Research

Publications

Below you can find a list of our published research.

7993 results

Cited 87 times since 2017 (11 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 69, Issue 17, 1 1 2017, Pages 2119-2129 Cardiac Resynchronization Therapy With Wireless Left Ventricular Endocardial Pacing: The SELECT-LV Study. Reddy VY, Miller MA, Neuzil P, Søgaard P, Butter C, Seifert M, Delnoy PP, van Erven L, Schalji M, Boersma LVA, Riahi S

Background: A total of 30% to 40% of patients with congestive heart failure eligible for cardiac resynchronization therapy (CRT) either do not respond to conventional CRT or remain untreated due to an inability or impediment to coronary sinus (CS) lead implantation. The WiSE-CRT system (EBR Systems, Sunnyvale, California) was developed to address this at-risk patient population by performing biventricular pacing via a wireless left ventricular (LV) endocardial pacing electrode. Objectives: The S... Abstract

Cited 4 times since 2017 (0.5 per year) source: EuropePMC

Journal of telemedicine and telecare, Volume 24, Issue 6, 29 5 2017, Pages 404-409 Comparison of the diagnostic accuracy of four smartphone-compatible blood pressure monitors in post-myocardial infarction patients. Treskes RW, Wolterbeek R, van der Velde ET, Eindhoven DC, Schalij MJ

Introduction Smartphone-compatible blood pressure devices may be a good alternative to enable self-measurement of blood pressure by patients. Furthermore, automatic transferral of data to the hospital allows for remote monitoring. To our knowledge, no study has compared four of these smartphone-compatible blood pressure devices. Methods Patients who were followed up for acute myocardial infarction were asked to participate during their outpatient clinic visit. After five minutes of rest, six blo... Abstract

Cited 5 times since 2017 (0.6 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 11, Issue 4, 27 4 2017, Pages 274-280 Coronary computed tomography angiography derived risk score in predicting cardiac events. Uusitalo V, Kamperidis V, de Graaf MA, Maaniitty T, Stenström I, Broersen A, Dijkstra J, Scholte AJ, Saraste A, Bax JJ, Knuuti J

Background: We evaluated the prognostic value of an integrated atherosclerosis risk score combining the markers of coronary plaque burden, location and composition as assessed by computed tomography angiography (CTA). Methods: 922 consecutive patients underwent CTA for suspected coronary artery disease (CAD). Patients without atherosclerosis (n = 261) and in whom quantitative CTA analysis was not feasible due to image quality, step-artefacts or technical factors related to image acquisition or d... Abstract

Cited 7 times since 2017 (0.9 per year) source: EuropePMC

European journal of radiology, Volume 93, 26 4 2017, Pages 1-8 Quantification of aortic annulus in computed tomography angiography: Validation of a fully automatic methodology. Gao X, Boccalini S, Kitslaar PH, Budde RPJ, Attrach M, Tu S, de Graaf MA, Ondrus T, Penicka M, Scholte AJHA, Lelieveldt BPF, Dijkstra J, Reiber JHC

Background: Automatic accurate measuring of the aortic annulus and determination of the optimal angulation of X-ray projection are important for the trans-catheter aortic valve replacement (TAVR) procedure. The objective of this study was to present a novel fully automatic methodology for the quantification of the aortic annulus in computed tomography angiography (CTA) images. Methods: CTA datasets of 26 patients were analyzed retrospectively with the proposed methodology, which consists of a kn... Abstract

Cited 9 times since 2017 (1.1 per year) source: EuropePMC

International journal of cardiology, Volume 240, 25 4 2017, Pages 20-24 Long-term mortality in patients with ST-segment elevation myocardial infarction is associated with anti-citrullinated protein antibodies. Hermans MPJ, van der Velden D, Montero Cabezas JM, Putter H, Huizinga TWJ, Kuiper J, Toes REM, Schalij MJ, Wouter Jukema J, van der Woude D

Background: Cardiovascular (CV) mortality is higher in patients with rheumatoid arthritis (RA), in particular when anti-citrullinated protein antibodies (ACPA) are present. Recently, ACPA have also been described in a cohort of patients without RA, but with coronary artery disease (CAD). It is however unknown if ACPA can consistently be found in patients with CAD, and if ACPA are associated with mortality in these patients. The purpose of this study was to assess the relationship between ACPA an... Abstract

Cited 22 times since 2017 (2.8 per year) source: EuropePMC

Antimicrobial agents and chemotherapy, Volume 61, Issue 5, 24 4 2017, Pages e02122-16 The Two-Component System ChtRS Contributes to Chlorhexidine Tolerance in Enterococcus faecium. Guzmán Prieto AM, Wijngaarden J, Braat JC, Rogers MRC, Majoor E, Brouwer EC, Zhang X, Bayjanov JR, Bonten MJM, Willems RJL, van Schaik W

Enterococcus faecium is one of the primary causes of nosocomial infections. Disinfectants are commonly used to prevent infections with multidrug-resistant E. faecium in hospitals. Worryingly, E. faecium strains that exhibit tolerance to disinfectants have already been described. We aimed to identify and characterize E. faecium genes that contribute to tolerance to the disinfectant chlorhexidine (CHX). We used a transposon mutant library, constructed in a multidrug-resistant E. faecium bloodstrea... Abstract

Cited 86 times since 2017 (10.9 per year) source: EuropePMC

European journal of pharmacology, Volume 816, 21 3 2017, Pages 107-115 Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis. Parma L, Baganha F, Quax PHA, de Vries MR

Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing evidence suggests that plaque neovascularization is an important contributor to plaque growth and instability. The vessels' immaturity, with profound structural and functional abnormalities, leads to recurrent intraplaque hemorrhage. This review discusses new insights of atherosclerotic neovascularization, including the effects of lea... Abstract

Cited 8 times since 2017 (1 per year) source: EuropePMC

International journal of cardiology, Volume 241, 20 3 2017, Pages 364-372 A novel 'splice site' HCN4 Gene mutation, c.1737+1 G>T, causes familial bradycardia, reduced heart rate response, impaired chronotropic competence and increased short-term heart rate variability. Hategan L, Csányi B, Ördög B, Kákonyi K, Tringer A, Kiss O, Orosz A, Sághy L, Nagy I, Hegedűs Z, Rudas L, Széll M, Varró A, Forster T, Sepp R

Background: The most important molecular determinant of heart rate regulation in sino-atrial pacemaker cells includes hyperpolarization-activated, cyclic nucleotide-gated ion channels, the major isoform of which is encoded by the HCN4 gene. Mutations affecting the HCN4 gene are associated primarily with sick sinus syndrome. Methods and results: A novel c.1737+1 G>T 'splice-site' HCN4 mutation was identified in a large family with familial bradycardia which co-segregated with the dis... Abstract

Cited 193 times since 2017 (24.3 per year) source: EuropePMC

Nature genetics, Volume 49, Issue 6, 17 3 2017, Pages 946-952 Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Christophersen IE, Rienstra M, Roselli C, Yin X, Geelhoed B, Barnard J, Lin H, Arking DE, Smith AV, Albert CM, Chaffin M, Tucker NR, Li M, Klarin D, Bihlmeyer NA, Low SK, Weeke PE, Müller-Nurasyid M, Smith JG, Brody JA, Niemeijer MN, Dörr M, Trompet S, Huffman J, Gustafsson S, Schurmann C, Kleber ME, Lyytikäinen LP, Seppälä I, Malik R, Horimoto ARVR, Perez M, Sinisalo J, Aeschbacher S, Thériault S, Yao J, Radmanesh F, Weiss S, Teumer A, Choi SH, Weng LC, Clauss S, Deo R, Rader DJ, Shah SH, Sun A, Hopewell JC, Debette S, Chauhan G, Yang Q, Worrall BB, Paré G, Kamatani Y, Hagemeijer YP, Verweij N, Siland JE, Kubo M, Smith JD, Van Wagoner DR, Bis JC, Perz S, Psaty BM, Ridker PM, Magnani JW, Harris TB, Launer LJ, Shoemaker MB, Padmanabhan S, Haessler J, Bartz TM, Waldenberger M, Lichtner P, Arendt M, Krieger JE, Kähönen M, Risch L, Mansur AJ, Peters A, Smith BH, Lind L, Scott SA, Lu Y, Bottinger EB, Hernesniemi J, Lindgren CM, Wong JA, Huang J, Eskola M, Morris AP, Ford I, Reiner AP, Delgado G, Chen LY, Chen YI,

Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,... Abstract

Cited 22 times since 2017 (2.8 per year) source: EuropePMC

Atherosclerosis, Volume 261, 13 2 2017, Pages 26-36 Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis. Welten SMJ, de Jong RCM, Wezel A, de Vries MR, Boonstra MC, Parma L, Jukema JW, van der Sluis TC, Arens R, Bot I, Agrawal S, Quax PHA, Nossent AY

Background and aims: We aimed at investigating the role of 14q32 microRNAs in intimal hyperplasia and accelerated atherosclerosis; two major contributors to restenosis. Restenosis occurs regularly in patients treated for coronary artery disease and peripheral arterial disease. We have previously shown that inhibition of 14q32 microRNAs leads to increased post-ischemic neovascularization, and microRNA miR-494 also decreased atherosclerosis, while increasing plaque stability. We hypothesized that... Abstract

Cited 16 times since 2017 (2 per year) source: EuropePMC

The American journal of cardiology, Volume 120, Issue 1, 12 2 2017, Pages 140-147 Effect of Aging on Left Atrial Compliance and Electromechanical Properties in Subjects Without Structural Heart Disease. Abou R, Leung M, Tonsbeek AM, Podlesnikar T, Maan AC, Schalij MJ, Ajmone Marsan N, Delgado V, Bax JJ

Aging is associated with changes in left atrial (LA) structure and function. The present study aimed at describing the effect of aging on LA properties in a large cohort of subjects without structural heart disease. We divided 386 subjects (mean age 58 years [range 16 to 91]; 188 men [49%]) clinically referred for echocardiography according to age groups. The P-wave dispersion (PWD), reflecting total atrial conduction time, was measured on a 12-lead surface electrocardiogram as the difference be... Abstract

Cited 10 times since 2017 (1.3 per year) source: EuropePMC

Radiology, Volume 284, Issue 3, 11 2 2017, Pages 758-765 Predictors of Knowledge and Image Interpretation Skill Development in Radiology Residents. Ravesloot CJ, van der Schaaf MF, Kruitwagen CLJJ, van der Gijp A, Rutgers DR, Haaring C, Ten Cate O, van Schaik JPJ

Purpose To investigate knowledge and image interpretation skill development in residency by studying scores on knowledge and image questions on radiology tests, mediated by the training environment. Materials and Methods Ethical approval for the study was obtained from the ethical review board of the Netherlands Association for Medical Education. Longitudinal test data of 577 of 2884 radiology residents who took semiannual progress tests during 5 years were retrospectively analyzed by using a no... Abstract

Cited 16 times since 2017 (2 per year) source: EuropePMC

PloS one, Volume 12, Issue 4, 6 1 2017, Pages e0174278 Static axial overloading primes lumbar caprine intervertebral discs for posterior herniation. Paul CP, de Graaf M, Bisschop A, Holewijn RM, van de Ven PM, van Royen BJ, Mullender MG, Smit TH, Helder MN

Introduction: Lumbar hernias occur mostly in the posterolateral region of IVDs and mechanical loading is an important risk factor. Studies show that dynamic and static overloading affect the nucleus and annulus of the IVD differently. We hypothesize there is also variance in the effect of overloading on the IVD's anterior, lateral and posterior annulus, which could explain the predilection of herniations in the posterolateral region. We assessed the regional mechanical and cellular response... Abstract

Cited 6 times since 2017 (0.8 per year) source: EuropePMC

International journal of stroke : official journal of the International Stroke Society, Volume 12, Issue 7, 6 1 2017, Pages 724-731 Cardiorespiratory fitness, cognition and brain structure after TIA or minor ischemic stroke. Boss HM, Van Schaik SM, Witkamp TD, Geerlings MI, Weinstein HC, Van den Berg-Vos RM

Background It is not known whether cardiorespiratory fitness is associated with better cognitive performance and brain structure in patients with a TIA or minor ischemic stroke. Aims To examine the association between cardiorespiratory fitness, cognition and brain structure in patients with a TIA and minor stroke. Methods The study population consisted of patients with a TIA or minor stroke with a baseline measurement of the peak oxygen consumption, a MRI scan of brain and neuropsychological ass... Abstract

Cited 3 times since 2017 (0.4 per year) source: EuropePMC

Cognitive science, Volume 42, Issue 1, 6 1 2017, Pages 77-102 Adaptive Anchoring Model: How Static and Dynamic Presentations of Time Series Influence Judgments and Predictions. Kusev P, van Schaik P, Tsaneva-Atanasova K, Juliusson A, Chater N

When attempting to predict future events, people commonly rely on historical data. One psychological characteristic of judgmental forecasting of time series, established by research, is that when people make forecasts from series, they tend to underestimate future values for upward trends and overestimate them for downward ones, so-called trend-damping (modeled by anchoring on, and insufficient adjustment from, the average of recent time series values). Events in a time series can be experienced... Abstract

Cited 10 times since 2017 (1.3 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 117, Issue 7, 6 1 2017, Pages 1412-1419 von Willebrand factor deficiency leads to impaired blood flow recovery after ischaemia in mice. de Vries MR, Peters EAB, Quax PHA, Nossent AY

Neovascularisation, i. e. arteriogenesis and angiogenesis, is an inflammatory process. Therefore attraction and extravasation of leukocytes is essential for effective blood flow recovery after ischaemia. Previous studies have shown that von Willebrand factor (VWF) is a negative regulator of angiogenesis. However, it has also been shown that VWF facilitates leukocyte attraction and extravasation. We aimed to investigate the role of VWF in arteriogenesis and angiogenesis during post-ischaemic neov... Abstract

Cited 33 times since 2017 (4.1 per year) source: EuropePMC

Annals of intensive care, Volume 7, Issue 1, 5 1 2017, Pages 40 Diagnostic accuracy of quantitative neuromuscular ultrasound for the diagnosis of intensive care unit-acquired weakness: a cross-sectional observational study. Witteveen E, Sommers J, Wieske L, Doorduin J, van Alfen N, Schultz MJ, van Schaik IN, Horn J, Verhamme C

Background: Neuromuscular ultrasound is a noninvasive investigation, which can be easily performed at the bedside on the ICU. A reduction in muscle thickness and increase in echo intensity over time have been described in ICU patients, but the relation to ICU-acquired weakness (ICU-AW) is unknown. We hypothesized that quantitative assessment of muscle and nerve parameters with ultrasound can differentiate between patients with and without ICU-AW. The aim of this cross-sectional study was to inve... Abstract

Cited 191 times since 2017 (24 per year) source: EuropePMC

The New England journal of medicine, Volume 376, Issue 26, 3 1 2017, Pages 2534-2544 Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism. Stott DJ, Rodondi N, Kearney PM, Ford I, Westendorp RGJ, Mooijaart SP, Sattar N, Aubert CE, Aujesky D, Bauer DC, Baumgartner C, Blum MR, Browne JP, Byrne S, Collet TH, Dekkers OM, den Elzen WPJ, Du Puy RS, Ellis G, Feller M, Floriani C, Hendry K, Hurley C, Jukema JW, Kean S, Kelly M, Krebs D, Langhorne P, McCarthy G, McCarthy V, McConnachie A, McDade M, Messow M, O'Flynn A, O'Riordan D, Poortvliet RKE, Quinn TJ, Russell A, Sinnott C, Smit JWA, Van Dorland HA, Walsh KA, Walsh EK, Watt T, Wilson R, Gussekloo J, TRUST Study Group

Background: The use of levothyroxine to treat subclinical hypothyroidism is controversial. We aimed to determine whether levothyroxine provided clinical benefits in older persons with this condition. Methods: We conducted a double-blind, randomized, placebo-controlled, parallel-group trial involving 737 adults who were at least 65 years of age and who had persisting subclinical hypothyroidism (thyrotropin level, 4.60 to 19.99 mIU per liter; free thyroxine level within the reference range). A tot... Abstract

Cited 82 times since 2017 (10.3 per year) source: Scopus

European heart journal, Volume 38, Issue 16, 1 1 2017, Pages 1207-1217 Transcatheter aortic valve thrombosis: the relation between hypo-attenuated leaflet thickening, abnormal valve haemodynamics, and stroke. Vollema EM, Kong WKF, Katsanos S, Kamperidis V, van Rosendael PJ, van der Kley F, de Weger A, Ajmone Marsan N, Delgado V, Bax JJ

Aims: The presence of hypo-attenuated leaflet thickening (HALT) and/or reduced leaflet motion on multi-detector row computed tomography (MDCT) has been proposed as a possible marker for early transcatheter aortic valve thrombosis. However, its association with abnormal valve haemodynamics on echocardiography (another potential marker of thrombosis) and clinical outcomes (stroke) remains unclear. The present study evaluated the prevalence of HALT on MDCT and abnormal valve haemodynamics on echoca... Abstract

Cited 6 times since 2017 (0.8 per year) source: EuropePMC

European journal of clinical nutrition, Volume 71, Issue 4, 1 1 2017, Pages 566 No association of alcohol use and the risk of ulcerative colitis or Crohn's disease: data from a European Prospective cohort study (EPIC). Bergmann MM, Hernandez V, Bernigau W, Boeing H, Chan SS, Luben R, Khaw KT, van Schaik F, Oldenburg B, Bueno-de-Mesquita B, Overvad K, Palli D, Masala G, Carbonnel F, Boutron-Ruault MC, Olsen A, Tjonneland A, Kaaks R, Katzke V, Riboli E, Hart AR

Abstract