1 1 2005, Pages 1333-1338 Long-term prediction of mortality in elderly persons by dobutamine stress echocardiography. Biagini E, Elhendy A, Schinkel AF, Rizzello V, Bax JJ, Sozzi FB, Kertai MD, van Domburg RT, Krenning BJ, Branzi A, Rapezzi C, Simoons ML, Poldermans D

Background: Dobutamine stress echocardiography (DSE) was shown to provide incremental prognostic information. However, its role in the prediction of mortality in elderly persons is not well defined. We assessed the value of DSE in the prediction of mortality and hard cardiac events during long-term follow-up in patients older than 65 years. Methods: We studied 1434 patients >65 years old (mean age 72 +/- 3 years) who underwent DSE for evaluation of coronary artery disease. Ischemia was define... Abstract

Cited 63 times since 2005 (3.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 7, 1 1 2005, Pages 1264-1269 The extent of perfusion-F18-fluorodeoxyglucose positron emission tomography mismatch determines mortality in medically treated patients with chronic ischemic left ventricular dysfunction. Desideri A, Cortigiani L, Christen AI, Coscarelli S, Gregori D, Zanco P, Komorovsky R, Bax JJ

Objectives: The purpose of this study was to assess the determinants of mortality in a large group of patients with ischemic cardiomyopathy who are treated medically and the impact of the extent of viable tissue on prognosis. Background: Whether the presence of viability drives mortality in patients with ischemic cardiomyopathy who are treated medically and whether the extent of viability is important are issues that are currently unclear. Methods: Two hundred sixty-one patients with ischemic ca... Abstract

Cited 191 times since 2005 (9.5 per year) source: EuropePMC

The American journal of medicine, Volume 118, Issue 10, 1 1 2005, Pages 1134-1141 Perioperative cardiovascular mortality in noncardiac surgery: validation of the Lee cardiac risk index. Boersma E, Kertai MD, Schouten O, Bax JJ, Noordzij P, Steyerberg EW, Schinkel AF, van Santen M, Simoons ML, Thomson IR, Klein J, van Urk H, Poldermans D

Purpose: The Lee risk index was developed to predict major cardiac complications in noncardiac surgery. We retrospectively evaluated its ability to predict cardiovascular death in the large cohort of patients who recently underwent noncardiac surgery in our institution. Methods: The administrative database of the Erasmus MC, Rotterdam, The Netherlands, contains information on 108 593 noncardiac surgical procedures performed from 1991 to 2000. The Lee index assigns 1 point to each of the followin... Abstract

Cited 13 times since 2005 (0.6 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 21, Issue 5, 1 1 2005, Pages 519-529 Evaluation of the Quantitative Gated SPECT (QGS) software program in the presence of large perfusion defects. America YG, Bax JJ, Dibbets-Schneider P, Pauwels EK, Van der Wall EE

Objectives: To evaluate the reproducibility and operator dependence for the quantitative regional left ventricular functional parameters (LVFP) assessed by Cedars-Sinai's Quantitative automated gated SPECT (QGS) software. Methods: The QGS algorithm was reviewed in detail and potential operator dependencies were defined. Series of prototypes were selected, consisting of (a) normal perfusion, (b) perfusion defects in all perfusion regions, (c) perfusion studies of patients with angiographic c... Abstract

Cited 10 times since 2005 (0.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 46, Issue 10, 1 1 2005, Pages 1589-1595 Association of ischemia on stress (99m)Tc-tetrofosmin myocardial perfusion imaging with all-cause mortality in patients with diabetes mellitus. Elhendy A, Huurman A, Schinkel AF, Bax JJ, van Domburg RT, Valkema R, Biagini E, Poldermans D

Unlabelled: Stress myocardial perfusion imaging is a useful method for evaluation of coronary artery disease (CAD) in patients with diabetes mellitus. However, its role in predicting all-cause mortality is not well defined. The aim of this study was to determine whether myocardial ischemia on stress myocardial perfusion imaging can predict all causes of death in patients with diabetes mellitus. Methods: We studied 297 patients with diabetes mellitus and known or suspected CAD by exercise or dobu... Abstract

Cited 2 times since 2005 (0.1 per year) source: EuropePMC

Journal of vascular surgery, Volume 42, Issue 4, 1 1 2005, Pages 825; author reply 826 Regarding "Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial". Schouten O, van Urk H, Feringa HH, Bax JJ, Poldermans D

Abstract

Cited 34 times since 2005 (1.7 per year) source: EuropePMC

Cancer research, Volume 65, Issue 20, 1 1 2005, Pages 9398-9405 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Lamfers ML, Gianni D, Tung CH, Idema S, Schagen FH, Carette JE, Quax PH, Van Beusechem VW, Vandertop WP, Dirven CM, Chiocca EA, Gerritsen WR

Oncolytic adenoviruses exhibiting tumor-selective replication are promising anticancer agents. Insertion and expression of a transgene encoding tissue inhibitor of metalloproteinase-3 (TIMP-3), which has been reported to inhibit angiogenesis and tumor cell infiltration and induce apoptosis, may improve the antitumor activity of these agents. To assess the effects of TIMP-3 gene transfer to glioma cells, a replication-defective adenovirus encoding TIMP-3 (Ad.TIMP-3) was employed. Ad.TIMP-3 infect... Abstract

Cited 52 times since 2005 (2.6 per year) source: EuropePMC

American heart journal, Volume 150, Issue 4, 1 1 2005, Pages 775-781 Comprehensive assessment of patients after coronary artery bypass grafting by 16-detector-row computed tomography. Salm LP, Bax JJ, Jukema JW, Schuijf JD, Vliegen HW, Lamb HJ, van der Wall EE, de Roos A

Background: Multidetector-row computed tomography (MDCT) is a versatile modality to evaluate stenoses in native coronary arteries and bypass grafts. Acquired MDCT data can additionally be used to assess left ventricular ejection fraction (LVEF). The purpose was to use MDCT for the assessment of bypass graft and coronary artery disease combined with evaluation of LVEF. Methods: Twenty-five patients underwent 16-detector-row CT examination and coronary angiography. Bypass grafts and nongrafted cor... Abstract