8684 results
Cited 40 times since 2018 (5.8 per year)
source: EuropePMC
Nature geoscience,
Volume 11, Issue 9, 1 1 2018, Pages 744-748
Increased water-use efficiency and reduced CO<sub>2</sub> uptake by plants during droughts at a continental-scale.
Peters W, van der Velde IR, van Schaik E, Miller JB, Ciais P, Duarte HF, van der Laan-Luijkx IT, van der Molen MK, Scholze M, Schaefer K, Vidale PL, Verhoef A, Wårlind D, Zhu D, Tans PP, Vaughn B, White JWC
Severe droughts in the Northern Hemisphere cause widespread decline of agricultural yield, reduction of forest carbon uptake, and increased CO2 growth rates in the atmosphere. Plants respond to droughts by partially closing their stomata to limit their evaporative water loss, at the expense of carbon uptake by photosynthesis. This trade-off maximizes their water-use efficiency, as measured for many individual plants under laboratory conditions and field experiments. Here we analyze the 13C/12C s...
Abstract
Metabolic brain disease,
Volume 33, Issue 6, 31 5 2018, Pages 1779-1780
Reply to 'contribution of the MRPS22 variant and a down mosaic to the phenotype'.
Kılıç M, Kılıç E, Yılmaz DY, Özgül RK
Abstract
Cited 32 times since 2018 (4.7 per year)
source: EuropePMC
Radiology,
Volume 288, Issue 3, 31 5 2018, Pages 638-655
Mitral Valve Imaging with CT: Relationship with Transcatheter Mitral Valve Interventions.
Weir-McCall JR, Blanke P, Naoum C, Delgado V, Bax JJ, Leipsic J
The role of noninvasive imaging to help guide transcatheter aortic valvular interventions is well established and has grown with the advances in the procedure. With the rapid development of new transcatheter mitral valve interventions there is both an opportunity and a challenge for noninvasive imaging to grow understanding of mitral valve anatomy and disease, help with patient selection, and improve downstream clinical outcomes. This review will discuss the role of both echocardiography and mul...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
Atherosclerosis,
Volume 278, 31 5 2018, Pages 317-318
The senescence of vascular smooth muscle cells in BAV-associated aortopathy.
Mohamed SA, Grewal N, Gittenberger-de Groot AC
Abstract
Cited 7 times since 2018 (1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 105, Issue 3, 30 5 2018, Pages 196-203
Prognostic value of chronic total occlusions detected on coronary computed tomographic angiography.
Opolski MP, Gransar H, Lu Y, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Chow BJ, Cury RC, DeLago A, Feuchtner GM, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei EC, Marques H, Pontone G, Raff G, Rubinshtein R, Shaw LJ, Villines TC, Gomez M, Jones EC, Peña JM, Min JK, Lin FY
Objective: Data describing clinical relevance of chronic total occlusion (CTO) identified by coronary CT angiography (CCTA) have not been reported to date. We investigated the prognosis of CTO on CCTA. Methods: We identified 22 828 patients without prior known coronary artery disease (CAD), who were followed for a median of 26 months. Based on CCTA, coronary lesions were graded as normal (no atherosclerosis), non-obstructive (1%-49%), moderate-to-severe (50%-99%) or totally occluded (100%). All-...
Abstract
Cited 1 times since 2018 (0.1 per year)
source: EuropePMC
Heart rhythm,
Volume 16, Issue 1, 29 5 2018, Pages 83-90
Defibrillation testing and clinical outcomes after implantable cardioverter-defibrillator implantation in patients in atrial fibrillation at the time of implant: An analysis from the SIMPLE trial.
Bogdan S, Glikson M, Connolly SJ, Wang J, Hohnloser SH, Appl U, Neuzener J, Mabo P, Vinolas X, Gadler F, van Erven L, Kautzner J, Meeks B, Pogue J, Healey JS
Background: The Shockless IMPLant Evaluation (SIMPLE) trial showed that defibrillation testing (DT) at the time of implantable cardioverter-defibrillator (ICD) implant did not improve shock efficacy or reduce mortality. There are no data regarding the risk of complications, including stroke, among patients with atrial fibrillation (AF) who undergo DT. Objective: The purpose of this prospectively planned substudy of SIMPLE was to evaluate the effect of DT vs no DT on clinical outcomes among patie...
Abstract
Cited 4 times since 2018 (0.6 per year)
source: EuropePMC
Journal of medical microbiology,
Volume 67, Issue 9, 27 4 2018, Pages 1348-1350
Mycoplasma amphoriforme vs M. pneumoniae: similarities and differences between patient characteristics in a regional hospital in the Netherlands.
van Schaik ML, Patberg KW, Wallinga JG, Wolfhagen MJHM, Bruijnesteijn van Coppenraet LES
Mycoplasma amphoriforme is a species closely related to Mycoplasma pneumoniae, thus far with unknown clinical impact. The application of optimized diagnostics, better capable of differentiating between these two micro-organisms, identified a significant patient population positive for M. amphoriforme. The PCR designed by Ling et al. was used on respiratory samples that originally tested positive for M. pneumoniae (n=78), and identified 29 retrospectively as M. amphoriforme. The aim of this study...
Abstract
Multimedia manual of cardiothoracic surgery : MMCTS,
Volume 2018, 26 4 2018
Subclavicular arteriovenous fistula for univentricular heart palliation.
Caldaroni F, Nevvazhay T, Vladimir S, Hazekamp M
Creation of a subclavicular arteriovenous fistula is a minimally invasive procedure that provides an additional source of arterial blood flow to the pulmonary arteries in patients who have a Glenn shunt but are unsuitable for or at high risk for Fontan completion.
Abstract
Cited 56 times since 2018 (8.1 per year)
source: EuropePMC
Nature communications,
Volume 9, Issue 1, 25 4 2018, Pages 2904
PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity.
van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin X, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kähönen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin H, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Silva Aldana CT, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Tarasov KV, Thorsteinsdottir U, Uitterlinden AG, Van Wagoner DR, Völke
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are over-represented in cardiac disease proc...
Abstract
Cited 10 times since 2018 (1.5 per year)
source: EuropePMC
Human pathology,
Volume 81, 25 4 2018, Pages 245-254
The theranostic target prostate-specific membrane antigen is expressed in medullary thyroid cancer.
Lodewijk L, Willems SM, Dreijerink KMA, de Keizer B, van Diest PJ, Schepers A, Morreau H, Bonenkamp HJ, Van Engen-van Grunsven IACH, Kruijff S, van Hemel BM, Links TP, Nieveen van Dijkum E, van Eeden S, Valk GD, Borel Rinkes IHM, Vriens MR
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 273, 24 4 2018, Pages 203-206
ECG derived ventricular gradient exceeds echocardiography in the early detection of pulmonary hypertension in scleroderma patients.
Meijer FMM, Kies P, Jongbloed MRM, van Wijngaarden SE, Swenne CA, Man S, Schalij MJ, de Vries-Bouwstra JK, Vliegen HW
Background: Patients with systemic sclerosis (SSc) are at risk for developing pulmonary hypertension (PH) which is a major cause of death in this population. Echocardiographic (TTE) derived pulmonary arterial pressure (PAP) can be unreliable for the early detection of PH. Previous studies demonstrate that the ECG derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) can detect PH in a heterogeneous population suspected of PH. The aim of this study is to assess...
Abstract
Cited 43 times since 2018 (6.3 per year)
source: EuropePMC
PLoS medicine,
Volume 15, Issue 7, 24 4 2018, Pages e1002614
High levels of sewage contamination released from urban areas after storm events: A quantitative survey with sewage specific bacterial indicators.
Olds HT, Corsi SR, Dila DK, Halmo KM, Bootsma MJ, McLellan SL
Background: Past studies have demonstrated an association between waterborne disease and heavy precipitation, and climate change is predicted to increase the frequency of these types of intense storm events in some parts of the United States. In this study, we examined the linkage between rainfall and sewage contamination of urban waterways and quantified the amount of sewage released from a major urban area under different hydrologic conditions to identify conditions that increase human risk of...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
European journal of preventive cardiology,
Volume 25, Issue 14, 23 4 2018, Pages 1523-1531
Combined use of polypill components in patients with type 2 diabetes mellitus.
Janssen VE, Visseren FL, de Boer A, Grobbee DE, Westerink J, van der Graaf Y, Lafeber M, SMART Study Group
Objectives A polypill containing aspirin, a statin and blood pressure (BP)-lowering agents has been proposed for the prevention of cardiovascular disease. To increase adherence and reduce the gaps between indicated and used therapy, a polypill might be of interest for patients with type 2 diabetes (T2DM). Our aim was to assess the prevalence of the combined use of polypill components in patients with T2DM over time. Methods The combined use of polypill components was assessed between 1996 and 20...
Abstract
Cited 14 times since 2018 (2 per year)
source: EuropePMC
BMJ quality & safety,
Volume 28, Issue 3, 21 3 2018, Pages 180-189
Connecting perspectives on quality and safety: patient-level linkage of incident, adverse event and complaint data.
de Vos MS, Hamming JF, Chua-Hendriks JJC, Marang-van de Mheen PJ
Background and objective: Incident, adverse event (AE) and complaint data are typically used separately, but may be related at the patient level with one event triggering a cascade of events, ultimately resulting in a complaint. This study examined relations between incidents, AEs and complaints that co-occurred in admissions. Methods: Independently and routinely collected incident, AE and complaint data were retrospectively linked for surgical admissions in an academic centre (2008-2014). Two i...
Abstract
Cited 8 times since 2018 (1.2 per year)
source: EuropePMC
Clinical and experimental rheumatology,
Volume 36 Suppl 113, Issue 4, 18 3 2018, Pages 109-117
To what extent do autoantibodies help to identify high-risk patients in systemic sclerosis?
Boonstra M, Mertens BJA, Bakker JA, Ninaber MK, Ajmone Marsan N, van der Helm-van Mil AHM, Scherer HU, Huizinga TWJ, de Vries-Bouwstra JK
Objectives: To evaluate the additive value of autoantibodies in identifying systemic sclerosis (SSc) patients with high complication risk. Methods: Patients entering the Combined Care In SSc cohort, Leiden University Medical Centre between April 2009 and May 2016 were included. Subgroups of patients were determined using hierarchical clustering, performed on Principal Component Analysis scores, 1) using baseline data of demographic and clinical variables only and 2) with additional use of antibo...
Abstract
Cited 18 times since 2018 (2.6 per year)
source: EuropePMC
PLoS genetics,
Volume 14, Issue 7, 18 3 2018, Pages e1007527
Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σV in response to lysozyme.
Lewerke LT, Kies PJ, Müh U, Ellermeier CD
Extra Cytoplasmic Function (ECF) σ factors are a diverse group of alternate σ factors bacteria use to respond to changes in the environment. The Bacillus subtilis ECF σ factor σV responds to lysozyme. In the absence of lysozyme, σV is held inactive by the anti-σ factor, RsiV. In the presence of lysozyme RsiV is degraded via regulated intramembrane proteolysis, which results in the release of σV and thus activation of lysozyme resistance genes. Signal peptidase is required to initiate degradation...
Abstract
Cited 37 times since 2018 (5.4 per year)
source: EuropePMC
Genome biology,
Volume 19, Issue 1, 17 3 2018, Pages 87
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM, Gasparini P, Gudbjartsson DF, Gudnason V, Hansen T, Kääb S,
Background: Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding regions and their underlying mechanisms remain unclear. Results: Here, we identify putative functional coding variation associated with changes in the QRS interval duration by combining Illumina HumanExome Bead...
Abstract
Cited 7 times since 2018 (1 per year)
source: EuropePMC
Heart rhythm,
Volume 15, Issue 12, 12 2 2018, Pages 1816-1822
Impact of atrial fibrillation on improvement of functional mitral regurgitation in cardiac resynchronization therapy.
van der Bijl P, Vo NM, Leung M, Ajmone Marsan N, Delgado V, Stone GW, Bax JJ
Background: Functional mitral regurgitation (FMR) and atrial fibrillation (AF) are frequent heart failure (HF) complications. Cardiac resynchronization therapy (CRT) can improve FMR; however, little is known about the influence of AF on FMR improvement. Objective: The purpose of this study was to investigate the mechanisms and impact of baseline AF on FMR improvement after CRT. Methods: CRT recipients with HF, AF, or sinus rhythm (SR) at baseline with moderate or severe FMR, were included from a...
Abstract
Cited 3 times since 2018 (0.4 per year)
source: EuropePMC
Pharmacogenomics,
Volume 19, Issue 11, 11 2 2018, Pages 895-903
CYP3A5 and ABCB1 polymorphisms in living donors do not impact clinical outcome after kidney transplantation.
Yang L, de Winter BC, van Schaik RH, Xie RX, Li Y, Andrews LM, Shuker N, Bahmany S, Koch B, van Gelder T, Hesselink DA
Aim: To investigate the association between donor CYP3A5 and ABCB1 polymorphisms and tacrolimus (Tac)-induced nephrotoxicity and renal function in kidney transplant recipients. Methods: The CYP3A5 6986A>G and ABCB1 3435C>T polymorphisms were determined in 237 recipients and donors. Results: There was no significant association between Tac-related nephrotoxicity and donor CYP3A5 and ABCB1 genotype. The donor ABCB1 3435C>T polymorphism was associated with estimated glomerular filtration r...
Abstract
Cited 37 times since 2018 (5.4 per year)
source: EuropePMC
The Lancet. Neurology,
Volume 17, Issue 8, 9 2 2018, Pages 689-698
Oral fingolimod for chronic inflammatory demyelinating polyradiculoneuropathy (FORCIDP Trial): a double-blind, multicentre, randomised controlled trial.
Hughes R, Dalakas MC, Merkies I, Latov N, Léger JM, Nobile-Orazio E, Sobue G, Genge A, Cornblath D, Merschhemke M, Ervin CM, Agoropoulou C, Hartung HP, FORCIDP Trial Investigators
Background: Fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis and was effective in experimental autoimmune neuritis in rats, a possible model for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to evaluate the efficacy of fingolimod in delaying disability progression in patients with CIDP who withdrew from currently effective treatments (intravenous immunoglobulin [IVIg] or corticosteroids). Methods: This double-blind, multicentre, rand...
Abstract
