Research

Publications

Below you can find a list of our published research.

6190 results

Journal of the American College of Cardiology, Volume 85, Issue 14, 1 1 2025, Pages 1471-1484 Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E, CAPRICE Co-Investigators

Background: The extent to which high-sensitivity cardiac troponin can predict cardiovascular disease (CVD) is uncertain. Objectives: We aimed to quantify the potential advantage of adding information on cardiac troponins to conventional risk factors in the prevention of CVD. Methods: We meta-analyzed individual-participant data from 15 cohorts, comprising 62,150 participants without prior CVD. We calculated HRs, measures of risk discrimination, and reclassification after adding cardiac troponin... Abstract

Diabetes care, Volume 48, Issue 4, 1 1 2025, Pages 596-604 Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial. Schwartz GG, Szarek M, Jukema JW, Cobbaert CM, Reijnders E, Bittner VA, Schwertfeger M, Bhatt DL, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Steg PG

Objective: Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. Research design and methods: In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA-insulin resistance [HOMA-IR]) and... Abstract

The Review of scientific instruments, Volume 96, Issue 4, 1 1 2025, Pages 044504 Controlled partial gravity platform for milligravity in drop tower experiments. Joeris K, Keulen M, Kollmer JE

We detail a platform for partial gravity environment and an experiment for simulated impacts on asteroid surfaces based on it. The partial gravity environment is created by a two stage approach: First, we place the experiment in the microgravity of a free-falling drop tower capsule in the ZARM (German acronym for Center of Applied Space Technology and Microgravity) Bremen drop tower. Second, we convert microgravity to partial gravity by steady acceleration of the experiment volume on a linear dr... Abstract

Cited 2 times since 2025 (24.2 per year) source: EuropePMC

Cardiovascular research, Volume 121, Issue 1, 1 1 2025, Pages 143-156 miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues. Senesi G, Lodrini AM, Mohammed S, Mosole S, Hjortnaes J, Veltrop RJA, Kubat B, Ceresa D, Bolis S, Raimondi A, Torre T, Malatesta P, Goumans MJ, Paneni F, Camici GG, Barile L, Balbi C, Vassalli G

Aims: Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR-24-3p regulates this process in animal models. Here, we investigated whether miR-24-3p plays similar roles in human models. Methods and results: Gain- and loss-of-function experiments were performed using human induced pluripotent stem cell-derived cardiomyoc... Abstract

Circulation. Cardiovascular imaging, 31 5 2025 AI-Quantitative CT Coronary Plaque Features Associate with a Higher Relative Risk in Women: CONFIRM2-Registry. Feuchtner GM, Lacaita PG, Bax JJ, Rodriguez F, Nakanishi R, Pontone G, Mushtaq S, Buechel RR, Gräni C, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho GW, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves Pereira PM, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, van Assen M, De Cecco CN, Foldyna B, Brendel JM, Cheng VY, Branch K, Bittencourt M, Bhatti S, Polsani Md V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Bloom S, Kamperidis V, Barbieri F, Aquino M, Danad I, van Rosendael A

Background: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative coronary computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACE). Methods: Global multicenter registry (CONFIRM2) including symptomatic patients with suspicion... Abstract

Journal of cardiothoracic and vascular anesthesia, 29 5 2025, Pages S1053-0770(25)00272-1 Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience. Pandey AK, Kougioumtzoglou AM, Lam BCY, Kho E, Eberl S, Dilai J, Koolbergen DR, Hermanns H

Objective: To delineate anesthesia management during the personalized external aortic root support (PEARS) procedure, with a focus on the use of multimodal monitoring and deliberate profound hypotension. Design: A single-center retrospective cohort study. Setting: Tertiary academic hospital. Participants: Patients undergoing the PEARS procedure due to aortic aneurysm. Interventions: None. Methods: Patient characteristics and anesthesia management are described, with particular emphasis on multim... Abstract

The international journal of cardiovascular imaging, 29 5 2025 Prognostic impact of left ventricular myocardial work in patients undergoing surgery for primary mitral regurgitation. Nabeta T, Peters F, Wu HW, Chua AP, Palmen M, Tomšič A, Marsan NA, Bax JJ, van der Bijl P

Purpose: Echocardiography-based, left ventricular myocardial work (LVMW) can assess LV function by incorporating LV afterload. This study aims to evaluate the prognostic value of LVMW indices in patients with primary mitral regurgitation (MR) undergoing mitral valve surgery. Methods and results: A total of 306 patients (mean age 63 ± 12 years, 68% male) with severe, primary MR who underwent surgery, were included. All patients underwent transthoracic echocardiography and LVMW indices were assess... Abstract

Clinical case reports, Volume 13, Issue 4, 28 4 2025, Pages e70282 A <i>PDLIM7</i> Variant in Familial Mitral Valve Prolapse: A Case Series. van Wijngaarden AL, Koopmann TT, Ruivenkamp CAL, Wu HW, Ajmone Marsan N, Barge-Schaapveld DQCM

In the presented case of familial mitral valve prolapse, whole exome sequencing was used to reveal a missense variant in the PDLIM7 gene. This gene is considered a possible novel candidate gene for familial MVP based on PDLIM7 knock-out mice and zebrafish showing mitral valve abnormalities. Abstract

European heart journal. Quality of care & clinical outcomes, 28 4 2025, Pages qcae106 Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings. Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis

European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician... Abstract

American heart journal plus : cardiology research and practice, Volume 53, 26 4 2025, Pages 100534 The clinical impact of prophylactic concomitant left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis. Zhao C, Girdauskas E, Schoones JW, Klautz RJM, Palmen M, Tomšič A

Background: Recently, concomitant left atrial appendage occlusion (LAAO) has emerged as prophylactic treatment option for preventing thromboembolic events in patients undergoing cardiac surgery with no known history of atrial fibrillation. The efficacy of prophylactic LAAO remains unknown. Methods: PubMed, Embase, Web of Science, Emcare, and the Cochrane Library were searched for studies on prophylactic LAAO in patients undergoing cardiac surgery. The primary endpoints were postoperative thrombo... Abstract

European heart journal. Cardiovascular Imaging, 25 4 2025, Pages jeaf093 CCTA-Derived Coronary Plaque Burden Offers Enhanced Prognostic Value Over CAC Scoring In Suspected CAD Patients. Dahdal J, Jukema RA, Maaniitty T, Nurmohamed NS, Raijmakers PG, Hoek R, Driessen RS, Twisk JWR, Bär S, Planken RN, van Royen N, Nijveldt R, Bax JJ, Saraste A, van Rosendael AR, Knaapen P, Knuuti J, Danad I

Aim: To assess the prognostic utility of coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA) - derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods and results: The study enrolled 2,404 patients with suspected CAD but without prior history of CAD. All participants underwent CAC scoring and CCTA, with plaque metrics quantified using an artificial intelligence (AI)-based tool (Cleerly, Inc). Percent atheroma volume (PAV)... Abstract

ESC heart failure, 23 4 2025 Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation. Tribouilloy C, Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y, Antoine C, Rusinaru D, Grigioni F, Ajmone Marsan N, van Wijngaarden A, Hochstadt A, Roussel JC, Thapa P, Hector M, Enriquez-Sarano M

Aims: Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR associated with asymptomatic DMR. Methods and results: The study included 1249 asymptomatic patients with moderate or severe DMR from the Mitral Regurgitation International Database-Quantitative (MIDA-Q) registry (mean age 64 ± 15 years, 25% female). Despite the asymptomatic status, absent/tri... Abstract

Journal of the American Heart Association, Volume 14, Issue 7, 21 3 2025, Pages e037531 Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts. Garoffolo G, Sluiter TJ, Thomas A, Piacentini L, Ruiter MS, Schiavo A, Salvi M, Saccu C, Zoli S, Chiesa M, Yokoyama T, Agrifoglio M, Soncini M, Fiore GB, Martelli F, Condorelli G, Madeddu P, Molinari F, Morbiducci U, Quax PHA, Spinetti G, de Vries MR, Pesce M

Background: Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in the intima layer, leading to progressive bypass stenosis. We previously showed that cyclic strain deriving from exposure to coronary flow induces the expression of the matricellular protein thrombospondin-1 in the human SV, promoting activation... Abstract

European journal of heart failure, 19 3 2025 Ventricular arrhythmias in acute heart failure. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Heart Rhythm Association (EHRA) and the Heart Failure Association (HFA) of the ESC. Gorenek B, Wijnmaalen AP, Goette A, Mert GO, Porter B, Gustafsson F, Dan GA, Ector J, Stuehlinger M, Spartalis M, Gosau N, Amir O, Chioncel O

Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate. New VAs during AHF have previously identified patients with higher in-hospital and 60-day morbidity and mortality. Risk stratific... Abstract

Annals of medicine and surgery (2012), Volume 87, Issue 4, 19 3 2025, Pages 1995-1999 Fostering an open surgical culture: strategies to eliminate inappropriate behavior in surgical practice. Blok JJ, Snijders HS, Huizing F, Schmitz RF, Kerstjens LJ, Sier VQ, Blok CC, Lijkwan MA, Schepers A

Surgery is a demanding and stressful profession. Unfortunately, inappropriate behavior is still not banished from the daily surgical practice and we are dealing with the negative consequences (e.g. negative working environments or burn-out). To adequately treat this type of behavior we first have to acknowledge its existence and create a proper path to discuss it inside our own ranks. The only manner to achieve this, is through an open culture. An 'open surgical culture' is the key, as... Abstract

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 18 3 2025 Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry. van der Rijst LP, van Luijk CM, van der Kamp S, Zuithoff NPA, de Boer JH, de Bruin-Weller MS, de Graaf M

Background: Dupilumab-associated ocular surface disease (DAOSD) is a common side effect in paediatric atopic dermatitis (AD) patients treated with dupilumab. However, long-term real-world safety data is limited. Therefore, this study investigates the incidence of DAOSD in paediatric AD patients treated with dupilumab and identifies associated risk factors. Methods: This prospective study included paediatric AD patients (aged 3-17 years) treated with dupilumab. Ocular symptoms were assessed every... Abstract

International journal of cardiology. Heart & vasculature, Volume 58, 17 3 2025, Pages 101654 Association of indexed aortic dimensions with the presence and extent of coronary artery ectasia in patients with acute coronary syndrome. van Oort MJH, Oliveri F, de Lange FWJ, Regeer MV, Bingen BO, Jukema JW, van der Kley F, Al Amri I, Montero-Cabezas JM

Background: Conflicting findings have been reported on the potential association between CAE and aortic dilatation. This study aimed to investigate the relationship between CAE extent and aortic dimensions in patients with acute coronary syndrome (ACS). Methods: This retrospective cohort study included 448 adult patients who underwent coronary angiography for ACS between 2004 and 2015. The cohort was divided into 224 patients with CAE and 224 control patients without CAE, matched for age, sex, a... Abstract

Pediatric cardiology, 13 2 2025 Fontan-Associated Liver Disease (FALD) in the EUROFontan Experience. An Insight into European Awareness. Gozzi A, Vedovelli L, Bergonzoni E, Cao I, Angeli E, Zanoni R, Biffanti R, Butera G, Dimopoulos K, Rocafort AG, Hazekamp MG, Kansky A, Lenoir M, Martens T, Meliota G, Meyns B, Nosal M, Napoleone CP, Rijnberg FM, Dolzer ES, Scrascia G, Vairo U, Van Puyvelde J, Di Salvo G, Montanaro C, Padalino MA

Fontan-Associated Liver Disease (FALD) is a dramatically emerging problem even if not precisely defined in term of debated diagnosis and surveillance protocols. We analyze FALD prevalence, clinical impact and implications in a European cohort of patients. It's a retrospective observational multicenter study including Fontan patients operated between 1990 and 2022. Anatomical, clinical, surgical and liver-related data were collected, defining FALD as a spectrum of time-related structural-fun... Abstract

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 5, 13 2 2025, Pages 576-584 Role of Perivascular Adipose Tissue in Vein Remodeling. Kruit N, Sluiter TJ, de Vries MR

Perivascular adipose tissue (PVAT) plays a crucial, yet underexplored, role in vein remodeling, which occurs after bypass surgery using a venous graft or creation of arteriovenous fistulae for hemodialysis access. PVAT exhibits significant heterogeneity in phenotype and tissue composition depending on the vascular bed, as well as its anatomic location within the vasculature. Through the excretion of adipokines, cytokines, and chemokines, PVAT can shape the vascular response to local and systemic... Abstract

Journal of lipid research, Volume 66, Issue 4, 13 2 2025, Pages 100778 Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R

Plasma 1H-NMR metabolomic measures have yielded significant insight into the pathophysiology of cardiometabolic disease, but their inter-related nature complicates causal inference and clinical interpretation. This study aimed to investigate the associations of unrelated 1H-NMR metabolomic profiles with coronary artery disease (CAD) and ischemic stroke (IS). Principal component (PC) analysis was performed on 168 1H-NMR metabolomic measures in 56,712 unrelated European participants from UK Bioban... Abstract