9618 results
Cited 3 times since 2011 (0.2 per year)
source: EuropePMC
The Cochrane database of systematic reviews,
Issue 5, 11 2 2011, Pages CD008128
Treatment of valvular heart disease during pregnancy for improving maternal and neonatal outcome.
Henriquez DD, Roos-Hesselink JW, Schalij MJ, Klautz RJ, Helmerhorst FM, de Groot CJ
Background: Valvular heart disease constitutes the majority of all causes of heart disease in pregnancy. In the presence of valvular heart disease, the necessary haemodynamic changes of pregnancy might cause heart failure, leading to severe maternal and fetal morbidity and even mortality. Treatment of valvular heart disease is indicated when patients experience a deterioration of symptoms and in case of a severe valvular lesion. Whether medical therapy or interventional therapy is the optimal tr...
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 4, Issue 4, 11 2 2011, Pages 486-493
ECG identification of scar-related ventricular tachycardia with a left bundle-branch block configuration.
Wijnmaalen AP, Stevenson WG, Schalij MJ, Field ME, Stephenson K, Tedrow UB, Koplan BA, Putter H, Epstein LM, Zeppenfeld K
Background: A left bundle-branch block (LBBB)-like pattern with a dominant S-wave in V(1) is common in idiopathic ventricular arrhythmias (VA). Discrimination between idiopathic and scar-related LBBB pattern VA has important clinical implications. We hypothesized that the VA QRS morphology is influenced by the presence of ventricular scar, allowing ECG discrimination of VA arising from structurally normal versus scarred myocardium. Methods and results: Twelve-lead ECGs of 297 LBBB pattern monomo...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
American heart journal,
Volume 161, Issue 6, 11 2 2011, Pages 1060-1066
Site of latest activation in patients eligible for cardiac resynchronization therapy: patterns of dyssynchrony among different QRS configurations and impact of heart failure etiology.
van Bommel RJ, Ypenburg C, Mollema SA, Borleffs CJ, Delgado V, Bertini M, Marsan NA, van der Wall EE, Schalij MJ, Bax JJ
Introduction: Cardiac resynchronization therapy (CRT) has emerged as a treatment option for patients with end-stage heart failure and a QRS duration ≥120 ms. Nonetheless, many patients with a prolonged QRS do not demonstrate left ventricular (LV) mechanical dyssynchrony, and discrepancies between electrical and mechanical dyssynchrony have been observed. In addition, several studies demonstrated that superior benefits after CRT could be achieved when the LV pacing lead was positioned at the most...
Abstract
Cited 114 times since 2011 (8 per year)
source: EuropePMC
Water research,
Volume 45, Issue 14, 10 2 2011, Pages 4081-4091
Detection of the human specific Bacteroides genetic marker provides evidence of widespread sewage contamination of stormwater in the urban environment.
Sauer EP, Vandewalle JL, Bootsma MJ, McLellan SL
Human sewage contamination of surface waters is a major human health concern. We found urban stormwater systems that collect and convey runoff from impervious surfaces act as a conduit for sewage originating from breeches in sanitary sewer infrastructure. A total of 828 samples at 45 stormwater outfalls were collected over a four-year period and assessed by culture based methods, PCR, and quantitative PCR (qPCR) to test for traditional and alternative indicators of fecal pollution. All outfalls...
Abstract
Cited 34 times since 2011 (2.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 108, Issue 3, 6 1 2011, Pages 435-439
Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood.
Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ
Chronic hypertension is a major concern in adults who have undergone resection of coarctation of the aorta (CoA) in childhood. In otherwise healthy subjects, exercise-induced hypertension is prognostic for chronic hypertension; however, the prognostic value in patients with CoA remains unknown. The aim of the present study was to evaluate the predictive value of exercise-induced hypertension for chronic hypertension in these patients. In the present prospective follow-up study, 74 patients with...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
Congenital heart disease,
Volume 6, Issue 3, 5 1 2011, Pages 219-227
The perspective of patients with congenital heart disease: does health care meet their needs?
Schoormans D, Sprangers MA, Pieper PG, van Melle JP, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ
Objective: A first step in the delivery of tailored care is answering the following question: does health care meet the needs of patients? Therefore patients' perspective on health care use and their needs was examined. The design used was cross-sectional questionnaire study. Patients: A total of 1109 adult congenital heart defect (CHD) patients attending one of eight Dutch hospitals were randomly selected from a national database (10% of all registered patients). Main outcome measures: Pat...
Abstract
Cited 1 times since 2011 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 18, Issue 3, 1 1 2011, Pages 393-395
Cardiac risk assessment in asymptomatic diabetes: combining [corrected] different imaging modalities and surrogate markers?
Scholte AJ
Abstract
Cited 12 times since 2011 (0.8 per year)
source: EuropePMC
Mycoses,
Volume 54, Issue 3, 1 1 2011, Pages 234-242
A rescue therapy with a combination of caspofungin and liposomal amphotericin B or voriconazole in children with haematological malignancy and refractory invasive fungal infections.
Yilmaz D, Balkan C, Ay Y, Akin M, Karapinar B, Kavakli K
Combination treatment of paediatric invasive fungal infections (IFIs) has rarely been reported. A total of 17 children with 19 IFI episodes were enrolled in the study. The median age of the patients was 5.3 (range 0.5-17) years. IFI was classified as proven in 4, probable in 12 and possible in 3 episodes. These patients received empiric antifungal treatment, which consisted of liposomal amphotericin B (LAmB) monotherapy for a median duration of 12 days (range 3-69 days). All patients were refrac...
Abstract
Cited 12 times since 2011 (0.8 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 13 Suppl 2, 1 1 2011, Pages ii32-8
Cardiac resynchronization therapy: a cost or an investment?
Boriani G, Mantovani LG, Biffi M, Schalij MJ, Martignani C, Leclercq C, Bax JJ, Auricchio A
Cost-effectiveness estimates can help optimize use of available financial resources and this is especially relevant for implementation of cardiac resynchronization therapy (CRT), given the high upfront costs and the timescale of expected benefits. All available cost-effectiveness estimates for devices with (CRT-P) or without (CRT-D) a defibrillator are based on results of randomized trials of selected patients, with a relatively brief follow-up. Extrapolation suggests that the cost effectiveness...
Abstract
Cited 25 times since 2011 (1.7 per year)
source: EuropePMC
The Journal of the Acoustical Society of America,
Volume 129, Issue 5, 1 1 2011, Pages EL210-15
Localization in speech mixtures by listeners with hearing loss.
Best V, Carlile S, Kopco N, van Schaik A
The ability of listeners with bilateral sensorineural hearing loss to localize a speech source in a multitalker mixture was measured. Five simultaneous words spoken by different talkers were presented over loudspeakers in a small room, and listeners localized one target word. Errors were significantly larger in this group compared to a control group with normal hearing. Localization of the target presented alone was not different between groups. The results suggest that hearing loss does not imp...
Abstract
Cited 50 times since 2011 (3.5 per year)
source: EuropePMC
Journal of neuropathology and experimental neurology,
Volume 70, Issue 5, 1 1 2011, Pages 386-398
Myelin and axon pathology in a long-term study of PMP22-overexpressing mice.
Verhamme C, King RH, ten Asbroek AL, Muddle JR, Nourallah M, Wolterman R, Baas F, van Schaik IN
We analyzed clinical and pathological disease in 2 peripheral myelin protein-22 (PMP22) overexpressing mouse models for 1.5 years. C22 mice have 7 and C3-PMP mice have 3 to 4 copies of the human PMP22 gene. C3-PMP mice showed no overt clinical signs at 3 weeks and developed mild neuromuscular impairment; C22 mice showed signs at 3 weeks that progressed to severe impairment. Adult C3-PMP mice had very similar, stable, low nerve conduction velocities similar to adults with human Charcot-Marie-Toot...
Abstract
Cited 45 times since 2011 (3.1 per year)
source: EuropePMC
Arthritis and rheumatism,
Volume 63, Issue 5, 1 1 2011, Pages 1265-1273
Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint.
Meeuwisse CM, van der Linden MP, Rullmann TA, Allaart CF, Nelissen R, Huizinga TW, Garritsen A, Toes RE, van Schaik R, van der Helm-van Mil AH
Objective: Rheumatoid arthritis (RA) is characterized by inflammation and joint destruction, with the degree of damage varying greatly among patients. Prediction of disease severity using known clinical and serologic risk factors is inaccurate. This study was undertaken to identify new serologic markers for RA severity using an in silico model of the rheumatic joint. Methods: An in silico model of a prototypical rheumatic joint was used to predict candidate markers associated with erosiveness. T...
Abstract
Cited 6 times since 2011 (0.4 per year)
source: EuropePMC
Pharmacogenomics,
Volume 12, Issue 5, 1 1 2011, Pages 597-610
Pharmacogenomics and personalized medicine in clinical practice.
Manolopoulos VG, Dechairo B, Huriez A, Kühn A, Llerena A, Llerena A, van Schaik RH, Yeo KT, Ragia G, Siest G
The Santorini Conference on prospective biology, genomics and pharmacogenomics occurs every 2 years. On 30 September to 2nd October 2010, the fifth meeting in this series took place in Santorini, Greece. This conference has established a tradition of organizing a workshop each time to address the most recent developments and key issues in pharmacogenomics. This year, the workshop was chaired by Bryan Dechairo and Alain Huriez, and was titled 'Pharmacogenomics and personalized medicine in cl...
Abstract
Cited 31 times since 2011 (2.2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 108, Issue 1, 27 4 2011, Pages 63-68
Comparison of long-term survival of men versus women with heart failure treated with cardiac resynchronization therapy.
Mooyaart EA, Marsan NA, van Bommel RJ, Thijssen J, Borleffs CJ, Delgado V, van der Wall EE, Schalij MJ, Bax JJ
Cardiac resynchronization therapy (CRT) is an established treatment of patients with heart failure. Several baseline characteristics can influence the CRT outcomes, and little is known about the effect of gender. The aim of the present study was to elucidate the gender-related differences in long-term survival after CRT. A total of 578 consecutive patients with heart failure underwent CRT. At baseline and 6 months after CRT, the clinical and echocardiographic parameters were obtained. All-cause...
Abstract
Cited 69 times since 2011 (4.8 per year)
source: EuropePMC
Clinical pediatrics,
Volume 50, Issue 9, 27 4 2011, Pages 807-815
Interprofessional team training in pediatric resuscitation: a low-cost, in situ simulation program that enhances self-efficacy among participants.
van Schaik SM, Plant J, Diane S, Tsang L, O'Sullivan P
Introduction: Simulation-based interprofessional team training is important to ensure high-quality, safe patient care, but several barriers exist, including diverging learning needs and schedules as well as limited available resources. Methods: The authors developed an in situ, simulation-based interprofessional team training program around pediatric emergencies for physicians, nurses, respiratory therapists, and pharmacists at their institution and performed an analysis of the program's im...
Abstract
Cited 135 times since 2011 (9.4 per year)
source: EuropePMC
Mucosal immunology,
Volume 4, Issue 5, 27 4 2011, Pages 554-563
Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial.
Gori A, Rizzardini G, Van't Land B, Amor KB, van Schaik J, Torti C, Quirino T, Tincati C, Bandera A, Bandera A, Knol J, Benlhassan-Chahour K, Trabattoni D, Bray D, Vriesema A, Welling G, Garssen J, Clerici M
Intestinal mucosal immune system is an early target for human immunodeficiency virus type 1 (HIV-1) infection, resulting in CD4(+) T-cell depletion, deterioration of gut lining, and fecal microbiota composition. We evaluated the effects of a prebiotic oligosaccharide mixture in highly active antiretroviral therapy (HAART)-naive HIV-1-infected adults. In a pilot double-blind, randomized, placebo-controlled study, 57 HAART-naive HIV-1-infected patients received a unique oligosaccharide mixture (15...
Abstract
Cited 2 times since 2011 (0.1 per year)
source: EuropePMC
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada,
Volume 17, Issue 3, 27 4 2011, Pages 452-460
Analysis of elemental composition of the eggshell before and after incubation in the loggerhead turtle ( Caretta caretta) in Oman.
Al-Bahry SN, Mahmoud IY, Melghit K, Al-Amri I
To date, there are limited studies on loggerhead turtle (Caretta caretta) eggshell ultrastructure and its elemental composition. Eggs were collected from turtle nests immediately after oviposition and post hatching. Three eggshell layers were recognized. The outer calcareous layer consists of loose nodular units of different shapes and sizes with loose attachment between the units, resulting in numerous spaces and openings. Each unit consists of CaCO3 crystals in aragonite (99%) and calcite (1%)...
Abstract
Cited 269 times since 2011 (18.8 per year)
source: EuropePMC
Journal of translational medicine,
Volume 9, 25 4 2011, Pages 47
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs.
Chen TS, Arslan F, Yin Y, Tan SS, Lai RC, Choo AB, Padmanabhan J, Lee CN, de Kleijn DP, Lim SK
Background: Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale production of these exosomes would require replenishment of hESC-MSC through derivation from hESCs and incur recurring costs for testing and validation of each new batch. Our aim was therefore to investigate if MYC immortalization of hESC-MSC...
Abstract
Cited 5 times since 2011 (0.3 per year)
source: EuropePMC
Transfusion medicine (Oxford, England),
Volume 21, Issue 4, 24 4 2011, Pages 236-246
The effect of RBC transfusions on cytokine gene expression after cardiac surgery in patients developing post-operative multiple organ failure.
Sitniakowsky LS, Later AF, van de Watering LM, Bogaerts M, Brand A, Klautz RJ, Smit NP, van Hilten JA
Aim: To determine the effect of red blood cell (RBC) transfusions during cardiac surgery on cytokine gene expression (GE) in relation to multiple organ failure (MOF) development after systemic inflammatory response syndrome (SIRS). Background: RBC transfusion in cardiac surgery patients is dose-dependently associated with post-operative MOF, possibly acting as a second hit after cardiopulmonary bypass. Methods: For this observational study, 29 patients divided into four groups of cardiac surgery...
Abstract
Cited 53 times since 2011 (3.7 per year)
source: EuropePMC
Basic research in cardiology,
Volume 106, Issue 5, 24 4 2011, Pages 829-847
In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1.
Bax NA, van Oorschot AA, Maas S, Braun J, van Tuyn J, de Vries AA, Groot AC, Goumans MJ
Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibroblasts, which contribute to cardiac repair. To understand what drives epicardial EMT, we used an in vitro model for human adult epicardial cells. These cells have an epithelium-like...
Abstract
