9618 results
Cited 12 times since 2021 (2.8 per year)
source: EuropePMC
Journal of the American Heart Association,
Volume 10, Issue 12, 2 1 2021, Pages e020080
Extent of Coronary Artery Disease in Patients With Stenotic Bicuspid Versus Tricuspid Aortic Valves.
Dolmaci OB, Legué J, Lindeman JHN, Driessen AHG, Klautz RJM, Van Brakel TJ, Siebelink HJ, Mertens BJA, Poelmann RE, Gittenberger-de Groot AC, Grewal N
Background Bicuspid aortic valve (BAV) is the most common congenital cardiac malformation, which is often complicated by aortic valve stenosis (AoS). In tricuspid aortic valve (TAV), AoS strongly associates with coronary artery disease (CAD) with common pathophysiological factors. Yet, it remains unclear whether AoS in patients with BAV is also associated with CAD. This study investigated the association between the aortic valve morphological features and the extent of CAD. Methods and Results A...
Abstract
Cited 24 times since 2021 (5.7 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 23, Issue 6, 1 1 2021, Pages 887-897
Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death.
Verstraelen TE, van Barreveld M, van Dessel PHFM, Boersma LVA, Delnoy PPHM, Tuinenburg AE, Theuns DAMJ, van der Voort PH, Kimman GP, Buskens E, Hulleman M, Allaart CP, Strikwerda S, Scholten MF, Meine M, Abels R, Maass AH, Firouzi M, Widdershoven JWMG, Elders J, van Gent MWF, Khan M, Vernooy K, Grauss RW, Tukkie R, van Erven L, Spierenburg HAM, Brouwer MA, Bartels GL, Bijsterveld NR, Borger van der Burg AE, Vet MW, Derksen R, Knops RE, Bracke FALE, Harden M, Sticherling C, Willems R, Friede T, Zabel M, Dijkgraaf MGW, Zwinderman AH, Wilde AAM
Aims: This study was performed to develop and externally validate prediction models for appropriate implantable cardioverter-defibrillator (ICD) shock and mortality to identify subgroups with insufficient benefit from ICD implantation. Methods and results: We recruited patients scheduled for primary prevention ICD implantation and reduced left ventricular function. Bootstrapping-based Cox proportional hazards and Fine and Gray competing risk models with likely candidate predictors were developed...
Abstract
Cited 5 times since 2021 (1.2 per year)
source: EuropePMC
Open heart,
Volume 8, Issue 1, 1 1 2021, Pages e001639
Discordant severity criteria in patients with moderate aortic stenosis: prognostic implications.
Pio SM, Amanullah MR, Butcher SC, Sin KY, Ajmone Marsan N, Pibarot P, Van Mieghem NM, Ding ZP, Généreux P, Leon MB, Ewe SH, Delgado V, Bax JJ
Background: The criteria to define the grade of aortic stenosis (AS)-aortic valve area (AVA) and mean gradient (MG) or peak jet velocity-do not always coincide into one grade. Although in severe AS, this discrepancy is well characterised, in moderate AS, the phenomenon of discordant grading has not been investigated and its prognostic implications are unknown. Objectives: To investigate the occurrence of discordant grading in patients with moderate AS (defined by an AVA between 1.0 cm² and 1.5 c...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
The Journal of clinical endocrinology and metabolism,
Volume 106, Issue 7, 1 1 2021, Pages e2527-e2534
Bone Material Strength Index as Measured by Impact Microindentation is Low in Patients with Primary Hyperparathyroidism.
Schoeb M, Winter EM, Sleddering MA, Lips MA, Schepers A, Snel M, Appelman-Dijkstra NM
Context: In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites but also at the spine, and fractures occur at higher BMD values than expected. We hypothesized that components of bone quality other than BMD are affected in PHPT as well. Objective: To evaluate bone material properties using impact microindentation (IMI) in PHPT p...
Abstract
Cited 28 times since 2021 (6.6 per year)
source: EuropePMC
Journal for immunotherapy of cancer,
Volume 9, Issue 6, 1 1 2021, Pages e002916
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem.
Poels K, Neppelenbroek SIM, Kersten MJ, Antoni ML, Lutgens E, Seijkens TTP
Antibody-mediated blockade of co-inhibitory molecules such as cytotoxic T lymphocyte-associated protein 4, PD1 and PDL1 elicits potent antitumor responses and improves the prognosis of many patients with cancer. As these immune checkpoint inhibitors (ICIs) are increasingly prescribed to a diverse patient population, a broad range of adverse effects is emerging. Atherosclerosis, a lipid-driven chronic inflammatory disease of the large arteries, may be aggravated by ICI treatment. In this review,...
Abstract
Cited 20 times since 2021 (4.7 per year)
source: EuropePMC
Frontiers in oncology,
Volume 11, 1 1 2021, Pages 678562
Therapy-Induced Tumor Cell Death: Friend or Foe of Immunotherapy?
van Schaik TA, Chen KS, Shah K
Combinatory treatments using surgery, radiotherapy and/or chemotherapy together with immunotherapy have shown encouraging results for specific subsets of tumors, but a significant proportion of tumors remains unsusceptible. Some of these inconsistencies are thought to be the consequence of an immunosuppressive tumor microenvironment (TME) caused by therapy-induced tumor cell death (TCD). An increased understanding of the molecular mechanisms governing TCD has provided valuable insights in specif...
Abstract
Cited 25 times since 2021 (5.9 per year)
source: EuropePMC
Clinica chimica acta; international journal of clinical chemistry,
Volume 520, 1 1 2021, Pages 168-171
What do we need to obtain high quality circulating tumor DNA (ctDNA) for routine diagnostic test in oncology? - Considerations on pre-analytical aspects by the IFCC workgroup cfDNA.
Danesi R, Lo YMD, Oellerich M, Beck J, Galbiati S, Re MD, Lianidou E, Neumaier M, van Schaik RHN
The analysis of circulating cell free DNA is an important tool for the analysis of tumor resistance, tumor heterogeneity, detection of minimal residual disease and detection of allograft rejection in kidney or heart transplant patients. The proper use of this technique is important, and starts with considering pre-analytic aspects. The current paper addresses some important technical considerations to ensure the proper and harmonized use of cfDNA techniques.
Abstract
Cited 60 times since 2021 (14.2 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 77, Issue 22, 1 1 2021, Pages 2796-2803
Moderate Aortic Stenosis in Patients With Heart Failure and Reduced Ejection Fraction.
Jean G, Van Mieghem NM, Gegenava T, van Gils L, Bernard J, Geleijnse ML, Vollema EM, El Azzouzi I, Spitzer E, Delgado V, Bax JJ, Pibarot P, Clavel MA
Background: The study investigators previously reported that moderate aortic stenosis (AS) is associated with a poor prognosis in patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) (HFrEF). However, the respective contribution of moderate AS versus HFrEF to the outcomes of these patients is unknown. Objectives: This study sought to determine the impact of moderate AS on outcomes in patients with HFrEF. Methods: The study included 262 patients with moderate AS...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 7, 1 1 2021, Pages 751-752
Characterization of the left ventricular response to hypertension: beyond global longitudinal strain.
van der Bijl P, Delgado V, Bax JJ
Abstract
Cited 7 times since 2021 (1.7 per year)
source: EuropePMC
Clinical rheumatology,
Volume 40, Issue 10, 31 5 2021, Pages 4071-4079
Comparison of the effectiveness of cyclophosphamide and rituximab treatment in patients with systemic sclerosis-related interstitial lung diseases: a retrospective, observational cohort study.
Yılmaz DD, Borekci S, Musellim B
Objectives: To compare the effectiveness of cyclophosphamide and rituximab in the treatment of patients with systemic sclerosis with pulmonary involvement (SSc-ILD). Methods: Symptoms and the respiratory function parameters of 34 patients receiving cyclophosphamide and 27 patients receiving rituximab for at least 24 months between 1996 and 2018 were compared. Results: It was observed that symptoms including cough, Raynaud's phenomenon, digital ulceration, diarrhea, and dysphagia, but not dy...
Abstract
Cited 468 times since 2021 (110.9 per year)
source: EuropePMC
Nature genetics,
Volume 53, Issue 6, 31 5 2021, Pages 840-860
The trans-ancestral genomic architecture of glycemic traits.
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y, Zhang X, Horikoshi M, Boutin TS, Mägi R, Waage J, Li-Gao R, Chan KHK, Yao J, Anasanti MD, Chu AY, Claringbould A, Heikkinen J, Hong J, Hottenga JJ, Huo S, Kaakinen MA, Louie T, März W, Moreno-Macias H, Ndungu A, Nelson SC, Nolte IM, North KE, Raulerson CK, Ray D, Rohde R, Rybin D, Schurmann C, Sim X, Southam L, Stewart ID, Wang CA, Wang Y, Wu P, Zhang W, Ahluwalia TS, Appel EVR, Bielak LF, Brody JA, Burtt NP, Cabrera CP, Cade BE, Chai JF, Chai X, Chang LC, Chen CH, Chen BH, Chitrala KN, Chiu YF, de Haan HG, Delgado GE, Demirkan A, Duan Q, Engmann J, Fatumo SA, Gayán J, Giulianini F, Gong JH, Gustafsson S, Hai Y, Hartwig FP, He J, Heianza Y, Huang T, Huerta-Chagoya A, Hwang MY, Jensen RA, Kawaguchi T, Kentistou KA, Kim YJ, Kleber ME, Kooner IK, Lai S, Lange LA, Langefeld CD, Lauzon M, Li M, Ligthart S, Liu J, Loh M, Long J, Lyssenko V, Mangino M, Marzi C, Montasser ME, Nag A, Nakatochi M, Noce D, Noordam R, Pistis G, Preuss M, Ra
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-ana...
Abstract
Cited 2 times since 2021 (0.5 per year)
source: EuropePMC
BMJ case reports,
Volume 14, Issue 5, 31 5 2021, Pages e240684
Management of two-level proximal femoral fractures.
Vluggen TPMJ, van Vugt R, Boonen B, Keulen MHF
We present the case of an 82-year-old female, who experienced a ground-level fall on the trochanter of the right femur. X-rays showed a proximal femoral fracture (PFF) with an unclear and unusual fracture pattern. Three-dimensional CT images were obtained and showed a displaced femoral neck fracture and ipsilateral fracture of the greater trochanter. Our patient underwent unipolar hemiarthroplasty and fixation of the greater trochanter with a hook plate and cable grip. At 11 months, functional o...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 158, 28 4 2021, Pages 18-24
Endobronchial ultrasound for T4 staging in patients with resectable NSCLC.
Kuijvenhoven JC, Livi V, Szlubowski A, Ninaber M, Stöger JL, Widya RL, Bonta PI, Crombag LC, Braun J, van Boven WJ, Trisolini R, Korevaar DA, Annema JT
Background: In lung cancer patients, accurate assessment of mediastinal and vascular tumor invasion (stage T4) is crucial for optimal treatment allocation and to prevent unnecessary thoracotomies. We assessed the diagnostic accuracy of linear endobronchial ultrasound (EBUS) for T4-status in patients with centrally located lung cancer. Methods: This is a retrospective study among consecutive patients who underwent EBUS for diagnosis and staging of lung cancer in four hospitals in The Netherlands...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Journal of interprofessional care,
25 4 2021, Pages 1-8
The impact of interprofessional perspective-taking on moral distress in the pediatric intensive care unit.
Kowalek K, Bochatay N, Ju M, Van Schaik S
Moral distress arises when constraints outside of healthcare professionals' control prohibit them from acting according to the ethically sound course of action. It can be triggered by poor communication and different perspectives between professionals. We examined whether and how taking the perspective of the other profession reduces moral distress among pediatric intensive care nurses and physicians. Using elements of a previously published scale, we created a Vignette-based Moral Distress...
Abstract
Cited 12 times since 2021 (2.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 151, 24 4 2021, Pages 1-9
Myocardial Work, an Echocardiographic Measure of Post Myocardial Infarct Scar on Contrast-Enhanced Cardiac Magnetic Resonance.
Mahdiui ME, van der Bijl P, Abou R, de Paula Lustosa R, van der Geest R, Ajmone Marsan N, Delgado V, Bax JJ
This study investigates the relation of non-invasive myocardial work and myocardial viability following ST-segment elevation myocardial infarction (STEMI) assessed on late gadolinium contrast enhanced cardiac magnetic resonance (LGE CMR) and characterizes the remote zone using non-invasive myocardial work parameters. STEMI patients who underwent primary percutaneous coronary intervention (PCI) were included. Several non-invasive myocardial work parameters were derived from speckle tracking strai...
Abstract
Cited 7 times since 2021 (1.7 per year)
source: EuropePMC
Journal of critical care,
Volume 65, 23 4 2021, Pages 36-41
Reduced quality of life in ICU survivors - the story behind the numbers: A mixed methods study.
Geense WW, de Graaf M, Vermeulen H, van der Hoeven J, Zegers M, van den Boogaard M
Purpose: To gain insight into the daily functioning of ICU survivors who reported a reduced quality of life (QoL) one year after ICU admission. Materials and methods: A two-phase mixed method study design. QoL was assessed using the SF-36 questionnaire before admission and after one year (Phase 1). Participants reporting a reduced QoL were invited for an in-depth interview (Phase 2). Interview data were coded thematically using the PROMIS framework. Results: Of the 797 participants, 173 (22%) re...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Echocardiography (Mount Kisco, N.Y.),
Volume 38, Issue 6, 21 3 2021, Pages 974-981
Assessment of human fetal cardiac autonomic nervous system development using color tissue Doppler imaging.
Zwanenburg F, Jongbloed MRM, van Geloven N, Ten Harkel ADJ, van Lith JMM, Haak MC
Objectives: Functional development of the fetal cardiac autonomic nervous system (cANS) plays a key role in fetal maturation and can be assessed through fetal heart rate variability (fHRV)-analysis, with each HRV parameter representing different aspects of cANS activity. Current available techniques, however, are unable to assess the fHRV parameters accurately throughout the whole pregnancy. This study aims to test the feasibility of color tissue Doppler imaging (cTDI) as a new ultrasound techni...
Abstract
Cited 20 times since 2021 (4.7 per year)
source: EuropePMC
Scientific data,
Volume 8, Issue 1, 21 3 2021, Pages 136
Global data on earthworm abundance, biomass, diversity and corresponding environmental properties.
Phillips HRP, Bach EM, Bartz MLC, Bennett JM, Beugnon R, Briones MJI, Brown GG, Ferlian O, Gongalsky KB, Guerra CA, König-Ries B, Krebs JJ, Orgiazzi A, Ramirez KS, Russell DJ, Schwarz B, Wall DH, Brose U, Decaëns T, Lavelle P, Loreau M, Mathieu J, Mulder C, van der Putten WH, Rillig MC, Thakur MP, de Vries FT, Wardle DA, Ammer C, Ammer S, Arai M, Ayuke FO, Baker GH, Baretta D, Barkusky D, Beauséjour R, Bedano JC, Birkhofer K, Blanchart E, Blossey B, Bolger T, Bradley RL, Brossard M, Burtis JC, Capowiez Y, Cavagnaro TR, Choi A, Clause J, Cluzeau D, Coors A, Crotty FV, Crumsey JM, Dávalos A, Cosín DJD, Dobson AM, Domínguez A, Duhour AE, van Eekeren N, Emmerling C, Falco LB, Fernández R, Fonte SJ, Fragoso C, Franco ALC, Fusilero A, Geraskina AP, Gholami S, González G, Gundale MJ, López MG, Hackenberger BK, Hackenberger DK, Hernández LM, Hirth JR, Hishi T, Holdsworth AR, Holmstrup M, Hopfensperger KN, Lwanga EH, Huhta V, Hurisso TT, Iannone BV, Iordache M, Irmler U, Ivask M, Jesús JB, Johnson-Maynard JL, Joschko
Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were req...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Cardiology in the young,
Volume 31, Issue 6, 21 3 2021, Pages 915-939
Consensus document on optimal management of patients with common arterial trunk.
Hazekamp MG, Barron DJ, Dangel J, Homfray T, Jongbloed MRM, Voges I
Abstract
Cited 19 times since 2021 (4.5 per year)
source: EuropePMC
Frontiers in endocrinology,
Volume 12, 20 3 2021, Pages 674841
Levothyroxine Treatment and Cardiovascular Outcomes in Older People With Subclinical Hypothyroidism: Pooled Individual Results of Two Randomised Controlled Trials.
Zijlstra LE, Jukema JW, Westendorp RGJ, Du Puy RS, Poortvliet RKE, Kearney PM, O'Keeffe L, Dekkers OM, Blum MR, Rodondi N, Collet TH, Quinn TJ, Sattar N, Stott DJ, Trompet S, den Elzen WPJ, Gussekloo J, Mooijaart SP
Background: The cardiovascular effects of treating older adults with subclinical hypothyroidism (SCH) are uncertain. Although concerns have been raised regarding a potential increase in cardiovascular side effects from thyroid hormone replacement, undertreatment may also increase the risk of cardiovascular events, especially for patients with cardiovascular disease (CVD). Objective: To determine the effects of levothyroxine treatment on cardiovascular outcomes in older adults with SCH. Methods:...
Abstract
