9618 results
Cited 25 times since 2011 (1.8 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 24, Issue 11, 9 2 2011, Pages 1183-1190
Real-time three-dimensional echocardiography: segmental analysis of the right ventricle in patients with repaired tetralogy of fallot.
van der Hulst AE, Roest AA, Holman ER, de Roos A, Blom NA, Bax JJ, Delgado V
Background: The accurate assessment of right ventricular (RV) function and dimensions has important prognostic implications in patients with repaired tetralogy of Fallot (ToF). Three-dimensional imaging is the preferred methodology to evaluate RV function. Novel postprocessing software applications to evaluate three-dimensional data have provided insight into RV function and dimensions by analyzing the various RV components (inlet, apical trabecular, outlet). The aim of this study was to charact...
Abstract
Cited 10 times since 2011 (0.7 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 143, Issue 3, 9 2 2011, Pages 569-575
Exercise capacity and cardiac reserve in children and adolescents with corrected pulmonary atresia with intact ventricular septum after univentricular palliation and biventricular repair.
Romeih S, Groenink M, Roest AA, van der Plas MN, Hazekamp MG, Mulder BJ, Blom NA
Objective: Management of pulmonary atresia with intact ventricular septum is challenging and depends on the severity of right ventricular hypoplasia. Clinical outcomes of biventricular repair seem favorable to univentricular palliation, but data on superiority of biventricular repair regarding exercise capacity are conflicting. We investigated the response to physical and pharmacologic stress in patients with surgically corrected pulmonary atresia with intact ventricular septum. Methods: Sixteen...
Abstract
Cited 29 times since 2011 (2.1 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 52, Issue 10, 9 2 2011, Pages 1559-1565
Cardiac sympathetic dysfunction in genotyped patients with arrhythmogenic right ventricular cardiomyopathy and risk of recurrent ventricular tachyarrhythmias.
Paul M, Wichter T, Kies P, Gerss J, Wollmann C, Rahbar K, Eckardt L, Breithardt G, Schober O, Schulze-Bahr E, Schäfers M
Unlabelled: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) typically present with ventricular tachyarrhythmias preferentially triggered by an elevated sympathetic tone. Previous studies demonstrated an impairment of the presynaptic catecholamine reuptake as assessed by (123)I-labeled norepinephrine analog on metaiodobenzylguanidine ((123)I-MIBG) SPECT. Mutations in the gene encoding for plakophilin-2 (PKP-2) are the most common cause of autosomal dominant ARVC (ARVC-9). In...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 108, Issue 12, 8 2 2011, Pages 1689-1696
Prevalence of dyssynchrony and relation with long-term outcome in patients after acute myocardial infarction.
Antoni ML, Boden H, Hoogslag GE, Ewe SH, Auger D, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, Delgado V
The impact of left ventricular (LV) dyssynchrony on the long-term outcomes of patients with acute myocardial infarction (AMI) remains unknown. The purpose of the present study was to evaluate the prevalence of LV dyssynchrony after AMI and the potential relation with adverse events. A total of 976 consecutive patients admitted with AMI treated with primary percutaneous coronary intervention were evaluated. Two-dimensional echocardiography was performed
Abstract
Cited 112 times since 2011 (8 per year)
source: EuropePMC
Pharmacogenomics,
Volume 12, Issue 10, 8 2 2011, Pages 1383-1396
Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients.
Elens L, van Schaik RH, Panin N, de Meyer M, Wallemacq P, Lison D, Mourad M, Haufroid V
Aims: CYP3A4 is involved in the oxidative metabolism of many drugs and xenobiotics including the immunosuppressants tacrolimus (Tac) and cyclosporine (CsA). The objective of the study was to assess the potential influence of a new functional SNP in CYP3A4 on the pharmacokinetic parameters assessed by dose requirements and trough blood levels of both calcineurin inhibitors (CNI) in stable renal transplant patients. Patients & methods: A total of 99 stable renal transplant patients receiving e...
Abstract
Cited 174 times since 2011 (12.5 per year)
source: EuropePMC
Clinical chemistry,
Volume 57, Issue 11, 8 2 2011, Pages 1574-1583
A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.
Elens L, Bouamar R, Hesselink DA, Haufroid V, van der Heiden IP, van Gelder T, van Schaik RH
Background: Tacrolimus (Tac) is a potent immunosuppressant with considerable toxicity. Tac pharmacokinetics varies between individuals and thus complicates its use in preventing rejection after kidney transplantation. This variability might be caused by genetic polymorphisms in metabolizing enzymes. Methods: We used TaqMan analyses to evaluate the impact of a newly discovered CYP3A4 (cytochrome P450, family 3, subfamily A, polypeptide 4) single-nucleotide polymorphism (SNP) (rs35599367C>T; CY...
Abstract
Cited 66 times since 2011 (4.7 per year)
source: EuropePMC
Current opinion in virology,
Volume 1, Issue 6, 3 1 2011, Pages 635-642
Predicting 'airborne' influenza viruses: (trans-) mission impossible?
Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Herfst S, Fouchier RA
Repeated transmission of animal influenza viruses to humans has prompted investigation of the viral, host, and environmental factors responsible for transmission via aerosols or respiratory droplets. How do we determine-out of thousands of influenza virus isolates collected in animal surveillance studies each year-which viruses have the potential to become 'airborne', and hence pose a pandemic threat? Here, using knowledge from pandemic, zoonotic and epidemic viruses, we postulate that...
Abstract
Cited 50 times since 2011 (3.6 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 92, Issue 3, 1 1 2011, Pages 973-979
Thirty-year experience with the arterial switch operation.
Lalezari S, Bruggemans EF, Blom NA, Hazekamp MG
Background: We evaluated the results of the arterial switch operation (ASO) being performed at our institution for more than 30 years and identified risk factors for mortality and reoperation. Methods: Clinical outcome of 332 consecutive patients with transposition of the great arteries undergoing ASO was retrospectively analyzed, using surgical reports, medical charts, and latest follow-up echocardiography. Statistical analysis was performed using the Kaplan-Meier method and univariable and mul...
Abstract
Cited 32 times since 2011 (2.3 per year)
source: EuropePMC
Clinical endocrinology,
Volume 75, Issue 3, 1 1 2011, Pages 277-284
New therapeutic options for metastatic malignant insulinomas.
de Herder WW, van Schaik E, Kwekkeboom D, Feelders RA
Insulinomas are the most common, functioning, pancreatic neuroendocrine tumours. The great majority (>90%) of insulinomas are nonmetastatic at presentation and can be surgically cured. The
Abstract
Cited 9 times since 2011 (0.6 per year)
source: EuropePMC
International journal of phytoremediation,
Volume 13, Issue 8, 1 1 2011, Pages 805-817
Nickel-induced changes in lipid peroxidation, antioxidative enzymes, and metal accumulation in Lemna gibba.
Yilmaz DD, Parlak KU
In this study, an experiment was carried out to study the process of stress adaptation in Lemna gibba grown under nickel stress (0-20 mg Ni L(-1)). The results showed that Ni concentrations in plants increased with increasing Ni supply levels and reached a maximum of 142.82 mg.kg1 DW at 0.5 mg x L(-1) Ni treatments. The level of photosynthetic pigments (Chl a, Chi b, and total Chl) and soluble proteins increased upon exposure to high Ni concentrations. At the same time, the level of malondialdeh...
Abstract
Cited 14 times since 2011 (1 per year)
source: EuropePMC
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer,
Volume 6, Issue 9, 1 1 2011, Pages 1510-1515
Transesophageal ultrasound-guided fine-needle aspiration for the mediastinal restaging of non-small cell lung cancer.
von Bartheld MB, Versteegh MI, Braun J, Willems LN, Rabe KF, Annema JT
Introduction: Selected patients with stage III (N2/N3) non-small cell lung cancer (NSCLC) who are downstaged to N0 by chemoradiation therapy might benefit from subsequent surgical resection of the tumor. How mediastinal lymph nodes can be best reevaluated is subject of debate. Transesophageal ultrasound-guided fine-needle aspiration (EUS-FNA) is a minimally invasive technique to sample mediastinal nodes. We assessed sensitivity and false-negative rate of EUS-FNA for the mediastinal restaging of...
Abstract
Cited 17 times since 2011 (1.2 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 102, Issue 4, 31 5 2011, Pages 265-273
Relationship between somatic cell count status and subsequent clinical mastitis in Dutch dairy cows.
van den Borne BH, Vernooij JC, Lupindu AM, van Schaik G, Frankena K, Lam TJ, Nielen M
High composite somatic cell counts (CSCC) in dairy cows may develop into clinical mastitis (CM), suggesting that prevention or intervention of high CSCC may prevent CM later in lactation. The objective of this study was to quantify the relationship between high CSCC in dairy cows and the first subsequent case of CM in the same lactation. Farmer-diagnosed cases of CM and test day CSCC measurements during 1 year of 13,917 cows in 196 randomly selected Dutch dairy herds were available for analysis....
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Human molecular genetics,
Volume 20, Issue 23, 30 5 2011, Pages 4748-4757
A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention.
Sampietro ML, Trompet S, Verschuren JJ, Talens RP, Deelen J, Heijmans BT, de Winter RJ, Tio RA, Doevendans PA, Ganesh SK, Nabel EG, Westra HJ, Franke L, van den Akker EB, Westendorp RG, Zwinderman AH, Kastrati A, Koch W, Slagboom PE, de Knijff P, Jukema JW
Percutaneous coronary intervention (PCI) has become an effective therapy to treat obstructive coronary artery diseases (CAD). However, one of the major drawbacks of PCI is the occurrence of restenosis in 5-25% of all initially treated patients. Restenosis is defined as the re-narrowing of the lumen of the blood vessel, resulting in renewed symptoms and the need for repeated intervention. To identify genetic variants that are associated with restenosis, a genome-wide association study (GWAS) was...
Abstract
Cited 111 times since 2011 (7.9 per year)
source: EuropePMC
European heart journal,
Volume 32, Issue 20, 30 5 2011, Pages 2541-2554
RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome.
Steg PG, Mehta SR, Jukema JW, Lip GY, Gibson CM, Kovar F, Kala P, Garcia-Hernandez A, Renfurm RW, Granger CB, RUBY-1 Investigators
Aims: To establish the safety, tolerability and most promising regimen of darexaban (YM150), a novel, oral, direct factor Xa inhibitor, for prevention of ischaemic events in acute coronary syndrome (ACS). Methods: In a 26-week, multi-centre, double-blind, randomized, parallel-group study, 1279 patients with recent high-risk non-ST-segment or ST-segment elevation ACS received one of six darexaban regimens: 5 mg b.i.d., 10 mg o.d., 15 mg b.i.d., 30 mg o.d., 30 mg b.i.d., or 60 mg o.d. or placebo,...
Abstract
Cited 30 times since 2011 (2.1 per year)
source: EuropePMC
Intensive care medicine,
Volume 37, Issue 10, 30 5 2011, Pages 1656-1663
Ventilator-associated pneumonia in children after cardiac surgery in The Netherlands.
Roeleveld PP, Guijt D, Kuijper EJ, Hazekamp MG, de Wilde RB, de Jonge E
Purpose: We conducted a retrospective cohort study in an academic tertiary care center to characterize ventilator-associated pneumonia (VAP) in pediatric patients after cardiac surgery in The Netherlands. Methods: All patients following cardiac surgery and mechanically ventilated for ≥24 h were included. The primary outcome was development of VAP. Secondary outcomes were duration of mechanical ventilation and length of ICU stay. Results: A total of 125 patients were enrolled. Their mean age was...
Abstract
Cited 33 times since 2011 (2.4 per year)
source: EuropePMC
Molecular ecology,
Volume 21, Issue 3, 29 5 2011, Pages 633-646
Causes and consequences of living in closed societies: lessons from a long-term socio-genetic study on Bechstein's bats.
Kerth G, VAN Schaik J
Understanding the ecological, behavioural and genetic factors influencing animal social systems is crucial to investigating the evolution of sociality. Despite the recent advances in population genetic methods and the analysis of social interactions, long-term studies exploring the causes and consequences of social systems in wild mammals are rare. Here, we provide a synthesis of 15 years of data on the Bechstein's bat (Myotis bechsteinii), a species that raises its young in closed societie...
Abstract
Cited 22 times since 2011 (1.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 14, Issue 1, 27 4 2011, Pages 112-116
Trans-venous lead removal without the use of extraction sheaths, results of >250 removal procedures.
de Bie MK, Fouad DA, Borleffs CJ, van Rees JB, Thijssen J, Trines SA, Bootsma M, Schalij MJ, van Erven L
Aims: The number of implanted cardiac rhythm devices has rapidly increased in the past decade. Subsequently, the need for lead extraction has also increased. Several techniques of lead removal have been documented from manual traction of the lead to lead extraction assisted with mechanical or laser sheaths. The goal of this study was to review our experience with lead removal using manual traction without the assistance of extraction sheaths. Methods and results: In the Leiden University Medical...
Abstract
Cited 270 times since 2011 (19.3 per year)
source: EuropePMC
Diabetes,
Volume 60, Issue 10, 26 4 2011, Pages 2624-2634
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, Kanoni S, Peden JF, Turrini F, Gustafsson S, Zabena C, Almgren P, Barker DJ, Barnes D, Dennison EM, Eriksson JG, Eriksson P, Eury E, Folkersen L, Fox CS, Frayling TM, Goel A, Gu HF, Horikoshi M, Isomaa B, Jackson AU, Jameson KA, Kajantie E, Kerr-Conte J, Kuulasmaa T, Kuusisto J, Loos RJ, Luan J, Makrilakis K, Manning AK, Martínez-Larrad MT, Narisu N, Nastase Mannila M, Ohrvik J, Osmond C, Pascoe L, Payne F, Sayer AA, Sennblad B, Silveira A, Stancáková A, Stirrups K, Swift AJ, Syvänen AC, Tuomi T, van 't Hooft FM, Walker M, Weedon MN, Xie W, Zethelius B, DIAGRAM Consortium, GIANT Consortium, MuTHER Consortium, CARDIoGRAM Consortium, C4D Consortium, Ongen H, Mälarstig A, Hopewell JC, Saleheen D, Chambers J, Parish S, Danesh J, Kooner J, Ostenson CG, Lind L, Cooper CC, Serrano-Ríos M, Ferrannini E, Forsen TJ, Clarke R, Franzosi MG, Seedorf U, Wat
Objective: Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. Research design and methods: We have conducted a meta-analysis of genome-wide association tests of ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasti...
Abstract
Cited 2063 times since 2011 (147.5 per year)
source: EuropePMC
European heart journal,
Volume 32, Issue 23, 26 4 2011, Pages 2999-3054
ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC).
Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, Ohman M, Petrie MC, Sonntag F, Uva MS, Storey RF, Wijns W, Zahger D, ESC Committee for Practice Guidelines
Abstract
Cited 15 times since 2011 (1.1 per year)
source: EuropePMC
European journal of heart failure,
Volume 13, Issue 10, 25 4 2011, Pages 1133-1139
The effect of cardiac resynchronization therapy on left ventricular diastolic function assessed with speckle-tracking echocardiography.
Shanks M, Antoni ML, Hoke U, Bertini M, Ng AC, Auger D, Marsan NA, van Erven L, Holman ER, Schalij MJ, Bax JJ, Delgado V
Aims: Changes in left ventricular (LV) diastolic function after cardiac resynchronization therapy (CRT) in relation to LV reverse remodelling and heart failure aetiology have not been extensively characterized. The aims of the study were to evaluate changes in LV diastolic function with speckle-tracking echocardiography in relation to: (i) cardiac resynchronization therapy response (LV remodelling) and (ii) heart failure aetiology. Methods and results: A total of 192 heart failure patients under...
Abstract
