Research

Publications

Below you can find a list of our published research.

6139 results

Cited 10 times since 2011 (0.7 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 13 Suppl 2, 1 1 2011, Pages ii32-8 Cardiac resynchronization therapy: a cost or an investment? Boriani G, Mantovani LG, Biffi M, Schalij MJ, Martignani C, Leclercq C, Bax JJ, Auricchio A

Cost-effectiveness estimates can help optimize use of available financial resources and this is especially relevant for implementation of cardiac resynchronization therapy (CRT), given the high upfront costs and the timescale of expected benefits. All available cost-effectiveness estimates for devices with (CRT-P) or without (CRT-D) a defibrillator are based on results of randomized trials of selected patients, with a relatively brief follow-up. Extrapolation suggests that the cost effectiveness... Abstract

Cited 28 times since 2011 (2 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 1, 27 4 2011, Pages 63-68 Comparison of long-term survival of men versus women with heart failure treated with cardiac resynchronization therapy. Mooyaart EA, Marsan NA, van Bommel RJ, Thijssen J, Borleffs CJ, Delgado V, van der Wall EE, Schalij MJ, Bax JJ

Cardiac resynchronization therapy (CRT) is an established treatment of patients with heart failure. Several baseline characteristics can influence the CRT outcomes, and little is known about the effect of gender. The aim of the present study was to elucidate the gender-related differences in long-term survival after CRT. A total of 578 consecutive patients with heart failure underwent CRT. At baseline and 6 months after CRT, the clinical and echocardiographic parameters were obtained. All-cause... Abstract

Cited 228 times since 2011 (16.4 per year) source: EuropePMC

Journal of translational medicine, Volume 9, 25 4 2011, Pages 47 Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs. Chen TS, Arslan F, Yin Y, Tan SS, Lai RC, Choo AB, Padmanabhan J, Lee CN, de Kleijn DP, Lim SK

Background: Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale production of these exosomes would require replenishment of hESC-MSC through derivation from hESCs and incur recurring costs for testing and validation of each new batch. Our aim was therefore to investigate if MYC immortalization of hESC-MSC... Abstract

Cited 5 times since 2011 (0.4 per year) source: EuropePMC

Transfusion medicine (Oxford, England), Volume 21, Issue 4, 24 4 2011, Pages 236-246 The effect of RBC transfusions on cytokine gene expression after cardiac surgery in patients developing post-operative multiple organ failure. Sitniakowsky LS, Later AF, van de Watering LM, Bogaerts M, Brand A, Klautz RJ, Smit NP, van Hilten JA

Aim: To determine the effect of red blood cell (RBC) transfusions during cardiac surgery on cytokine gene expression (GE) in relation to multiple organ failure (MOF) development after systemic inflammatory response syndrome (SIRS). Background: RBC transfusion in cardiac surgery patients is dose-dependently associated with post-operative MOF, possibly acting as a second hit after cardiopulmonary bypass. Methods: For this observational study, 29 patients divided into four groups of cardiac surgery... Abstract

Cited 45 times since 2011 (3.2 per year) source: EuropePMC

Basic research in cardiology, Volume 106, Issue 5, 24 4 2011, Pages 829-847 In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1. Bax NA, van Oorschot AA, Maas S, Braun J, van Tuyn J, de Vries AA, Groot AC, Goumans MJ

Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibroblasts, which contribute to cardiac repair. To understand what drives epicardial EMT, we used an in vitro model for human adult epicardial cells. These cells have an epithelium-like... Abstract

Cited 9 times since 2011 (0.6 per year) source: EuropePMC

Emergency medicine journal : EMJ, Volume 29, Issue 4, 21 3 2011, Pages 301-305 The utility of EEG in the emergency department. Yigit O, Eray O, Mihci E, Yilmaz D, Arslan S, Eray B

Background and aim: Seizure-related visits are common in the emergency department (ED) but the clinical situations for ordering emergency electroencephalography (EEG) are unclear. The aim of this study is to identify which clinical conditions meet with the pathological EEG and whether patient management is changed by abnormal results. Methods: A retrospective chart review study of all patients visiting the ED with a seizure or symptoms mimicking a seizure was performed. Patients who recorded an... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Applied nursing research : ANR, Volume 25, Issue 3, 20 3 2011, Pages 158-163 Examining barriers to emergency contraception use. Kisa S, Zeyneloğlu S, Yilmaz D, Verim E

Using a cross-sectional survey research design, this study examined barriers to emergency contraception (EC) use among a sample of 318 Turkish women. Only 34% of the respondents reported being aware of EC methods, and about 20% had actually used EC. More than 90% of the participant women considered use of EC methods as a sin. The results of the study showed that the major barriers to EC use are lack of awareness and common misconceptions about EC methods. This study highlights the need of educat... Abstract

Cited 11 times since 2011 (0.8 per year) source: EuropePMC

Neuromodulation : journal of the International Neuromodulation Society, Volume 14, Issue 3, 19 3 2011, Pages 258-65; discussion 265 Subcutaneous electrical nerve stimulation: a feasible and new method for the treatment of patients with refractory angina. Buiten MS, DeJongste MJ, Beese U, Kliphuis C, Durenkamp A, Staal MJ

Introduction: Patients suffering from chronic angina pectoris, insufficiently controllable with medication and revascularization, are an increasing medical and psychosocial problem. Although spinal cord stimulation (SCS) is proven to employ, safe, long-term anti-angina, and anti-ischemic effects for these patients, the use of SCS in this group remains limited. The reason for this restricted use is largely unknown. However, among other reasons, it may be related to the difficulties in positioni... Abstract

Cited 43 times since 2011 (3.1 per year) source: EuropePMC

Circulation, Volume 123, Issue 17, 18 3 2011, Pages 1864-1872 Genetic predictors of fibrin D-dimer levels in healthy adults. Smith NL, Huffman JE, Strachan DP, Huang J, Dehghan A, Trompet S, Lopez LM, Shin SY, Baumert J, Vitart V, Bis JC, Wild SH, Rumley A, Yang Q, Uitterlinden AG, Stott DJ, Davies G, Carter AM, Thorand B, Polašek O, McKnight B, Campbell H, Rudnicka AR, Chen MH, Buckley BM, Harris SE, Peters A, Pulanic D, Lumley T, de Craen AJ, Liewald DC, Gieger C, Campbell S, Ford I, Gow AJ, Luciano M, Porteous DJ, Guo X, Sattar N, Tenesa A, Cushman M, Slagboom PE, Visscher PM, Spector TD, Illig T, Rudan I, Bovill EG, Wright AF, McArdle WL, Tofler G, Hofman A, Westendorp RG, Starr JM, Grant PJ, Karakas M, Hastie ND, Psaty BM, Wilson JF, Lowe GD, O'Donnell CJ, Witteman JC, Jukema JW, Deary IJ, Soranzo N, Koenig W, Hayward C

Background: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and results: A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21 052 European-ancestry adults. Plasma levels of D-dimer were measur... Abstract

Cited 8 times since 2011 (0.6 per year) source: EuropePMC

Contemporary clinical trials, Volume 32, Issue 4, 17 3 2011, Pages 586-591 Rationale and design of a trial on the role of bosentan in Fontan patients: improvement of exercise capacity? Schuuring MJ, Vis JC, Bouma BJ, van Dijk AP, van Melle JP, Pieper PG, Vliegen HW, Sieswerda GT, Mulder BJ

Background: The Fontan circulation is a palliative procedure performed in patients with complex congenital heart disease (CHD), making transpulmonary blood flow dependent on the systemic venous pressure. In a Fontan circulation a low pulmonary vascular resistance (PVR) is crucial, as is epitomized by the observation that a high PVR is a strong predictor of mortality. Long-term follow-up has shown that PVR may rise many years after the Fontan procedure has been performed, possibly due to micro-em... Abstract

Cited 438 times since 2011 (31.4 per year) source: EuropePMC

Journal of surgical oncology, Volume 104, Issue 3, 14 2 2011, Pages 323-332 The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. Schaafsma BE, Mieog JS, Hutteman M, van der Vorst JR, Kuppen PJ, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the founda... Abstract

ISRN cardiology, Volume 2011, 11 2 2011, Pages 638764 Increased B-type natriuretic Peptide concentration is associated with reduced coronary vasoreactivity in patients with dilated cardiomyopathy but not in healthy young subjects. Sundell J, Engblom E, Koistinen J, Ylitalo A, Laine H, Kalliokoski R, Airaksinen KE, Bax JJ, Knuuti J

Background/Aims. Natriuretic peptides are associated with the cardiovascular disease risk under a range of different circumstances. However, less is known about whether this association is found also in young healthy subjects. Methods. 9 patients with dilated cardiomyopathy and 26 healthy young subjects were studied. The myocardial blood flow measurements were performed basally and during adenosine infusion using PET. Results. S-proBNP concentrations were significantly higher (2153 ± 1964 versus... Abstract

Cited 43 times since 2011 (3.1 per year) source: EuropePMC

The American journal of cardiology, Volume 107, Issue 12, 8 2 2011, Pages 1725-1729 Positive remodeling on coronary computed tomography as a marker for plaque vulnerability on virtual histology intravascular ultrasound. Kröner ES, van Velzen JE, Boogers MJ, Siebelink HM, Schalij MJ, Kroft LJ, de Roos A, van der Wall EE, Jukema JW, Reiber JH, Schuijf JD, Bax JJ

Coronary computed tomographic angiography allows direct evaluation of the vessel wall and thus positive remodeling, which is a marker of vulnerability. The purpose of this study was to assess the association between positive remodeling on computed tomography angiogram (CTA) and vulnerable plaque characteristics on virtual histologic intravascular ultrasound (VH IVUS) images. Forty-five patients (78% men, 58 ± 11 years old) underwent computed tomographic angiography followed by VH IVUS. On CTA, t... Abstract

Cited 18 times since 2011 (1.3 per year) source: EuropePMC

Cellular and molecular life sciences : CMLS, Volume 68, Issue 22, 2 1 2011, Pages 3741-3756 Different roles of the human Orc6 protein in the replication initiation process. Thomae AW, Baltin J, Pich D, Deutsch MJ, Ravasz M, Zeller K, Gossen M, Hammerschmidt W, Schepers A

In eukaryotes, binding of the six-subunit origin recognition complex (ORC) to DNA provides an interactive platform for the sequential assembly of pre-replicative complexes. This process licenses replication origins competent for the subsequent initiation step. Here, we analyze the contribution of human Orc6, the smallest subunit of ORC, to DNA binding and pre-replicative complex formation. We show that Orc6 not only interacts with Orc1-Orc5 but also with the initiation factor Cdc6. Biochemical a... Abstract

Cited 9 times since 2011 (0.6 per year) source: EuropePMC

Ocular immunology and inflammation, Volume 19, Issue 2, 1 1 2011, Pages 135-138 Ocular findings in subacute sclerosing panencephalitis. Yuksel D, Sonmez PA, Yilmaz D, Senbil N, Gurer Y

Purpose: The aim of this study was to evaluate the ocular manifestations of subacute sclerosing panencephalitis (SSPE) and to investigate possible risk factors in a relatively large series of patients. Methods: In this prospective study, patients who were diagnosed with SSPE and had undergone ophthalmic examination were included. Results: Of the 59 patients with SSPE, 25 (42.4%) had ocular findings. Ocular involvement was bilateral in 22 (88%) patients. The most characteristic fundus findings in... Abstract

Cited 139 times since 2011 (10 per year) source: EuropePMC

Molecular imaging and biology, Volume 13, Issue 2, 1 1 2011, Pages 199-207 Optical image-guided surgery--where do we stand? Keereweer S, Kerrebijn JD, van Driel PB, Xie B, Kaijzel EL, Snoeks TJ, Que I, Hutteman M, van der Vorst JR, Mieog JS, Vahrmeijer AL, van de Velde CJ, Baatenburg de Jong RJ, Löwik CW

In cancer surgery, intra-operative assessment of the tumor-free margin, which is critical for the prognosis of the patient, relies on the visual appearance and palpation of the tumor. Optical imaging techniques provide real-time visualization of the tumor, warranting intra-operative image-guided surgery. Within this field, imaging in the near-infrared light spectrum offers two essential advantages: increased tissue penetration of light and an increased signal-to-background-ratio of contrast agen... Abstract

Cited 1 times since 2011 (0.1 per year) source: EuropePMC

Cardiology in the young, Volume 21, Issue 2, 1 1 2011 Assessment of proximal right coronary artery and cardiac dimensions with low-dose volumetric computed tomographic angiography in a child. Roest AA, Hazekamp MG, Kroft LJ

Abstract

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 18, Issue 2, 1 1 2011, Pages 368-370 Subvalvular hypertrophic calcification of the mitral annulus: [(18)F]FDG-PET-CT, MRI, and echocardiography findings. Persigehl T, Maintz D, Kies P, Heindel W, Schober O, Tiemann K, Rahbar K

Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 18, Issue 2, 1 1 2011, Pages 205-213 Treatment of types II-IV endoleaks by injecting biocompatible elastomer (PDMS) in the aneurysm sac: an in vitro study. Bosman WM, Hinnen JW, van der Steenhoven TJ, de Vries AC, Brom HL, Jacobs MJ, Hamming JF

Purpose: To investigate if an elastomer [polydimethylsiloxane (PDMS)] can be used to effectively treat endoleaks after endovascular aneurysm repair. Methods: A latex aneurysm (36-mm inner diameter sac, 15-mm inner diameter neck) was attached to an in vitro circulation model. The aneurysm was excluded from the circulation by placing an unstented polyester graft. Endoleak types II-IV were created using different setups. While the circulation setup running, the aneurysm was filled with contrast med... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

Radiology, Volume 260, Issue 1, 1 1 2011, Pages 88-97 Corrected tetralogy of Fallot: comparison of tissue doppler imaging and velocity-encoded MR for assessment of performance and temporal activation of right ventricle. van der Hulst AE, Roest AA, Delgado V, Kroft LJ, Holman ER, Blom NA, Bax JJ, de Roos A, Westenberg JJ

Purpose: To compare velocity-encoded (VE) magnetic resonance (MR) imaging with tissue Doppler imaging to assess right ventricular (RV) peak systolic velocities and timing of velocities in patients with corrected tetralogy of Fallot and healthy subjects. Materials and methods: Local institutional review board approval was obtained; patients or their parents gave informed consent. Thirty-three patients (20 male, 13 female; median age, 12 years; interquartile range [IQR], 11-15 years; age range, 8-... Abstract