Research

Publications

Below you can find a list of our published research.

8799 results

Journal of Crohn's & colitis, Volume 19, Issue 1, 1 1 2025, Pages jjaf002 Diagnosing Crohn's disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn's disease in perianal fistulas (PREFAB). Munster LJ, Hanna LN, Hart AL, Tozer PJ, Buskens CJ, van der Bilt JDW, TOpCLASS perianal Crohn’s disease Consortium, the Dutch Initiative on Crohn and Colitis (ICC) and the Initiative on Crohn and Colitis - Surgery (ICC-S)

Background: The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn's disease (CD) in patients with perianal fistula(s) (PAF). Methods: A panel of international experts in the field of proctology/inflammatory bowel disease was invited to participate. In the first round (electronic survey), participants were asked to anonymously provide their opinion probing (1) the relevance and use of clinical characteristics suggestive of under... Abstract

JAMA dermatology, Volume 161, Issue 1, 1 1 2025, Pages 12-21 Drug Survival of Dupilumab, Methotrexate, and Cyclosporine A in Children With Atopic Dermatitis. van der Rijst LP, Kamphuis E, Schuttelaar MLA, Hurmuz R, Seyger MMB, Caron AGM, Zuithoff NPA, Nguyen NT, Kamsteeg M, de Bruin-Weller MS, Pasmans SGMA, Middelkamp-Hup MA, de Graaf M

Importance: Dupilumab, methotrexate (MTX), and cyclosporine A (CsA) are valuable treatment options for pediatric patients with refractory moderate to severe atopic dermatitis (AD). Yet, comparative data on these treatments in pediatric patients are scarce. Objective: To evaluate drug survival of dupilumab, MTX, and CsA, and identify associated predictors in a multicenter daily practice cohort study of pediatric patients with AD. Design, setting, and participants: This multicenter daily practice... Abstract

Digital health, Volume 11, 1 1 2025, Pages 20552076241288724 Sleep as a window of cardiometabolic health: The potential of digital sleep and circadian biomarkers. van den Brink WJ, Oosterman JE, Smid DJ, de Vries HJ, Atsma DE, Overeem S, Wopereis S

Digital biomarkers are quantifiable and objective indicators of a person's physiological function, behavioral state or treatment response, that can be captured using connected sensor technologies such as wearable devices and mobile apps. We envision that continuous and 24-h monitoring of the underlying physiological and behavioral processes through digital biomarkers can enhance early diagnostics, disease management, and self-care of cardiometabolic diseases. Cardiometabolic diseases, which... Abstract

Journal of the Society for Cardiovascular Angiography & Interventions, Volume 4, Issue 2, 31 5 2025, Pages 102492 Navigating Treble Clef Aorta: A Challenge for Transfemoral Transcatheter Aortic Valve Replacement-A Case Report. Anwar HS, Montero-Cabezas JM, Van Der Kley F

Transcatheter aortic valve replacement (TAVR) has emerged as a widely approved intervention for managing severe aortic stenosis. As the number of patients undergoing TAVR continues to rise, certain cases present unique challenges, particularly in relation to vascular access. This report highlights a case of successful transfemoral TAVR performed in a patient with an exceptionally tortuous and elongated aortic arch, characterized by significant curvature reminiscent of the treble clef musical sym... Abstract

The Canadian journal of cardiology, Volume 41, Issue 5, 31 5 2025, Pages 899-910 The Role of the Axonal Guidance Cue Semaphorin 3A in Innervation of the Postnatal Heart in Health and Disease. Koppel CJ, De Henau CMS, Vreeken D, DeRuiter MC, Jongbloed MRM, van Gils JM

During cardiac development, the heart is innervated by the autonomous nervous system. After development, neurons of the autonomic nervous system have limited capacity for growth and regeneration. However, in recent decades, it has become clear that cardiac nerves can regenerate after cardiac damage. Excessive reinnervation, so-called sympathetic hyperinnervation, may render patients vulnerable to ventricular arrhythmias and heart failure. Several studies have investigated axonal guidance cues as... Abstract

Allergy, Volume 80, Issue 4, 26 4 2024, Pages 1006-1014 Genotype-Guided Asthma Treatment Reduces Exacerbations in Children: Meta-Analysis of Two Randomized Control Trials. Slob EMA, Vijverberg SJH, Ruffles T, Noij LCE, Biermann J, Brouwer AFJ, van den Brink K, de Bruin-Kok A, Van Ewijk BE, Haarman E, Hammer SC, Hashimoto S, Hogarth F, Jones CJ, Kamps AWA, Kersten ETG, de Kleer I, Lipworth BJ, Littleford R, Mérelle M, Moeller A, Palmer CNA, Pilvinyte K, Rutjes NW, van Schaik RHN, Smith HE, Tavendale R, Terheggen-Lagro SWJ, Turner S, Twisk JWR, Vaessen-Verberne A, Verwaal M, de Vries T, Wesseling J, Pijnenburg MW, Koppelman GH, Mukhopadhyay S, Maitland-van der Zee AH

Background: Long-acting beta2-agonists (LABA) in combination with inhaled corticosteroids (ICS) are commonly used to treat asthma, however, some children lack response to the addition of LABA. This might be partially due to the presence of the Arg16Gly polymorphism, encoded by rs1042713 G>A in the ADRB2 gene. Carrying the A allele (Arg16) at this variant has been associated with an increased risk of exacerbations despite LABA treatment. We investigated whether genotype-guided treatment improv... Abstract

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, 26 4 2024, Pages 15266028241309267 Diagnostic Performance of the Maximal Systolic Acceleration for Detecting a Significant Stenosis in the Aortoiliac and Popliteal Pathway: A Retrospective Cohort Study. Willems SA, Dolfing SG, van Wissen RC, van der Meer RW, van Schaik J, van der Vorst JR, Schepers A, Hamming JF, Brouwers JJWM

Introduction: Identifying peripheral arterial disease (PAD) remains challenging with currently used bedside tests. The maximal systolic acceleration (ACCmax) is a promising noninvasive parameter measured by duplex ultrasonography and reflects the arterial perfusion proximal to its measurement point. The principal aim of this study was to analyze the diagnostic accuracy of the ACCmax for detecting significant stenosis in different arterial segments, which could be useful in clinical decision-maki... Abstract

EBioMedicine, Volume 111, 25 4 2024, Pages 105518 Simplifying coronary artery disease risk stratification: development and validation of a questionnaire-based alternative comparable to clinical risk tools. Kokkorakis M, Folkertsma P, Anagnostakis F, Sirotin N, Agarwal M, Shantouf R, Henning RH, Pijl H, Wolffenbuttel BHR, Bax JJ, Atsma DE, Castela Forte J, Mantzoros CS, van Dam S

Background: Coronary artery disease (CAD) comprises one of the leading causes of morbidity and mortality both in the European population and globally. All established clinical risk stratification scores and models require blood lipids and physical measurements. The latest reports of the European Commission suggest that attracting health professionals to collect these data can be challenging, both from a logistic and cost perspective, which limits the usefulness of established models and makes th... Abstract

BMC infectious diseases, Volume 24, Issue 1, 23 4 2024, Pages 1460 Nosocomial transmission of NDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center associated with patients from Ukraine. Smit WL, Wunderink HF, Kluytmans JAJW, Tissing WJE, van Dijkhuizen EHP, Loeffen YGT, Hendrickx APA, Dutch CPE Surveillance Study Group

We studied nosocomial transmission of multidrug-resistant blaNDM-1-containing Klebsiella pneumoniae ST147 in a Dutch pediatric oncology center. Whole-genome multilocus sequence typing revealed two genetic clusters consisting of 2 and 5 K. pneumoniae isolates, both from Ukrainian medical evacuees and Dutch patients. Ukrainian patients were colonized at admission, and two Dutch patients developed bacteremia. Temporal and spatial transmission links were assessed and sampling of sinks revealed envir... Abstract

Cited 2 times since 2024 (4.1 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 111, Issue 2, 23 4 2024, Pages 62-68 Evolving use and clinical outcomes of coronary intravascular lithotripsy: insights from an international, multicentre registry. van Oort MJH, Al Amri I, Bingen BO, Oliveri F, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is increasingly used for treatment of coronary artery calcification. This study aimed to evaluate contemporary utilisation patterns, safety and efficacy of IVL in an unselected real-world patient cohort. Methods: We included 454 patients undergoing IVL from May 2019 to February 2024 across seven centres in two European countries. Key endpoints included device success, technical success, procedural success, IVL-related complications and major adverse ca... Abstract

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, Volume 127, 23 4 2024, Pages 105707 Europe-wide distribution and bat-host specific lineages in the malarial parasite Polychromophilus murinus revealed through genetic screening of bat flies. Timm L, Rosskopf SP, Werb O, van Schaik J, Schaer J

Malaria parasites of the genus Polychromophilus commonly infect vespertilionid and miniopterid bats, and are transmitted by bat flies (Nycteribiidae). While Polychromophilus murinus has been recorded sporadically in Europe, its host range, distribution and phylogeographic structure have not been explored. Here we investigate the prevalence and genetic diversity of P. murinus infections in 1131 bat flies collected from seven European bat species, focusing on Basilia nana, collected from its prima... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 168, 23 4 2024, Pages D8394 [Quick decisionmaking for acute pulmonary embolism patients]. Op de Hoek LJ, Montero Cabezas JM, den Exter PL, Al Amri I, Elzo Kraemer CV, Klok FA

Treatment options for patients with severe pulmonary embolism (PE) have increased substantially over the past decade. Although systemic thrombolysis is still the reperfusion therapy of choice for hemodynamically unstable PE patients, several new catheter guided reperfusion therapies have emerged as possibly safer alternatives. These therapies are increasingly implemented in clinical practice even though their efficacy and safety are yet to be proven by clinical outcome studies. Along with the ri... Abstract

International journal of cardiology. Congenital heart disease, Volume 19, 20 3 2024, Pages 100560 Using machine learning analysis to describe patterns in tissue Doppler and speckle tracking echocardiography in patients with transposition of the great arteries after arterial switch operation. Terol Espinosa de Los Monteros C, van der Palen RLF, Van den Eynde J, Rammeloo L, Hazekamp MG, Blom NA, Kuipers IM, Ten Harkel ADJ

Background: Advanced echocardiographic techniques such as Tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) can detect more subtle changes in ventricular performance. We aimed to study the ventricular performance in patients with transposition of the great arteries (TGA) at mid-term follow-up after the arterial switch operation (ASO) with advanced echocardiographic techniques. In addition, we sought to discover new clinical phenotypes using unsupervised machine learning. M... Abstract

BMJ open, Volume 14, Issue 12, 20 3 2024, Pages e086629 DIAMACC: protocol of a prospective diagnostic accuracy study of the maximal systolic acceleration to detect peripheral arterial disease in patients with diabetes-related foot ulceration in the Netherlands. Willems S, Schepers A, Hamming J, Brouwers JJWM

Introduction: Foot ulcers are one of the most serious complications of diabetes, leading to significant risks on amputation and mortality. Peripheral arterial disease (PAD) is an important factor for the development and the outcome of diabetic foot ulcers (DFU). Although prompt and accurate detection of PAD is critical to reduce complications, its diagnosis can be challenging with currently used bedside tests (such as ankle-brachial index and toe pressure) due to medial arterial calcification. A... Abstract

Journal of pediatric nursing, Volume 80, 19 3 2024, Pages e170-e179 Development and validation of the social determinants of health screening scale-parent form. Yılmaz D, Güney R

Background: The American Academy of Pediatrics recommends screening children for social determinants of health (SDOH). Purpose: This study aimed to develop a valid and reliable tool for screening SDOH in children and adolescents aged 0-18 through their parents. Design and methods: This methodological research was conducted with parents of 748 children admitted to a hospital in Turkey. An item pool was created from a literature review and interviews with 30 healthcare professionals. The scale... Abstract

Journal of the American Heart Association, Volume 14, Issue 1, 18 3 2024, Pages e036206 Prognostic Implications of Right Ventricular Dysfunction in Severe Degenerative Mitral Regurgitation. Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y, Antoine C, Rusinaru D, Grigioni F, Ajmone Marsan N, van Wijngaarden A, Hochstadt A, Roussel JC, Diouf M, Thapa P, Michelena HI, Enriquez-Sarano M, Tribouilloy C

Background: The prevalence and impact of right ventricular dysfunction (RVD) in degenerative mitral regurgitation (DMR) is unknown. We aimed to determine whether RVD assessed by echocardiography in routine clinical practice is independently associated with mortality in patients with DMR. Methods and results: We used data from the MIDA-Q (Mitral Regurgitation International DAtabase-Quantitative) registry, which included patients with isolated DMR due to mitral valve prolapse from January 2003 to... Abstract

The Lancet. Microbe, Volume 6, Issue 2, 18 3 2024, Pages 100942 Immune responses to SARS-CoV-2 in sub-Saharan Africa and western Europe: a retrospective, population-based, cross-sectional study. Mbow M, Hoving D, Cisse M, Diallo I, Honkpehedji YJ, Huisman W, Pothast CR, Jongsma MLM, König MH, de Kroon AC, Linh LTK, Azimi S, Tak T, Kruize YCM, Kurniawan F, Dia YA, Zhang JLH, Prins C, Roukens AHE, de Vries JJC, Wammes LJ, Smits HH, Adegnika AA, Zlei M, Kuijpers TW, Wieske L, Dieye A, Mboup S, Kremsner PG, Eftimov F, Velavan TP, Berlin I, Heemskerk MHM, Yazdanbakhsh M, Jochems SP, BEAT-COVID consortium, COVID-19 Leiden University Medical Center study team

Background: SARS-CoV-2 has been associated with a higher proportion of asymptomatic infections and lower mortality in sub-Saharan Africa than high-income countries. However, there is currently a lack of data on cellular immune responses to SARS-CoV-2 in people living in Africa compared with people in high-income regions of the world. We aimed to assess geographical variation in peripheral and mucosal immune responses. Methods: In this retrospective, population-based, cross-sectional study, we an... Abstract

BMC infectious diseases, Volume 24, Issue 1, 18 3 2024, Pages 1444 The frequency of serious bacterial infection in febrile infants less than 90 days infected with SARS-CoV-2 and other respiratory viral pathogens. Yigit H, Ulusoy E, Guneysu ST, Colak O, Gultekingil A, Guleryuz OD, Yilmaz D, Duman M, Teksam O

Background: The primary aim of this study was to compare the groups, SARS-CoV-2-positive and -negative patients, in terms of the frequency of SBI. The SARS-CoV-2-positive group was compared with the other-RVPs-positive group as a secondary evaluation in terms of serious bacterial infection (SBI). Methods: This retrospective multicenter cohort study was conducted at four university hospitals from March 2020 to December 2021. Patients under 90 days old, with a measured fever of ≥ 38 °C, who were t... Abstract

Journal of dairy science, Volume 108, Issue 3, 17 3 2024, Pages 2780-2794 Dutch bovine viral diarrhea virus control program: Evaluation 2018-2023. Strous EEC, Bisschop PIH, van Schaik G, Mars MH, Waldeck HWF, Scherpenzeel CGM, de Roo B, Wever P, Santman-Berends IMGA

Since 2018, Dutch dairy farmers have been obliged to opt for 1 of 4 routes to achieve bovine viral diarrhea virus (BVDV) freedom in the national BVDV eradication program. This observational study evaluated efficacy of the total BVDV program using indicators such as the number of persistently infected (PI) cattle, the percentage of dairy herds with a BVDV-free status, and the percentage of BVDV-free dairy herds with evidence of introduction of BVDV, as well as a cost calculation per route. The Du... Abstract

Multiple sclerosis and related disorders, Volume 93, 15 3 2024, Pages 106205 Children with MOG-IgG positive bilateral optic neuritis misdiagnosed as fulminant idiopathic intracranial hypertension. Wendel EM, Tibussek D, Barisic N, Bertolini A, Panzer A, Chang P, Geis T, Knierim E, Nikolaus M, Nosadini M, Sartori S, Schoene-Bake JC, Yilmaz D, Reindl M, Pakeerathan T, Ayzenberg I, Rostásy K

Background: Fulminant idiopathic intracranial hypertension (IIH) is characterized by headache, rapid decrease of vision and elevated CSF-opening pressure. Objective: To delineate a subgroup of MOGAD mimicking fulminant IIH. Methods: In this case series children with MOGAD with vision loss, optic disc swelling and elevated CSF opening pressure, initially diagnosed with fulminant IIH, were included. Results: 8 MOGAD patients (median age 12.5y, f:m = 7:1) with an initial diagnosis of fulminant IIH... Abstract