Research

Publications

Below you can find a list of our published research.

9618 results

Cited 2 times since 2000 (0.1 per year) source: EuropePMC

Journal of spinal disorders, Volume 13, Issue 1, 1 1 2000, Pages 88-89 Lumbar facet joint morphology. van Schaik JP

Cited 7 times since 2000 (0.3 per year) source: EuropePMC

International journal of cardiac imaging, Volume 16, Issue 1, 1 1 2000, Pages 35-41 Imaging of an aneurysm of the sinus of Valsalva with transesophageal echocardiography, contrast angiography and MRI. Baur LH, Vliegen HW, van der Wall EE, Hazekamp M, Bootsma M, de Roos A, Bruschke AV

A sinus of Valsalva aneurysm is an uncommon congenital defect, which requires appropriate diagnosis with either echocardiography, magnetic resonance imaging or contrast angiography. Treatment consists of aortic valve repair. We describe a young woman with an aneurysm of the non-coronary sinus of Valsalva, an atrial septal defect and pulmonary insufficiency. The different imaging techniques and possibilities of surgical correction are described. Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

Journal of inherited metabolic disease, Volume 23, Issue 1, 1 1 2000, Pages 91-92 Pyridoxine-responsive nephrocalcinosis and glycolic aciduria in two siblings without hyperoxaluria and with normal alanine: glyoxalate aminotransferase activity. Kist-van Holthe JE, Onkenhout W, van der Heijden AJ

Abstract

Cited 23 times since 2000 (0.9 per year) source: EuropePMC

Vision research, Volume 40, Issue 4, 1 1 2000, Pages 445-453 The development of symmetrical OKN in infants: quantification based on OKN acuity for nasalward versus temporalward motion. Lewis TL, Maurer D, Chung JY, Holmes-Shannon R, Van Schaik CS

We quantified OKN asymmetry in 140 normal infants, 3-24 months old, by varying spatial frequency to determine OKN acuity for temporal-to-nasal (T-N) versus nasal-to-temporal (N-T) motion. At all ages, OKN acuity was asymmetrical (better for T-N than for N-T motion) but the size of the asymmetry decreased from 3.2 to 0.7 octaves between 3-24 months, primarily because of improvements in OKN acuity for N-T motion. The results suggest that immaturities in the cortical pathways involved in OKN persis... Abstract

Cited 1 times since 2000 (0 per year) source: EuropePMC

Biology of the neonate, Volume 78, Issue 2, 1 1 2000, Pages 98-105 Influence of inhibition of nitric oxide synthesis on cardiac function in the newborn lamb after hypoxic-ischemic injury. Dorrepaal CA, van Bel F, Steendijk P, Shadid M, van de Velde ET, Moison RM, Berger HM, Baan J

The aim of the present study was to investigate the effect of immediate post-hypoxic-ischemic (HI) inhibition of nitric oxide synthesis by N(omega)-nitro-L-arginine (NLA) on cardiac function and reactive oxygen species production. Fifteen newborn lambs were subjected to severe HI. Upon resuscitation 5 received 10 mg NLA/kg, 4 40 mg NLA/kg and 6 a placebo. Left ventricular (LV) contractility, cardiac output (CO), non-protein-bound iron (NPBI), ratio of reduced/oxidized ascorbic acid, alpha-tocoph... Abstract

Cited 24 times since 2000 (0.9 per year) source: EuropePMC

British journal of cancer, Volume 82, Issue 1, 1 1 2000, Pages 112-117 Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues. van Schaik RH, Wierikx CD, Timmerman MA, Oomen MH, van Weerden WM, van der Kwast TH, van Steenbrugge GJ, de Jong FH

The possible role of activin in the regulation of malignant prostatic growth was studied using RNAase protection assays of activin receptors, inhibin/activin subunits and follistatin mRNAs in the human prostatic carcinoma cell lines LNCaP-FGC, -R and -LNO, in human prostatic carcinoma xenografts and in human prostatic tissue. Activin receptor types IA (ActRIA), IB (ActRIB), IIA (ActRIIA) and IIB (ActRIIB) mRNAs were generally expressed in prostate epithelial cells, with significantly lower level... Abstract

Cited 71 times since 2000 (2.8 per year) source: EuropePMC

Brain, behavior and evolution, Volume 55, Issue 1, 1 1 2000, Pages 44-52 Comparative tests of primate cognition: different scaling methods produce different results. Deaner RO, Nunn CL, van Schaik CP

Although early comparative studies supported hypotheses that ecological demands selected for primate cognition, later work indicated that social demands were more important. One difference between earlier and later studies is that earlier studies scaled brain structures by (A) taking residuals from an interspecific regression of the brain structure in question on body mass, whereas later studies scaled them by (B) taking residuals from an interspecific regression of the brain structure in questi... Abstract

Cited 25 times since 2000 (1 per year) source: EuropePMC

Clinical & experimental metastasis, Volume 18, Issue 6, 1 1 2000, Pages 445-453 Antibodies to PAI-1 alter the invasive and migratory properties of human tumour cells in vitro. Brooks TD, Slomp J, Quax PH, De Bart AC, Spencer MT, Verheijen JH, Charlton PA

Recent reports suggest that elevated levels of plasminogen activator inhibitor-1 (PAI-1) may contribute to tumour progression. The studies reported here were designed to help elucidate PAI-1's contribution to the invasive and migratory phenotype. Antibodies to PA-1 dose-dependently, and significantly, inhibited the invasive and migratory potential of human HT1080 fibrosarcoma cells, as did an antibody to uPA and the plasmin inhibitor aprotinin. Invasion of the human melanoma cell line, BLM,... Abstract

Cited 17 times since 2000 (0.7 per year) source: EuropePMC

British medical bulletin, Volume 56, Issue 3, 1 1 2000, Pages 824-836 Male germ cell transplantation: an experimental approach with a clinical perspective. Schlatt S, von Schönfeldt V, Schepers AG

Germ cell transplantation was developed in strains of mice. The infusion of germ cell preparations into the seminiferous tubules of infertile hosts led to repopulation of the testis with donor germ cells and restored fertility. Meanwhile, this technique has become a powerful tool to study the expansion of the testicular stem cell population and the kinetics of spermatogonial proliferation and re-induction of spermatogenesis. Further approaches, such as the transfer of rat/hamster/rabbit germ cel... Abstract

Psychological research, Volume 64, Issue 2, 1 1 2000, Pages 93-104 Perceptual inertia: spatial attention and warning foreperiod? Wienese M, La Heij W, van der Heijden AH, Shiffrin RM

Perceptual inertia refers to a potential explanation for the observation that during a short period after stimulus onset, the visual system is insensitive to discriminatory detail. The present study attempted to replicate this empirical result in a simple one-item letter-identification task. The results provided little if any support for the construct of perceptual inertia. In the five experiments reported, evidence consistent with perceptual inertia was only obtained in Experiment 5. However, t... Abstract

Cited 56 times since 2000 (2.2 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 278, Issue 1, 1 1 2000, Pages H100-5 Improved contractile performance of right ventricle in response to increased RV afterload in newborn lamb. de Vroomen M, Cardozo RH, Steendijk P, van Bel F, Baan J

Pulmonary hypertension results in an increased afterload for the right ventricle (RV). To determine the effects of this increased afterload on RV contractile performance, we examined RV performance before and during 4 h of partial balloon occlusion of the pulmonary artery and again after releasing the occlusion in nine newborn lambs. RV contractile performance was quantified by indexes derived from systolic RV pressure-volume relations obtained by a combined pressure-conductance catheter during... Abstract

Cited 9 times since 1999 (0.3 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 82, Issue 6, 1 1 1999, Pages 697-703 Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair. Niezen RA, Helbing WA, van Der Wall EE, van Der Geest RJ, Vliegen HW, de Roos A

Objective: To assess left ventricular function in adult Fallot patients with residual pulmonary regurgitation. Setting: The radiology department of a tertiary referral centre. Patients: 14 patients with chronic pulmonary regurgitation and right ventricular volume overload after repair of tetralogy of Fallot and 10 healthy subjects were studied using magnetic resonance imaging. Main outcome measures: Biventricular volumes, global biventricular function, and regional left ventricular function were... Abstract

Cited 44 times since 1999 (1.7 per year) source: EuropePMC

Circulation research, Volume 85, Issue 10, 1 1 1999, Pages 931-939 Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells. Engelse MA, Neele JM, van Achterberg TA, van Aken BE, van Schaik RH, Pannekoek H, de Vries CJ

Activin is a member of the transforming growth factor-beta superfamily, and it modulates the proliferation and differentiation of various target cells. In this study, we investigated the role of activin in the initiation and progression of human atherosclerosis. The expression of activin, its physiological inhibitor follistatin, and activin receptors were assayed in human vascular tissue specimens that represented various stages of atherogenesis. In situ hybridization experiments revealed activi... Abstract

Cited 12 times since 1999 (0.5 per year) source: EuropePMC

Experimental eye research, Volume 69, Issue 5, 1 1 1999, Pages 505-510 Autofluorescence distribution along the corneal axis in diabetic and healthy humans. Van Schaik HJ, Coppens J, Van den Berg TJ, Van Best JA

Corneal autofluorescence, as measured with a commercial scanning fluorophotometer (lambda(exc): 415-491 nm; lambda(em): 515-630 nm), is increased in patients with diabetes mellitus. However, such fluorophotometers register an average fluorescence signal over all corneal layers as a consequence of their limited axial resolution of 0.5 mm. In order to determine the location of the fluorophores responsible for the increased corneal autofluorescence measured in diabetics, an attempt was made to meas... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Annals of human genetics, Volume 63, Issue Pt 6, 1 1 1999, Pages 499-510 Analysis of lipoprotein lipase haplotypes reveals associations not apparent from analysis of the constituent loci. Hallman DM, Groenemeijer BE, Jukema JW, Boerwinkle E, Kastelein JJ

Simultaneously analysing genotype effects at several closely-linked loci may be preferable to analysing them separately, but can be difficult, due to multiple genotype classes, small class sizes, and non-independence induced by associations among loci. Analysis of haplotype effects offers an alternative approach. We studied effects of haplotypes comprising 3 loci (5' to 3': PvuII, HindIII, and Ser 447 -Stop) in the lipoprotein lipase (LPL) gene on plasma lipid levels and LPL activity,... Abstract

Cited 205 times since 1999 (7.9 per year) source: EuropePMC

The American journal of cardiology, Volume 84, Issue 10, 1 1 1999, Pages 1192-1197 The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Shepherd J, Blauw GJ, Murphy MB, Cobbe SM, Bollen EL, Buckley BM, Ford I, Jukema JW, Hyland M, Gaw A, Lagaay AM, Perry IJ, Macfarlane PW, Meinders AE, Sweeney BJ, Packard CJ, Westendorp RG, Twomey C, Stott DJ

The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomized, double-blind, placebo-controlled trial designed to test the hypothesis that treatment with pravastatin will diminish risk of subsequent major vascular events in a cohort of men and women (70 to 82 years old) with preexisting vascular disease or significant risk of developing this condition. Five thousand eight hundred four men and women in addition to receiving advice on diet and smoking, have been randomized... Abstract

Cited 13 times since 1999 (0.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 6, Issue 6, 1 1 1999, Pages 577-582 Automated ejection fraction determination from gated myocardial FDG-PET data. Willemsen AT, Siebelink HJ, Blanksma PK, Paans AM

Background: The aim of this study was to determine the potential of the automated calculation of the left ventricular ejection fraction from gated myocardial positron emission tomography (PET) scans. Methods: We retrospectively analyzed the data of 20 patients who underwent both gated fluorine 18 deoxyglucose (FDG)-PET and equilibrium radionuclide angiography (ERNA). Gated PET data were analyzed by 2 independent programs (ie, quantitative gated single photon emission computed tomography [QGS]) o... Abstract

Cited 55 times since 1999 (2.1 per year) source: EuropePMC

Perception & psychophysics, Volume 61, Issue 8, 1 1 1999, Pages 1646-1661 Relative mislocalization of briefly presented stimuli in the retinal periphery. Müsseler J, van der Heijden AH, Mahmud SH, Deubel H, Ertsey S

We studied the ability to localize flashed stimuli, using a relative judgment task. When observers are asked to localize the peripheral position of a probe with respect to the midposition of a spatially extended comparison stimulus, they tend to judge the probe as being more toward the periphery than is the midposition of the comparison stimulus. We report seven experiments in which this novel phenomenon was explored. They reveal that the mislocalization occurs only when the probe and the compar... Abstract

Cited 1 times since 1999 (0 per year) source: EuropePMC

Acta psychologica, Volume 103, Issue 1-2, 1 1 1999, Pages 91-102 The effect of noise in a single-item localization and identification task. Van der Heijden AH, Brouwer RF

Shiu and Pashler ((1994). Negligible effect of spatial precuing on identification of single digits. Journal of Experimental Psychology: Human Perception of Performance, 20, 1037-1054) argue that in single-item identification and localization tasks irrelevant, small, elements can induce costs. For explaining the results, they advance a Noise Reduction explanation as an alternative for the traditional Signal Enhancement explanation. The results of a single-item identification and localization task... Abstract

Cited 3 times since 1999 (0.1 per year) source: EuropePMC

International journal of neural systems, Volume 9, Issue 5, 1 1 1999, Pages 441-446 Human localisation of band-pass filtered noise. van Schaik A, Jin C, Carlile S

In this work we study the influence and relationship of five different acoustical cues to the human sound localisation process. These cues are: interaural time delay, interaural level difference, interaural spectrum, monaural spectrum, and band-edge spectral contrast. Of particular interest was the synthesis and integration of the different cues to produce a coherent and robust percept of spatial location. The relative weighting and role of the different cues was investigated using band-pass fil... Abstract