Research

Publications

Below you can find a list of our published research.

6221 results

Cited 6 times since 1997 (0.2 per year) source: EuropePMC

Circulation, Volume 96, Issue 3, 1 1 1997, Pages 1025-1030 Hemodynamic effects of chronic prenatal ventricular pacing for the treatment of complete atrioventricular block. Liddicoat JR, Klein JR, Reddy VM, Klautz RJ, Teitel DF, Hanley FL

Background: Increasing the heart rate of the fetus with cardiac failure caused by complete AV block (CAVB) may allow delivery of a full-term, stable neonate with preserved ventricular function. Direct fetal pacing may be a feasible method to achieve this, but the effect of pacing on the structure and function of the rapidly developing fetal heart is unknown. Methods and results: CAVB was created in fetal lambs at 80% gestation by cryoablating the AV node. Epicardial ventricular pacing at 130 bpm... Abstract

Cited 37 times since 1997 (1.3 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 64, Issue 2, 1 1 1997, Pages 521-525 Modified ultrafiltration after cardiopulmonary bypass in pediatric cardiac surgery. Draaisma AM, Hazekamp MG, Frank M, Anes N, Schoof PH, Huysmans HA

Background: Cardiopulmonary bypass in children results in considerable water retention, especially in neonates and small infants. Dilution of plasma proteins increases water loss into the extravascular compartments. Excessive total body water may prolong ventilatory support and may contribute to a prolongation of intensive care convalescence. After discontinuation of cardiopulmonary bypass, modified ultrafiltration can be used to withdraw plasma water from the total circulating volume. Methods:... Abstract

Cited 28 times since 1997 (1 per year) source: EuropePMC

The Prostate, Volume 32, Issue 3, 1 1 1997, Pages 196-204 Plasminogen activator and matrix metalloproteinase production and extracellular matrix degradation by rat prostate cancer cells in vitro: correlation with metastatic behavior in vivo. Quax PH, de Bart AC, Schalken JA, Verheijen JH

Background: The plasminogen activation (PA) and metalloproteinase (MMP) system are involved in tumor cell migration and invasion. Methods: The proteolytic activity of cell lines originating from the rat Dunning R-3327 prostate tumor was analyzed by measuring in vitro extracellular matrix degradation, enzyme activity, and mRNA levels of enzymes, inhibitors, and receptors, and compared with their known metastatic behavior in vivo. Results: Only the highly metastatic sublines AT-3, MATLu, and MATLy... Abstract

Cited 33 times since 1997 (1.2 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 78, Issue 2, 1 1 1997, Pages 880-886 The migration of human smooth muscle cells in vitro is mediated by plasminogen activation and can be inhibited by alpha2-macroglobulin receptor associated protein. Wijnberg MJ, Quax PH, Nieuwenbroek NM, Verheijen JH

The plasminogen activation system is thought to be important in cell migration processes. A role for this system during smooth muscle cell migration after vascular injury has been suggested from several animal studies. However, not much is known about its involvement in human vascular remodelling. We studied the involvement of the plasminogen activation system in human smooth muscle cell migration in more detail using an in vitro wound assay and a matrix invasion assay. Inhibition of plasmin act... Abstract

Cited 5 times since 1997 (0.2 per year) source: EuropePMC

European heart journal, Volume 18, Issue 8, 1 1 1997, Pages 1313-1321 Beneficial effect of enalapril on left ventricular remodelling in patients with a severe residual stenosis after acute anterior wall infarction. Baur LH, Schipperheyn JJ, van der Wall EE, van der Velde EA, Schalij MJ, van Eck-Smit BL, van der Laarse A, Voogd PJ, Sedney MI, Reiber JH, Bruschke AV

Objective: The present study was designed to evaluate the effects of early angiotensin converting enzyme (ACE) inhibition on left ventricular enlargement in patients with anterior wall infarction following reperfusion therapy. Methods: Seventy-one consecutive patients with an anterior wall myocardial infarction were randomly allocated to enalapril (n = 36) or placebo (n = 35). All patients received either thrombolytic therapy (n = 46) or underwent primary coronary angioplasty (n = 25). Medicatio... Abstract

Cited 9 times since 1997 (0.3 per year) source: EuropePMC

European journal of pediatrics, Volume 156, Issue 7, 1 1 1997, Pages 516-520 The value of MRI in diagnosing vascular abnormalities causing stridor. Beekman RP, Beek FJ, Hazekamp MG, Meijboom EJ

Unlabelled: In a 2 year period seven patients who presented with stridor, without respiratory compromise, and three patients without obstructive symptoms were prospectively selected, and underwent MRI. In eight patients with a vascular ring and a pulmonary sling, MRI delineated the vascular abnormality and normal great vessels were found in two patients. Conclusion: MRI successfully delineates the great vessels and demonstrates the presence of a vascular ring and pulmonary sling. Abstract

Cited 15 times since 1997 (0.5 per year) source: EuropePMC

Biochemical and biophysical research communications, Volume 236, Issue 3, 1 1 1997, Pages 544-548 Autosomal recessive liver phosphorylase kinase deficiency caused by a novel splice-site mutation in the gene encoding the liver gamma subunit (PHKG2). van Beurden EA, de Graaf M, Wendel U, Gitzelmann R, Berger R, van den Berg IE

To facilitate mutation analysis of patients with an autosomal recessive form of liver phosphorylase kinase deficiency, the genomic structure of the gene encoding the testis/liver gamma subunit (PHKG2) was established. The gene consist of 10 exons. The translation start site is located in exon 2. Analysis of DNA from two female siblings, affected with liver phosphorylase kinase deficiency, by exon specific amplification followed by direct sequencing, revealed a single donor splice site mutation i... Abstract

Cited 25 times since 1997 (0.9 per year) source: EuropePMC

Circulation, Volume 96, Issue 2, 1 1 1997, Pages 429-435 Functional evaluation of lipid-lowering therapy by pravastatin in the Regression Growth Evaluation Statin Study (REGRESS) Aengevaeren WR, Uijen GJ, Jukema JW, Bruschke AV, van der Werf T

Background: Lipid-lowering therapy during 2 years in the Regression Growth Evaluation Statin Study (REGRESS) was associated with less progression of coronary atherosclerosis in the pravastatin group compared with the placebo group. The effect of lipid-lowering therapy on the functional state of the coronary circulation is less well known. The purpose of this study was to evaluate this effect. Methods and results: In a substudy of REGRESS, 69 patients were randomized to pravastatin or placebo. Th... Abstract

Cited 9 times since 1997 (0.3 per year) source: EuropePMC

International journal of cardiac imaging, Volume 13, Issue 3, 1 1 1997, Pages 179-189 Ischemic heart disease: value of MR techniques. van der Wall EE, van Rugge FP, Vliegen HW, Reiber JH, de Roos A, Bruschke AV

Background: The cardiovascular applications of magnetic resonance (MR) techniques in coronary artery disease have increased considerably in recent years. Technical advantages of MR imaging are the excellent spatial resolution, the characterization of myocardial tissue, and the potential for three-dimensional imaging. These characteristics allow the accurate assessment of left ventricular mass and volume, the differentiation of infarcted from normal tissue, and the determination of systolic wall... Abstract

Cited 144 times since 1997 (5.1 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 94, Issue 11, 1 1 1997, Pages 5843-5847 Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. Danen-Van Oorschot AA, Fischer DF, Grimbergen JM, Klein B, Zhuang S, Falkenburg JH, Backendorf C, Quax PH, Van der Eb AJ, Noteborn MH

The chicken anemia virus protein apoptin induces a p53-independent, Bcl-2-insensitive type of apoptosis in various human tumor cells. Here, we show that, in vitro, apoptin fails to induce programmed cell death in normal lymphoid, dermal, epidermal, endothelial, and smooth-muscle cells. However, when normal cells are transformed they become susceptible to apoptosis by apoptin. Long-term expression of apoptin in normal human fibroblasts revealed that apoptin has no toxic or transforming activity i... Abstract

Cited 20 times since 1997 (0.7 per year) source: EuropePMC

Theriogenology, Volume 47, Issue 6, 1 1 1997, Pages 1275-1295 Equine arteritis virus. Glaser AL, Chirnside ED, Horzinek MC, de Vries AA

Equine arteritis virus (EAV) is a small, enveloped, positive-stranded RNA virus, in the family Arteriviridae , W.H.ich can infect both horses and donkeys. While the majority of EAV infections are asymptomatic, acutely infected animals may develop a wide range of clinical signs, including pyrexia, limb and ventral edema, depression, rhinitis, and conjunctivitis. The virus may cause abortion and has caused mortality in neonates. After natural EAV infection, most horses develop a solid, long-term i... Abstract

Cited 16 times since 1997 (0.6 per year) source: EuropePMC

Pediatric research, Volume 41, Issue 3, 1 1 1997, Pages 321-326 Oxidative stress during post-hypoxic-ischemic reperfusion in the newborn lamb: the effect of nitric oxide synthesis inhibition. Dorrepaal CA, van Bel F, Moison RM, Shadid M, van de Bor M, Steendijk P, Berger HM

Post-hypoxic-ischemic (HI) reperfusion induces endothelium and neurons to produce excessive amounts of nitric oxide and superoxide, leading to peroxynitrite formation, release of protein-bound metal ions (i.e. iron), and cytotoxic oxidants. We produced severe HI in 18 newborn lambs and serially determined plasma prooxidants (non-protein-bound iron), lipid peroxidation (malondialdehyde), and antioxidative capacity [ratio of ascorbic acid/dehydroascorbic acid (AA/DHA), alpha-tocopherol, sulfhydryl... Abstract

Cited 77 times since 1997 (2.7 per year) source: EuropePMC

The American journal of cardiology, Volume 79, Issue 6, 1 1 1997, Pages 773-776 Value of fast gradient echo magnetic resonance angiography as an adjunct to coronary arteriography in detecting and confirming the course of clinically significant coronary artery anomalies. Vliegen HW, Doornbos J, de Roos A, Jukema JW, Bekedam MA, van der Wall EE

We investigated the additional value of magnetic resonance (MR) angiography in 12 patients with clinically significant coronary anomalies. In 5 patients, the referring cardiologist requested additional evaluation because coronary arteriography was inconclusive about the course of the anomaly. For comparison, 7 patients with known anomalous coronary arteries were collected from our database. In these patients, there had been no doubt about the course of the anomalous coronary arteries. MR angiogr... Abstract

Cited 96 times since 1997 (3.4 per year) source: EuropePMC

Circulation, Volume 95, Issue 4, 1 1 1997, Pages 924-931 Detection and quantification of dysfunctional myocardium by magnetic resonance imaging. A new three-dimensional method for quantitative wall-thickening analysis. Holman ER, Buller VG, de Roos A, van der Geest RJ, Baur LH, van der Laarse A, Bruschke AV, Reiber JH, van der Wall EE

Background: Regional left ventricular dysfunction is a major consequence of myocardial ischemia, and its extent determines long-term prognosis. Accurate and reproducible analysis of left ventricular dysfunction is therefore useful for risk stratification and patient management. Methods and results: Short-axis cardiac cine magnetic resonance (MR) imaging was performed in 25 patients after anterior myocardial infarction at 21 +/- 2.1 days after the acute onset. The MR images were analyzed with the... Abstract

Cited 19 times since 1997 (0.7 per year) source: EuropePMC

British journal of rheumatology, Volume 36, Issue 1, 1 1 1997, Pages 9-15 Bone matrix degradation by the plasminogen activation system. Possible mechanism of bone destruction in arthritis. Ronday HK, Smits HH, Quax PH, van der Pluijm G, Löwik CW, Breedveld FC, Verheijen JH

The observed increase in urokinase-type plasminogen activator (u-PA) and its receptor (u-PAR) in synovial tissue of patients with rheumatoid arthritis (RA) suggests pathophysiological involvement of the plasminogen activation (PA) system in inflammatory joint disease. In the present study, we investigated the capacity of the PA system to degrade non-mineralized and mineralized bone-like matrix in vitro as a model for bone destruction. Transfected mouse LB6 cell lines, that expressed either human... Abstract

Cited 3 times since 1997 (0.1 per year) source: EuropePMC

Tijdschrift voor diergeneeskunde, Volume 122, Issue 1, 1 1 1997, Pages 2-7 [Equine arteritis virus: clinical symptoms and prevention]. Glaser AL, de Vries AA, Rottier PJ, Horzinek MC, Colenbrander B

Sero-epidemiological surveys have revealed that equine arteritis virus (EAV) is prevalent in most European countries. The virus causes sporadic cases of respiratory disease and abortion in horses, the incidence of which has increased in recent years. Mares and geldings eliminate virus after acute infection, but 30% to 60% of stallions become persistently infected. In these animals, EAV is maintained within the reproductive tract and is shed continuously in the semen. Persistent infection with EA... Abstract

Cited 2 times since 1997 (0.1 per year) source: EuropePMC

Pediatric research, Volume 41, Issue 1, 1 1 1997, Pages 57-64 Perinatal left ventricular performance in fetal sheep: interaction between oxygen ventilation and contractility. Berning RA, Klautz RJ, Teitel DF

Left ventricular (LV) output nearly triples at birth, in association with increases in serum catecholamines. Similar increases in catecholamines in utero, however, do not increase output. We hypothesized that catecholamines increase contractility in utero, but that output cannot increase until LV loading conditions are changed by oxygen ventilation. To address this hypothesis, we studied nine fetal sheep acutely placed in a warm water bath (40 degrees C). Conductance and manometric catheters wer... Abstract

Cited 1 times since 1997 (0 per year) source: EuropePMC

Biology of the neonate, Volume 72, Issue 4, 1 1 1997, Pages 227-234 Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need. de Beaufort AJ, Lopes Cardozo RH, Dorrepaal CA, Steendijk P, Van Der Velde ET, Van Bel F

Inhibition of nitric oxide (NO) production may reduce post-hypoxic-ischemic (HI) neonatal brain damage, but may also induce pulmonary hypertension by inhibiting endogenous NO production in the pulmonary vascular bed. The aim of this study was to evaluate the effect of nitric oxide inhibition on pulmonary artery pressure and oxygen need after hypoxic ischemia. Severe HI was produced in 18 newborn lambs. After completion of HI the lambs were divided into three groups of 6 animals receiving either... Abstract

Cited 8 times since 1997 (0.3 per year) source: EuropePMC

Advances in peritoneal dialysis. Conference on Peritoneal Dialysis, Volume 13, 1 1 1997, Pages 72-76 Restriction coefficients of low molecular weight solutes and macromolecules during peritoneal dialysis. Ho-dac-Pannekeet MM, Koopmans JG, Struijk DG, Krediet RT

The intrinsic permeability of the peritoneal membrane can be functionally represented by the restriction coefficient (RC). The RC can be calculated as the exponent of the power relation between the mass transfer area coefficients (MTACs) of various solutes and their free diffusion coefficients in water. When the RC = 1.0, transport is determined by free diffusion only, as is expected for low molecular weight (LMW) solutes. A RC > 1.0 suggests that transport is restricted by the peritoneal mem... Abstract

Cited 14 times since 1997 (0.5 per year) source: EuropePMC

British journal of cancer, Volume 75, Issue 10, 1 1 1997, Pages 1447-1453 Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan. Borel Rinkes IH, de Vries MR, Jonker AM, Swaak TJ, Hack CE, Nooyen PT, Wiggers T, Eggermont AM

Isolated limb perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan is well tolerated and highly effective in irresectable sarcoma and melanoma. No data are available on isolated hepatic perfusion (IHP) with these drugs for irresectable hepatic malignancies. This study was undertaken to assess the feasibility of such an approach by analysing hepatic and systemic toxicity of IHP with TNF-alpha with and without melphalan in pigs. Ten healthy pigs underwent IHP. After vascular isola... Abstract