6139 results
Cited 250 times since 2010 (16.7 per year)
source: EuropePMC
Circulation,
Volume 121, Issue 17, 19 3 2010, Pages 1941-1950
Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome: a prognostic study.
Hellings WE, Peeters W, Moll FL, Piers SR, van Setten J, Van der Spek PJ, de Vries JP, Seldenrijk KA, De Bruin PC, Vink A, Velema E, de Kleijn DP, Pasterkamp G
Background: Identification of patients at risk for primary and secondary manifestations of atherosclerotic disease progression is based mainly on established risk factors. The atherosclerotic plaque composition is thought to be an important determinant of acute cardiovascular events, but no prospective studies have been performed. The objective of the present study was to investigate whether atherosclerotic plaque composition is associated with the occurrence of future vascular events. Methods a...
Abstract
Cited 17 times since 2010 (1.1 per year)
source: EuropePMC
Leukemia research,
Volume 34, Issue 10, 14 2 2010, Pages 1275-1281
DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia.
Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, Arinç E
It is now well established that genetic polymorphisms impairing the DNA repair capacity can disrupt the genomic integrity and potentially modulate individual's susceptibility to various cancers. In this study, we investigated the possible association of X-ray repair cross-complimenting group 1 (XRCC1) Arg399Gln and Arg194Trp variants with the risk of incidence of childhood acute lymphoblastic leukemia (ALL) in Turkish population comprised of 190 healthy controls and 167 ALL patients. For Ar...
Abstract
Cited 207 times since 2010 (13.9 per year)
source: EuropePMC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
Volume 24, Issue 9, 12 2 2010, Pages 3135-3144
Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology.
Talens RP, Boomsma DI, Tobi EW, Kremer D, Jukema JW, Willemsen G, Putter H, Slagboom PE, Heijmans BT
The prospect of finding epigenetic risk factors for complex diseases would be greatly enhanced if DNA from existing biobanks, which is generally extracted from whole blood, could be used to perform epigenetic association studies. We characterized features of DNA methylation at 16 candidate loci, 8 of which were imprinted, in DNA samples from the Netherlands Twin Register biobank. Except for unmethylated or fully methylated sites, CpG methylation varied considerably in a sample of 30 unrelated in...
Abstract
Cited 12 times since 2010 (0.8 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 40, Issue 1, 10 2 2010, Pages 65-70
Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer.
Bosman WM, Vlot J, van der Steenhoven TJ, van den Berg O, Hamming JF, de Vries AC, Brom HL, Jacobs MJ
Objective: This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model. Design: Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created. Material: The formulation used in the experiments consisted of a two-component addition-cure...
Abstract
Cited 15 times since 2010 (1 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 140, Issue 6, 9 2 2010, Pages 1338-1344
Long-term effects of surgical ventricular restoration with additional restrictive mitral annuloplasty and/or coronary artery bypass grafting on left ventricular function: six-month follow-up by pressure-volume loops.
ten Brinke EA, Klautz RJ, Tulner SA, Verwey HF, Bax JJ, Schalij MJ, van der Wall EE, Versteegh MI, Dion RA, Steendijk P
Objectives: Previous studies demonstrated beneficial short-term effects of surgical ventricular restoration on mechanical dyssynchrony and left ventricular function and improved midterm and long-term clinical parameters. However, long-term effects on systolic and diastolic left ventricular function are still largely unknown. Methods: We studied 9 patients with ischemic dilated cardiomyopathy who underwent surgical ventricular restoration with additional restrictive mitral annuloplasty and/or cor...
Abstract
Cited 35 times since 2010 (2.3 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 17, Issue 3, 9 2 2010, Pages 470-478
Diagnostic accuracy of 64-slice computed tomography coronary angiography for the detection of in-stent restenosis: a meta-analysis.
Carrabba N, Schuijf JD, de Graaf FR, Parodi G, Maffei E, Valenti R, Palumbo A, Weustink AC, Mollet NR, Accetta G, Cademartiri F, Antoniucci D, Bax JJ
Background: We sought to evaluate the diagnostic accuracy of 64-slice multi-detector row computed tomography (MDCT) compared with invasive coronary angiography for in-stent restenosis (ISR) detection. Methods: MEDLINE, Cochrane library, and BioMed Central database searches were performed until April 2009 for original articles. Inclusion criteria were (1) 64-MDCT was used as a diagnostic test for ISR, with >50% diameter stenosis selected as the cut-off criterion for significant ISR, using inva...
Abstract
Cited 6 times since 2010 (0.4 per year)
source: EuropePMC
Circulation,
Volume 121, Issue 13, 1 1 2010, Pages e261-2
Images in cardiovascular medicine. Direct endoscopic visual assessment of a transcatheter aortic valve implantation and performance in the Physioheart, an isolated working heart platform.
de Weger A, van Tuijl S, Stijnen M, Steendijk P, de Hart J
Abstract
Cited 19 times since 2010 (1.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 96, Issue 8, 1 1 2010, Pages 621-624
22q11.2 Deletion Syndrome is under-recognised in adult patients with tetralogy of Fallot and pulmonary atresia.
van Engelen K, Topf A, Keavney BD, Goodship JA, van der Velde ET, Baars MJ, Snijder S, Moorman AF, Postma AV, Mulder BJ
Background: Three quarters of patients with 22q11.2 Deletion Syndrome (22q11.2DS) have congenital heart disease (CHD), typically conotruncal heart defects. Although it is currently common practice to test all children with typical CHD for 22q11.2DS, many adult patients have not been tested in the past and therefore 22q11.2DS might be under-recognised in adults. Objectives: To determine the prevalence of 22q11.2DS in adults with tetralogy of Fallot (TOF) and pulmonary atresia (PA)/ventricular sep...
Abstract
Cited 4 times since 2010 (0.3 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 96, Issue 7, 1 1 2010, Pages 560-572
Non-invasive imaging: Non-invasive assessment of coronary artery disease in diabetes.
Van de Veire NR, Djaberi R, Schuijf JD, Bax JJ
Abstract
Cited 26 times since 2010 (1.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 3, Issue 4, 1 1 2010, Pages 429-439
Recent developments in heart failure imaging.
Marwick TH, Raman SV, Carrió I, Bax JJ
Despite the central role of echocardiography in its primary assessment, heart failure is a condition in which access to multiple cardiovascular imaging modalities is important. A number of important observations relative to this topic have been made in the last year, including the assessment of left ventricular synchrony, myocardial mechanics, heart failure with preserved ejection fraction, metabolic imaging, assessment of myocardial viability, and fusion imaging.
Abstract
Cited 95 times since 2010 (6.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 55, Issue 15, 1 1 2010, Pages 1611-1618
Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy.
Akdim F, Stroes ES, Sijbrands EJ, Tribble DL, Trip MD, Jukema JW, Flaim JD, Su J, Yu R, Baker BF, Wedel MK, Kastelein JJ
Objectives: The aim of this study was to evaluate the efficacy and safety of mipomersen in hypercholesterolemic subjects taking stable statin therapy. Background: Mipomersen is an apolipoprotein (apo) B synthesis inhibitor that has demonstrated significant reductions in apo B and low-density lipoprotein (LDL) cholesterol in Phase 1 clinical trials in healthy volunteers. Methods: A randomized, placebo-controlled, dose-escalation Phase 2 study was designed to evaluate the effects of mipomersen in...
Abstract
Cited 13 times since 2010 (0.9 per year)
source: EuropePMC
BMC geriatrics,
Volume 10, 1 1 2010, Pages 17
Impact of valvular heart disease on activities of daily living of nonagenarians: the Leiden 85-plus study a population based study.
van Bemmel T, Delgado V, Bax JJ, Gussekloo J, Blauw GJ, Westendorp RG, Holman ER
Background: Data on the prevalence of valvular heart disease in very old individuals are scarce and based mostly on in-hospital series. In addition, the potential detrimental effect of valvular heart disease on the activities of daily living is unknown. The present study evaluated the prevalence of significant valvular heart disease and the impact of valvular heart disease on the activities of daily living in community dwelling nonagenarians. Nested within the Leiden 85-plus study, a population...
Abstract
Cited 20 times since 2010 (1.3 per year)
source: EuropePMC
World journal of surgery,
Volume 34, Issue 4, 1 1 2010, Pages 852-860
Factors predicting outcome of total thyroidectomy in young patients with multiple endocrine neoplasia type 2: a nationwide long-term follow-up study.
Schreinemakers JM, Vriens MR, Valk GD, de Groot JW, Plukker JT, Bax K, Hamming JF, van der Luijt RB, Aronson DC, Borel Rinkes IH
BACKGROUND Multiple endocrine neoplasia type 2 (MEN 2) is caused by a RET mutation in chromosome 10. All MEN 2 patients develop medullary thyroid carcinoma (MTC). The age-related risk of MTC is associated with the type of RET mutation. Our aim was to identify prognostic factors associated with recurrent MTC in MEN 2 patients. METHODS In a nationwide case-control study, all patients who underwent total thyroidectomy in the Netherlands under the age of 20 years were classified into standard (1), h...
Abstract
Cited 1 times since 2010 (0.1 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 26, Issue 6, 1 1 2010, Pages 661-664
Positron emission tomography; viable tool in patients pre-CABG?
van der Wall EE, Siebelink HM, Scholte AJ, Bax JJ
Abstract
Cited 5 times since 2010 (0.3 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 52, Issue 1, 29 5 2010, Pages 152-158
The effect of injectable biocompatible elastomer (PDMS) on the strength of the proximal fixation of endovascular aneurysm repair grafts: an in vitro study.
Bosman WM, van der Steenhoven TJ, Suárez DR, Valstar ER, de Vries AC, Brom HL, Jacobs MJ, Hamming JF
Purpose: One of the major concerns in the long-term success of endovascular aneurysm repair (EVAR) is stent graft migration, which can cause type I endoleak and even aneurysm rupture. Fixation depends on the mechanical forces between the graft and both the aortic neck and the blood flow. Therefore, there are anatomical restrictions for EVAR, such as short and angulated necks. To improve the fixation of EVAR grafts, elastomer (PDMS) can be injected in the aneurysm sac. The support given by the el...
Abstract
Cited 14 times since 2010 (0.9 per year)
source: EuropePMC
Journal of biomedicine & biotechnology,
Volume 2010, 22 4 2010, Pages 702836
Novel approaches to treat experimental pulmonary arterial hypertension: a review.
Umar S, Steendijk P, Ypey DL, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A
Background: Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by an increase in pulmonary artery pressure leading to right ventricular (RV) hypertrophy, RV failure, and ultimately death. Current treatments can improve symptoms and reduce severity of the hemodynamic disorder but gradual deterioration in their condition often necessitates a lung transplant. Methods and results: In experimental models of PAH, particularly the model of monocrotaline-induced pulmonary...
Abstract
Cited 7 times since 2010 (0.5 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 51, Issue 5, 20 3 2010, Pages 1230-1237
Aortic customize: a new alternative endovascular approach to aortic aneurysm repair using injectable biocompatible elastomer. An in vitro study.
Bosman WM, van der Steenhoven TJ, Hinnen JW, Kaptein BL, de Vries AC, Brom HL, Jacobs MJ, Hamming JF
Purpose: Aortic Customize is a new concept for endovascular aortic aneurysm repair in which a non polymerized elastomer is injected to fill the aneurysm sac around a balloon catheter. The aim of this in vitro study was to investigate the extent of aneurysm wall stress reduction by the presence of a noncompliant elastomer cuff. Methods: A thin-walled latex aneurysm (inner radius sac 18 mm, inner radius neck 8 mm), equipped with 12 tantalum markers, was attached to an in vitro circulation model. F...
Abstract
Cited 22 times since 2010 (1.5 per year)
source: EuropePMC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society,
Volume 19, Issue 9, 19 3 2010, Pages 1540-1544
Spinal decompensation in degenerative lumbar scoliosis.
de Vries AA, Mullender MG, Pluymakers WJ, Castelein RM, van Royen BJ
Due to the aging population, degenerative scoliosis is a growing clinical problem. It is associated with back pain and radicular symptoms. The pathogenesis of degenerative scoliosis lies in degenerative changes of the spinal structures, such as the intervertebral disc, the facet joints and the vertebrae itself. Possibly muscle weakness also plays a role. However, it is not clear what exactly causes the decompensation to occur and what determines the direction of the curve. It is known that in th...
Abstract
European heart journal,
Volume 31, Issue 9, 16 3 2010, Pages 1038-1040
Genetics of ACS and recurrent MI/cardiac death: are we getting to the heart of the (atherosclerotic) matter?
Monraats PS, Jukema JW
Abstract
Cited 123 times since 2010 (8.2 per year)
source: EuropePMC
Vaccine,
Volume 28, Issue 20, 11 2 2010, Pages 3571-3581
Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naïve human volunteers.
van Dissel JT, Arend SM, Prins C, Bang P, Tingskov PN, Lingnau K, Nouta J, Klein MR, Rosenkrands I, Ottenhoff TH, Kromann I, Doherty TM, Andersen P
Though widely used, the BCG vaccine has had little apparent effect on rates of adult pulmonary tuberculosis. Moreover, the risk of disseminated BCG disease in immunocompromised individuals means that improved TB vaccines ideally need to be able to efficiently prime mycobacterially-naïve individuals as well as boost individuals previously vaccinated with BCG. Protective immunity against Mycobacterium tuberculosis is thought to depend on the generation of a Th1-type cellular immune response charac...
Abstract
