Research

Publications

Below you can find a list of our published research.

9618 results

Cited 43 times since 2011 (3.1 per year) source: EuropePMC

PloS one, Volume 6, Issue 9, 28 4 2011, Pages e25244 High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa. Kranzer K, van Schaik N, Karmue U, Middelkoop K, Sebastian E, Lawn SD, Wood R, Bekker LG

Objectives: To measure HIV prevalence and uptake of HIV counseling and testing (HCT) in a peri-urban South African community. To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test Methods: A random sample of 10% of the adult population (≥15 years) were invited to attend a mobile HCT service. Study procedures included a questionnaire, HIV testing and CD4 counts. Predictors for previous testing were dete... Abstract

Cited 31 times since 2011 (2.2 per year) source: EuropePMC

American journal of physiology. Lung cellular and molecular physiology, Volume 302, Issue 1, 23 4 2011, Pages L56-67 Phosphodiesterase 4 inhibition attenuates persistent heart and lung injury by neonatal hyperoxia in rats. de Visser YP, Walther FJ, Walther FJ, Laghmani el H, Steendijk P, Middeldorp M, van der Laarse A, Wagenaar GT

Phosphodiesterase (PDE) 4 inhibitors are potent anti-inflammatory drugs with antihypertensive properties, and their therapeutic role in bronchopulmonary dysplasia (BPD) is still controversial. We studied the role of PDE4 inhibition with piclamilast on normal lung development and its therapeutic value on pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) in neonatal rats with hyperoxia-induced lung injury, a valuable model for premature infants with severe BPD. The cardiopulmonar... Abstract

Cited 2 times since 2011 (0.1 per year) source: EuropePMC

Revista espanola de cardiologia, Volume 64, Issue 11, 22 4 2011, Pages 1035-1044 [Three-dimensional imaging in cardiac resynchronization therapy]. Auger D, Schalij MJ, Bax JJ, Delgado V

Cardiac resynchronization therapy improves clinical symptoms and prognosis of heart failure patients. However, it has been shown that up to 40% of patients do not respond to this therapy. Three main determinants of cardiac resynchronization therapy response have been identified: left ventricular dyssynchrony, left ventricular lead position, and extent and location of myocardial scar tissue. Two-dimensional echocardiography is the first imaging technique to evaluate patients who may be candidates... Abstract

Cited 179 times since 2011 (12.9 per year) source: EuropePMC

PLoS genetics, Volume 7, Issue 9, 22 4 2011, Pages e1002260 Large-scale gene-centric analysis identifies novel variants for coronary artery disease. IBC 50K CAD Consortium

Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European desc... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Atherosclerosis, Volume 220, Issue 2, 21 3 2011, Pages 413-417 Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, Ford I, Jukema JW, de Craen AJ, Westendorp RG, Shepherd J, Packard C, Buckley BM, Schaefer EJ

Our goal was to determine whether genetic variation at genes affecting statin metabolism or targets of statin therapy would influence low density lipoprotein (LDL) cholesterol lowering with pravastatin, baseline heart disease, or cardiac endpoints on trial. We examined associations of single nucleotide polymorphisms (SNPs) at the liver X receptor alpha (LXRA, rs12221497), and the solute carrier organic anion transporter (SLCO1B1, rs4149056 and rs2306283) gene loci with these variables. We studie... Abstract

Cited 82 times since 2011 (5.9 per year) source: EuropePMC

The breast journal, Volume 17, Issue 6, 21 3 2011, Pages 661-668 Methotrexate in the management of idiopathic granulomatous mastitis: review of 108 published cases and report of four cases. Akbulut S, Yilmaz D, Bakir S

This study aimed to discuss the role of agents, such as steroids and methotrexate (MTX), in the treatment of patients with idiopathic granulomatous mastitis (IGM). Using Pubmed and Google Scholar data bases, a retrospective study was carried out on IGM cases treated with steroids and/or MTX between 1972 and 2010. Four IGM cases treated with MTX at our clinic were also summarized in this study. A total of 541 IGM cases since 1972, including ours, were retrospectively analyzed. Steroid treatment 5... Abstract

Cited 23 times since 2011 (1.7 per year) source: EuropePMC

Blood, Volume 118, Issue 20, 21 3 2011, Pages 5613-5621 High BRE expression predicts favorable outcome in adult acute myeloid leukemia, in particular among MLL-AF9-positive patients. Noordermeer SM, Sanders MA, Gilissen C, Tönnissen E, van der Heijden A, Döhner K, Bullinger L, Jansen JH, Valk PJ, van der Reijden BA

Aberrations in protein ubiquitination have recently been identified in the pathogenesis of acute myeloid leukemia (AML). We studied whether expression changes of more than 1600 ubiquitination related genes correlated with clinical outcome in 525 adult AML patients. High expression of one of these genes, BRE, was observed in 3% of the cases and predicted favorable prognosis independently of known prognostic factors (5-year overall survival: 57%). Remarkably, unsupervised expression profiling show... Abstract

Cited 28 times since 2011 (2 per year) source: EuropePMC

Journal of agricultural and food chemistry, Volume 59, Issue 19, 19 3 2011, Pages 10564-10571 Genotype and environment effects on the contents of vitamins B1, B2, B3, and B6 in wheat grain. Shewry PR, Van Schaik F, Ravel C, Charmet G, Rakszegi M, Bedo Z, Ward JL

The total contents of thiamine (vitamin B1), riboflavin (B2), and pyridoxine (B6) and the bioavailable forms of niacin (B3) were determined on wholemeal flours of 24 winter wheat varieties grown on four sites (United Kingdom, Poland, France, and Hungary) in 2007 and of two spring varieties grown on the same sites with the exception of Poland. The contents of vitamins B1 (5.53-13.55 μg/g dw), B2 (0.77-1.40 μg/g dw), and B6 (1.27-2.97 μg/g dw) were within the ranges reported previously, while the... Abstract

Cited 117 times since 2011 (8.4 per year) source: EuropePMC

Animal cognition, Volume 15, Issue 2, 17 3 2011, Pages 223-238 How does cognition evolve? Phylogenetic comparative psychology. MacLean EL, Matthews LJ, Hare BA, Nunn CL, Anderson RC, Aureli F, Brannon EM, Call J, Drea CM, Emery NJ, Haun DB, Herrmann E, Jacobs LF, Platt ML, Rosati AG, Sandel AA, Schroepfer KK, Seed AM, Tan J, van Schaik CP, Wobber V

Now more than ever animal studies have the potential to test hypotheses regarding how cognition evolves. Comparative psychologists have developed new techniques to probe the cognitive mechanisms underlying animal behavior, and they have become increasingly skillful at adapting methodologies to test multiple species. Meanwhile, evolutionary biologists have generated quantitative approaches to investigate the phylogenetic distribution and function of phenotypic traits, including cognition. In part... Abstract

Cited 64 times since 2011 (4.6 per year) source: EuropePMC

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, Volume 30, Issue 12, 17 3 2011, Pages 1352-1359 Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients. Gijsen V, Mital S, van Schaik RH, Soldin OP, Soldin SJ, van der Heiden IP, Nulman I, Koren G, de Wildt SN

Background: Tacrolimus is one of the commonly used immunosuppressive drugs for pediatric heart transplants. Large variation exists in pharmacokinetics during the direct post-transplant period, resulting in an increased risk of adverse events. Limited data are available on the interaction of age, CYP3A5 and ABCB1 genotype, and disease severity on the variation in disposition and outcome in pediatric heart transplant recipients. Method: We studied the relationship between age and CYP3A5 and ABCB1... Abstract

Cited 54 times since 2011 (3.9 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 96, Issue 11, 14 2 2011, Pages 3381-3389 Improved control of severe hypoglycemia in patients with malignant insulinomas by peptide receptor radionuclide therapy. van Schaik E, van Vliet EI, Feelders RA, Krenning EP, Khan S, Kamp K, Valkema R, van Nederveen FH, Teunissen JJ, Kwekkeboom DJ, de Herder WW

Context: Insulinomas are relatively rare neuroendocrine tumors of the pancreas. Only 10% are considered malignant. Control of insulin hypersecretion and hypoglycemia in patients with malignant insulinomas may be extremely difficult. Different medications and chemotherapy schedules have been used. Patients: Five patients with metastatic insulinomas and severe, poorly controllable, hypoglycemia are described. These patients required continuous glucose infusion to control severe hypoglycemia, which... Abstract

Cited 16 times since 2011 (1.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 98, Issue 3, 13 2 2011, Pages 232-237 Age- and gender-specific differences in the prognostic value of CT coronary angiography. Yiu KH, de Graaf FR, Schuijf JD, van Werkhoven JM, Marsan NA, Veltman CE, de Roos A, Pazhenkottil A, Kroft LJ, Boersma E, Herzog B, Leung M, Maffei E, Leung DY, Kaufmann PA, Cademartiri F, Bax JJ, Jukema JW

Objective: To evaluate the potential age- and gender-specific differences in the incidence and prognostic value of coronary artery disease (CAD) in patients undergoing CT coronary angiography (CTA). Design and patients: In this multicentre prospective registry study, 2432 patients (mean age 57 ± 12, 56% male) underwent CTA for suspected CAD. Patients were stratified into four groups according to age Abstract

Cited 190 times since 2011 (13.6 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 9, Issue 1, 13 2 2011, Pages 53-62 Restenosis after PCI. Part 1: pathophysiology and risk factors. Jukema JW, Verschuren JJ, Ahmed TA, Quax PH

Restenosis is a complex disease for which the pathophysiological mechanisms have not yet been fully elucidated, but are thought to include inflammation, proliferation, and matrix remodeling. Over the years, many predictive clinical, biological, (epi)genetic, lesion-related, and procedural risk factors for restenosis have been identified. These factors are not only useful in risk stratification of patients, they also contribute to our understanding of this condition. Furthermore, these factors pr... Abstract

Cited 9 times since 2011 (0.6 per year) source: EuropePMC

Environmental toxicology, Volume 28, Issue 11, 13 2 2011, Pages 644-651 Sublethal toxicity of esbiothrin relationship with total antioxidant status and in vivo genotoxicity assessment in fish (Cyprinus carpio L., 1758) using the micronucleus test and comet assay. Selvi M, Cavaş T, Cağlan Karasu Benli A, Koçak Memmi B, Cinkılıç N, Dinçel AS, Vatan O, Yılmaz D, Sarıkaya R, Zorlu T, Erkoç F

Esbiothrin, synthetic pyrethroid with quick activity against insects, is widely used against household pests and in public health. Despite widespread use, data on ecotoxicity and genotoxic effects are extremely scarce. The aim of the present study is to evaluate the genotoxic potential of esbiothrin on a model fish species Cyprinus carpio L., 1758 (Pisces: Cyprinidae, koi) using the micronucleus test and comet assay in peripheral blood erythrocytes. Effects of two sublethal exposure concentratio... Abstract

Cited 65 times since 2011 (4.7 per year) source: EuropePMC

Evolution; international journal of organic evolution, Volume 66, Issue 1, 13 2 2011, Pages 191-199 Large brains buffer energetic effects of seasonal habitats in catarrhine primates. van Woerden JT, Willems EP, van Schaik CP, Isler K

Ecological factors have been shown to be important for brain size evolution. In this comparative study among catarrhine primates, we examine two different ways in which seasonality may be related to brain size. First, seasonality may impose energetic constraints on the brain because it forces animals to deal with periods of food scarcity (Expensive Brain hypothesis). Second, seasonality may act as a selective pressure to increase brain size, as behavioral flexibility helps to overcome periods of... Abstract

Cited 25 times since 2011 (1.8 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 1, 13 2 2011, Pages 66-73 Prophylactic implantable cardioverter-defibrillator treatment in the elderly: therapy, adverse events, and survival gain. van Rees JB, Borleffs CJ, Thijssen J, de Bie MK, van Erven L, Cannegieter SC, Bax JJ, Schalij MJ

Aims: In elderly patients, obscurity remains regarding the benefit of implantable cardioverter-defibrillator (ICD) treatment as primary prevention of sudden cardiac death. This study assesses implant rates, therapy, adverse events, and survival gain in the elderly primary prevention ICD patient. Methods and results: A total of 1395 patients treated with an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center were included and allocated to three groups accord... Abstract

Cited 16 times since 2011 (1.1 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 23, Issue 1, 13 2 2011, Pages 74-80 Toward magnetic resonance-guided electroanatomical voltage mapping for catheter ablation of scar-related ventricular tachycardia: a comparison of registration methods. Tao Q, Milles J, VAN Huls VAN Taxis C, Lamb HJ, Reiber JH, Zeppenfeld K, VAN DER Geest RJ

Introduction: Integration of preprocedural delayed enhanced magnetic resonance imaging (DE-MRI) with electroanatomical voltage mapping (EAVM) may provide additional high-resolution substrate information for catheter ablation of scar-related ventricular tachycardias (VT). Accurate and fast image integration of DE-MRI with EAVM is desirable for MR-guided ablation. Methods and results: Twenty-six VT patients with large transmural scar underwent catheter ablation and preprocedural DE-MRI. With diffe... Abstract

Cited 31 times since 2011 (2.2 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 25, Issue 12, 12 2 2011, Pages 4445-4456 CodY regulation is required for full virulence and heme iron acquisition in Bacillus anthracis. Château A, van Schaik W, Six A, Aucher W, Fouet A

Capsule and toxin are the major virulence factors of Bacillus anthracis. The B. anthracis pleiotropic regulator CodY activates toxin gene expression by post-translationally regulating the accumulation of the global regulator AtxA. However, the role of CodY on B. anthracis capsulation and virulence of encapsulated strains has been unknown. The role of CodY in B. anthracis virulence was studied in mouse and guinea pig models. Spore outgrowth and dissemination of the vegetative cells was followed i... Abstract

Cited 325 times since 2011 (23.3 per year) source: EuropePMC

Nature genetics, Volume 43, Issue 10, 11 2 2011, Pages 1005-1011 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dörr M, Bis JC, Aspelund T, Esko T, Janssens AC, Zhao JH, Heath S, Laan M, Fu J, Pistis G, Luan J, Arora P, Lucas G, Pirastu N, Pichler I, Jackson AU, Webster RJ, Zhang F, Peden JF, Schmidt H, Tanaka T, Campbell H, Igl W, Milaneschi Y, Hottenga JJ, Vitart V, Chasman DI, Trompet S, Bragg-Gresham JL, Alizadeh BZ, Chambers JC, Guo X, Lehtimäki T, Kühnel B, Lopez LM, Polašek O, Boban M, Nelson CP, Morrison AC, Pihur V, Ganesh SK, Hofman A, Kundu S, Mattace-Raso FU, Rivadeneira F, Sijbrands EJ, Uitterlinden AG, Hwang SJ, Vasan RS, Wang TJ, Bergmann S, Vollenweider P, Waeber G, Laitinen J, Pouta A, Zitting P, McArdle WL, Kroemer HK, Völker U, Völzke H, Glazer NL, Taylor KD, Harris TB, Alavere H, Haller T, Keis A, Tammesoo ML, Aulchenko Y, Barroso I, Khaw KT, Galan P, Hercberg S, Lathrop M, Eyheramendy S, Org E, Org E, Sõber S, Lu X, Nolte IM, Penninx BW, Corre T,

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31... Abstract

Cited 57 times since 2011 (4.1 per year) source: EuropePMC

PloS one, Volume 6, Issue 9, 9 2 2011, Pages e24164 Human embryonic and fetal mesenchymal stem cells differentiate toward three different cardiac lineages in contrast to their adult counterparts. Ramkisoensing AA, Pijnappels DA, Askar SF, Passier R, Swildens J, Goumans MJ, Schutte CI, de Vries AA, Scherjon S, Mummery CL, Schalij MJ, Atsma DE

Mesenchymal stem cells (MSCs) show unexplained differences in differentiation potential. In this study, differentiation of human (h) MSCs derived from embryonic, fetal and adult sources toward cardiomyocytes, endothelial and smooth muscle cells was investigated. Labeled hMSCs derived from embryonic stem cells (hESC-MSCs), fetal umbilical cord, bone marrow, amniotic membrane and adult bone marrow and adipose tissue were co-cultured with neonatal rat cardiomyocytes (nrCMCs) or cardiac fibroblasts... Abstract