8309 results
Cited 4 times since 2014 (0.4 per year)
source: Scopus
The international journal of cardiovascular imaging,
Volume 31, Issue 1, 17 3 2014, Pages 37-43
Pericardial effusion following transcatheter aortic valve implantation: echocardiography and multi-detector row computed tomography evaluation.
Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Regeer M, Al-Amri I, Karalis I, Palmen M, de Weger A, Marsan NA, Bax JJ, Delgado V
Although pericardial effusion (PE) early after transcatheter aortic valve implantation (TAVI) has been reported in few registries, late PE at follow-up remains unexplored. Particularly, after transapical TAVI, diagnosis of PE with transthoracic echocardiography (TTE) may be challenging. The present evaluation assessed the incidence of PE early after TAVI and at 1 month follow-up using TTE and multi-detector computed tomography (MDCT). The agreement between TTE and MDCT to diagnose the presence a...
Abstract
Cited 27 times since 2014 (2.6 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 18, Issue 10, 15 3 2014, Pages 2020-2030
Complement factor C5a induces atherosclerotic plaque disruptions.
Wezel A, de Vries MR, Lagraauw HM, Foks AC, Kuiper J, Quax PH, Bot I
Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE(-/-) mice. After 24 days, when advanced plaques had developed, C5a or PBS was applied locally at the lesion site in a pluronic gel. Three days later mice were killed to examine the acute effect of C5a on late stage atherosclerosis. A signi...
Abstract
Cited 129 times since 2014 (12.2 per year)
source: EuropePMC
Circulation,
Volume 130, Issue 15, 14 2 2014, Pages 1225-1235
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL, Jukema JW, Chasman DI, Albert CM, Ebana Y, Furukawa T, Macfarlane PW, Harris TB, Darbar D, Dörr M, Holst AG, Svendsen JH, Hofman A, Uitterlinden AG, Gudnason V, Isobe M, Malik R, Dichgans M, Rosand J, Van Wagoner DR, METASTROKE Consortium, AFGen Consortium, Benjamin EJ, Milan DJ, Melander O, Heckbert SR, Ford I, Liu Y, Barnard J, Olesen MS, Stricker BH, Tanaka T, Kääb S, Ellinor PT
Background: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. Methods and results: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. F...
Abstract
Cited 3 times since 2014 (0.3 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 8, 14 2 2014, Pages e105019
Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques.
Rutten B, Tersteeg C, Vrijenhoek JE, van Holten TC, Elsenberg EH, Mak-Nienhuis EM, de Borst GJ, Jukema JW, Pijls NH, Waltenberger J, van Zonneveld AJ, Moll FL, McClellan E, Stubbs A, Pasterkamp G, Hoefer I, de Groot PG, Roest M
Objective: Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. Methods: Platelet reactivity was determined by measuring platelet P-selectin expression after platelet stimulation with increasing concentrations of adenosine diphosphate...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 6, 12 2 2014, Pages 1072-1074
The potential role of gated myocardial perfusion SPECT imaging in patient selection for cardiac resynchronization therapy.
Marsan NA, Bax JJ
Abstract
Cited 26 times since 2014 (2.5 per year)
source: EuropePMC
Journal of surgical oncology,
Volume 110, Issue 7, 11 2 2014, Pages 845-850
Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging.
Schaafsma BE, Verbeek FP, Elzevier HW, Tummers QR, van der Vorst JR, Frangioni JV, van de Velde CJ, Pelger RC, Vahrmeijer AL
Background and objectives: Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Methods: Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (co...
Abstract
Cited 9 times since 2014 (0.9 per year)
source: EuropePMC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Volume 73, 10 2 2014, Pages 105-112
Evaluation of in vitro cytotoxicity and genotoxicity of copper-zinc alloy nanoparticles in human lung epithelial cells.
Kumbıçak U, Cavaş T, Cinkılıç N, Kumbıçak Z, Vatan O, Yılmaz D
In the present study, in vitro cytotoxic and genotoxic effect of copper-zinc alloy nanoparticles (Cu-Zn ANPs) on human lung epithelial cells (BEAS-2B) were investigated. XTT test and clonogenic assay were used to determine cytotoxic effects. Cell death mode and intracellular reactive oxygen species formations were analyzed using M30, M65 and ROS Elisa assays. Genotoxic effects were evaluated using micronucleus, comet and γ-H2AX foci assays. Cu-Zn ANPs were characterized by transmission electron...
Abstract
Cited 54 times since 2014 (5.1 per year)
source: EuropePMC
International journal of cancer,
Volume 136, Issue 6, 8 2 2014, Pages 1434-1444
Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.
Groenendijk FH, Mellema WW, van der Burg E, Schut E, Hauptmann M, Horlings HM, Willems SM, van den Heuvel MM, Jonkers J, Smit EF, Bernards R
The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. We further show in a phase II clinical trial in...
Abstract
Cited 222 times since 2014 (21 per year)
source: EuropePMC
American heart journal,
Volume 168, Issue 5, 7 1 2014, Pages 682-689
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial.
Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Rorick T, Sasiela WJ, Shirodaria C, Szarek M, Tamby JF, Tricoci P, White H, Zeiher A, Steg PG
Background: Following acute coronary syndrome (ACS), the risk for future cardiovascular events is high and is related to levels of low-density lipoprotein cholesterol (LDL-C) even within the setting of intensive statin treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL receptor expression and circulating levels of LDL-C. Antibodies to PCSK9 can produce substantial and sustained reductions of LDL-C. The ODYSSEY Outcomes trial tests the hypothesis that treatment with al...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 10, 4 1 2014, Pages 855-857
Value of intraoperative electrical parameters obtained during implantation of cardiac resynchronization therapy devices for the prediction of reverse remodeling.
de Riva-Silva M, López-Gil M, Salgado-Aranda R, Fontenla-Cerezuela A, Salguero-Bodes R, Arribas-Ynsaurriaga F
Abstract
Cited 14 times since 2014 (1.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 176, Issue 3, 3 1 2014, Pages 788-793
RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice.
Louwe MC, Karper JC, de Vries MR, Nossent AY, Bastiaansen AJ, van der Hoorn JW, Willems van Dijk K, Rensen PC, Steendijk P, Smit JW, Quax PH
Background: Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signaling, would lead to aggravated cardiac dysfunction after MI. Methods and results: First, whole blood from RP105-/- and wild-type (WT) ma...
Abstract
Cited 21 times since 2014 (2 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 86, Issue 1, 2 1 2014, Pages 73-77
Retrospective evaluation of thromboembolic events in patients with non-small cell lung cancer treated with platinum-based chemotherapy.
Mellema WW, van der Hoek D, Postmus PE, Smit EF
Objectives: Thromboembolic events (TE) are common in patients with cancer and are potentially life-threatening. In lung cancer, little is known about thrombosis during chemotherapy treatment. The aim of this study was to describe the incidence of TE in patients with non-small cell lung cancer (NSCLC), occurring during treatment with platinum-based chemotherapy. Methods: We retrospectively selected patients with NSCLC treated with platinum-based chemotherapy at the VU University Medical Center Am...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 7, Issue 4, 1 1 2014, Pages 567-569
The ideal end point for ablation in postinfarction ventricular tachycardia: one may not fit all.
Zeppenfeld K
Abstract
Cited 18 times since 2014 (1.7 per year)
source: EuropePMC
Nutrition, metabolism, and cardiovascular diseases : NMCD,
Volume 25, Issue 1, 1 1 2014, Pages 93-99
The role of insulin resistance in the association between body fat and autonomic function.
Hillebrand S, Swenne CA, Gast KB, Maan AC, le Cessie S, Jukema JW, Rosendaal FR, den Heijer M, de Mutsert R
Background and aim: Excess body fat is associated with altered autonomic function. We investigated whether this association is mediated by insulin resistance. Methods and results: Cross-sectional analysis of a subgroup of the Netherlands Epidemiology of Obesity study with measurements of autonomic function (heart rate variability calculated as mean interbeat interval, standard deviation of all normal intervals (SDNN), low frequency (LF) power and high frequency (HF) power). We measured BMI(kg/m²...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Der Urologe. Ausg. A,
Volume 53, Issue 8, 1 1 2014, Pages 1136-1145
[The demographic development in Germany : challenge and chances for urology].
Schneider AW, Fichtner J
Urology is affected by the demographic development in Germany more than any other medical discipline. Despite a relatively stable total population, by the year 2040 there will be an absolute and relevant increase in urological diseases caused only by the demographic development in the population. This is particularly true for the increase in oncological treatment just in the field of the discipline of urology. Even now the current numbers for tumor development in Germany (RKI 2014) in the urolog...
Abstract
Cited 106 times since 2014 (10 per year)
source: EuropePMC
Circulation research,
Volume 115, Issue 8, 1 1 2014, Pages 696-708
Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia.
Welten SM, Bastiaansen AJ, de Jong RC, de Vries MR, Peters EA, Boonstra MC, Sheikh SP, La Monica N, Kandimalla ER, Quax PH, Nossent AY
Rationale: Effective neovascularization is crucial for recovery after cardiovascular events. Objective: Because microRNAs regulate expression of up to several hundred target genes, we set out to identify microRNAs that target genes in all pathways of the multifactorial neovascularization process. Using www.targetscan.org, we performed a reverse target prediction analysis on a set of 197 genes involved in neovascularization. We found enrichment of binding sites for 27 microRNAs in a single microR...
Abstract
Cited 21 times since 2014 (2 per year)
source: EuropePMC
Magnetic resonance in medicine,
Volume 72, Issue 2, 1 1 2014, Pages 409-417
Quantitative T2 mapping of the mouse heart by segmented MLEV phase-cycled T2 preparation.
Coolen BF, Simonis FF, Geelen T, Moonen RP, Arslan F, Paulis LE, Nicolay K, Strijkers GJ
Purpose: A high-quality, reproducible, multi-slice T2-mapping protocol for the mouse heart is presented. Methods: A T2-prepared sequence with composite 90° and 180° radiofrequency pulses in a segmented MLEV phase cycling scheme was developed. The T2-mapping protocol was optimized using simulations and evaluated with phantoms. Results: Repeatability for determination of myocardial T2 values was assessed in vivo in n = 5 healthy mice on 2 different days. The average baseline T2 of the left ventric...
Abstract
Cited 4 times since 2014 (0.4 per year)
source: Scopus
Perfusion,
Volume 30, Issue 4, 1 1 2014, Pages 295-301
Sevoflurane-enriched blood cardioplegia: the intramyocardial delivery of a volatile anesthetic.
van der Baan A, Kortekaas KA, van Es E, Meier S, Klautz RJ, Engbers FH
Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with a sevoflurane vaporizer was integrated into the blood cardioplegia system of an adult bypass system. In addition, a gas ble...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
Circulation research,
Volume 115, Issue 4, 1 1 2014, Pages e6-7
Cardiac anisotropy, regeneration, and rhythm.
Pijnappels DA, Schalij MJ, Atsma DE, de Vries AA
Abstract
Cited 11 times since 2014 (1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 7-8, 1 1 2014, Pages 336-343
Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter?
Korteland NM, Kluin J, Klautz RJ, Roos-Hesselink JW, Versteegh MI, Bogers AJ, Takkenberg JJ
Aims: Assess and compare among Dutch cardiothoracic surgeons and cardiologists: opinion on (1) patient involvement, (2) conveying risk in aortic valve selection, and (3) aortic valve preferences. Methods and results: A survey among 117 cardiothoracic surgeons and cardiologists was conducted. Group responses were compared using the Mann-Whitney U test. Most respondents agreed that patients should be involved in decision-making, with surgeons leaning more toward patient involvement (always: 83 % v...
Abstract
