9618 results
Cited 41 times since 2021 (8.9 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 107, Issue 21, 15 3 2021, Pages 1725-1730
Sacubitril/valsartan in the treatment of systemic right ventricular failure.
Zandstra TE, Nederend M, Jongbloed MRM, Kiès P, Vliegen HW, Bouma BJ, Tops LF, Schalij MJ, Egorova AD
Objective: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients. Methods: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circ...
Abstract
Cited 86 times since 2021 (18.7 per year)
source: EuropePMC
Genome biology,
Volume 22, Issue 1, 14 2 2021, Pages 36
SPIN reveals genome-wide landscape of nuclear compartmentalization.
Wang Y, Zhang Y, Zhang R, van Schaik T, Zhang L, Sasaki T, Peric-Hupkes D, Chen Y, Gilbert DM, van Steensel B, Belmont AS, Ma J
We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function. As a proof-of-principle, we use SPIN to integrate nuclear compartment mapping (TSA-seq and DamID) and chromatin interaction data (Hi-C) from K562 cells to identify 10 spatial compartmentalization states genome-wide relative to nuclear speckles, lamina, and putative...
Abstract
Cited 17 times since 2021 (3.7 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 7, 13 2 2021, Pages 1410-1421
Topological Data Analysis of Coronary Plaques Demonstrates the Natural History of Coronary Atherosclerosis.
Hwang D, Kim HJ, Lee SP, Lim S, Koo BK, Kim YJ, Kook W, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic JA, Maffei E, Pontone G, Raff GL, Shin S, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Lin FY, Virmani R, Samady H, Stone PH, Narula J, Bax JJ, Shaw LJ, Min JK, Chang HJ
Objectives: This study sought to identify distinct patient groups and their association with outcome based on the patient similarity network using quantitative coronary plaque characteristics from coronary computed tomography angiography (CTA). Background: Coronary CTA can noninvasively assess coronary plaques quantitatively. Methods: Patients who underwent 2 coronary CTAs at a minimum of 24 months' interval were analyzed (n = 1,264). A similarity Mapper network of patients was built by top...
Abstract
Cited 5 times since 2021 (1.1 per year)
source: EuropePMC
International journal of molecular sciences,
Volume 22, Issue 2, 13 2 2021, Pages E755
Cell-Based Tracers as Trojan Horses for Image-Guided Surgery.
Sier VQ, de Vries MR, van der Vorst JR, Vahrmeijer AL, van Kooten C, Cruz LJ, de Geus-Oei LF, Ferreira V, Sier CFM, Alves F, Muthana M
Surgeons rely almost completely on their own vision and palpation to recognize affected tissues during surgery. Consequently, they are often unable to distinguish between different cells and tissue types. This makes accurate and complete resection cumbersome. Targeted image-guided surgery (IGS) provides a solution by enabling real-time tissue recognition. Most current targeting agents (tracers) consist of antibodies or peptides equipped with a radiolabel for Positron Emission Tomography (PET) an...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Journal of virology,
Volume 95, Issue 3, 13 2 2021, Pages e01492-20
Human Noroviruses Attach to Intestinal Tissues of a Broad Range of Animal Species.
Villabruna N, Schapendonk CME, Aron GI, Koopmans MPG, de Graaf M
Human noroviruses are the most common nonbacterial cause of gastroenteritis outbreaks, with new variants and genotypes frequently emerging. The origin of these new viruses is unknown; however, animals have been proposed as a potential source, as human noroviruses have been detected in animal species. Here, we investigated the potential of animals to serve as a reservoir of human noroviruses by testing norovirus attachment to formalin-fixed intestinal tissues of a range of potential reservoir ani...
Abstract
Cited 51 times since 2021 (11.1 per year)
source: EuropePMC
Circulation,
Volume 143, Issue 11, 13 2 2021, Pages 1109-1122
Clinical Efficacy and Safety of Alirocumab After Acute Coronary Syndrome According to Achieved Level of Low-Density Lipoprotein Cholesterol: A Propensity Score-Matched Analysis of the ODYSSEY OUTCOMES Trial.
Schwartz GG, Gabriel Steg P, Bhatt DL, Bittner VA, Diaz R, Goodman SG, Jukema JW, Kim YU, Li QH, Manvelian G, Pordy R, Sourdille T, White HD, Szarek M, ODYSSEY OUTCOMES Committees and Investigators
Background: Recent international guidelines have lowered recommended target levels of low-density lipoprotein cholesterol (LDL-C) for patients at very high risk for major adverse cardiovascular events (MACE). However, uncertainty persists whether additional benefit results from achieved LDL-C levels below the conventional targets. Inferences from previous analyses are limited because patients who achieve lower versus higher LDL-C on lipid-lowering therapy differ in other characteristics prognost...
Abstract
The Journal of thoracic and cardiovascular surgery,
Volume 161, Issue 5, 12 2 2021, Pages e371-e372
A bigger picture for valve charts.
Vriesendorp MD, de Lind van Wijngaarden RAF, Klautz RJM
Abstract
Cited 13 times since 2021 (2.8 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 12 2 2021, Pages 825
Higher social tolerance in wild versus captive common marmosets: the role of interdependence.
de Oliveira Terceiro FE, Arruda MF, van Schaik CP, Araújo A, Burkart JM
Social tolerance in a group reflects the balance between within-group competition and interdependence: whereas increased competition leads to a reduction in social tolerance, increased interdependence increases it. Captivity reduces both feeding competition and interdependence and can therefore affect social tolerance. In independently breeding primates, social tolerance has been shown to be higher in captivity, indicating a strong effect of food abundance. It is not known, however, how social t...
Abstract
Cited 2 times since 2021 (0.4 per year)
source: EuropePMC
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners,
Volume 27, Issue 4, 12 2 2021, Pages 939-953
Clinical controversies in the treatment of cancer-associated venous thromboembolism.
Nachar VR, Schepers AJ
Cancer-associated venous thromboembolism (VTE) is a common complication of malignancy. Patients with cancer exhibit risk factors for both recurrent VTE and major or minor bleeding. Direct oral anticoagulants (DOACs) are an attractive treatment option; however, there is a lack of consensus among national guidelines for choice between DOACs and LMWH, agent selection, dosing strategy, and duration of anticoagulation. Characteristics of the thrombotic event, the malignancy, the patient, and the anti...
Abstract
Cited 82 times since 2021 (17.8 per year)
source: EuropePMC
Biomedicines,
Volume 9, Issue 1, 9 2 2021, Pages 57
Endothelial Dysfunction in Pulmonary Hypertension: Cause or Consequence?
Kurakula K, Smolders VFED, Tura-Ceide O, Jukema JW, Quax PHA, Goumans MJ
Pulmonary arterial hypertension (PAH) is a rare, complex, and progressive disease that is characterized by the abnormal remodeling of the pulmonary arteries that leads to right ventricular failure and death. Although our understanding of the causes for abnormal vascular remodeling in PAH is limited, accumulating evidence indicates that endothelial cell (EC) dysfunction is one of the first triggers initiating this process. EC dysfunction leads to the activation of several cellular signalling path...
Abstract
Cited 6 times since 2021 (1.3 per year)
source: EuropePMC
Scientific reports,
Volume 11, Issue 1, 8 2 2021, Pages 113
Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats.
Van Schaik L, Kettle C, Green R, Sievers W, Hale MW, Irving HR, Whelan DR, Rathner JA
The role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the brain implicated in stimulating BAT thermogenesis. This study tests the hypothesis that central administration of caffeine is sufficient to activate BAT. Low doses of caffeine administered either systemically (intravenous [IV]; 10 mg/kg) and cent...
Abstract
Cited 52 times since 2021 (11.3 per year)
source: EuropePMC
European urology oncology,
Volume 4, Issue 2, 8 2 2021, Pages 182-191
Prognostic Value of the WHO1973 and WHO2004/2016 Classification Systems for Grade in Primary Ta/T1 Non-muscle-invasive Bladder Cancer: A Multicenter European Association of Urology Non-muscle-invasive Bladder Cancer Guidelines Panel Study.
van Rhijn BWG, Hentschel AE, Bründl J, Compérat EM, Hernández V, Čapoun O, Bruins HM, Cohen D, Rouprêt M, Shariat SF, Mostafid AH, Zigeuner R, Dominguez-Escrig JL, Burger M, Soukup V, Gontero P, Palou J, van der Kwast TH, Babjuk M, Sylvester RJ, Multi-center EAU Non-Muscle-Invasive Bladder Cancer Guidelines Panel Study Consortium on the WHO1973 WHO 2004 2016 Classification Systems for Grade
Background: In the current European Association of Urology (EAU) non-muscle-invasive bladder cancer (NMIBC) guideline, two classification systems for grade are advocated: WHO1973 and WHO2004/2016. Objective: To compare the prognostic value of these WHO systems. Design, setting, and participants: Individual patient data for 5145 primary Ta/T1 NMIBC patients from 17 centers were collected between 1990 and 2019. The median follow-up was 3.9 yr. Outcome measurements and statistical analysis: Univari...
Abstract
Cited 16 times since 2021 (3.5 per year)
source: EuropePMC
PLoS genetics,
Volume 17, Issue 1, 7 1 2021, Pages e1009262
Harder, better, faster, stronger: Colistin resistance mechanisms in Escherichia coli.
Janssen AB, van Schaik W
Abstract
Cited 252 times since 2021 (54.6 per year)
source: EuropePMC
European urology,
Volume 79, Issue 4, 6 1 2021, Pages 480-488
European Association of Urology (EAU) Prognostic Factor Risk Groups for Non-muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel.
Sylvester RJ, Rodríguez O, Hernández V, Turturica D, Bauerová L, Bruins HM, Bründl J, van der Kwast TH, Brisuda A, Rubio-Briones J, Seles M, Hentschel AE, Kusuma VRM, Huebner N, Cotte J, Mertens LS, Volanis D, Cussenot O, Subiela Henríquez JD, de la Peña E, Pisano F, Pešl M, van der Heijden AG, Herdegen S, Zlotta AR, Hacek J, Calatrava A, Mannweiler S, Bosschieter J, Ashabere D, Haitel A, Côté JF, El Sheikh S, Lunelli L, Algaba F, Alemany I, Soria F, Runneboom W, Breyer J, Nieuwenhuijzen JA, Llorente C, Molinaro L, Hulsbergen-van de Kaa CA, Evert M, Kiemeney LALM, N'Dow J, Plass K, Čapoun O, Soukup V, Dominguez-Escrig JL, Cohen D, Palou J, Gontero P, Burger M, Zigeuner R, Mostafid AH, Shariat SF, Rouprêt M, Compérat EM, Babjuk M, van Rhijn BWG
Background: The European Association of Urology (EAU) prognostic factor risk groups for non-muscle-invasive bladder cancer (NMIBC) are used to provide recommendations for patient treatment after transurethral resection of bladder tumor (TURBT). They do not, however, take into account the widely used World Health Organization (WHO) 2004/2016 grading classification and are based on patients treated in the 1980s. Objective: To update EAU prognostic factor risk groups using the WHO 1973 and 2004/201...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
European radiology,
Volume 31, Issue 7, 6 1 2021, Pages 5068-5076
Associations between left ventricular function, vascular function and measures of cerebral small vessel disease: a cross-sectional magnetic resonance imaging study of the UK Biobank.
van Hout MJP, Dekkers IA, Westenberg JJM, Schalij MJ, Scholte AJHA, Lamb HJ
Objectives: Impaired cardiovascular function has been associated with cognitive deterioration; however, to what extent cardiovascular dysfunction plays a role in structural cerebral changes remains unclear. We studied whether vascular and left ventricular (LV) functions are associated with measures of cerebral small vessel disease (cSVD) in the middle-aged general population. Methods: In this cross-sectional analysis of the UK Biobank, 4366 participants (54% female, mean age 61 years) underwent...
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 4, 6 1 2021, Pages 451-452
Left Ventricular Myocardial Work Indices: A Potential Step Forward for the Assessment of Myocardial Performance in Severe Aortic Stenosis: Reply to "Is It Fair to Use the Current Estimation of Myocardial Work in Patients with Significant Aortic Stenosis?"
Fortuni F, Bax JJ, Delgado V, Ajmone Marsan N
Abstract
Cited 12 times since 2021 (2.6 per year)
source: EuropePMC
Talanta,
Volume 225, 6 1 2021, Pages 122071
Investigation of the pathway dependent endocytosis of gold nanoparticles by surface-enhanced Raman scattering.
Yılmaz D, Culha M
Endocytosis is a critical mechanism providing not only internalization of biomacromolecular structures but also communication with the environment where cells reside. Due to being the first step at the interaction interface, the route of cellular uptake has a major role governing the intracellular destinations and behaviors of molecular and non-molecular species including nanoparticles. To this end, various methods employing variety of techniques are investigated. In this study, surface-enhanced...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
Health expectations : an international journal of public participation in health care and health policy,
Volume 24, Issue 2, 6 1 2021, Pages 456-467
Patient and public involvement cultures and the perceived impact in the vulnerable context of palliative care: A qualitative study.
Melchior I, van der Heijden A, Stoffers E, Suntjens F, Moser A
Background: Cultural values are crucial to the practice and impact of patient and public involvement (PPI) in research. Objective: To understand different PPI cultures among research teams and the impacts of PPI associated with each culture type. Design: A participatory action research design. Setting and participants: The setting was 10 palliative care research projects. Seventeen patients and members of the public and 31 researchers participated. Intervention: A programme consisting of four co...
Abstract
Cited 2 times since 2021 (0.4 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 14, Issue 1, 5 1 2021, Pages e011107
Computed Tomography-Derived Transesophageal Echocardiographic Views: Step Forward for Procedural Planning of Transcatheter Tricuspid Valve Annuloplasty.
Fortuni F, Hirasawa K, Marques AI, Pio SM, Chimed S, Lustosa R, Tjahjadi C, Wang X, Bax JJ, Ajmone Marsan N, Delgado V
Abstract
Cited 109 times since 2021 (23.6 per year)
source: EuropePMC
Nature communications,
Volume 12, Issue 1, 5 1 2021, Pages 24
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.
Lagou V, Mägi R, Hottenga JJ, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D, Jansen R, Min JL, Dimas AS, Ulrich A, Zudina L, Gådin JR, Jiang L, Faggian A, Bonnefond A, Fadista J, Stathopoulou MG, Isaacs A, Willems SM, Navarro P, Tanaka T, Jackson AU, Montasser ME, O'Connell JR, Bielak LF, Webster RJ, Saxena R, Stafford JM, Pourcain BS, Timpson NJ, Salo P, Shin SY, Amin N, Smith AV, Li G, Verweij N, Goel A, Ford I, Johnson PCD, Johnson T, Kapur K, Thorleifsson G, Strawbridge RJ, Rasmussen-Torvik LJ, Esko T, Mihailov E, Fall T, Fraser RM, Mahajan A, Kanoni S, Giedraitis V, Kleber ME, Silbernagel G, Meyer J, Müller-Nurasyid M, Ganna A, Sarin AP, Yengo L, Shungin D, Luan J, Horikoshi M, An P, Sanna S, Boettcher Y, Rayner NW, Nolte IM, Zemunik T, Iperen EV, Kovacs P, Hastie ND, Wild SH, McLachlan S, Campbell S, Polasek O, Carlson O, Egan J, Kiess W, Willemsen G, Kuusisto J, Laakso M, Dimitriou M, Hicks AA, Rauramaa R, Bandinelli S, Thorand B, Liu Y, Miljkovic I, Lind L, Doney A, Perola M, Hingorani A,
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic component underlying this phenomenon is not established. We assess sex-dimorphic (73,089/50,404 women and 67,506/47,806 men) and sex-combined (151,188/105,056 individuals) fasting glucose/fasting insulin genetic effects via genome-wide association stu...
Abstract
