6882 results
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The American journal of cardiology,
Volume 152, 20 3 2021, Pages 11-18
Prognostic Value of Multilayer Left Ventricular Global Longitudinal Strain in Patients with ST-segment Elevation Myocardial Infarction with Mildly Reduced Left Ventricular Ejection Fractions.
Abou R, Goedemans L, Montero-Cabezas JM, Prihadi EA, El Mahdiui M, Schalij MJ, Ajmone Marsan N, Bax JJ, Delgado V
Multilayer (epi-, mid- and endocardium) left ventricular (LV) global longitudinal strain (GLS) reflects the extent of myocardial damage after ST-segment myocardial infarction (STEMI). However, the prognostic implications of multilayer LV GLS remain unclear. We studied the association between multilayer LV GLS and prognosis in patients with mildly reduced or preserved LV ejection fraction (EF) after STEMI. Patients with first STEMI and LVEF>45% were evaluated retrospectively. Baseline multilay...
Abstract
Cited 8 times since 2021 (2.2 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 18 3 2021, Pages 12899
Lipid biomarkers in statin users with coronary artery disease annotated by coronary computed tomography angiography.
Michelucci E, Giorgi ND, Finamore F, Smit JM, Scholte AJHA, Signore G, Rocchiccioli S
Molecular markers are suggested to improve the diagnostic and prognostic accuracy in patients with coronary artery disease (CAD) beyond current clinical scores based on age, gender, symptoms and traditional risk factors. In this context, plasma lipids are emerging as predictors of both plaque composition and risk of future events. We aim to identify plasma lipid biomarkers associated to CAD indexes of stenosis severity, plaque lipid content and a comprensive score of CAD extent and its risk. We...
Abstract
Cited 34 times since 2021 (9.2 per year)
source: EuropePMC
Nature communications,
Volume 12, Issue 1, 18 3 2021, Pages 3799
Vimentin intermediate filaments stabilize dynamic microtubules by direct interactions.
Schaedel L, Lorenz C, Schepers AV, Klumpp S, Köster S
The cytoskeleton determines cell mechanics and lies at the heart of important cellular functions. Growing evidence suggests that the manifold tasks of the cytoskeleton rely on the interactions between its filamentous components-actin filaments, intermediate filaments, and microtubules. However, the nature of these interactions and their impact on cytoskeletal dynamics are largely unknown. Here, we show in a reconstituted in vitro system that vimentin intermediate filaments stabilize microtubules...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
ACS omega,
Volume 6, Issue 25, 16 3 2021, Pages 16649-16660
Comparative Study: Impacts of Ca and Mg Salts on Iron Oxygen Carriers in Chemical Looping Combustion of Biomass.
Yilmaz D, Steenari BM, Leion H
Chemical looping combustion (CLC) is one of the most promising methods for carbon capture and storage (CCS). An oxygen carrier, i.e., a mineral that can be oxidized and reduced, is used to convert the fuel in the process. The produced CO2 is inherently separated from the air components that enables easier CCS. The use of biomass-based fuels is desirable since it can lead to negative CO2 emissions. On the other hand, alkali compounds from the biomass may interact with the oxygen carrier causing p...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
AJR. American journal of roentgenology,
Volume 217, Issue 6, 16 3 2021, Pages 1344-1352
Impact of Dose Reduction Strategies on Image Quality of Coronary CTA in Real-World Clinical Practice: A Subanalysis of PROTECTION VI Registry Data.
Stocker TJ, Nühlen N, Schmermund A, Leipsic J, Grove EL, Deseive S, Bax JJ, Maurovich-Horvat P, Otton J, Hadamitzky M, Chen MY, Naoum C, Andreini D, Rubinshtein R, Massberg S, Hausleiter J
BACKGROUND. Dose reduction strategies for coronary CTA (CCTA) have been underused in clinical practice given concern that the strategies may lower image quality. OBJECTIVE. The purpose of this study was to explore associations between dose reduction strategies and CCTA image quality in real-world clinical practice. METHODS. This subanalysis of the international Prospective Multicenter Registry on Radiation Dose Estimates of Cardiac CT Angiography in Daily Practice in 2017 (PROTECTION VI) study i...
Abstract
Cited 10 times since 2021 (2.7 per year)
source: EuropePMC
Frontiers in public health,
Volume 9, 16 3 2021, Pages 568822
Creating a Social Learning Environment for and by Older Adults in the Use and Adoption of Smartphone Technology to Age in Place.
den Haan M, Brankaert R, Kenning G, Lu Y
Smartphone technologies can support older adults in their daily lives as they age in place at home. However, they may struggle to use these technologies which impacts acceptance, adoption, and sustainable use. Peer to peer community learning has the potential to support older adults to learn using (smartphone) technologies. This paper studies such a learning community approach and how it can support older adults to learn using and adopt the smartphone application GoLivePhone. This technology ass...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
EJNMMI physics,
Volume 8, Issue 1, 16 3 2021, Pages 48
Experimental validation of absolute SPECT/CT quantification for response monitoring in patients with coronary artery disease.
van de Burgt A, Dibbets-Schneider P, Slump CH, Scholte AJHA, Atsma DE, de Geus-Oei LF, van Velden FHP
Background: Quantitative SPECT enables absolute quantification of uptake in perfusion defects. The aim of this experimental study is to assess quantitative accuracy and precision of a novel iterative reconstruction technique (Evolution; GE Healthcare) for the potential application of response monitoring using 99mTc-tetrofosmin SPECT/CT in patients with coronary artery disease (CAD). Methods: Acquisitions of an anthropomorphic torso phantom with cardiac insert containing defects (with varying siz...
Abstract
JACC. Asia,
Volume 1, Issue 1, 15 3 2021, Pages 49-52
The Multidimensionality of Coronary Artery Disease: Combining, Conflating and Changing.
Min JK, Budoff MJ, Bax JJ
Abstract
Cited 10 times since 2021 (2.7 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 6, 13 2 2021, Pages 70
How Cardiac Embryology Translates into Clinical Arrhythmias.
Rivaud MR, Blok M, Jongbloed MRM, Boukens BJ
The electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of transcription factors that guide expression of specific ion channels. Genome-wide association studies have shown that small variations in genetic regions are key to the expression of these transcription factors and thereby modulate the electrical function...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology,
Volume 17, Issue 2, 11 2 2021, Pages e156-e157
Computed tomography-derived transoesophageal echocardiographic views for preprocedural planning of direct transcatheter mitral valve annuloplasty.
Fortuni F, van der Kley F, Ajmone Marsan N, Delgado V
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
European heart journal. Digital health,
Volume 2, Issue 3, 11 2 2021, Pages 511-520
Development of a patient-oriented Hololens application to illustrate the function of medication after myocardial infarction.
Hilt AD, Hierck BP, Eijkenduijn J, Wesselius FJ, Albayrak A, Melles M, Schalij MJ, Scherptong RWC
Aims: Statin treatment is one of the hallmarks of secondary prevention after myocardial infarction. Adherence to statins tends to be difficult and can be improved by patient education. Novel technologies such as mixed reality (MR) expand the possibilities to support this process. To assess if an MR medication-application supports patient education focused on function of statins after myocardial infarction. Methods and results: A human-centred design-approach was used to develop an MR statin tool...
Abstract
Cited 6 times since 2021 (1.6 per year)
source: EuropePMC
Journal of internal medicine,
Volume 290, Issue 3, 10 2 2021, Pages 715-727
Renal function in patients with significant tricuspid regurgitation: pathophysiological mechanisms and prognostic implications.
Butcher SC, Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, Ajmone Marsan N, Bax JJ, Delgado V
Background: The pathophysiological mechanisms linking tricuspid regurgitation (TR) and chronic kidney disease (CKD) remain unknown. This study aimed to determine which pathophysiological mechanisms related to TR are independently associated with renal dysfunction and to evaluate the impact of renal impairment on long-term prognosis in patients with significant (≥ moderate) secondary TR. Methods: A total of 1234 individuals (72 [IQR 63-78] years, 50% male) with significant secondary TR were follo...
Abstract
Metabolomics : Official journal of the Metabolomic Society,
Volume 17, Issue 6, 9 2 2021, Pages 57
Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study.
Wang W, van Dijk KW, Wijsman CA, Rozing MP, Mooijaart SP, Beekman M, Slagboom PE, Jukema JW, Noordam R, van Heemst D
Background: Insulin is the key regulator of glucose metabolism, but it is difficult to dissect direct insulin from glucose-induced effects. We aimed to investigate the effects of hyperinsulemia on metabolomic measures under euglycemic conditions in nondiabetic participants. Methods: We assessed concentrations of 151 metabolomic measures throughout a two-step hyperinsulinemic euglycemic clamp procedure. We included 24 participants (50% women, mean age = 62 [s.d. = 4.2] years) and metabolomic meas...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
BMC medical education,
Volume 21, Issue 1, 8 2 2021, Pages 332
The effect of peer modelling and discussing modelled feedback principles on medical students' feedback skills: a quasi-experimental study.
van Blankenstein FM, O'Sullivan JF, Saab N, Steendijk P
Background: Teaching is an important professional skill for physicians and providing feedback is an important part of teaching. Medical students can practice their feedback skills by giving each other peer feedback. Therefore, we developed a peer feedback training in which students observed a peer that modelled the use of good feedback principles. Students then elaborated on the modelled feedback principles through peer discussion. This combination of peer modelling and discussing the modelled f...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 4 1 2021, Pages 12249
Author Correction: Increased Ca<sup>2+</sup> content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete's heart model.
Gazdag P, Oravecz K, Acsai K, Demeter-Haludka V, Ördög B, Szlovák J, Kohajda Z, Polyák A, Barta BA, Oláh A, Radovits T, Merkely B, Papp JG, Baczkó I, Varró A, Nagy N, Prorok J
Abstract
Cited 12 times since 2021 (3.2 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 12, 2 1 2021, Pages e020080
Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves.
Dolmaci OB, Legué J, Lindeman JHN, Driessen AHG, Klautz RJM, Van Brakel TJ, Siebelink HJ, Mertens BJA, Poelmann RE, Gittenberger-de Groot AC, Grewal N
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A...
Abstract
Cited 15 times since 2021 (4 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 23, Issue 6, 1 1 2021, Pages 887-897
Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death.
Verstraelen TE, van Barreveld M, van Dessel PHFM, Boersma LVA, Delnoy PPHM, Tuinenburg AE, Theuns DAMJ, van der Voort PH, Kimman GP, Buskens E, Hulleman M, Allaart CP, Strikwerda S, Scholten MF, Meine M, Abels R, Maass AH, Firouzi M, Widdershoven JWMG, Elders J, van Gent MWF, Khan M, Vernooy K, Grauss RW, Tukkie R, van Erven L, Spierenburg HAM, Brouwer MA, Bartels GL, Bijsterveld NR, Borger van der Burg AE, Vet MW, Derksen R, Knops RE, Bracke FALE, Harden M, Sticherling C, Willems R, Friede T, Zabel M, Dijkgraaf MGW, Zwinderman AH, Wilde AAM
Aims: This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock and mortality to identify subgroups with insufficient benefit from ICD implantation. Methods and results: We recruited patients scheduled for primary prevention ICD implantation and reduced left ventricular function. Bootstrapping-based Cox proportional hazards and Fine and Gray competing risk models with likely candidate predictors were developed...
Abstract
Cited 3 times since 2021 (0.8 per year)
source: EuropePMC
Open heart,
Volume 8, Issue 1, 1 1 2021, Pages e001639
Discordant severity criteria in patients with moderate aortic stenosis: prognostic implications.
Pio SM, Amanullah MR, Butcher SC, Sin KY, Ajmone Marsan N, Pibarot P, Van Mieghem NM, Ding ZP, Généreux P, Leon MB, Ewe SH, Delgado V, Bax JJ
Background: The criteria to define the grade of aortic stenosis (AS)-aortic valve area (AVA) and mean gradient (MG) or peak jet velocity-do not always coincide into one grade. Although in severe AS, this discrepancy is well characterised, in moderate AS, the phenomenon of discordant grading has not been investigated and its prognostic implications are unknown. Objectives: To investigate the occurrence of discordant grading in patients with moderate AS (defined by an AVA between 1.0 cm² and 1.5 c...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 106, Issue 7, 1 1 2021, Pages e2527-e2534
Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism.
Schoeb M, Winter EM, Sleddering MA, Lips MA, Schepers A, Snel M, Appelman-Dijkstra NM
Context: In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites but also at the spine, and fractures occur at higher BMD values than expected. We hypothesized that components of bone quality other than BMD are affected in PHPT as well. Objective: To evaluate bone material properties using impact microindentation (IMI) in PHPT p...
Abstract
Cited 24 times since 2021 (6.4 per year)
source: EuropePMC
Journal for immunotherapy of cancer,
Volume 9, Issue 6, 1 1 2021, Pages e002916
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem.
Poels K, Neppelenbroek SIM, Kersten MJ, Antoni ML, Lutgens E, Seijkens TTP
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated protein 4, PD1 and PDL1 elicits potent antitumor responses and improves the prognosis of many patients with cancer. As these immune checkpoint inhibitors (ICIs) are increasingly prescribed to a diverse patient population, a broad range of adverse effects is emerging. Atherosclerosis, a lipid-driven chronic inflammatory disease of the large arteries, may be aggravated by ICI treatment. In this review,...
Abstract
