9618 results
Cited 16 times since 2021 (4.1 per year)
source: EuropePMC
Journal for immunotherapy of cancer,
Volume 9, Issue 10, 1 1 2021, Pages e003671
Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy.
Kortekaas KE, Santegoets SJ, Tas L, Ehsan I, Charoentong P, van Doorn HC, van Poelgeest MIE, Mustafa DAM, van der Burg SH
Background: A profound insight into the immune landscape of vulvar squamous cell carcinoma (VSCC) is lacking. Here, an in-depth interrogation of T cell infiltration, local immune contexture, signaling pathways and checkpoint molecule expression was performed in early-stage and late-stage VSCC. Methods: The type, location, and infiltration pattern of T cells were studied in 109 patients with primary VSCC FIGO stage I-III. RNA expression of genes involved in immune oncology and oncogenic signaling...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 11, 1 1 2021, Pages 1255-1256
Haemodynamic response to COVID-19 and its outcome implications.
van der Bijl P, Bax JJ
Abstract
Cited 11 times since 2021 (2.8 per year)
source: EuropePMC
Environmental science & technology,
Volume 55, Issue 20, 30 5 2021, Pages 13770-13782
Optical Properties of Water for Prediction of Wastewater Contamination, Human-Associated Bacteria, and Fecal Indicator Bacteria in Surface Water at Three Watershed Scales.
Corsi SR, De Cicco LA, Hansen AM, Lenaker PL, Bergamaschi BA, Pellerin BA, Dila DK, Bootsma MJ, Spencer SK, Borchardt MA, McLellan SL
Relations between spectral absorbance and fluorescence properties of water and human-associated and fecal indicator bacteria were developed for facilitating field sensor applications to estimate wastewater contamination in waterways. Leaking wastewater conveyance infrastructure commonly contaminates receiving waters. Methods to quantify such contamination can be time consuming, expensive, and often nonspecific. Human-associated bacteria are wastewater specific but require discrete sampling and l...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
The Journal of social psychology,
Volume 164, Issue 1, 30 5 2021, Pages 12-26
No evidence for modulation of facial mimicry by attachment tendencies in adulthood: an EMG investigation.
Vacaru SV, van Schaik JE, Spiess L, Hunnius S
Mimicking another individual functions as a social glue: it smoothens the interaction and fosters affiliation. Here, we investigated whether the intrinsic motivation to affiliate with others, stemming from attachment relationships, modulates individuals' engagement in facial mimicry (FM). Participants (N = 100; MAge = 24.54 years, SDAge = 3.90 years) observed faces with happy, sad, and neutral expressions, while their facial muscle activity was recorded with electromyography. Attachment was...
Abstract
Cited 11 times since 2021 (2.8 per year)
source: EuropePMC
Journal of pharmaceutical sciences,
Volume 111, Issue 3, 30 5 2021, Pages 734-742
Caffeic Acid Phenethyl Ester Loaded Electrospun Nanofibers for Wound Dressing Application.
Kaya S, Yilmaz DE, Akmayan I, Egri O, Arasoglu T, Derman S
Electrospinning is an advantageous method with a wide usage area, which enables the production of materials consisting of nano-thickness fibers. In this study, caffeic acid phenethyl ester (CAPE) molecule was loaded onto the poly(lactic-co-glycolic acid) (PLGA) nanofibers and obtained nanofibers were physicochemically and biologically investigated for the first time in the literature. The existence of CAPE molecules, loaded on PLGA membranes by dropping and spraying methods, was evaluated by a c...
Abstract
Cited 11 times since 2021 (2.8 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 6, 28 4 2021, Pages 4425-4443
HFA of the ESC position paper on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider Part 3: at the hospital and discharge.
Gustafsson F, Ben Avraham B, Chioncel O, Hasin T, Grupper A, Shaul A, Nalbantgil S, Hammer Y, Mullens W, Tops LF, Elliston J, Tsui S, Milicic D, Altenberger J, Abuhazira M, Winnik S, Lavee J, Piepoli MF, Hill L, Hamdan R, Ruhparwar A, Anker S, Crespo-Leiro MG, Coats AJS, Filippatos G, Metra M, Rosano G, Seferovic P, Ruschitzka F, Adamopoulos S, Barac Y, De Jonge N, Frigerio M, Goncalvesova E, Gotsman I, Itzhaki Ben Zadok O, Ponikowski P, Potena L, Ristic A, Jaarsma T, Ben Gal T
The growing population of left ventricular assist device (LVAD)-supported patients increases the probability of an LVAD- supported patient hospitalized in the internal or surgical wards with certain expected device related, and patient-device interaction complication as well as with any other comorbidities requiring hospitalization. In this third part of the trilogy on the management of LVAD-supported patients for the non-LVAD specialist healthcare provider, definitions and structured approach t...
Abstract
Cited 4 times since 2021 (1 per year)
source: EuropePMC
Journal of cardiovascular development and disease,
Volume 8, Issue 10, 28 4 2021, Pages 121
Deficient Myocardial Organization and Pathological Fibrosis in Fetal Aortic Stenosis-Association of Prenatal Ultrasound with Postmortem Histology.
Zwanenburg F, DeRuiter MC, Wisse LJ, van Munsteren CJ, Bartelings MM, Goumans MJ, Ten Harkel ADJ, Jongbloed MRM, Haak MC
In fetal aortic stenosis (AS), it remains challenging to predict left ventricular development over the course of pregnancy. Myocardial organization, differentiation and fibrosis could be potential biomarkers relevant for biventricular outcome. We present four cases of fetal AS with varying degrees of severity and associate myocardial deformation on fetal ultrasound with postmortem histopathological characteristics. During routine fetal echocardiography, speckle tracking recordings of the cardiac...
Abstract
Cited 38 times since 2021 (9.8 per year)
source: EuropePMC
BMJ (Clinical research ed.),
Volume 374, 28 4 2021, Pages n2134
Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study.
Slieker RC, van der Heijden AAWA, Siddiqui MK, Langendoen-Gort M, Nijpels G, Herings R, Feenstra TL, Moons KGM, Bell S, Elders PJ, 't Hart LM, Beulens JWJ
Objectives: To identify and assess the quality and accuracy of prognostic models for nephropathy and to validate these models in external cohorts of people with type 2 diabetes. Design: Systematic review and external validation. Data sources: PubMed and Embase. Eligibility criteria: Studies describing the development of a model to predict the risk of nephropathy, applicable to people with type 2 diabetes. Methods: Screening, data extraction, and risk of bias assessment were done in duplicate. El...
Abstract
Cited 6 times since 2021 (1.5 per year)
source: EuropePMC
Peptides,
Volume 146, 28 4 2021, Pages 170664
Mendelian randomization study of the relation between adiponectin and heart function, unravelling the paradox.
Christen T, de Mutsert R, Lamb HJ, van Dijk KW, le Cessie S, Rosendaal FR, Jukema JW, Trompet S
High adiponectin concentrations are generally regarded as beneficial with regard to cardiometabolic health, but have been paradoxically associated with increased cardiovascular disease risk, specifically heart failure, in individuals at high cardiovascular risk. We aimed to investigate the association between adiponectin and heart function parameters, and inversely, we estimated the effect of genetically-determined heart function and NT-proBNP as the main marker of heart failure on adiponectin u...
Abstract
Cited 14 times since 2021 (3.6 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 22 4 2021, Pages 18797
Derivation and characterisation of endothelial cells from patients with chronic thromboembolic pulmonary hypertension.
Tura-Ceide O, Smolders VFED, Aventin N, Morén C, Guitart-Mampel M, Blanco I, Piccari L, Osorio J, Rodríguez C, Rigol M, Solanes N, Malandrino A, Kurakula K, Goumans MJ, Quax PHA, Peinado VI, Castellà M, Barberà JA
Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to comprehensively analyze the endothelial function, molecular signature, and mitochondrial profile of CTEPH-derived endothelial cells to better understand the pathophysiological mechanisms of endothelial dysfunction behind CTEPH, and to identify potential novel targets for the prevention and treatment of the...
Abstract
Cited 13 times since 2021 (3.3 per year)
source: EuropePMC
NPJ genomic medicine,
Volume 6, Issue 1, 21 3 2021, Pages 76
Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures.
Rydzewski NR, Peterson E, Lang JM, Yu M, Laura Chang S, Sjöström M, Bakhtiar H, Song G, Helzer KT, Bootsma ML, Chen WS, Shrestha RM, Zhang M, Quigley DA, Aggarwal R, Small EJ, Wahl DR, Feng FY, Zhao SG
We are now in an era of molecular medicine, where specific DNA alterations can be used to identify patients who will respond to specific drugs. However, there are only a handful of clinically used predictive biomarkers in oncology. Herein, we describe an approach utilizing in vitro DNA and RNA sequencing and drug response data to create TreAtment Response Generalized Elastic-neT Signatures (TARGETS). We trained TARGETS drug response models using Elastic-Net regression in the publicly available G...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 344, 21 3 2021, Pages 1-7
Comparison of guidelines for diagnosing suspected stable angina and the additional value of the calcium score.
Rijlaarsdam-Hermsen D, van Domburg RT, Deckers JW, Kuijpers D, van Dijkman PRM
Background The performance of current diagnostic algorithms of the American College of Cardiology/American Heart Association (ACC/AHA), National Institute for Health and Care Excellence (NICE) and European Society of Cardiology (ESC) in patients with stable chest pain and coronary artery calcium (CAC) remains a matter of debate. We compared their merits in patients with CAC and investigated the additional value of the CAC score to improve diagnostic accuracy and risk stratification. Methods and...
Abstract
Cited 18 times since 2021 (4.6 per year)
source: EuropePMC
Frontiers in immunology,
Volume 12, 20 3 2021, Pages 754712
<i>Coxiella burnetii</i> Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model.
Fratzke AP, Gregory AE, van Schaik EJ, Samuel JE
Q-VAX®, a whole cell, formalin-inactivated vaccine, is the only vaccine licensed for human use to protect against Coxiella burnetii, the cause of Q fever. Although this vaccine provides long-term protection, local and systemic reactogenic responses are common in previously sensitized individuals which prevents its use outside of Australia. Despite the importance of preventing these adverse reactions to develop widely accepted, novel vaccines against C. burnetii, little is understood about the un...
Abstract
Cited 1 times since 2021 (0.3 per year)
source: EuropePMC
Journal of visualized experiments : JoVE,
Issue 175, 17 3 2021
Automated, High-Throughput Detection of Bacterial Adherence to Host Cells.
Yang J, Qin QM, Van Schaik E, Samuel JE, de Figueiredo P
Identification of emerging bacterial pathogens is critical for human health and security. Bacterial adherence to host cells is an essential step in bacterial infections and constitutes a hallmark of potential threat. Therefore, examining the adherence of bacteria to host cells can be used as a component of bacterial threat assessment. A standard method for enumerating bacterial adherence to host cells is to co-incubate bacteria with host cells, harvest the adherent bacteria, plate the harvested...
Abstract
Cited 41 times since 2021 (10.5 per year)
source: EuropePMC
Frontiers in physiology,
Volume 12, 16 3 2021, Pages 665298
Asymmetry and Heterogeneity: Part and Parcel in Cardiac Autonomic Innervation and Function.
Zandstra TE, Notenboom RGE, Wink J, Kiès P, Vliegen HW, Egorova AD, Schalij MJ, De Ruiter MC, Jongbloed MRM
The cardiac autonomic nervous system (cANS) regulates cardiac adaptation to different demands. The heart is an asymmetrical organ, and in the selection of adequate treatment of cardiac diseases it may be relevant to take into account that the cANS also has sidedness as well as regional differences in anatomical, functional, and molecular characteristics. The left and right ventricles respond differently to adrenergic stimulation. Isoforms of nitric oxide synthase, which plays an important role i...
Abstract
Cited 10 times since 2021 (2.6 per year)
source: EuropePMC
European urology focus,
Volume 8, Issue 4, 15 3 2021, Pages 995-1002
Overall Survival of Patients Receiving Cisplatin or Carboplatin for Primary Metastatic Urothelial Carcinoma of the Bladder: A Contemporary Dutch Nationwide Cohort Study.
Richters A, Boormans JL, van der Heijden MS, van der Heijden AG, Meijer RP, Mehra N, Kiemeney LALM, Aben KKH
Background: Cisplatin is preferred to carboplatin when treating metastatic urothelial carcinoma of the bladder (mUCB), despite its greater toxicity. Randomised studies underpinning this have been performed in noncontemporary populations with limitations in sample sizes and analyses, affecting their validity in current clinical practice. Objective: To estimate overall survival (OS) and assess the benefit of cisplatin-based regimens over carboplatin-based regimens in a contemporary cohort of patie...
Abstract
Cited 5 times since 2021 (1.3 per year)
source: EuropePMC
European heart journal. Case reports,
Volume 5, Issue 10, 15 3 2021, Pages ytab333
Case series, chemotherapy-induced cardiomyopathy: mind the family history!
Moghadasi S, Fijn R, Beeres SLMA, Bikker H, Jongbloed JDH, Josephus Jitta D, Kroep JR, Lekanne Deprez RH, Vos YJ, de Vreede MJM, Antoni ML, Barge-Schaapveld DQCM
Background: Cardiotoxicity presenting as cardiomyopathy is a common side effect in cancer treatment especially with anthracyclines. The role of genetic predisposition is still being investigated. Case summary: Four unrelated patients with a familial burden for cardiac disease, who developed cardiomyopathy after anthracycline treatment are presented. Case 1 received chemotherapy for breast cancer and developed a dilated left ventricle just after treatment. Her father had died unexpectedly while b...
Abstract
Cited 20 times since 2021 (5.1 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 14, Issue 9, 15 3 2021, Pages e012142
Prognostic Implications of Left Ventricular Myocardial Work Indices in Patients With Secondary Mitral Regurgitation.
Yedidya I, Lustosa RP, Fortuni F, van der Bijl P, Namazi F, Vo NM, Meucci MC, Ajmone Marsan N, Bax JJ, Delgado V
Background: Assessment of left ventricular (LV) function in patients with secondary mitral regurgitation (SMR) remains challenging but is an important parameter for risk stratification. The association of LV myocardial work components (work index [GWI], constructive [GCW] and wasted [GWW] work, and work efficiency) derived from pressure-strain loops obtained with speckle tracking echocardiography, and all-cause mortality in patients with SMR was investigated. Methods: LV myocardial GWI, GCW, GWW...
Abstract
Cited 10 times since 2021 (2.5 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 6, 14 2 2021, Pages 4394-4408
HFA of the ESC Position paper on the management of LVAD supported patients for the non LVAD specialist healthcare provider Part 1: Introduction and at the non-hospital settings in the community.
Ben Avraham B, Crespo-Leiro MG, Filippatos G, Gotsman I, Seferovic P, Hasin T, Potena L, Milicic D, Coats AJS, Rosano G, Ruschitzka F, Metra M, Anker S, Altenberger J, Adamopoulos S, Barac YD, Chioncel O, De Jonge N, Elliston J, Frigeiro M, Goncalvesova E, Grupper A, Hamdan R, Hammer Y, Hill L, Itzhaki Ben Zadok O, Abuhazira M, Lavee J, Mullens W, Nalbantgil S, Piepoli MF, Ponikowski P, Ristic A, Ruhparwar A, Shaul A, Tops LF, Tsui S, Winnik S, Jaarsma T, Gustafsson F, Ben Gal T
The accepted use of left ventricular assist device (LVAD) technology as a good alternative for the treatment of patients with advanced heart failure together with the improved survival of the LVAD-supported patients on the device and the scarcity of donor hearts has significantly increased the population of LVAD-supported patients. The expected and non-expected device-related and patient-device interaction complications impose a significant burden on the medical system exceeding the capacity of...
Abstract
Cited 7 times since 2021 (1.8 per year)
source: EuropePMC
ESC heart failure,
Volume 8, Issue 6, 14 2 2021, Pages 4409-4424
Heart Failure Association of the European Society of Cardiology position paper on the management of left ventricular assist device-supported patients for the non-left ventricular assist device specialist healthcare provider: Part 2: at the emergency department.
Milicic D, Ben Avraham B, Chioncel O, Barac YD, Goncalvesova E, Grupper A, Altenberger J, Frigeiro M, Ristic A, De Jonge N, Tsui S, Lavee J, Rosano G, Crespo-Leiro MG, Coats AJS, Seferovic P, Ruschitzka F, Metra M, Anker S, Filippatos G, Adamopoulos S, Abuhazira M, Elliston J, Gotsman I, Hamdan R, Hammer Y, Hasin T, Hill L, Itzhaki Ben Zadok O, Mullens W, Nalbantgil S, Piepoli MF, Ponikowski P, Potena L, Ruhparwar A, Shaul A, Tops LF, Winnik S, Jaarsma T, Gustafsson F, Ben Gal T
The improvement in left ventricular assist device (LVAD) technology and scarcity of donor hearts have increased dramatically the population of the LVAD-supported patients and the probability of those patients to present to the emergency department with expected and non-expected device-related and patient-device interaction complications. The ageing of the LVAD-supported patients, mainly those supported with the 'destination therapy' indication, increases the risk for those patients to...
Abstract
