7503 results
Cited 3 times since 2024 (1.7 per year)
source: EuropePMC
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Volume 30, Issue 7, 28 4 2024, Pages 930-936
Intradermal delivery of the third dose of the mRNA-1273 SARS-CoV-2 vaccine: safety and immunogenicity of a fractional booster dose.
Roozen GVT, Prins MLM, Prins C, Janse JJ, de Gruyter HLM, Pothast CR, Huisman W, Koopman JPR, Lamers OAC, Kuijer M, Myeni SK, van Binnendijk RS, Hartog GD, Heemskerk MHM, Jochems SP, Feltkamp MCW, Kikkert M, Rosendaal FR, Roestenberg M, Visser LG, Roukens AHE
Objectives: The aim of this study was to assess the safety and immunogenicity of a dose-sparing fractional intradermal (ID) booster strategy with the mRNA-1273 COVID-19 vaccine. Methods: COVID-19 naive adults aged 18-30 years were recruited from a previous study on primary vaccination regimens that compared 20 μg ID vaccinations with 100 μg intramuscular (IM) vaccinations with mRNA-1273 as the primary vaccination series. Participants previously immunized with ID regimens were randomly assigned (...
Abstract
Cited 4 times since 2024 (2.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 221, 28 4 2024, Pages 37-43
Association of Left Atrial Appendage Morphology and Function With Stroke and Transient Ischemic Attack in Atrial Fibrillation Patients.
Simon J, Smit JM, El Mahdiui M, Száraz L, van Rosendael AR, Zsarnóczay E, Nagy AI, Gellér L, van der Geest RJ, Bax JJ, Maurovich-Horvat P, Merkely B
We aimed to correlate left atrial appendage (LAA) structure and function with the history of stroke/transient ischemic attack (TIA) in patients with atrial fibrillation (AF). We analyzed the data of 649 patients with AF who were scheduled for catheter ablation. Patients underwent cardiac computed tomography and transesophageal echocardiography before ablation. The LAA morphologies depicted by cardiac computed tomography were categorized into 4 groups: cauliflower, chicken wing, swan, and windsoc...
Abstract
Cited 1 times since 2024 (0.6 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 18, 28 4 2024, Pages 1335422
Optimizing event-based neural networks on digital neuromorphic architecture: a comprehensive design space exploration.
Xu Y, Shidqi K, van Schaik GJ, Bilgic R, Dobrita A, Wang S, Meijer R, Nembhani P, Arjmand C, Martinello P, Gebregiorgis A, Hamdioui S, Detterer P, Traferro S, Konijnenburg M, Vadivel K, Sifalakis M, Tang G, Yousefzadeh A
Neuromorphic processors promise low-latency and energy-efficient processing by adopting novel brain-inspired design methodologies. Yet, current neuromorphic solutions still struggle to rival conventional deep learning accelerators' performance and area efficiency in practical applications. Event-driven data-flow processing and near/in-memory computing are the two dominant design trends of neuromorphic processors. However, there remain challenges in reducing the overhead of event-driven proc...
Abstract
Cited 69 times since 2024 (39.8 per year)
source: EuropePMC
The lancet. Diabetes & endocrinology,
Volume 12, Issue 5, 27 4 2024, Pages 306-319
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis.
Cholesterol Treatment Trialists’ (CTT) Collaboration Electronic address: ctt@ndphoxacuk, Cholesterol Treatment Trialists’ (CTT) Collaboration
Background: Previous meta-analyses of summary data from randomised controlled trials have shown that statin therapy increases the risk of diabetes, but less is known about the size or timing of this effect, or who is at greatest risk. We aimed to address these gaps in knowledge through analysis of individual participant data from large, long-term, randomised, double-blind trials of statin therapy. Methods: We conducted a meta-analysis of individual participant data from randomised controlled tri...
Abstract
Pediatric radiology,
Volume 54, Issue 5, 27 4 2024, Pages 859-861
CT, MR, and isotope data of a mummified child from Zagreb Cathedral, Croatia: giving voice to the past through imaging.
Van Schaik K, Prenc M, Tomorad M, Štimac I, Novak M, Eppenberger P, Cavka M
Abstract
Cited 2 times since 2024 (1.2 per year)
source: EuropePMC
Simulation in healthcare : journal of the Society for Simulation in Healthcare,
Volume 20, Issue 1, 25 4 2024, Pages 33-41
A Scoping Review of Interprofessional Simulation-Based Team Training Programs.
Bochatay N, Ju M, O'Brien BC, van Schaik SM
Summary statement: Interprofessional simulation-based team training (ISBTT) is promoted as a strategy to improve collaboration in healthcare, and the literature documents benefits on teamwork and patient safety. Teamwork training in healthcare is traditionally grounded in crisis resource management (CRM), but it is less clear whether ISBTT programs explicitly take the interprofessional context into account, with complex team dynamics related to hierarchy and power. This scoping review examined k...
Abstract
Cited 20 times since 2024 (11.5 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 83, Issue 15, 25 4 2024, Pages 1403-1414
Effect of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Congenital Heart Disease.
Neijenhuis RML, MacDonald ST, Zemrak F, Mertens BJA, Dinsdale A, Hunter A, Walker NL, Swan L, Reddy S, Rotmans JI, Jukema JW, Jongbloed MRM, Veldtman GR, Egorova AD
Background: Heart failure (HF) is the principal cause of morbidity and mortality in adults with congenital heart disease (ACHD). Robust evidence-based treatment options are lacking. Objectives: This study aims to evaluate the safety, tolerability, and short-term HF-related effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in a real-world ACHD population. Methods: All patients with ACHD treated with SGLT2i in 4 European ACHD centers were included in this retrospective study. Data were...
Abstract
Cited 1 times since 2024 (0.6 per year)
source: EuropePMC
Journal of affective disorders,
Volume 355, 21 3 2024, Pages 95-103
Internet-based emotion regulation training aimed at reducing violent revictimization and depressive symptoms in victimized depressed patients: Results of a randomized controlled trial.
Christ C, van Schaik DJF, Kikkert MJ, de Waal MM, Dozeman E, Hulstijn HL, Koomen LM, Krah IM, Schut DM, Beekman ATF, Dekker JJM
Background: Depressed patients who have become victim of violence are prone to revictimization. However, no evidence-based interventions aimed at reducing revictimization in this group exist. Methods: This multicenter randomized controlled trial evaluated the effectiveness of an internet-based emotion regulation training (iERT) added to TAU in reducing revictimization, emotion dysregulation, and depressive symptoms in recently victimized, depressed patients compared to TAU alone. Adult outpatien...
Abstract
Precision radiation oncology,
Volume 8, Issue 1, 21 3 2024, Pages 47-58
Stereotactic radiotherapy: An educational narrative review.
Khan AMH, Hashmi SFA, Li B, Shaukat F, Ahmed Y, Alfishawy M, Al-Amri I, Bashir R, Altaf F, Yilmaz S, Khalid J, Mandhari ZA, Pervez N, Rassou SC, Mula-Hussain L
Stereotactic radiotherapy is a term collectively used to describe the radiation treatment techniques that allow for the delivery of highly precise ionizing radiation. It is usually a high dose per session in single or few fractions. This treatment approach has been in medical use for over six decades and has primarily evolved in the last two decades. Many patients benefit from this unique non-conventional radiotherapy approach. Its indications include various malignant, benign and functional pro...
Abstract
Cited 2 times since 2024 (1.1 per year)
source: EuropePMC
Frontiers in cellular and infection microbiology,
Volume 14, 19 3 2024, Pages 1282183
Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria.
van Schaik EJ, Fratzke AP, Gregory AE, Dumaine JE, Samuel JE
Obligate intracellular bacteria have remained those for which effective vaccines are unavailable, mostly because protection does not solely rely on an antibody response. Effective antibody-based vaccines, however, have been developed against extracellular bacteria pathogens or toxins. Additionally, obligate intracellular bacteria have evolved many mechanisms to subvert the immune response, making vaccine development complex. Much of what we know about protective immunity for these pathogens has...
Abstract
Cited 3 times since 2024 (1.7 per year)
source: EuropePMC
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 50, Issue 6, 19 3 2024, Pages 108278
Staging laparoscopy in gastric cancer patients: From a Dutch nationwide Delphi consensus towards a standardized protocol.
van der Sluis K, Guchelaar NAD, Triemstra L, Mathijssen RHJ, Ruurda JP, Wijnhoven BPL, van Sandick JW, Collaborators
Background: Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. Methods: All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The study involved an initial questionnaire with a 3-point Likert scale, an online...
Abstract
Cited 3 times since 2024 (1.7 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 37, Issue 7, 19 3 2024, Pages 666-673
Prognostic Value of Follow-up Measures of Left Ventricular Global Longitudinal Strain in Patients With ST-Segment Elevation Myocardial Infarction.
Caunite L, Myagmardorj R, Galloo X, Laenens D, Stassen J, Nabeta T, Yedidya I, Meucci MC, Kuneman JH, van den Hoogen IJ, van Rosendael SE, Wu HW, van den Brand VM, Giuca A, Trusinskis K, van der Bijl P, Bax JJ, Ajmone Marsan N
Introduction: After ST-segment elevation myocardial infarction (STEMI), follow-up imaging is currently recommended only in patients with left ventricular ejection fraction (LVEF) 7% remained independently associated with the end point (hazard ratio, 2.5 [95% CI, 1.5-4.1]; P
Abstract
Cited 3 times since 2024 (1.7 per year)
source: EuropePMC
JTCVS open,
Volume 19, 19 3 2024, Pages 68-90
Current definitions of hemodynamic structural valve deterioration after bioprosthetic aortic valve replacement lack consistency.
Velders BJJ, Vriesendorp MD, Asch FM, Reardon MJ, Dagenais F, Moront MG, Sabik Iii JF, Groenwold RHH, Klautz RJM
Objective: New echocardiographic definitions have been proposed for hemodynamic structural valve deterioration. We aimed to study their consistency in classifying structural valve deterioration after surgical aortic valve replacement. Methods: Data were used of patients undergoing surgical aortic valve replacement in a multicenter, prospective cohort study with a 5-year follow-up. All patients received the same stented bioprosthesis. Echocardiographic parameters were assessed by an independent c...
Abstract
Cited 2 times since 2024 (1.1 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 116, Issue 3, 18 3 2024, Pages 690-702
Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort.
Mc Laughlin AM, Helland T, Klima F, Koolen SLW, van Schaik RHN, Mathijssen RHJ, Neven P, Swen JJ, Guchelaar HJ, Dalenc F, White-Koning M, Michelet R, Mikus G, Schroth W, Mürdter T, Brauch H, Schwab M, Søiland H, Mellgren G, Thomas F, Kloft C, Hertz DL, CYP2D6 Endoxifen Percentage Activity Model (CEPAM) Consortium
Tamoxifen is widely used in patients with hormone receptor-positive breast cancer. The polymorphic enzyme CYP2D6 is primarily responsible for metabolic activation of tamoxifen, resulting in substantial interindividual variability of plasma concentrations of its most important metabolite, Z-endoxifen. The Z-endoxifen concentration thresholds below which tamoxifen treatment is less efficacious have been proposed but not validated, and prospective trials of individualized tamoxifen treatment to ach...
Abstract
Cited 2 times since 2024 (1.1 per year)
source: EuropePMC
Arthritis research & therapy,
Volume 26, Issue 1, 16 3 2024, Pages 70
Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis.
Pollastro S, Musters A, Balzaretti G, Niewold I, van Schaik B, Hässler S, Verhoef CM, Pallardy M, van Kampen A, Mariette X, de Vries N, ABIRISK Consortium
Background: Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself. Methods: The B-cell receptor (BCR) repertoire was prospectively analyzed in peripheral blood samples of twenty-eight RA patients undergoing rituximab therapy. Timepoints of achieved BCR-depletion and -repopulation were defined based on the percentage of unmutated BCRs in the repertoire. The predictive value of early BCR-depleti...
Abstract
Heart rhythm,
Volume 21, Issue 10, 16 3 2024, Pages 1779-1786
Comparing adolescent- and adult-onset unexplained cardiac arrest: Results from the Dutch Idiopathic VF Registry.
Verheul LM, Hoeksema WF, Groeneveld SA, Mulder BA, Bootsma M, Alings M, Evertz R, Blank AC, Kammeraad JAE, Clur SB, Yap SC, Postema PG, Wilde AAM, Volders PGA, Hassink RJ
Background: Current cohorts of patients with idiopathic ventricular fibrillation (IVF) primarily include adult-onset patients. Underlying causes of sudden cardiac arrest vary with age; therefore, underlying causes and disease course may differ for adolescent-onset vs adult-onset patients. Objective: The purpose of this study was to compare adolescent-onset with adult-onset patients having an initially unexplained cause of VF. Methods: The study included 39 patients with an index event aged ≤19 y...
Abstract
Cited 4 times since 2024 (2.3 per year)
source: EuropePMC
European urology,
Volume 85, Issue 6, 15 3 2024, Pages e180
Corrigendum to "European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines" [Eur. Urol. 85 (2024) 17-31].
Alfred Witjes J, Bruins HM, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebiaco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, Mariappan P, van der Heijden AG
Abstract
Cited 4 times since 2024 (2.3 per year)
source: EuropePMC
ACS omega,
Volume 9, Issue 12, 15 3 2024, Pages 14054-14062
Propolis-Loaded Poly(lactic-<i>co</i>-glycolic Acid) Nanofibers: An <i>In Vitro</i> Study.
Geyik F, Kaya S, Yılmaz DE, Demirci H, Akmayan İ, Özbek T, Acar S
Nanofibers have high potential through their high porosity, small pore sizes, lightweight materials, and their ability to mimic the extracellular matrix structure for use in the manufacture of wound dressings for wound treatment. In this study, poly(lactic-co-glycolic acid) (PLGA) nanofibers were produced by electrospinning. Propolis was loaded into the PLGA nanofibers by the dropping method. The average diameters and effects of propolis loading on the morphology of 37.5, 50, and 100% propolis-l...
Abstract
Cited 4 times since 2024 (2.3 per year)
source: EuropePMC
Journal of dairy science,
Volume 107, Issue 8, 14 2 2024, Pages 5754-5778
A Living Lab approach to understanding dairy farmers' technology and data needs to improve herd health: Focus groups from 6 European countries.
Doidge C, Ånestad LM, Burrell A, Frössling J, Palczynski L, Pardon B, Veldhuis A, Bokma J, Carmo LP, Hopp P, Guelbenzu-Gonzalo M, Meunier NV, Ordell A, Santman-Berends I, van Schaik G, Kaler J
For successful development and adoption of technology on dairy farms, farmers need to be included in the innovation process. However, the design of agricultural technologies usually takes a top-down approach with little involvement of end-users at the early stages. Living Labs offer a methodology that involve end-users throughout the development process and emphasize the importance of understanding users' needs. Currently, exploration of dairy farmers' technology needs has been limited...
Abstract
Cited 5 times since 2024 (2.8 per year)
source: EuropePMC
Frontiers in veterinary science,
Volume 11, 14 2 2024, Pages 1337661
Review state-of-the-art of output-based methodological approaches for substantiating freedom from infection.
Meletis E, Conrady B, Hopp P, Lurier T, Frössling J, Rosendal T, Faverjon C, Carmo LP, Hodnik JJ, Ózsvári L, Kostoulas P, van Schaik G, Comin A, Nielen M, Knific T, Schulz J, Šerić-Haračić S, Fourichon C, Santman-Berends I, Madouasse A
A wide variety of control and surveillance programmes that are designed and implemented based on country-specific conditions exists for infectious cattle diseases that are not regulated. This heterogeneity renders difficult the comparison of probabilities of freedom from infection estimated from collected surveillance data. The objectives of this review were to outline the methodological and epidemiological considerations for the estimation of probabilities of freedom from infection from surveil...
Abstract
