9618 results
Cited 41 times since 2011 (2.9 per year)
source: EuropePMC
Arthritis care & research,
Volume 63, Issue 6, 1 1 2011, Pages 909-917
Randomized comparison of a multidisciplinary team care program with usual care in patients with systemic sclerosis.
Schouffoer AA, Ninaber MK, Beaart-van de Voorde LJ, van der Giesen FJ, de Jong Z, Stolk J, Voskuyl AE, Scherptong RW, van Laar JM, Schuerwegh AJ, Huizinga TW, Vlieland TP
Objective: To compare the effectiveness of a multidisciplinary team care program with usual outpatient care in patients with systemic sclerosis (SSc; scleroderma). Methods: We performed a randomized controlled trial comparing a 12-week multidisciplinary team care program (1 day per week; individual treatments, group exercises, and group education) with outpatient clinic care. Outcome measures included the Hand Mobility in Scleroderma (HAMIS) test, grip strength, maximal mouth opening (MMO), 6-mi...
Abstract
Cited 4 times since 2011 (0.3 per year)
source: EuropePMC
The Journal of cardiovascular surgery,
Volume 52, Issue 3, 1 1 2011, Pages 363-369
Ruptured abdominal aortic aneurysm: endovascular or open approach in a Dutch general hospital.
Van Schaik DE, Dolmans DE, Ho G, Geenen GP, Vos L, Van Der Waal JC, De Groot HG, Van Der Laan L
Aim: We compared the outcomes of 56 patients with a ruptured abdominal aortic aneurysm (RAAA) who underwent either open repair or emergency endovascular aneurysm repair (eEVAR) in a general hospital. It seems feasible that the availability of eEVAR for treatment of RAAA could lead to a decrease in hospital mortality. Methods: We analyzed all admitted patients with a RAAA, between January 2006 and April 2008, eEVAR is compared to open repair. We studied 30 days mortality, intensive care unit stay...
Abstract
Cited 25 times since 2011 (1.8 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 33, Issue 3, 1 1 2011, Pages 369-371
CYP3A5 genotype is not related to the intrapatient variability of tacrolimus clearance.
Pashaee N, Bouamar R, Hesselink DA, Roodnat JI, van Schaik RH, Weimar W, van Gelder T
Background: The risk of long-term chronic allograft nephropathy and graft loss after kidney transplantation is increased in patients with a high intrapatient variability of tacrolimus (Tac) clearance. Methods: To test whether this intrapatient variability is associated with an individual's CYP3A5 genotype, we measured the intrapatient variability in Tac clearance in a cohort of 208 kidney transplant recipients treated with Tac and mycophenolate mofetil. Results: Tac dose requirement was sig...
Abstract
Cited 308 times since 2011 (21.7 per year)
source: EuropePMC
Frontiers in neuroscience,
Volume 5, 31 5 2011, Pages 73
Neuromorphic silicon neuron circuits.
Indiveri G, Linares-Barranco B, Hamilton TJ, van Schaik A, Etienne-Cummings R, Delbruck T, Liu SC, Dudek P, Häfliger P, Renaud S, Schemmel J, Cauwenberghs G, Arthur J, Hynna K, Folowosele F, Saighi S, Serrano-Gotarredona T, Wijekoon J, Wang Y, Boahen K
Hardware implementations of spiking neurons can be extremely useful for a large variety of applications, ranging from high-speed modeling of large-scale neural systems to real-time behaving systems, to bidirectional brain-machine interfaces. The specific circuit solutions used to implement silicon neurons depend on the application requirements. In this paper we describe the most common building blocks and techniques used to implement these circuits, and present an overview of a wide range of neu...
Abstract
Cited 4 times since 2011 (0.3 per year)
source: EuropePMC
The Journal of arthroplasty,
Volume 27, Issue 3, 31 5 2011, Pages 454-460
A prospective randomized clinical trial comparing tibial baseplate fixation with or without screws in total knee arthroplasty: a radiographic evaluation.
Schepers A, Cullingworth L, van der Jagt DR
In a randomized prospective study, we compared the use of tibial screws with screwless tibial baseplate fixation in uncemented total knee arthroplasty and report the results of 154 prostheses at a mean follow-up of 5 years. Patients were mobilized within 24 hours and continued with partial weight-bearing for up to 6 weeks postoperatively. There were no significant differences in radiologic results and revision rates. Radiographic outcomes do not seem to be influenced by the use of screws in tibi...
Abstract
Cited 47 times since 2011 (3.3 per year)
source: EuropePMC
Pediatric nephrology (Berlin, Germany),
Volume 26, Issue 8, 27 4 2011, Pages 1275-1283
Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study.
Taal HR, Geelhoed JJ, Steegers EA, Hofman A, Moll HA, Lequin M, van der Heijden AJ, Jaddoe VW
An adverse fetal environment leads to smaller kidneys, with fewer nephrons, which might predispose an individual to the development of kidney disease and hypertension in adult life. In a prospective cohort study among 1,072 children followed from early fetal life onward, we examined whether maternal smoking during pregnancy, as a significant adverse fetal exposure, is associated with fetal (third trimester of pregnancy, n = 1,031) and infant kidney volume (2 years of age, n = 538) measured by ul...
Abstract
Cited 25 times since 2011 (1.8 per year)
source: EuropePMC
Nucleic acids research,
Volume 39, Issue Web Server issue, 27 4 2011, Pages W450-4
CoPub update: CoPub 5.0 a text mining system to answer biological questions.
Fleuren WW, Verhoeven S, Frijters R, Heupers B, Polman J, van Schaik R, de Vlieg J, Alkema W
In this article, we present CoPub 5.0, a publicly available text mining system, which uses Medline abstracts to calculate robust statistics for keyword co-occurrences. CoPub was initially developed for the analysis of microarray data, but we broadened the scope by implementing new technology and new thesauri. In CoPub 5.0, we integrated existing CoPub technology with new features, and provided a new advanced interface, which can be used to answer a variety of biological questions. CoPub 5.0 allo...
Abstract
Cited 22 times since 2011 (1.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 28, Issue 4, 26 4 2011, Pages 865-876
Performance and efficacy of 320-row computed tomography coronary angiography in patients presenting with acute chest pain: results from a clinical registry.
van Velzen JE, de Graaf FR, Kroft LJ, de Roos A, Reiber JH, Bax JJ, Jukema JW, Schuijf JD, Schalij MJ, van der Wall EE
The purpose of this study was to evaluate the performance of 320-row computed tomography angiography (CTA) in the identification of significant coronary artery disease (CAD) in patients presenting with acute chest pain and to examine the relation to outcome during follow-up. A total of 106 patients with acute chest pain underwent CTA to evaluate presence of CAD. Each CTA was classified as: normal, non-significant CAD (
Abstract
Cited 65 times since 2011 (4.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 97, Issue 16, 25 4 2011, Pages 1332-1337
Left atrial strain is related to adverse events in patients after acute myocardial infarction treated with primary percutaneous coronary intervention.
Antoni ML, ten Brinke EA, Atary JZ, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Delgado V
Background: Left atrial (LA) maximal volume is of prognostic value in patients after acute myocardial infarction (AMI). Recently, LA mechanical function and LA strain have been introduced as alternative methods to assess LA performance more accurately. Objective: To evaluate the relation between LA volume, mechanical function and strain, and adverse events in patients after AMI. Methods: Patients with AMI underwent two-dimensional echocardiography within 48 h of admission. LA volume and LA perfo...
Abstract
Cited 147 times since 2011 (10.3 per year)
source: EuropePMC
Circulation,
Volume 123, Issue 23, 23 4 2011, Pages 2690-2700
Arrhythmogenic right ventricular dysplasia/cardiomyopathy: pathogenic desmosome mutations in index-patients predict outcome of family screening: Dutch arrhythmogenic right ventricular dysplasia/cardiomyopathy genotype-phenotype follow-up study.
Cox MG, van der Zwaag PA, van der Werf C, van der Smagt JJ, Noorman M, Bhuiyan ZA, Wiesfeld AC, Volders PG, van Langen IM, Atsma DE, Dooijes D, van den Wijngaard A, Houweling AC, Jongbloed JD, Jordaens L, Cramer MJ, Doevendans PA, de Bakker JM, Wilde AA, van Tintelen JP, Hauer RN
Background: Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an autosomal dominant inherited disease with incomplete penetrance and variable expression. Causative mutations in genes encoding 5 desmosomal proteins are found in ≈50% of ARVD/C index patients. Previous genotype-phenotype relation studies involved mainly overt ARVD/C index patients, so follow-up data on relatives are scarce. Methods and results: One hundred forty-nine ARVD/C index patients (111 male patients; age...
Abstract
Cited 9 times since 2011 (0.6 per year)
source: EuropePMC
Genomics,
Volume 98, Issue 2, 23 4 2011, Pages 90-95
Looking ultra deep: short identical sequences and transcriptional slippage.
Ritz K, van Schaik BD, Jakobs ME, Aronica E, Tijssen MA, van Kampen AH, Baas F
Studying transcriptomes by ultra deep sequencing provides an in-depth picture of transcriptional regulation and it facilitates the detection of rare transcriptional events. Using ultra deep sequencing of amplicons we identified known isoforms and also various new low frequency variants. Most of these variants likely involve the splicing machinery except for two events that we named variations affecting multiple exons, which are mainly deletions affecting parts of adjacent exons and intra-exonic...
Abstract
Cited 110 times since 2011 (7.7 per year)
source: EuropePMC
Journal of the American Academy of Dermatology,
Volume 65, Issue 2, 20 3 2011, Pages 320-327
Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants.
de Graaf M, Breur JMPJ, Raphaël MF, Vos M, Breugem CC, Pasmans SGMA
Background: Infantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option. Objective: To describe the effects and side effects of propranolol treatment in 28 children with (complicated) IH. Methods: A protocol for treatment of IH with propranolol was designed and implemented. Propranolol was administered to 28 children (21 girls and 7 boys, mean age at onset of treatment: 8.8 months). Re...
Abstract
Cited 51 times since 2011 (3.6 per year)
source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists,
Volume 240, Issue 7, 20 3 2011, Pages 1670-1680
Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells.
Egorova AD, Van der Heiden K, Van de Pas S, Vennemann P, Poelma C, DeRuiter MC, Goumans MJ, Gittenberger-de Groot AC, ten Dijke P, Poelmann RE, Hierck BP
Endothelial cells (EC) translate biomechanical forces into functional and phenotypic responses that play important roles in cardiac development. Specifically, EC in areas of high shear stress, i.e., in the cardiac outflow tract and atrioventricular canal, are characterized by high expression of Krüppel-like factor 2 (Klf2) and by transforming growth factor-beta (Tgfβ)-driven endothelial-to-mesenchymal transition. Extraembryonic venous obstruction (venous clip model) results in congenital heart m...
Abstract
Cited 90 times since 2011 (6.3 per year)
source: EuropePMC
Gut,
Volume 61, Issue 2, 20 3 2011, Pages 235-240
Thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease.
van Schaik FD, van Oijen MG, Smeets HM, van der Heijden GJ, Siersema PD, Oldenburg B
Background and aims: Previous studies have suggested a chemopreventive effect of 5-aminosalicylic acid (5-ASA) therapy in patients with inflammatory bowel disease (IBD). This effect has not been reported in IBD patients using thiopurines. We investigated the association between thiopurine or 5-ASA use and the risk of advanced neoplasia (AN), including high-grade dysplasia and colorectal cancer, in a large cohort of patients with IBD in the Netherlands. Methods: PALGA, the nationwide network and...
Abstract
The international journal of cardiovascular imaging,
Volume 28, Issue 3, 19 3 2011, Pages 563-565
Does heart rate influence CMR image quality of the coronary vessel wall?
van der Wall EE, Kröner EJ, Siebelink HM, Scholte AJ, Schalij MJ
Abstract
Cited 10 times since 2011 (0.7 per year)
source: EuropePMC
PloS one,
Volume 6, Issue 5, 16 3 2011, Pages e18609
The dyad symmetry element of Epstein-Barr virus is a dominant but dispensable replication origin.
Ott E, Norio P, Ritzi M, Schildkraut C, Schepers A
OriP, the latent origin of Epstein-Barr virus (EBV), consists of two essential elements: the dyad symmetry (DS) and the family of repeats (FR). The function of these elements has been predominantly analyzed in plasmids transfected into transformed cells. Here, we examined the molecular functions of DS in its native genomic context and at an ectopic position in the mini-EBV episome. Mini-EBV plasmids contain 41% of the EBV genome including all information required for the proliferation of human B...
Abstract
Cited 13 times since 2011 (0.9 per year)
source: EuropePMC
Drug discovery today,
Volume 16, Issue 13-14, 13 2 2011, Pages 555-568
A molecular informatics view on best practice in multi-parameter compound optimization.
Lusher SJ, McGuire R, Azevedo R, Boiten JW, van Schaik RC, de Vlieg J
The difference between biologically active molecules and drugs is that the latter balance an array of related and unrelated properties required for administration to patients. Inevitability, during optimization, some of these multiple factors will conflict. Although informatics has a crucial role in addressing the challenges of modern compound optimization, it is arguably still undervalued and underutilized. We present here some of the basic requirements of multi-parameter drug design, the cruci...
Abstract
Cited 5 times since 2011 (0.4 per year)
source: EuropePMC
Current medical research and opinion,
Volume 27, Issue 7, 12 2 2011, Pages 1347-1357
How to reduce the incidence of contrast induced acute kidney injury after cardiac invasive procedures, a review and practical recommendations.
de Bie MK, van Rees JB, Herzog CA, Rabelink TJ, Schalij MJ, Jukema JW
Background: Contrast induced acute kidney injury is an important complication after cardiac (invasive) procedures and is associated with substantial morbidity and mortality. The aim of the current article is to provide a comprehensive overview of the current knowledge regarding contrast induced acute kidney injury. Methods: Current literature was reviewed and relevant articles were selected. Articles were identified through MEDLINE and Pubmed selecting articles, limited between 1980 and 2010. Re...
Abstract
Cited 78 times since 2011 (5.5 per year)
source: EuropePMC
Cytometry. Part B, Clinical cytometry,
Volume 80, Issue 5, 12 2 2011, Pages 271-281
Flow cytometric characterization of cerebrospinal fluid cells.
de Graaf MT, de Jongste AH, Kraan J, Boonstra JG, Sillevis Smitt PA, Gratama JW
Flow cytometry facilitates the detection of a large spectrum of cellular characteristics on a per cell basis, determination of absolute cell numbers and detection of rare events with high sensitivity and specificity. White blood cell (WBC) counts in cerebrospinal fluid (CSF) are important for the diagnosis of many neurological disorders. WBC counting and differential can be performed by microscopy, hematology analyzers, or flow cytometry. Flow cytometry of CSF is increasingly being considered as...
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Journal of clinical pharmacology,
Volume 52, Issue 5, 12 2 2011, Pages 704-716
Integration of pharmacogenetics and pharmacogenomics in drug development: implications for regulatory and medical decision making in pediatric diseases.
Piana C, Surh L, Furst-Recktenwald S, Iolascon A, Jacqz-Aigrain EM, Jonker I, Russo R, van Schaik RH, Wessels J, Della Pasqua OE
This article aims to provide an overview of the current situation regarding pharmacogenetic and pharmacogenomic (PG) studies in pediatrics, with a special focus on the role of PG data in the regulatory decision-making process. Despite the gap in pharmacogenetic research due to the lack of translational studies in adults and children, several technologies exist in drug development and biomarkers validation, which could supply valuable information concerning labeling and dosing recommendations. If...
Abstract
