Research

Publications

Below you can find a list of our published research.

6232 results

Cited 29 times since 2015 (2.8 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 20, Issue 4, 22 4 2015, Pages 520-530 Mortality after cardiac surgery in patients with liver cirrhosis classified by the Child-Pugh score. Jacob KA, Hjortnaes J, Kranenburg G, de Heer F, Kluin J

Liver cirrhosis is a known risk factor for postoperative mortality in patients undergoing cardiac surgery. Clinical assessment of liver cirrhosis using the widely accepted Child-Pugh (CP) score is thus vital for evaluation of surgical options and perioperative care. However, detailed mortality rates as a consequence of liver cirrhosis are unclear. This review aimed to stratify the risk of short-term ( Abstract

Cited 59 times since 2015 (5.7 per year) source: EuropePMC

Journal of virology, Volume 89, Issue 7, 21 3 2015, Pages 3763-3775 Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses. Koel BF, Mögling R, Chutinimitkul S, Fraaij PL, Burke DF, van der Vliet S, de Wit E, Bestebroer TM, Rimmelzwaan GF, Osterhaus AD, Smith DJ, Fouchier RA, de Graaf M

Unlabelled: The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from neutralizing antibodies, affect viral fitness, and change receptor preference. In this study, we constructed mutants with substitutions in the hemagglutinin of A/Netherlands/602/0... Abstract

Cited 21 times since 2015 (2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 48, Issue 6, 18 3 2015, Pages 833-40; discussion 840-1 Comprehensive rhythm evaluation in a large contemporary Fontan population. Bossers SS, Duppen N, Kapusta L, Maan AC, Duim AR, Bogers AJ, Hazekamp MG, van Iperen G, Helbing WA, Blom NA

Objectives: Rhythm disturbances are an important cause of morbidity in Fontan patients. Currently, the total cavopulmonary connection is performed by using the intra-atrial lateral tunnel (ILT) ('baffle ILT' or 'prosthetic ILT'), or the extracardiac conduit (ECC). The aim of the study was to evaluate rhythm abnormalities and compare the surgical techniques in a contemporary cohort. Methods: In a cross-sectional multicentre study, 115 patients (age 12.5 ± 3.1 years) underwent... Abstract

Cited 3 times since 2015 (0.3 per year) source: EuropePMC

Cardiorenal medicine, Volume 5, Issue 1, 16 3 2015, Pages 69-78 Neuronal nitric oxide synthase-dependent amelioration of diastolic dysfunction in rats with chronic renocardiac syndrome. Bongartz LG, Soni S, Cramer MJ, Steendijk P, Gaillard CA, Verhaar MC, Doevendans PA, van Veen TA, Joles JA, Braam B

We have recently described the chronic renocardiac syndrome (CRCS) in rats with renal failure, cardiac dysfunction and low nitric oxide (NO) availability by combining subtotal nephrectomy and transient low-dose NO synthase (NOS) inhibition. Cardiac gene expression of the neuronal isoform of NOS (nNOS) was induced. Hence, we studied the role of nNOS, in vivo cardiac function and β-adrenergic response in our CRCS model by micromanometer/conductance catheter. Left ventricular (LV) hemodynamics were... Abstract

Cited 25 times since 2015 (2.4 per year) source: EuropePMC

Journal of the American Academy of Dermatology, Volume 72, Issue 3, 13 2 2015, Pages 465-472 Is cardiovascular evaluation necessary prior to and during beta-blocker therapy for infantile hemangiomas?: A cohort study. Raphael MF, Breugem CC, Vlasveld FA, de Graaf M, Slieker MG, Pasmans SG, Breur JM

Background: Although consensus guidelines for pretreatment evaluation and monitoring of propranolol therapy in patients with infantile hemangiomas (IH) have been formulated, little is known about the cardiovascular side effects. Objectives: We sought to analyze cardiovascular evaluations in patients with IH at baseline and during treatment with an oral beta-blocker. Methods: Data from 109 patients with IH were retrospectively analyzed. Patient and family history, pretreatment electrocardiogram (... Abstract

Cited 12 times since 2015 (1.1 per year) source: EuropePMC

Acta physiologica (Oxford, England), Volume 213, Issue 3, 9 2 2015, Pages 653-663 Mild hypothermia induces incomplete left ventricular relaxation despite spontaneous bradycardia in pigs. Schwarzl M, Alogna A, Zirngast B, Steendijk P, Verderber J, Zweiker D, Huber S, Maechler H, Pieske BM, Post H

Aim: Mild hypothermia (MH) decreases left ventricular (LV) end-diastolic capacitance. We sought to clarify whether this results from incomplete relaxation. Methods: Ten anaesthetized pigs were cooled from normothermia (NT, 38 °C) to MH (33 °C). LV end-diastolic pressure (LVPed), volume (LVVed) and pressure-volume relationships (EDPVRs) were determined during stepwise right atrial pacing. LV capacitance (i.e. LVVed at LVPed of 10 mmHg, LV VPed10) was derived from the EDPVR. Pacing-induced changes... Abstract

Cited 7 times since 2015 (0.7 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 20, Issue 4, 6 1 2015, Pages 499-503 Hybrid branch pulmonary artery stent placement in adults with congenital heart disease. Lynch W, Boekholdt SM, Hazekamp MG, de Winter RJ, Koolbergen DR

Objectives: Valuable treatment modalities for branch pulmonary artery (BPA) stenoses are surgical patch angioplasty, percutaneous BPA stenting and hybrid stent placement. The purpose of this study was to report our institutional experience with hybrid stent placement to relieve BPA stenoses. Methods: Between August 2007 and May 2014, 7 adults (5 females) with congenital heart disease (CHD) had elective intraoperative BPA stent placement. All 7 patients had undergone previous surgery [6 tetralogy... Abstract

Cited 27 times since 2015 (2.6 per year) source: EuropePMC

European heart journal. Acute cardiovascular care, Volume 5, Issue 1, 5 1 2015, Pages 3-12 Opportunities for improvement in anti-thrombotic therapy and other strategies for the management of acute coronary syndromes: Insights from EPICOR, an international study of current practice patterns. Bueno H, Sinnaeve P, Annemans L, Danchin N, Licour M, Medina J, Pocock S, Sánchez-Covisa J, Storey RF, Jukema JW, Zeymer U, Van de Werf F, EPICOR Investigators

Aims: To describe international patterns and opportunities for improvement of pre- and in-hospital care of patients hospitalized for acute coronary syndromes (ACS), with special focus on anti-thrombotic therapy. Methods and results: EPICOR (long-tErm follow-uP of anti-thrombotic management patterns In acute CORonary syndrome patients), an international, cohort study, which enrolled 10,568 consecutive ACS survivors from 555 hospitals in 20 countries across Europe and Latin America (September 2010... Abstract

Cited 5 times since 2015 (0.5 per year) source: EuropePMC

European heart journal, Volume 36, Issue 4, 2 1 2015, Pages 206-213 The year in cardiology 2014: imaging. Gaemperli O, Marsan NA, Delgado V, Bax JJ

Abstract

Cited 38 times since 2015 (3.6 per year) source: EuropePMC

Kardiologia polska, Volume 73, Issue 12, 1 1 2015, Pages 1207-1294 [2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation]. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S

Abstract

Cited 94 times since 2015 (9 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 17 Suppl 1, 1 1 2015, Pages i1-75 Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association. Raatikainen MJ, Arnar DO, Zeppenfeld K, Merino JL, Levya F, Hindriks G, Kuck KH

Aims: There has been large variations in the use of invasive electrophysiological therapies in the member countries of the European Society of Cardiology (ESC). The aim of this analysis was to provide comprehensive information on cardiac implantable electronic device (CIED) and catheter ablation therapy trends in the ESC countries over the last five years. Methods: The European Heart Rhythm Association (EHRA) has collected data on CIED and catheter ablation therapy since 2008. Last year 49 of th... Abstract

Cited 87 times since 2015 (8.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 65, Issue 3, 1 1 2015, Pages 246-254 The risk for type B aortic dissection in Marfan syndrome. den Hartog AW, Franken R, Zwinderman AH, Timmermans J, Scholte AJ, van den Berg MP, de Waard V, Pals G, Mulder BJ, Groenink M

Background: Aortic dissections involving the descending aorta are a major clinical problem in patients with Marfan syndrome. Objectives: The purpose of this study was to identify clinical parameters associated with type B aortic dissection and to develop a risk model to predict type B aortic dissection in patients with Marfan syndrome. Methods: Patients with the diagnosis of Marfan syndrome and magnetic resonance imaging or computed tomographic imaging of the aorta were followed for a median of... Abstract

Cited 28 times since 2015 (2.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 1, 1 1 2015, Pages 20-25 High survival rate of 43% in out-of-hospital cardiac arrest patients in an optimised chain of survival. Boyce LW, Vliet Vlieland TP, Bosch J, Wolterbeek R, Volker G, van Exel HJ, Heringhaus C, Schalij MJ, Goossens PH

Aims: Survival to hospital discharge after out-of-hospital cardiac arrest (OHCA) varies widely. This study describes short-term survival after OHCA in a region with an extensive care path and a follow-up of 1 year. Methods: Consecutive patients ≥16 years admitted to the emergency department between April 2011 and December 2012 were included. In July 2014 a follow-up took place. Socio-demographic data, characteristics of the OHCA and interventions were described and associations with survival wer... Abstract

Cited 7 times since 2014 (0.7 per year) source: EuropePMC

PloS one, Volume 9, Issue 12, 31 5 2015, Pages e111156 No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. Baumert J, Huang J, McKnight B, Sabater-Lleal M, Steri M, Chu AY, Trompet S, Lopez LM, Fornage M, Teumer A, Tang W, Rudnicka AR, Mälarstig A, Hottenga JJ, Kavousi M, Lahti J, Tanaka T, Hayward C, Huffman JE, Morange PE, Rose LM, Basu S, Rumley A, Stott DJ, Buckley BM, de Craen AJ, Sanna S, Masala M, Biffar R, Homuth G, Silveira A, Sennblad B, Goel A, Watkins H, Müller-Nurasyid M, Rückerl R, Taylor K, Chen MH, de Geus EJ, Hofman A, Witteman JC, de Maat MP, Palotie A, Davies G, Siscovick DS, Kolcic I, Wild SH, Song J, McArdle WL, Ford I, Sattar N, Schlessinger D, Grotevendt A, Franzosi MG, Illig T, Waldenberger M, Lumley T, Tofler GH, Willemsen G, Uitterlinden AG, Rivadeneira F, Räikkönen K, Chasman DI, Folsom AR, Lowe GD, Westendorp RG, Slagboom PE, Cucca F, Wallaschofski H, Strawbridge RJ, Seedorf U, Koenig W, Bis JC, Mukamal KJ, van Dongen J, Widen E, Franco OH, Starr JM, Liu K, Ferrucci L, Polasek O, Wilson JF, Oudot-Mellakh T, Campbell H, Navarro P, Bandinelli S, Eriksson J, Boomsma DI, Dehghan A, Clarke R

Plasma fibrinogen is an acute phase protein playing an important role in the blood coagulation cascade having strong associations with smoking, alcohol consumption and body mass index (BMI). Genome-wide association studies (GWAS) have identified a variety of gene regions associated with elevated plasma fibrinogen concentrations. However, little is yet known about how associations between environmental factors and fibrinogen might be modified by genetic variation. Therefore, we conducted large-sc... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 22, Issue 3, 30 5 2015, Pages 408-418 Clinical topic: Nuclear imaging in hypertrophic cardiomyopathy. Delgado V, Bax JJ

Non-invasive cardiac imaging plays a central role in the diagnosis and management of patients with hypertrophic cardiomyopathy. Transthoracic echocardiography is the imaging technique of first choice to evaluate wall thickness, left ventricular systolic and diastolic function, presence of left ventricular outflow tract obstruction, and abnormal mitral anatomy, whereas cardiac magnetic resonance provides additional information on tissue characterization (replacement fibrosis) using late gadoliniu... Abstract

Cited 21 times since 2014 (2 per year) source: EuropePMC

The journals of gerontology. Series A, Biological sciences and medical sciences, Volume 70, Issue 8, 24 4 2014, Pages 982-988 Associations Between Thrombin Generation and the Risk of Cardiovascular Disease in Elderly Patients: Results From the PROSPER Study. Loeffen R, Winckers K, Ford I, Jukema JW, Robertson M, Stott DJ, Spronk HM, ten Cate H, Lowe GD, PROSPER Study Group

Background: Hypercoagulability may be an important contributor to the pathophysiology of atherosclerosis and atherothrombosis. As thrombin fulfills a central role in coagulation and links to several cellular mechanisms involved in arterial disease, we hypothesized that thrombin generation is associated with cardiovascular events in elderly patients. Methods: We studied the relationship between plasma thrombin generation and incident coronary heart disease (CHD) and stroke in the PROspective Stud... Abstract

Cited 12 times since 2014 (1.1 per year) source: Scopus

The American journal of cardiology, Volume 115, Issue 5, 18 3 2014, Pages 664-669 Effect of aortic regurgitation following transcatheter aortic valve implantation on outcomes. Ewe SH, Muratori M, van der Kley F, Pepi M, Delgado V, Tamborini G, Fusini L, de Weger A, Gripari P, Bartorelli A, Bax JJ, Marsan NA

The prognosis of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) and the changes in AR grade over time remain unclear. This study evaluated the midterm survival associated with AR after TAVI and examined the evolution of AR over time and its effect on cardiac performance. Successful TAVI was performed in 314 patients (age 81 ± 7 years, 36% men). Serial transthoracic echocardiography and clinical assessment were available in 175 patients who survived >12 months.... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 149, Issue 4, 18 3 2014, Pages 968 Long-term follow-up after the arterial switch operation: Not as perfect as we would have hoped? Hazekamp MG

Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Behavior modification, Volume 39, Issue 3, 16 3 2014, Pages 390-412 Cognitive behavior therapy for anxiety in people with dementia: a clinician guideline for a person-centered approach. Charlesworth G, Sadek S, Schepers A, Spector A

This article describes a 10-session cognitive-behavioral therapy (CBT) used in a randomized controlled trial with people with anxiety and mild-to-moderate dementia. The aim of the therapy is to reduce symptoms of anxiety by increasing a sense of safety and self-efficacy. The therapy is characterized by a person-centered approach to CBT, using individual tailoring to accommodate for cognitive deficits and other challenges. Three phases of therapy are described: (a) socialization to model (includi... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Injury, Volume 46, Issue 5, 16 3 2014, Pages 863-869 Impact of combat events on first responders: experiences of the armed conflict in Uruzgan, Afghanistan. Hoencamp R, Idenburg FJ, Vermetten E, Tan E, Plat MC, Hoencamp E, Leenen LP, Hamming JF

Introduction: Care for battle casualties demands special skills from medics, nurses, and tactical commanders. To date, no inventory has been performed evaluating the first responders (medics, nurses and tactical commanders) around battle casualties. Method: This observational cohort study was conducted amongst the first responders (n=195) who were deployed to Southern Afghanistan (2009-2010) in three Marine companies. The survey focused on four main topics: (1) participants general background, (... Abstract