Research

Publications

Below you can find a list of our published research.

9618 results

Cited 41 times since 2011 (2.9 per year) source: EuropePMC

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Volume 29, Issue 24, 18 3 2011, Pages 3240-3246 Dextromethorphan as a phenotyping test to predict endoxifen exposure in patients on tamoxifen treatment. de Graan AJ, Teunissen SF, de Vos FY, Loos WJ, van Schaik RH, de Jongh FE, de Vos AI, van Alphen RJ, van der Holt B, Verweij J, Seynaeve C, Beijnen JH, Mathijssen RH

Purpose: Tamoxifen, a widely used agent for the prevention and treatment of breast cancer, is mainly metabolized by CYP2D6 and CYP3A to form its most abundant active metabolite, endoxifen. Interpatient variability in toxicity and efficacy of tamoxifen is substantial. Contradictory results on the value of CYP2D6 genotyping to reduce the variable efficacy have been reported. In this pharmacokinetic study, we investigated the value of dextromethorphan, a known probe drug for both CYP2D6 and CYP3A e... Abstract

Cited 58 times since 2011 (4.1 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 31, Issue 10, 14 2 2011, Pages 2338-2344 Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk. Welsh P, Murray HM, Ford I, Trompet S, de Craen AJ, Jukema JW, Stott DJ, McInnes IB, Packard CJ, Westendorp RG, Sattar N, PROSPER Study Group

Objective: The goal of this study was to examine the association of the antiinflammatory interleukin-10 (IL-10) with risk of cardiovascular disease (CVD). Methods and results: In the PROSPER (PROspective Study of Pravastatin in the Elderly at Risk) cohort, we related baseline concentrations of circulating IL-10 to risk of CVD events in a nested case (n=819)-control (n=1618) study of 3.2 years of follow-up. Circulating IL-10 showed few strong associations with classical risk factors but was posit... Abstract

Cited 42 times since 2011 (3 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 34, Issue 3, 14 2 2011, Pages 526-531 Age-related and regional changes of aortic stiffness in the Marfan syndrome: assessment with velocity-encoded MRI. Westenberg JJ, Scholte AJ, Vaskova Z, van der Geest RJ, Groenink M, Labadie G, van den Boogaard PJ, Radonic T, Hilhorst-Hofstee Y, Mulder BJ, Kroft LJ, Reiber JH, de Roos A

Purpose: To study age-related change in aortic stiffness in patients with Marfan syndrome (MFS) versus healthy volunteers using velocity-encoded (VE) MRI. Materials and methods: Twenty-five MFS patients (age range, 18-63 years; mean age 36 ± 14 years, 13 men) and 25 age-/gender-matched healthy volunteers were examined with VE-MRI. Aortic stiffness was expressed by pulse wave velocity (PWV), assessed in the proximal and distal part of the aorta and in the total aorta. PWV was compared between pat... Abstract

Cited 24 times since 2011 (1.7 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 108, Issue 30, 11 2 2011, Pages 12343-12347 Soils on exposed Sunda shelf shaped biogeographic patterns in the equatorial forests of Southeast Asia. Slik JW, Aiba S, Bastian M, Brearley FQ, Cannon CH, Eichhorn KA, Fredriksson G, Kartawinata K, Laumonier Y, Mansor A, Marjokorpi A, Meijaard E, Morley RJ, Nagamasu H, Nilus R, Nurtjahya E, Payne J, Permana A, Poulsen AD, Raes N, Riswan S, van Schaik CP, Sheil D, Sidiyasa K, Suzuki E, van Valkenburg JL, Webb CO, Wich S, Yoneda T, Zakaria R, Zweifel N

The marked biogeographic difference between western (Malay Peninsula and Sumatra) and eastern (Borneo) Sundaland is surprising given the long time that these areas have formed a single landmass. A dispersal barrier in the form of a dry savanna corridor during glacial maxima has been proposed to explain this disparity. However, the short duration of these dry savanna conditions make it an unlikely sole cause for the biogeographic pattern. An additional explanation might be related to the coarse s... Abstract

Cited 26 times since 2011 (1.8 per year) source: EuropePMC

European radiology, Volume 21, Issue 11, 7 1 2011, Pages 2285-2296 Diagnostic performance of 320-slice multidetector computed tomography coronary angiography in patients after coronary artery bypass grafting. de Graaf FR, van Velzen JE, Witkowska AJ, Schuijf JD, van der Bijl N, Kroft LJ, de Roos A, Reiber JH, Bax JJ, de Grooth GJ, Jukema JW, van der Wall EE

Objectives: To evaluate the diagnostic performance of 320-slice computed tomography coronary angiography (CTA) in the evaluation of patients with prior coronary artery bypass grafting (CABG). Invasive coronary angiography (ICA) served as the standard of reference, using a quantitative approach. Methods: CTA studies were performed using CT equipment with 320 detector-rows, each 0.5 mm wide, and a gantry rotation time of 0.35 s. All grafts, recipient and nongrafted vessels were deemed interpretabl... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

European journal of radiology, Volume 81, Issue 9, 2 1 2011, Pages 2042-2048 Accurate perioperative flow measurement of the portal vein and hepatic and renal artery: a role for preoperative MRI? Vermeulen MA, Ligthart-Melis GC, Buijsman R, Siroen MP, van de Poll MC, Boelens PG, Dejong CH, van Schaik C, Hofman MB, van Leeuwen PA

Background: Quantification of abdominal blood flow is essential for a variety of gastrointestinal and hepatic topics such as liver transplantation or metabolic flux measurement, but those need to be performed during surgery. It is not clear whether Duplex Doppler Ultrasound during surgery or MRI before surgery is the tool to choose. Objective: To examine whether preoperative evaluation of abdominal blood flow using MRI could prove to be a useful and reliable alternative for the perioperative son... Abstract

Cited 13 times since 2011 (0.9 per year) source: EuropePMC

Heart failure reviews, Volume 16, Issue 4, 1 1 2011, Pages 411-423 The role of nuclear imaging in the failing heart: myocardial blood flow, sympathetic innervation, and future applications. Boogers MJ, Fukushima K, Bengel FM, Bax JJ

Heart failure represents a common disease affecting approximately 5 million patients in the United States. Several conditions play an important role in the development and progression of heart failure, including abnormalities in myocardial blood flow and sympathetic innervation. Nuclear imaging represents the only imaging modality with sufficient sensitivity to assess myocardial blood flow and sympathetic innervation of the failing heart. Although nuclear imaging with single-photon emission comp... Abstract

Cited 14 times since 2011 (1 per year) source: EuropePMC

Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 453-459 Predictive power of T-wave alternans and of ventricular gradient hysteresis for the occurrence of ventricular arrhythmias in primary prevention cardioverter-defibrillator patients. Man S, De Winter PV, Maan AC, Thijssen J, Borleffs CJ, van Meerwijk WP, Bootsma M, van Erven L, van der Wall EE, Schalij MJ, Burattini L, Burattini R, Swenne CA

Background and purpose: Left ventricular ejection fraction lacks specificity to predict sudden cardiac death in heart failure. T-wave alternans (TWA; beat-to-beat T-wave instability, often measured during exercise) is deemed a promising noninvasive predictor of major cardiac arrhythmic event. Recently, it was demonstrated that TWA during recovery from exercise has additional predictive value. Another mechanism that potentially contributes to arrhythmogeneity is exercise-recovery hysteresis in ac... Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, Volume 19, Issue 7, 1 1 2011, Pages 678-679 Successful electroconvulsive therapy in a 95-year-old man with a cardiac pacemaker--a case report. Gosselink MJ, Schenkeveld KW, Trines SA, van Vliet IM

Abstract

Cited 3 times since 2011 (0.2 per year) source: EuropePMC

Pediatric research, Volume 70, Issue 1, 1 1 2011, Pages 37-43 Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias. Hahurij ND, Kolditz DP, Bökenkamp R, Markwald RR, Schalij MJ, Poelmann RE, Gittenberger-De Groot AC, Blom NA

Atrioventricular reentry tachycardia (AVRT) requiring an accessory atrioventricular pathway (AP) is the most common type of arrhythmia in the perinatal period. The etiology of these arrhythmias is not fully understood as well as their capability to dissipate spontaneously in the first year of life. Temporary presence of APs during annulus fibrosus development might cause this specific type of arrhythmias. To study the presence of APs, electrophysiological recordings of ventricular activation pat... Abstract

Cited 15 times since 2011 (1.1 per year) source: EuropePMC

Journal of electrocardiology, Volume 44, Issue 4, 1 1 2011, Pages 410-415 Influence of the vectorcardiogram synthesis matrix on the power of the electrocardiogram-derived spatial QRS-T angle to predict arrhythmias in patients with ischemic heart disease and systolic left ventricular dysfunction. Man S, Algra AM, Schreurs CA, Borleffs CJ, Scherptong RW, van Erven L, van der Wall EE, Cannegieter SC, Schalij MJ, Swenne CA

Background and purpose: Several studies have demonstrated that the spatial mean QRS-T angle (SA) predicts cardiac events and mortality. Spatial mean QRS-T angle is a vectorcardiographic variable. Because in clinical practice, 12-lead standard electrocardiograms (ECGs) are recorded rather than vectorcardiograms (VCGs) according to Frank, VCGs are commonly obtained by synthesizing them from 12-lead ECGs, by using a VCG synthesis matrix. Hence, the thus computed SA is an estimate of the real SA mea... Abstract

Cited 29 times since 2011 (2.1 per year) source: EuropePMC

Journal of dairy science, Volume 94, Issue 7, 1 1 2011, Pages 3568-3574 The use of a radiotelemetric ruminal bolus to detect body temperature changes in lactating dairy cattle. Alzahal O, Alzahal H, Steele MA, Van Schaik M, Kyriazakis I, Duffield TF, McBride BW

The objective of this study was to validate the efficacy of a radiotelemetric bolus (RTB) to detect changes in ruminal temperature resulting from (1) systemic illnesses that are associated with febrile responses and (2) subacute ruminal acidosis (SARA). Eight rumen-fistulated, lactating Holstein cows (586±37 kg of body weight, 106±18 d in milk) were used in a replicated 4 × 4 Latin square design with a 2 × 2 factorial arrangement. Each period consisted of 21 d. The factors were 2 diets, a modera... Abstract

The Annals of thoracic surgery, Volume 92, Issue 1, 1 1 2011, Pages 166 Invited commentary. Hazekamp MG

Abstract

Cited 12 times since 2011 (0.8 per year) source: EuropePMC

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Volume 12, Issue 4, 1 1 2011, Pages e160-5 Role of real-time reverse transcription polymerase chain reaction for detection of respiratory viruses in critically ill children with respiratory disease: Is it time for a change in algorithm? Aramburo A, van Schaik S, Louie J, Boston E, Messenger S, Wright C, Lawrence Drew W

Objectives: To identify the respiratory viral pathogens associated with acute lower respiratory tract infection in critically ill pediatric patients by using real-time reverse transcription-polymerase chain reaction, and compare results with those of direct fluorescence antibody assay testing. Design: Observational cohort study. Setting: Pediatric intensive care unit at a tertiary care academic hospital. Patients: Pediatric patients admitted to the pediatric intensive care unit with severe respi... Abstract

Cited 49 times since 2011 (3.5 per year) source: EuropePMC

Journal of dairy science, Volume 94, Issue 7, 1 1 2011, Pages 3213-3228 Invited review: associations between variables of routine herd data and dairy cattle welfare indicators. de Vries M, Bokkers EA, Dijkstra T, van Schaik G, de Boer IJ

As farm animal welfare is high on the political and societal agendas of many countries, considerable pressure exists to establish audit programs in which farm animal welfare is routinely monitored. On-farm assessment of animal welfare, however, is time-consuming and costly. A promising strategy to monitor animal welfare more efficiently is to first estimate the level of animal welfare on a farm based on routine herd data that are available in national databases. It is not currently known which v... Abstract

Cited 58 times since 2011 (4.1 per year) source: EuropePMC

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, Volume 47, Issue 2, 30 5 2011, Pages 90-97 Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy. Hutteman M, van der Vorst JR, Mieog JS, Bonsing BA, Hartgrink HH, Kuppen PJ, Löwik CW, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Background: Intraoperative visualization of pancreatic tumors has the potential to improve radical resection rates. Intraoperative visualization of the common bile duct and bile duct anastomoses could be of added value. In this study, we explored the use of indocyanine green (ICG) for these applications and attempted to optimize injection timing and dose. Methods: Eight patients undergoing a pancreaticoduodenectomy were injected intravenously with 5 or 10 mg ICG. During and after injection, the... Abstract

Cited 28 times since 2011 (2 per year) source: EuropePMC

Stroke research and treatment, Volume 2011, 30 5 2011, Pages 424759 Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality. Trompet S, Pons D, Kanse SM, de Craen AJ, Ikram MA, Verschuren JJ, Zwinderman AH, Doevendans PA, Tio RA, de Winter RJ, Slagboom PE, Westendorp RG, Jukema JW

Introduction. The FSAP-Marburg I polymorphism (1704G > A), which reduces FSAP activity, is associated with late complications of carotid stenosis in humans. Therefore, this study examines the influence of the Marburg I polymorphism and the closely linked Marburg II polymorphism (1280G > C) on various cardiovascular outcomes in two large independent study populations. Methods. The two Marburg polymorphisms in the HABP2 gene encoding FSAP were genotyped in a large population of elderly patie... Abstract

Cited 6 times since 2011 (0.4 per year) source: EuropePMC

Psychotherapy and psychosomatics, Volume 80, Issue 5, 30 5 2011, Pages 313-315 Treating chronic symptoms of depression in the virtual clinic: findings on chronicity of depression in patients treated with internet-based computerized cognitive behaviour therapy for depression. Wiersma JE, Titov N, Van Schaik DJ, Van Oppen P, Beekman AT, Cuijpers P, Andrews GA

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Cited 12 times since 2011 (0.8 per year) source: EuropePMC

The American journal of cardiology, Volume 108, Issue 5, 28 4 2011, Pages 711-717 Prediction of response to cardiac resynchronization therapy combining two different three-dimensional analyses of left ventricular dyssynchrony. Auger D, Bertini M, Marsan NA, Hoke U, Ewe SH, Thijssen J, Witkowski TG, Yiu KH, Ng AC, van der Wall EE, Schalij MJ, Bax JJ, Delgado V

Triplane tissue synchronization imaging (TSI) and real-time 3-dimensional echocardiography (RT3DE) provide different characterizations of left ventricular (LV) mechanics and dyssynchrony. Triplane TSI assesses differences in time to peak systolic segmental myocardial tissue velocities, whereas RT3DE evaluates differences in time to minimum end-systolic regional volumes. Whether an approach using the 2 3D techniques predicts better significant reverse remodeling after cardiac resynchronization th... Abstract

Cited 30 times since 2011 (2.1 per year) source: EuropePMC

PloS one, Volume 6, Issue 6, 28 4 2011, Pages e21278 Forest fruit production is higher on Sumatra than on Borneo. Wich SA, Vogel ER, Larsen MD, Fredriksson G, Leighton M, Yeager CP, Brearley FQ, van Schaik CP, Marshall AJ

Background: Various studies have shown that the population densities of a number of forest vertebrates, such as orangutans, are higher on Sumatra than Borneo, and that several species exhibit smaller body sizes on Borneo than Sumatra and mainland Southeast Asia. It has been suggested that differences in forest fruit productivity between the islands can explain these patterns. Here we present a large-scale comparison of forest fruit production between the islands to test this hypothesis. Methodol... Abstract