Research

Publications

Below you can find a list of our published research.

7971 results

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

Turkish neurosurgery, 17 3 2018 Immunohistochemical Evaluation of Hemostatic Changes in Glioblastoma Multiforme and Low-Grade Astrocytoma. Haciyakupoğlu E, Yilmaz DM, Walter J, Erdoğan Ş, Haciyakupoğlu S, Kuhn SA

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation. Material and methods: Specimens from 35 case... Abstract

Cited 19 times since 2018 (2.9 per year) source: EuropePMC

European radiology, Volume 29, Issue 4, 15 3 2018, Pages 2117-2126 Noninvasive CT-based hemodynamic assessment of coronary lesions derived from fast computational analysis: a comparison against fractional flow reserve. Siogkas PK, Anagnostopoulos CD, Liga R, Exarchos TP, Sakellarios AI, Rigas G, Scholte AJHA, Papafaklis MI, Loggitsi D, Pelosi G, Parodi O, Maaniitty T, Michalis LK, Knuuti J, Neglia D, Fotiadis DI

Objectives: Application of computational fluid dynamics (CFD) to three-dimensional CTCA datasets has been shown to provide accurate assessment of the hemodynamic significance of a coronary lesion. We aim to test the feasibility of calculating a novel CTCA-based virtual functional assessment index (vFAI) of coronary stenoses > 30% and ≤ 90% by using an automated in-house-developed software and to evaluate its efficacy as compared to the invasively measured fractional flow reserve (FFR). Method... Abstract

Cited 2 times since 2018 (0.3 per year) source: EuropePMC

International journal of chronic obstructive pulmonary disease, Volume 13, 12 2 2018, Pages 3297-3306 A systematic diagnostic evaluation combined with an internet-based self-management support system for patients with asthma or COPD. van Buul AR, Wildschut TS, Bonten TN, Kasteleyn MJ, Slats AM, Chavannes NH, Taube C

Introduction: An (inter)national systematic approach for patients with asthma COPD referred to secondary care is lacking. Therefore, a novel systematic approach was designed and tested in clinical practice. Methods: This was a retrospective observational study of data from the electronic record system of the Leiden University Medical Center. Asthma and COPD patients were included if they were evaluated with a novel systematic approach or if they had a new record for asthma or COPD and received u... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 19, Issue 1, 12 2 2018, Pages 366 The acceptance of the clinical photographic posture assessment tool (CPPAT). Fortin C, van Schaik P, Aubin-Fournier JF, Bettany-Saltikov J, Bernard JC, Ehrmann Feldman D

Background: There is a lack of evidence-based quantitative clinical methods to adequately assess posture. Our team developed a clinical photographic posture assessment tool (CPPAT) and implemented this tool in clinical practice to standardize posture assessment. The objectives were to determine the level of acceptance of the CPPAT and to document predictors as well as facilitators of and barriers to the acceptance of this tool by clinicians doing posture re-education. Methods: This is a prospect... Abstract

Cited 5 times since 2018 (0.8 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 57, Issue 2, 11 2 2018, Pages 229-237 The Value of Sigmoidoscopy to Detect Colonic Ischaemia After Ruptured Abdominal Aortic Aneurysm Repair. Jalalzadeh H, van Schaik TG, Duin JJ, Indrakusuma R, van Beek SC, Vahl AC, Wisselink W, Balm R, Koelemay MJW

Objectives: Diagnosing colonic ischaemia (CI) after ruptured abdominal aortic aneurysm (RAAA) repair is challenging. This study determined the diagnostic value of sigmoidoscopy in patients suspected of CI after RAAA repair. Methods: This was a retrospective multicentre cohort study. Patients who underwent RAAA repair in three hospitals in Amsterdam, the Netherlands, between 2004 and 2011 (AJAX cohort) were included. Sigmoidoscopies were carried out based on clinical judgment. Endoscopy results w... Abstract

Cited 39 times since 2018 (5.9 per year) source: EuropePMC

Clinical research in cardiology : official journal of the German Cardiac Society, Volume 108, Issue 5, 8 2 2018, Pages 520-538 Apolipoproteins A1, B, and apoB/apoA1 ratio are associated with first ST-segment elevation myocardial infarction but not with recurrent events during long-term follow-up. Bodde MC, Hermans MPJ, Jukema JW, Schalij MJ, Lijfering WM, Rosendaal FR, Romijn FPHTM, Ruhaak LR, van der Laarse A, Cobbaert CM

Introduction: The current way to assess the risk of cardiovascular disease (CVD) is to measure conventional lipid and lipoprotein cholesterol fractions. Despite the success of statin treatment, residual cardiovascular risk remains high. Therefore, the value of extensive serum apolipoprotein (apo) profiling to assess the risk of ST-segment elevation myocardial infarction (STEMI) and of major adverse cardiac events (MACE) in patients with STEMI was investigated in a case-control design. Methods an... Abstract

Cited 1141 times since 2018 (171.5 per year) source: EuropePMC

Nature genetics, Volume 50, Issue 11, 8 2 2018, Pages 1505-1513 Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, Nano J, Gieger C, Trompet S, Lecoeur C, Preuss MH, Prins BP, Guo X, Bielak LF, Below JE, Bowden DW, Chambers JC, Kim YJ, Ng MCY, Petty LE, Sim X, Zhang W, Bennett AJ, Bork-Jensen J, Brummett CM, Canouil M, Ec Kardt KU, Fischer K, Kardia SLR, Kronenberg F, Läll K, Liu CT, Locke AE, Luan J, Ntalla I, Nylander V, Schönherr S, Schurmann C, Yengo L, Bottinger EP, Brandslund I, Christensen C, Dedoussis G, Florez JC, Ford I, Franco OH, Frayling TM, Giedraitis V, Hackinger S, Hattersley AT, Herder C, Ikram MA, Ingelsson M, Jørgensen ME, Jørgensen T, Kriebel J, Kuusisto J, Ligthart S, Lindgren CM, Linneberg A, Lyssenko V, Mamakou V, Meitinger T, Mohlke KL, Morris AD, Nadkarni G, Pankow JS, Peters A, Sattar N, Stančáková A, Strauch K, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Witte DR, Dupuis J, Peyser PA, Zeggini E, Loos

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency 2); (iii) substantially improve fine-mapping of causal v... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 373, Issue 1760, 8 2 2018, Pages 20170408 Widespread reduction in sun-induced fluorescence from the Amazon during the 2015/2016 El Niño. Koren G, van Schaik E, Araújo AC, Boersma KF, Gärtner A, Killaars L, Kooreman ML, Kruijt B, van der Laan-Luijkx IT, von Randow C, Smith NE, Peters W

The tropical carbon balance dominates year-to-year variations in the CO2 exchange with the atmosphere through photosynthesis, respiration and fires. Because of its high correlation with gross primary productivity (GPP), observations of sun-induced fluorescence (SIF) are of great interest. We developed a new remotely sensed SIF product with improved signal-to-noise in the tropics, and use it here to quantify the impact of the 2015/2016 El Niño Amazon drought. We find that SIF was strongly suppres... Abstract

Cited 6 times since 2018 (0.9 per year) source: EuropePMC

Philosophical transactions of the Royal Society of London. Series B, Biological sciences, Volume 373, Issue 1760, 8 2 2018, Pages 20180084 Changes in surface hydrology, soil moisture and gross primary production in the Amazon during the 2015/2016 El Niño. van Schaik E, Killaars L, Smith NE, Koren G, van Beek LPH, Peters W, van der Laan-Luijkx IT

The 2015/2016 El Niño event caused severe changes in precipitation across the tropics. This impacted surface hydrology, such as river run-off and soil moisture availability, thereby triggering reductions in gross primary production (GPP). Many biosphere models lack the detailed hydrological component required to accurately quantify anomalies in surface hydrology and GPP during droughts in tropical regions. Here, we take the novel approach of coupling the biosphere model SiBCASA with the advanced... Abstract

Cited 12 times since 2018 (1.8 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 107, Issue 4, 6 1 2018, Pages 1195-1201 Outcomes of Valve Repair for Degenerative Disease in Patients With Mitral Annular Calcification. Tomšič A, Hiemstra YL, van Brakel TJ, Versteegh MIM, Marsan NA, Klautz RJM, Palmen M

Background: The risk factors for the development of mitral annular calcification (MAC) in degenerative mitral valve disease and the effect it may have on patient-and valve-related outcomes require further evaluation. Methods: Between January 2002 and December 2015, 627 patients underwent mitral valve operations for degenerative disease. MAC was seen in 75 patients (12%); 73 (97%) underwent valve repair (6 without annuloplasty ring implantation) and 2 (3%) underwent valve replacement after an uns... Abstract

Cited 13 times since 2018 (2 per year) source: EuropePMC

Genetics in medicine : official journal of the American College of Medical Genetics, Volume 21, Issue 5, 5 1 2018, Pages 1199-1208 Variants affecting diverse domains of MEPE are associated with two distinct bone disorders, a craniofacial bone defect and otosclerosis. Schrauwen I, Valgaeren H, Tomas-Roca L, Sommen M, Altunoglu U, Wesdorp M, Beyens M, Fransen E, Nasir A, Vandeweyer G, Schepers A, Rahmoun M, van Beusekom E, Huentelman MJ, Offeciers E, Dhooghe I, Huber A, Van de Heyning P, Zanetti D, De Leenheer EMR, Gilissen C, Hoischen A, Cremers CW, Verbist B, de Brouwer APM, Padberg GW, Pennings R, Kayserili H, Kremer H, Van Camp G, van Bokhoven H

Purpose: To characterize new molecular factors implicated in a hereditary congenital facial paresis (HCFP) family and otosclerosis. Methods: We performed exome sequencing in a four-generation family presenting nonprogressive HCFP and mixed hearing loss (HL). MEPE was analyzed using either Sanger sequencing or molecular inversion probes combined with massive parallel sequencing in 89 otosclerosis families, 1604 unrelated affected subjects, and 1538 unscreened controls. Results: Exome sequencing i... Abstract

Cited 7 times since 2018 (1.1 per year) source: EuropePMC

Frontiers in physiology, Volume 9, 4 1 2018, Pages 1381 Myocyte Remodeling Due to Fibro-Fatty Infiltrations Influences Arrhythmogenicity. De Coster T, Claus P, Seemann G, Willems R, Sipido KR, Panfilov AV

The onset of cardiac arrhythmias depends on the electrophysiological and structural properties of cardiac tissue. Electrophysiological remodeling of myocytes due to the presence of adipocytes constitutes a possibly important pathway in the pathogenesis of atrial fibrillation. In this paper we perform an in-silico study of the effect of such myocyte remodeling on the onset of atrial arrhythmias and study the dynamics of arrhythmia sources-spiral waves. We use the Courtemanche model for atrial myo... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

International journal of cardiology, Volume 280, 1 1 2018, Pages 19-28 Chest pain in the absence of obstructive coronary artery disease: A critical review of current concepts focusing on sex specificity, microcirculatory function, and clinical implications. Zijlstra LE, Bootsma M, Jukema JW, Schalij MJ, Vliegen HW, Bruschke AVG

Patients presenting with chest pain suggestive of coronary artery disease (CAD) who at coronary arteriography appear to be free of obstructive disease have presented a diagnostic and therapeutic challenge since the 1970's. Studies in female patient populations have suggested that this is predominantly a women's syndrome usually caused by microvascular endothelial dependent and independent dysfunction. A critical review of the literature focusing on studies including both women and men... Abstract

Cited 13 times since 2018 (1.9 per year) source: EuropePMC

European heart journal. Quality of care & clinical outcomes, Volume 4, Issue 4, 1 1 2018, Pages 239-245 Privacy of patient data in quality-of-care registries in cardiology and cardiothoracic surgery: the impact of the new general data protection regulation EU-law. Wierda E, Eindhoven DC, Schalij MJ, Borleffs CJW, Amoroso G, van Veghel D, Mitchell CR, de Mol BAJM, Hirsch A, Ploem MC

Quality-of-care registries have been shown to improve quality of healthcare and should be facilitated and encouraged. The data of these registries are also very valuable for medical data research. While fully acknowledging the importance of re-using already available data for research purposes, there are concerns about how the applicable privacy legislation is dealt with. These concerns are also articulated in the new European law on privacy, the 'General Data Protection Regulation' (G... Abstract

Cited 3 times since 2018 (0.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 26, Issue 10, 1 1 2018, Pages 473-483 Appropriate use criteria for optical coherence tomography guidance in percutaneous coronary interventions : Recommendations of the working group of interventional cardiology of the Netherlands Society of Cardiology. IJsselmuiden AJJ, Zwaan EM, Oemrawsingh RM, Bom MJ, Dankers FJWM, de Boer MJ, Camaro C, van Geuns RJM, Daemen J, van der Heijden DJ, Jukema JW, Kraaijeveld AO, Meuwissen M, Schölzel BE, Pundziute G, van der Harst P, van Ramshorst J, Dirksen MT, Zivelonghi C, Agostoni P, van der Heyden JAS, Wykrzykowska JJ, Scholte MJ, Nef HM, Kofflard MJM, van Royen N, Alings M, Kedhi E

Introduction: Optical coherence tomography (OCT) enables detailed imaging of the coronary wall, lumen and intracoronary implanted devices. Responding to the lack of specific appropriate use criteria (AUC) for this technique, we conducted a literature review and a procedure for appropriate use criteria. Methods: Twenty-one of all 184 members of the Dutch Working Group on Interventional Cardiology agreed to evaluate 49 pre-specified cases. During a meeting, factual indications were established whe... Abstract

Cited 33 times since 2018 (4.9 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 103, Issue 10, 1 1 2018, Pages 3658-3667 The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data. Wopereis DM, Du Puy RS, van Heemst D, Walsh JP, Bremner A, Bakker SJL, Bauer DC, Cappola AR, Ceresini G, Degryse J, Dullaart RPF, Feller M, Ferrucci L, Floriani C, Franco OH, Iacoviello M, Iervasi G, Imaizumi M, Jukema JW, Khaw KT, Luben RN, Molinaro S, Nauck M, Patel KV, Peeters RP, Psaty BM, Razvi S, Schindhelm RK, van Schoor NM, Stott DJ, Vaes B, Vanderpump MPJ, Völzke H, Westendorp RGJ, Rodondi N, Cobbaert CM, Gussekloo J, den Elzen WPJ, Thyroid Studies Collaboration

Context: Anemia and thyroid dysfunction often co-occur, and both increase with age. Human data on relationships between thyroid disease and anemia are scarce. Objective: To investigate the cross-sectional and longitudinal associations between clinical thyroid status and anemia. Design: Individual participant data meta-analysis. Setting: Sixteen cohorts participating in the Thyroid Studies Collaboration (n = 42,162). Main outcome measures: Primary outcome measure was anemia (hemoglobin Abstract

Cited 30 times since 2018 (4.5 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 40, Issue 5, 1 1 2018, Pages 515-525 Liquid Biopsies to Monitor Solid Organ Transplant Function: A Review of New Biomarkers. Verhoeven JGHP, Boer K, Van Schaik RHN, Manintveld OC, Huibers MMH, Baan CC, Hesselink DA

Despite modern immunosuppressive therapy, allograft rejection remains a major cause of solid organ transplant dysfunction. For clinical care, organ transplant function is routinely monitored by measuring biomarkers that, depending on the organ transplanted, include serum creatinine, N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP), and aspartate aminotransferase. All can be measured easily in clinical chemistry laboratories. The main problem with these biomarkers is that they have... Abstract

Cited 203 times since 2018 (30.4 per year) source: EuropePMC

Clinical pharmacokinetics, Volume 57, Issue 10, 1 1 2018, Pages 1229-1254 Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics. de Man FM, Goey AKL, van Schaik RHN, Mathijssen RHJ, Bins S

Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is characterized by several dose-limiting toxicities and large interindividual pharmacokinetic variability. Irinotecan has a highly complex metabolism, including hydrolyzation by carboxylesterases to its active metabolite SN-38, which is 100- to 1000-fold more active compared with irinotecan... Abstract

Cited 4 times since 2018 (0.6 per year) source: EuropePMC

Journal of graduate medical education, Volume 10, Issue 5, 1 1 2018, Pages 573-582 Leadership Observation and Feedback Tool: A Novel Instrument for Assessment of Clinical Leadership Skills. Oza SK, van Schaik S, Boscardin CK, Pierce R, Miao E, Lockspeiser T, Tad-Y D, Aagaard E, Kuo AK

Background: While leadership training is increasingly incorporated into residency education, existing assessment tools to provide feedback on leadership skills are only applicable in limited contexts. Objective: We developed an instrument, the Leadership Observation and Feedback Tool (LOFT), for assessing clinical leadership. Methods: We used an iterative process to develop the tool, beginning with adapting the Leadership Practices Inventory to create an open-ended survey for identification of c... Abstract

Cited 89 times since 2018 (13.3 per year) source: EuropePMC

European heart journal, Volume 39, Issue 39, 1 1 2018, Pages 3574-3581 Development of significant tricuspid regurgitation over time and prognostic implications: new insights into natural history. Prihadi EA, van der Bijl P, Gursoy E, Abou R, Mara Vollema E, Hahn RT, Stone GW, Leon MB, Ajmone Marsan N, Delgado V, Bax JJ

Aims: To evaluate the risk factors influencing the development of significant (moderate and severe) tricuspid regurgitation (TR), and its impact on all-cause mortality in large registry of referral centre. Methods and results: In 1000 patients (mean age 68 ± 13 years; 50.9% male) with documented significant TR, clinical, and echocardiographic data were retrospectively analysed when the echocardiogram showed none/mild TR. Patients with congenital heart disease were excluded. The study population... Abstract