6397 results
Nederlands tijdschrift voor geneeskunde,
Volume 169, 13 2 2025, Pages D8782
[Cognitive bias in surgery: correctable failure or inevitably human?]
Hamming JF, Adriaanse MA
A review in the Annals of Surgery addressed the role of cognitive bias and heuristics in creating surgical complications and death. Bias and heuristics in decision making is not new, but the fact that surgeons and clinicians in general are influenced by them is apparently still noteworthy. The idea that clinicians act purely rational or should persists. But doctors are not computers. Nevertheless interventions aiming at improving behaviour of clinicians is based on the assumption that more knowl...
Abstract
International journal of cardiology,
Volume 444, 11 2 2025, Pages 134023
Sex differences in plaque burden and outcomes in symptomatic patients with suspected coronary artery disease.
Molnar D, Knuuti J, Bax JJ, Saraste A, Maaniitty T
Background: Sex-related differences in coronary artery disease (CAD) burden and outcomes are increasingly recognized but not fully understood, particularly when assessed using advanced imaging techniques. Objectives: To investigate sex differences in coronary plaque characteristics and their association with long-term cardiovascular outcomes in symptomatic patients undergoing coronary computed tomography angiography (CTA). Methods: A total of 2271 symptomatic patients without prior obstructive C...
Abstract
The Pediatric infectious disease journal,
11 2 2025
Pediatric Preseptal and Orbital Cellulitis: A Comparative Study of Clinical, Radiologic, and Laboratory Features.
Şahin A, Tanriverdi Kaymaz C, Kara Aksay A, Pekçevik Y, Ekemen Keleş Y, Üstündağ G, Elvan Tüz A, Tasar S, Arslan Maden A, Karadağ Öncel E, Yilmaz D
Background: This study aimed to evaluate and compare the clinical, laboratory and radiologic characteristics, as well as treatment approaches, in pediatric patients diagnosed with preseptal and orbital cellulitis. Methods: This descriptive, retrospective, cross-sectional study included pediatric patients treated at a tertiary care center between January 2019 and December 2023. Demographic, clinical, etiologic, laboratory and radiologic data were analyzed. Results: Among 244 patients, 233 (95.5%)...
Abstract
Frontiers in cardiovascular medicine,
Volume 12, 10 2 2025, Pages 1682714
Nordic consensus document on Evolut FX+ transcatheter aortic valve implantation: optimizing index implantation and longer-term outcomes.
Khokhar AA, Savontaus M, Al-Ani A, Terkselsen CJ, Bieliauskas G, van der Heijden A, Amin AAA, James S, Russell K, De Backer O
Transcatheter aortic valve replacement (TAVI) is an established treatment strategy for patients with severe symptomatic aortic stenosis (AS). Multiple landmark randomized controlled trials have consistently demonstrated the safety, efficacy, and longer-term durability of the CoreValve/Evolut (Medtronic, MN, USA) transcatheter aortic valve (TAV) platform in treating severe AS. These findings have supported the expansion of TAVI to younger patients with longer life expectancy, in whom an optimized...
Abstract
European heart journal. Case reports,
Volume 9, Issue 12, 10 2 2025, Pages ytaf561
Giant coronary artery aneurysms: a case series and management recommendations.
Vink AS, Grundeken MJD, Straver B, Robbers-Visser D, Bouma BJ, Koolbergen DR, De Winter RJ, Beijk MAM
Background: Coronary artery aneurysms (CAAs) are a rare clinical entity, and little is known about their natural history, prognosis, and management. Invasive management of patients with CAA is challenging not only because of this limited understanding but also due to the technical challenges associated with both percutaneous and surgical interventions. Case summary: We describe the management of seven cases with giant CAAs in an elective setting. Our first case demonstrates successful percutaneo...
Abstract
BJPsych open,
Volume 11, Issue 6, 10 2 2025, Pages e271
Reducing functional dysconnectivity in people with schizophrenia spectrum disorders.
Wunderlich S, Keeser D, Spaeth J, Yilmaz D, Maurus I, Alici C, Schmitt A, Falkai P, Stoecklein S, Roell L
Background: The dysconnection hypothesis of schizophrenia posits that widespread synaptic inefficiencies lead to altered macroscale brain connectivity, contributing to symptom severity and cognitive deficits in individuals with schizophrenia spectrum disorders (SSD). Emerging evidence suggests that physical exercise may help to ameliorate these connectivity abnormalities and associated clinical impairments. Aims: This study investigated whether reductions in functional dysconnectivity following...
Abstract
Cited 1 times since 2025 (12.2 per year)
source: EuropePMC
NEJM evidence,
10 2 2025, Pages EVIDoa2500268
Zalunfiban at First Medical Contact for ST-Elevation Myocardial Infarction.
Van't Hof AWJ, Gibson CM, Rikken SAOF, Januzzi JL, Granger CB, van Beurden A, Rasoul S, Ruiters L, Vainer J, Verburg A, Arslan F, Jukema JW, Durieux M, Polad J, van Vliet R, van den Branden BJL, Magro M, Remkes W, Beelen J, Hermanides R, Tolsma R, Gosselink M, Vinereanu D, Chioncel V, van de Hoef TP, Boomars R, Arkenbout KE, van Houwelingen GK, Hengstman G, van de Wetering H, Pisters R, Kala P, Merkely B, Ecollan P, Lapostolle F, Giugliano RP, Welsh RC, Levy M, Arias-Mendoza A, Baron N, Cociorva D, Wittes J, Unger EF, Coller BS, Ten Berg JM, Montalescot G
Background: Zalunfiban is a glycoprotein IIb/IIIa (integrin αIIbβ3) inhibitor designed for subcutaneous administration on first medical contact with patients with suspected ST-segment elevation myocardial infarction (STEMI). Methods: An international, double-blind, placebo-controlled trial randomly assigned patients with STEMI in a 1:1:1 ratio to receive a single subcutaneous injection of zalunfiban (0.11 mg/kg or 0.13 mg/kg) or placebo. The primary efficacy end point was a hierarchical proporti...
Abstract
Thrombosis research,
Volume 256, 9 2 2025, Pages 109533
Predicting clinically relevant bleeding in new-onset atrial fibrillation patients initiating oral anticoagulant therapy: External validation of the AF-BLEED score.
van der Horst SFB, Chu G, Seelig J, Trinks-Roerdink EM, Voorhout L, de Vries TAC, van Alem AP, Beukema RJ, Boersma LVA, Brouwer MA, Ten Cate H, Faber LM, de Groot JR, Gu YL, den Hartog FR, de Jong JSSG, de Jong Y, Kirchhof CJHJ, Kleijwegt FS, Klok FA, Kruip MJHA, Lenderink T, Luermans JG, Meeder JG, Otten AM, Pisters R, Pos L, Prins FJ, Römer TJ, Smeets F, Tahapary GJM, Theunissen LJHJ, Tieleman RG, Timmer SAJ, Tichelaar V, Trines SA, van der Voort P, Velthuis S, de Vrey EA, Walhout RJ, Hemels MEW, Rutten FH, Geersing GJ, Huisman MV
Background: Atrial fibrillation/flutter (AF/AFL) is associated with an increased stroke risk, for which oral anticoagulation (OAC) is often indicated. Bleeding risk assessment is crucial in these patients to mitigate bleeding complications, yet AF guidelines do not recommend the use of any bleeding risk score (e.g., HAS-BLED) due to concerns about predictive accuracy. The AF-adapted VTE-BLEED (AF-BLEED) score was developed to predict major bleeding (MB) post-OAC initiation. Aims: Evaluate the in...
Abstract
The Journal of invasive cardiology,
7 1 2025
Vascular access and mortality outcomes: insights from the Percutaneous Coronary Interventions registry from the Netherlands Heart Registration.
Karalis I, Timmermans MJ, Tuccillo A, Jukema JW, Derks L, Verbeek EC, Amoroso G, PCI Registration Committee of the Netherlands Heart Registration (NHR)
Objectives: While the transradial approach (TRA) is associated with fewer bleeding complications than the transfemoral approach (TFA), its effect on mortality outcomes in real-world clinical practice remains unclear. This study examines the relationship between vascular access site and mortality in patients undergoing percutaneous coronary intervention (PCI). Methods: This retrospective cohort study used prospectively collected data from the Netherlands Heart Registration, including 130,813 PCI...
Abstract
Multiple sclerosis (Houndmills, Basingstoke, England),
Volume 31, Issue 14, 6 1 2025, Pages 1641-1650
Epigenetic age and telomere length correlations in pediatric-onset multiple sclerosis.
Yang JH, Race J, Sumowski P, Jacques K, Fardad S, Fair A, Hazlett A, Lin J, Yilmaz D, Aaen G, Abrams A, Benson L, Casper TC, Chitnis T, Gorman M, Lotze T, Krupp L, Mar S, Ness J, Rensel M, Rose J, Schreiner T, Tillema JM, Waldman A, Wheeler Y, Barcellos LF, Waubant E, Graves JS
Background: Age is the strongest factor determining disease expression in multiple sclerosis (MS). We previously demonstrated biological age acceleration in pediatric-onset MS (POMS) compared to controls with both epigenetic clocks (DNAm) and telomere length (TL). It is unknown whether these markers report overlapping or distinct aging-related processes. Objectives: To determine the correlation between DNAm and TL aging markers. Methods: We conducted a cross-sectional case-control study within t...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 22, 6 1 2025, Pages e040726
Prognostic Value of a Coronary Computed Tomography Angiography-Derived Ischemia Algorithm: Comparison Against Hybrid Coronary Computed Tomography Angiography/Positron Emission Tomography Imaging.
Maaniitty T, Bär S, Nabeta T, Bax JJ, Saraste A, Knuuti J
Background: Artificial intelligence-guided quantitative computed tomography ischemia (AI-QCTischemia) is a novel machine-learning method for predicting myocardial ischemia from coronary computed tomography angiography (CCTA). This observational cohort study aimed to compare the long-term prognostic value of AI-QCTischemia with hybrid CCTA/positron emission tomography (PET) myocardial perfusion imaging in suspected coronary artery disease (CAD). Methods: Symptomatic patients with suspected CAD un...
Abstract
Journal of manipulative and physiological therapeutics,
5 1 2025, Pages S0161-4754(25)00063-6
Effectiveness of Thoracic Spine Manipulation for Upper Quadrant Musculoskeletal Disorders: A Systematic Review.
Thoomes EJ, Tilborghs G, Heneghan NR, Falla D, De Graaf M
Objective: Thoracic high-velocity low-amplitude thrust (Tx-HVLAT) manipulation is a form of conservative management recommended as an effective treatment option for patients with upper quadrant musculoskeletal disorders (UQMD). This systematic review aimed to update the current evidence on the effectiveness of Tx-HVLAT for patients with UQMD on pain, disability, and performance outcome measures. Methods: Electronic libraries of the Cochrane Controlled Trials Register, MEDLINE, EMBASE, CINAHL, PE...
Abstract
American heart journal,
Volume 292, 3 1 2025, Pages 107295
Evolocumab before percutaneous coronary intervention for acute myocardial infarction: Design of the AMUNDSEN trial.
Montalescot G, Bolognese L, Bartus S, Cequier-Fillat A, Thiele H, Mach F, Jukema JW, Ferrari E, Souteyrand G, Bouleti C, Range G, Chioccioli M, Picchi A, Batias-Moreau L, Esposito G, Braik N, Redjimi N, Duband B, Guedeney P, Zeitouni M, Brochard K, Silvain J, Vicaut E, AMUNDSEN investigators of the ACTION Study Group
Rationale: PCSK9 inhibitors are currently recommended as third-line therapy for post-myocardial infarction (MI) patients, added to high-dose statin, ezetimibe, and potentially bempedoic acid when the LDL-C target of
Abstract
Cited 30 times since 2025 (281.6 per year)
source: EuropePMC
European heart journal,
Volume 46, Issue 44, 1 1 2025, Pages 4635-4736
2025 ESC/EACTS Guidelines for the management of valvular heart disease.
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Lancet (London, England),
Volume 406, Issue 10519, 1 1 2025, Pages 2577-2587
Contemporary, non-invasive imaging diagnosis of chronic coronary artery disease.
van der Bijl P, Gulati M, Saraste A, Marwick T, Kwong R, Blankstein R, Nieman K, Sengupta PP, van Rosendael A, Knuuti J, Bangalore S, Bax JJ
Coronary artery disease is one of the leading causes of morbidity and mortality worldwide. Although it can present with an acute coronary syndrome, it is often characterised by long periods of stability, known as chronic coronary artery disease. This Review presents a comprehensive overview of the diagnosis of the disease, with a focus on cardiac imaging. We discuss various cardiac imaging modalities, including CT coronary angiography, stress echocardiogram, stress single-photon emission CT, PET...
Abstract
Annals of vascular surgery,
Volume 123, 1 1 2025, Pages 502-513
Rupture Risk of Large Abdominal Aortic Aneurysms: A Scoping Review.
Paping JHM, Bulder RMA, Lancaster E, Chang RW, Putter H, Hamming JF, Lindeman JH
Background: Abdominal aortic aneurysm (AAA) management is currently dictated by the 55 mm intervention threshold. While it has been suggested that this intervention threshold is too conservative, the rupture risk of AAAs larger than 55 mm is discussed differently. This scoping review aims to critically summarize and review the available evidence with respect to the rupture risk of larger AAA. Methods: A quantitative and qualitative evaluation of the available literature on the rupture risk of la...
Abstract
Cited 1 times since 2025 (9.4 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 29, Issue 21, 1 1 2025, Pages e70933
Breaking (Light) Barriers: Photoacoustics in Atherosclerotic Diseases.
van Dijk K, de Vries MR
Photoacoustic imaging (PAI) is an emerging imaging modality that provides high-resolution, spatiotemporal insights into anatomical structures, functional parameters and molecular characteristics of tissues. By leveraging both endogenous absorbers, such as lipids and collagen, and exogenous contrast agents like nanoparticles and molecular dyes, PAI offers a comprehensive approach to characterising atherosclerosis. This review describes the technical principles underlying various PAI modalities an...
Abstract
Journal of cardiac failure,
Volume 31, Issue 11, 1 1 2025, Pages 1661-1671
Diagnosing HFpEF in Patients With Unexplained Dyspnea by Using Invasive Left Ventricular Pressure-Volume Loops.
Gessner R, Hübner AC, Stöbe S, Rudolph UM, Unger L, Schmeisser A, Steendijk P, Uhe T, Stegmann T, Lavall D, Hagendorff A, Laufs U, Wachter R
Background: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging. Noninvasive diagnostic algorithms have been proposed but not tested against the gold standard, ie, invasive measurement of left ventricular (LV) pressure-volume loops (PVL). This study's aim was to estimate the prevalence of HFpEF in euvolemic patients with unexplained exertional dyspnea by using LV PVL and to validate noninvasive diagnostic algorithms. Methods and results: We included patient...
Abstract
The British journal of surgery,
Volume 112, Issue 11, 1 1 2025, Pages znaf177
The science and art of decision-making in surgery.
Bisset CN, Baigrie R, Dames N, Corbett S, Hill S, Macdermid E, Sier VQ, van der Vorst JR, Rehman U, Sarwar MS, Brennan PA, Cleland J, Ellis R, Bryan JE, Ketley A, Morgan JL, Gogalniceanu P, Kaafarani HMA, Liang R, Moug SJ
Abstract
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology,
Volume 80, 31 5 2025, Pages 107789
Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology.
Bacour N, Zafar M, Kargin N, Zinganshin B, Poelmann R, Klautz RJM, Elefteriades J, Grewal N
Objective: Despite a voluminous literature on aortopathy, comparatively little attention has been paid to the lamellar architecture of the aortic wall, including the number and distribution of these layers. This study compares the lamellar organization of the developing aorta in individuals with a bicuspid (BAV) versus tricuspid aortic valve (TAV) and includes a literature review on aortic lamellae in mammals and adult humans. Methods: Non-dilated ascending aortic wall samples (n = 83) were anal...
Abstract
