Research

Publications

Below you can find a list of our published research.

9618 results

Cited 7 times since 2021 (1.6 per year) source: EuropePMC

Journal of patient safety, Volume 17, Issue 2, 1 1 2021, Pages e91-e97 The Association Between Complications, Incidents, and Patient Experience: Retrospective Linkage of Routine Patient Experience Surveys and Safety Data. de Vos MS, Hamming JF, Boosman H, Marang-van de Mheen PJ

Objectives: Linkage of safety data to patient experience data may provide information to improve surgical care. This retrospective observational study aimed to assess associations between complications, incidents, patient-reported problems, and overall patient experience. Methods: Routinely collected data from safety reporting on complications and incidents, as well as patient-reported problems and experience on the Picker Patient Experience Questionnaire 15, covering seven experience dimensions... Abstract

Cited 7 times since 2021 (1.6 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 22, Issue 4, 1 1 2021, Pages 367-371 The EACVI survey on cardiac imaging in cardio-oncology. Stankovic I, Dweck MR, Marsan NA, Bergler-Klein J, Holte E, Manka R, Schulz-Menger J, Sitges M, Haugaa KH

Early and late cardiovascular (CV) toxicities related to many cancer treatments may complicate the clinical course of patients, offsetting therapeutic benefits, and altering prognosis. The early detection, monitoring, and treatment of cardiotoxicity have therefore become essential parts of cancer patient care. CV imaging is a cornerstone of every cardio-oncology unit, but its use may vary across Europe because of the non-uniform availability of advanced imaging techniques and differences in the... Abstract

Cited 4 times since 2021 (0.9 per year) source: EuropePMC

Infection prevention in practice, Volume 3, Issue 2, 28 4 2021, Pages 100129 Association of environmental surface contamination with hand hygiene and infections in nursing homes: a prospective cohort study. Teesing GR, de Graaf M, Petrignani M, Erasmus V, Klaassen CHW, Schapendonk CME, Verduijn-Leenman A, Schols JMGA, Vos MC, Koopmans MPG, Richardus JH, Voeten H

Background: Little is known about the presence of infections in nursing home residents, the causative micro-organisms, how hand hygiene (HH) influences the presence of infections in residents, and the extent to which environmental contamination is associated with the incidence of infection among residents. Aims: To establish if environmental contamination can be used as an indicator for HH compliance, and if environmental contamination is associated with the incidence of infection. Methods: Envi... Abstract

Cited 3 times since 2021 (0.7 per year) source: EuropePMC

Trials, Volume 22, Issue 1, 27 4 2021, Pages 168 MEDIASTinal staging of non-small cell lung cancer by endobronchial and endoscopic ultrasonography with or without additional surgical mediastinoscopy (MEDIASTrial): a statistical analysis plan. Bousema JE, Annema JT, van der Heijden EHFM, Verhagen AFTM, Dijkgraaf MGW, van den Broek FJC, MEDIASTrial study group

Background: Invasive mediastinal nodal staging is recommended by guidelines in selected patients with resectable non-small cell lung cancer (NSCLC). Endosonography is recommended as initial staging technique, followed by confirmatory mediastinoscopy in case of negative N2 or N3 cytology after endosonography. Confirmatory mediastinoscopy however is under debate owing its limited additional diagnostic value, its associated morbidity and its delay in the start of lung cancer treatment. The MEDIASTr... Abstract

Cited 29 times since 2021 (6.5 per year) source: EuropePMC

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Volume 46, Issue 7, 26 4 2021, Pages 1307-1314 The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial. Browning M, Bilderbeck AC, Dias R, Dourish CT, Kingslake J, Deckert J, Goodwin GM, Gorwood P, Guo B, Harmer CJ, Morriss R, Reif A, Ruhe HG, van Schaik A, Simon J, Sola VP, Veltman DJ, Elices M, Lever AG, Menke A, Scanferla E, Stäblein M, Dawson GR

Depressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications. Personalised medicine offers a means of reducing this delay; however, the clinical effectiveness of personalised approaches to antidepressant treatment has not previously been tested. We assessed the clinical effectiveness of using a predictive algorithm, based on behavioural tests of affective cognition and subjective symptoms, to guide antidepressant treatmen... Abstract

Cited 3 times since 2021 (0.7 per year) source: EuropePMC

Prenatal diagnosis, Volume 41, Issue 6, 26 4 2021, Pages 754-765 The prognosis of common arterial trunk from a fetal perspective: A prenatal cohort study and systematic literature review. van Nisselrooij AEL, Herling L, Clur SA, Linskens IH, Pajkrt E, Rammeloo LA, Ten Harkel ADJ, Hazekamp MG, Blom NA, Haak MC

Objective: The limited number of large fetal cohort studies on common arterial trunk (CAT) impedes prenatal counseling at midgestation. This study evaluates the prognosis of CAT from a fetal perspective. Method: Fetuses with a prenatally diagnosed CAT were extracted from the PRECOR registry (2002-2016). We evaluated fetal and postnatal survival and the presence of additional morbidity at last follow-up. Literature databases were searches systematically for additional cases. Results: Thirty-eight... Abstract

Cited 12 times since 2021 (2.7 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 8, Issue 3, 26 4 2021, Pages 25 The Clinical Spectrum of Kommerell's Diverticulum in Adults with a Right-Sided Aortic Arch: A Case Series and Literature Overview. van Rosendael PJ, Stöger JL, Kiès P, Vliegen HW, Hazekamp MG, Koolbergen DR, Lamb HJ, Jongbloed MRM, Egorova AD

Background: Kommerell's diverticulum is a rare vascular anomaly characterized as an outpouch at the onset of an aberrant subclavian artery. In the variant of a right-sided aortic arch, the trachea and esophagus are enclosed dorsally by the arch. In the configuration of an aberrant left subclavian artery, a Kommerell's diverticulum and persisting ductus arteriosus or ductal ligament enclose the lateral side, forming a vascular ring which may result in (symptomatic) esophageal or trachea... Abstract

Cited 16 times since 2021 (3.6 per year) source: EuropePMC

The American journal of cardiology, Volume 147, 25 4 2021, Pages 109-115 Sex-Specific Differences in Etiology and Prognosis in Patients With Significant Tricuspid Regurgitation. Dietz MF, Prihadi EA, van der Bijl P, Fortuni F, Marques AI, Ajmone Marsan N, Bax JJ, Delgado V

The aim of this study was to assess differences in etiology, comorbidities, echocardiographic parameters, and prognosis between men and women with significant tricuspid regurgitation (TR). Clinical and echocardiographic characteristics of 1569 patients (age 71 [62 to 78] years) at first diagnosis of significant TR were compared between men and women. Patients with congenital heart disease or previous tricuspid valve surgery were excluded. TR etiologies were defined as primary, left valvular dise... Abstract

Cited 9 times since 2021 (2 per year) source: EuropePMC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 39, Issue 11, 23 4 2021, Pages 1264-1273 High Prevalence of Weight Gain in Childhood Brain Tumor Survivors and Its Association With Hypothalamic-Pituitary Dysfunction. van Schaik J, van Roessel IMAA, Schouten-van Meeteren NAYN, van Iersel L, Clement SC, Boot AM, Claahsen-van der Grinten HL, Fiocco M, Janssens GO, van Vuurden DG, Michiels EM, Han SKS, van Trotsenburg PASP, Vandertop PWP, Kremer LCM, van Santen HM

Purpose: Childhood brain tumor survivors (CBTS) are at risk for developing obesity, which negatively influences cardiometabolic health. The prevalence of obesity in CBTS may have been overestimated in previous cohorts because of inclusion of children with craniopharyngioma. On the contrary, the degree of weight gain may have been underestimated because of exclusion of CBTS who experienced weight gain, but were neither overweight nor obese. Weight gain may be an indicator of underlying hypothalam... Abstract

Cited 25 times since 2021 (5.6 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 110, Issue 1, 23 4 2021, Pages 169-178 Avoiding Tacrolimus Underexposure and Overexposure with a Dosing Algorithm for Renal Transplant Recipients: A Single Arm Prospective Intervention Trial. Francke MI, Andrews LM, Le HL, van de Wetering J, Clahsen-van Groningen MC, van Gelder T, van Schaik RHN, van der Holt B, de Winter BCM, Hesselink DA

Bodyweight-based tacrolimus dosing followed by therapeutic drug monitoring is standard clinical care after renal transplantation. However, after transplantation, a meager 38% of patients are on target at first steady-state and it can take up to 3 weeks to reach the target tacrolimus predose concentration (C0 ). Tacrolimus underexposure and overexposure is associated with an increased risk of rejection and drug-related toxicity, respectively. To minimize subtherapeutic and supratherapeutic tacrol... Abstract

Cited 9 times since 2021 (2 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 164, Issue 5, 23 4 2021, Pages 1488-1497.e3 Mitral valve repair for isolated posterior mitral valve leaflet prolapse: The effect of respect and resect techniques on left ventricular function. van Wijngaarden AL, Tomšič A, Mertens BJA, Fortuni F, Delgado V, Bax JJ, Klautz RJM, Marsan NA, Palmen M

Objective: Posterior mitral valve leaflet prolapse repair can be performed by leaflet resection or chordal replacement techniques. The impact of these techniques on left ventricular function remains a topic of debate, considering the presumed better preservation of mitral-ventricular continuity when leaflet resection is avoided. We explored the effect of different posterior mitral valve leaflet repair techniques on postoperative left ventricular function. Methods: In total, 125 patients were inc... Abstract

Cited 38 times since 2021 (8.5 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 61, Issue 5, 23 4 2021, Pages 779-786 Type 2 Endoleak With or Without Intervention and Survival After Endovascular Aneurysm Repair. Mulay S, Geraedts ACM, Koelemay MJW, Balm R, ODYSSEUS study group

Objective: The aims of the present study were to examine the impact of type 2 endoleaks (T2EL) on overall survival and to determine the need for secondary intervention after endovascular aneurysm repair (EVAR). Methods: A multicentre retrospective cohort study in the Netherlands was conducted among patients with an infrarenal abdominal aortic aneurysm (AAA) who underwent EVAR between 2007 and 2012. The primary endpoint was overall survival for patients with (T2EL+) or without (T2EL-) a T2EL. Sec... Abstract

Cited 32 times since 2021 (7.1 per year) source: EuropePMC

Journal of cardiovascular development and disease, Volume 8, Issue 2, 22 4 2021, Pages 23 Characterization of Degenerative Mitral Valve Disease: Differences between Fibroelastic Deficiency and Barlow's Disease. van Wijngaarden AL, Kruithof BPT, Vinella T, Barge-Schaapveld DQCM, Ajmone Marsan N

Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency (FED) and Barlow's disease. The aim of this review was to describe the main histological, clinical and echocardiographic features of patients with FED and Barlow's disease, highlighting the differences in diagnosis, risk stratification and patient management,... Abstract

Cited 26 times since 2021 (5.8 per year) source: EuropePMC

Neurology, Volume 96, Issue 8, 22 4 2021, Pages e1110-e1123 Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke: Meta-analysis From 7 Prospective Cohorts. Vojinovic D, Kalaoja M, Trompet S, Fischer K, Shipley MJ, Li S, Havulinna AS, Perola M, Salomaa V, Yang Q, Sattar N, Jousilahti P, Amin N, Satizabal CL, Taba N, Sabayan B, Vasan RS, Ikram MA, Stott DJ, Ala-Korpela M, Jukema JW, Seshadri S, Kettunen J, Kivimaki M, Esko T, van Duijn CM

Objective: To conduct a comprehensive analysis of circulating metabolites and incident stroke in large prospective population-based settings. Methods: We investigated the association of metabolites with risk of stroke in 7 prospective cohort studies including 1,791 incident stroke events among 38,797 participants in whom circulating metabolites were measured by nuclear magnetic resonance technology. The relationship between metabolites and stroke was assessed with Cox proportional hazards regres... Abstract

Cited 17 times since 2021 (3.8 per year) source: EuropePMC

Journal of the American Heart Association, Volume 10, Issue 5, 22 4 2021, Pages e018565 Clinical Course Long After Atrial Switch: A Novel Risk Score for Major Clinical Events. Woudstra OI, Zandstra TE, Vogel RF, van Dijk APJ, Vliegen HW, Kiès P, Jongbloed MRM, Egorova AD, Doevendans PAFM, Konings TC, Mulder BJM, Tanck MWT, Meijboom FJ, Bouma BJ

Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on the emerging risks remain scarce. We assessed the risk for events during the clinical course in adulthood, and provided a novel risk score for event-free survival. Methods and Results This multicenter study observed 167 patients with transposition of the great arteries corrected by an atrial... Abstract

Cited 2 times since 2021 (0.4 per year) source: EuropePMC

European journal of applied physiology, Volume 121, Issue 5, 22 4 2021, Pages 1405-1418 Biventricular function in exercise during autonomic (thoracic epidural) block. Wink J, Steendijk P, Tsonaka R, de Wilde RBP, Friedericy HJ, Braun J, Veering BT, Aarts LPHJ, Wouters PF

Background: Blockade of cardiac sympathetic fibers by thoracic epidural anesthesia (TEA) was previously shown to reduce right and left ventricular systolic function and effective pulmonary arterial elastance. At conditions of constant paced heart rate, cardiac output and systemic hemodynamics were unchanged. In this study, we further investigated the effect of cardiac sympathicolysis during physical stress and increased oxygen demand. Methods: In a cross-over design, 12 patients scheduled to und... Abstract

Cited 23 times since 2021 (5.1 per year) source: EuropePMC

ESC heart failure, Volume 8, Issue 2, 22 4 2021, Pages 1541-1551 Clinical and economic impact of HeartLogic™ compared with standard care in heart failure patients. Treskes RW, Beles M, Caputo ML, Cordon A, Biundo E, Maes E, Egorova AD, Schalij MJ, Van Bockstal K, Grazioli-Gauthier L, Vanderheyden M, Bartunek J, Auricchio A, Beeres SLMA, Heggermont WA

Aims: The implantable cardiac defibrillator/cardiac resynchronization therapy with defibrillator-based HeartLogic™ algorithm has recently been developed for early detection of impending decompensation in heart failure (HF) patients; but whether this novel algorithm can reduce HF hospitalizations has not been evaluated. We investigated if activation of the HeartLogic algorithm reduces the number of hospital admissions for decompensated HF in a 1 year post-activation period as compared with a 1 ye... Abstract

Cited 4 times since 2021 (0.9 per year) source: EuropePMC

European heart journal. Digital health, Volume 2, Issue 2, 22 4 2021, Pages 215-223 Potential of eHealth smart technology in optimization and monitoring of heart failure treatment in adults with systemic right ventricular failure. Nederend M, Zandstra TE, Kiès P, Jongbloed MRM, Vliegen HW, Treskes RW, Schalij MJ, Atsma DE, Egorova AD

Aims: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA are prone to heart failure and arrhythmias. This study evaluated feasibility, patient adherence, and satisfaction of a smart technology-based care pathway for heart failure treatment optimization in these patients. Methods and results: Patients with symptomatic sRV failure eligible for initiation of sacubitril/valsartan were provided w... Abstract

Cited 9 times since 2021 (2 per year) source: EuropePMC

Trials, Volume 22, Issue 1, 19 3 2021, Pages 155 Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in chronic inflammatory demyelinating polyradiculoneuropathy: protocol of an international, randomised, double-blind, placebo-controlled trial (OPTIC). Bus SRM, Zambreanu L, Abbas A, Rajabally YA, Hadden RDM, de Haan RJ, de Borgie CAJM, Lunn MP, van Schaik IN, Eftimov F, OPTIC study group

Background: International guidelines recommend either intravenous immunoglobulin (IVIg) or corticosteroids as first-line treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). IVIg treatment usually leads to rapid improvement and is generally safe, but does not seem to lead to long-term remissions. Corticosteroids act more slowly and are associated with more side effects, but may induce long-term remissions. The hypothesis of this study is that combined IVIg and corticos... Abstract

Cited 5 times since 2021 (1.1 per year) source: EuropePMC

Frontiers in immunology, Volume 11, 19 3 2021, Pages 609624 Characterization and Monitoring of Antigen-Responsive T Cell Clones Using T Cell Receptor Gene Expression Analysis. Pollastro S, de Bourayne M, Balzaretti G, Jongejan A, van Schaik BDC, Niewold ITG, van Kampen AHC, Maillère B, de Vries N

High-throughput T-cell receptor repertoire sequencing constitutes a powerful tool to study T cell responses at the clonal level. However, it does not give information on the functional phenotype of the responding clones and lacks a statistical framework for quantitative evaluation. To overcome this, we combined datasets from different experiments, all starting from the same blood samples. We used a novel, sensitive, UMI-based protocol to perform repertoire analysis on experimental replicates. Ap... Abstract