Research

Publications

Below you can find a list of our published research.

6131 results

Studies in health technology and informatics, Volume 194, 1 1 2013, Pages 126-132 How to co-develop services, work, and information systems in healthcare: the daisy approach. Korpela M, Ikävalko P, Luukkonen I, Martikainen S, Palmén M, Tiihonen T, Toivanen M, Vainikainen V

Information systems in healthcare need to be designed and developed in a collaborative way. However, existing collaborative methodologies for the parallel development of healthcare work and information systems are vague and fragmented. Furthermore, they neither address people-centred healthcare nor limited-resource contexts. In this paper we introduce an emerging holistic approach, based on a unifying theoretical basis, for co-developing the services, work and information systems in healthcare.... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 8, Issue 9, 1 1 2013, Pages 1103-1109 How should I treat acute aortic annulus rupture during transcatheter aortic valve implantation? Debonnaire P, Van Herck PL, Katsanos S, van der Kley F, de Weger A, Palmen M, Marsan NA, Schalij MJ, Delgado V

Abstract

Cited 11 times since 2013 (0.9 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 1, 1 1 2013, Pages 6-13 Myocardial bridging: what have we learned in the past and will new diagnostic modalities provide new insights? Bruschke AV, Veltman CE, de Graaf MA, Vliegen HW

The clinical significance of myocardial bridging has been a subject of discussion and controversy since the introduction of coronary arteriography (CAG) in the early 1960s. More recently computed tomography coronary angiography (CTCA) has made it possible to visualise the overlying muscular bands and appears to have a higher sensitivity for detecting myocardial bridging than CAG. Combining CTCA with invasive techniques such as CAG should make it possible to improve our understanding of the patho... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 157, Issue 23, 1 1 2013, Pages A6354 [Feedback during laparoscopic training]. Spruit EN, Band GP, Hamming JF

A recent Danish study showed that instructor feedback significantly reduced the duration of training time needed for acquiring laparoscopic skills. While there is a clear advantage to trainees reaching a predetermined expert level of performance more rapidly, this does not necessarily imply that the skills were also acquired more efficiently. Experiencing continual feedback while undergoing a training task could reduce the level of difficulty in performing it; the presence of an instructor can a... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 157, Issue 7, 1 1 2013, Pages A5928 [Adhesiolysis during abdominal surgery: substantial risks]. Hamming JF, Bonsing BA

Surgeons from the Dutch St. Radboud University Medical Centre recently presented the results of a prospective study on adhesiolysis in abdominal surgery. In this methodologically sound study, the authors provided substantial data on the consequences of adhesiolysis. Most patients who have undergone an abdominal operation in the past appear to have adhesions. During an adhesiolysis procedure, 10% of patients suffer intestinal damage, the operating time is prolonged and blood loss is more severe.... Abstract

Cited 18 times since 2013 (1.5 per year) source: EuropePMC

Thrombosis research, Volume 131 Suppl 1, 1 1 2013, Pages S39-41 Venous thromboembolism in neonates and children--update 2013. Nowak-Göttl U, Janssen V, Manner D, Kenet G

Thromboses (VTE) in children were associated with medical diseases with and without acquired or inherited thrombophilic risk factors (IT). Disease recurrence rates vary between 3% in children with a first event during the neonatal period and 21% in children with idiopathic VTE. Recently reported systematic reviews showed significant associations between VTE and factor V G1691A or factor II G20210A mutations, protein C, protein S and antithrombin deficiency, more pronounced when combined IT were... Abstract

Cited 36 times since 2013 (3 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 6, Issue 1, 1 1 2013, Pages 42-52 Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias. van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K

Objectives: This study aimed to evaluate the feasibility and accuracy of real-time integration of multidetector computed tomography (MDCT) derived coronary anatomy and epicardial fat distribution and its impact on electroanatomical mapping and ablation. Background: Epicardial catheter ablation for ventricular arrhythmias (VA) is an important therapeutic option in patients after endocardial ablation failure. However, epicardial mapping and ablation are limited by the presence of coronary arteries... Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

The journal of gene medicine, Volume 15, Issue 1, 1 1 2013, Pages 1-11 Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells. Janssen JM, Liu J, Skokan J, Gonçalves MA, de Vries AA

Background: The AdEasy system has acquired preeminence amongst the various methods for producing first-generation, early region 1 (E1)-deleted human adenovirus (HAdV) vectors (AdVs) as a result of the fast and reproducible recovery of full-length AdV genomes via homologous recombination in Escherichia coli. Methods: From the classical AdEasy system, a new production platform was derived to assemble first- and second-generation [i.e. E1- plus early region 2A (E2A)-deleted] AdVs displaying on thei... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 157, Issue 51, 1 1 2013, Pages A7059 [The bionic heart patient: care about aftercare]. Schalij MJ

During the last few decades, care for heart patients has significantly improved. The enormous increase in the number of diagnostic and therapeutic options has resulted in a much better prognosis for many patients with cardiovascular disorders. Implantable cardioverter defibrillators (ICDs) and resynchronization therapy combined with ICDs decrease the risk of sudden death due to ventricular arrhythmias and improve symptoms related to cardiovascular failure. Percutaneous valve implants and percuta... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

Asian Pacific journal of cancer prevention : APJCP, Volume 14, Issue 5, 1 1 2013, Pages 3281-3288 Determining the awareness of and compliance with breast cancer screening among Turkish residential women. Yilmaz D, Bebis H, Ortabag T

Background: Breast cancer is the leading cause of cancer-related deaths in women. Despite being associated with high morbidity and mortality, breast cancer is a disease that can be diagnosed and treated early. Materials and methods: In this cross-sectional study of 321 women, data were collected by Questionnaire, Breast Cancer Risk Assessment Form and Champion's Health Belief Model Scale. Mann-Whitney U, Kruskal-Wallis, Chi- squared tests and logistic regression were used in the statistical... Abstract

Cited 44 times since 2013 (3.6 per year) source: EuropePMC

The British journal of dermatology, Volume 168, Issue 1, 1 1 2013, Pages 93-98 Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma. van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Hutteman M, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. Objectives: To assess the potential of intraoperative NIR fluorescence imaging to improve SLN mapping in patients with melanoma and to examine t... Abstract

Cited 3 times since 2013 (0.2 per year) source: EuropePMC

Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention, Volume 16, Issue Pt 3, 1 1 2013, Pages 147-154 Improved myocardial scar characterization by super-resolution reconstruction in late gadolinium enhanced MRI. Dzyubachyk O, Tao Q, Poot DH, Lamb H, Zeppenfeld K, Lelieveldt BP, van der Geest RJ

Image resolution is an important factor for accurate myocardial scar assessment from late gadolinium enhanced (LGE) MR. It has been shown that the conventionally used short-axis (SA) LGE acquisition with anisotropic resolution may overestimate the scar size due to partial volume effect, undermining the prognostic and diagnostic accuracy of LGE MRI in critical clinical applications. In this work, we present a method for combining three complementary anisotropic orthogonal LGE sequences of the hea... Abstract

Cited 19 times since 2013 (1.6 per year) source: EuropePMC

Indian pacing and electrophysiology journal, Volume 13, Issue 1, 1 1 2013, Pages 14-33 Radiofrequency catheter ablation of idiopathic right ventricular outflow tract arrhythmias. Calvo N, Jongbloed M, Zeppenfeld K

Idiopathic ventricular arrhythmias (VA) consist of various subtypes of VA that occur in the absence of clinically apparent structural heart disease. Affected patients account for approximately 10% of all patients referred for evaluation of ventricular tachycardia (VT). Arrhythmias arising from the outflow tract (OT) are the most common subtype of idiopathic VA and more than 70-80% of idiopathic VTs or premature ventricular contractions (PVCs) originate from the right ventricular (RV) OT. Idiopat... Abstract

Cited 10 times since 2012 (0.8 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 56, 26 4 2012, Pages 116-128 Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction. Arslan F, Smeets MB, Buttari B, Profumo E, Riganò R, Akeroyd L, Kara E, Timmers L, Sluijter JP, van Middelaar B, den Ouden K, Pasterkamp G, Lim SK, de Kleijn DP

Decreased haptoglobin (Hp) functionality due to allelic variations is associated with worsened outcome in patients after myocardial infarction (MI). However, mechanisms through which haptoglobin deficiency impairs cardiac repair remain to be elucidated. In the present study, we identified novel molecular alterations mediated by Hp involved in early and late cardiac repair responses after left coronary artery ligation in Hp(-/-) and wild-type (WT) mice. We observed a higher mortality rate in Hp(-... Abstract

Cited 19 times since 2012 (1.6 per year) source: EuropePMC

Atherosclerosis, Volume 227, Issue 1, 24 4 2012, Pages 95-99 Determinants of calcification growth in atherosclerotic carotid arteries; a serial multi-detector CT angiography study. van Gils MJ, Bodde MC, Cremers LG, Dippel DW, van der Lugt A

Background: Little is known about the natural course of atherosclerotic plaque in the carotid artery bifurcation. This study investigated the growth pattern of calcifications in atherosclerotic carotid arteries and its determinants using serial multi-detector CT angiography (MDCTA). Methods: From a cohort of consecutive patients with TIA or ischemic stroke and a baseline MCDTA scan of the carotid arteries, subjects were invited for a follow-up scan after 4-6 years. Calcification volumes were sco... Abstract

Cited 50 times since 2012 (4.1 per year) source: EuropePMC

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume 53, 21 3 2012, Pages 359-363 Radioprotection by two phenolic compounds: chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro. Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, Tunc S, Ozkan L, Bilaloglu R

The present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was use... Abstract

Cited 51 times since 2012 (4.2 per year) source: EuropePMC

PloS one, Volume 7, Issue 12, 20 3 2012, Pages e52438 Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Poortvliet RK, Ford I, Lloyd SM, Sattar N, Mooijaart SP, de Craen AJ, Westendorp RG, Jukema JW, Packard CJ, Gussekloo J, de Ruijter W, Stott DJ

Variability in blood pressure predicts cardiovascular disease in young- and middle-aged subjects, but relevant data for older individuals are sparse. We analysed data from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) study of 5804 participants aged 70-82 years with a history of, or risk factors for cardiovascular disease. Visit-to-visit variability in blood pressure (standard deviation) was determined using a minimum of five measurements over 1 year; an inception cohort... Abstract

Cited 44 times since 2012 (3.6 per year) source: EuropePMC

European journal of heart failure, Volume 15, Issue 5, 18 3 2012, Pages 581-588 Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study. Nanchen D, Stott DJ, Gussekloo J, Mooijaart SP, Westendorp RG, Jukema JW, Macfarlane PW, Cornuz J, Rodondi N, Buckley BM, Ford I, Sattar N, de Craen AJ, PROSPER Group

Aims: Resting heart rate is a promising modifiable cardiovascular risk marker in older adults, but the mechanisms linking heart rate to cardiovascular disease are not fully understood. We aimed to assess the association between resting heart rate and incident heart failure (HF) and cardiovascular mortality, and to examine whether these associations might be attributable to systemic inflammation and endothelial dysfunction. Methods and results: We studied 4084 older adults aged 70-82 years with k... Abstract

Cited 97 times since 2012 (7.9 per year) source: EuropePMC

Circulation, Volume 127, Issue 3, 17 3 2012, Pages 322-330 Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial. van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ

Background: The role of angiotensin II receptor blockers in patients with a systemic right ventricle has not been elucidated. Methods and results: We conducted a multicenter, double-blind, parallel, randomized controlled trial of angiotensin II receptor blocker valsartan 160 mg twice daily compared with placebo in patients with a systemic right ventricle caused by congenitally or surgically corrected transposition of the great arteries. The primary end point was change in right ventricular eject... Abstract

Cited 7 times since 2012 (0.6 per year) source: EuropePMC

European journal of radiology, Volume 82, Issue 4, 14 2 2012, Pages 680-685 High field carotid vessel wall imaging: a study on reproducibility. Kröner ES, Westenberg JJ, van der Geest RJ, Brouwer NJ, Doornbos J, Kooi ME, van der Wall EE, Lamb HJ, Siebelink HJ

Purpose: Currently, a multi-contrast protocol, including a combination of five MR-sequences is used as reference standard for morphologic imaging and quantitative measurements of the carotid artery vessel wall. The purpose of this study is to investigate the scan-rescan reproducibility together with intra- and inter-observer reproducibility of each of the five MR-sequences. Methods: Twenty healthy volunteers (55% male, mean age=26 years) underwent repeated MR-examinations (3T-Philips-MRI) of the... Abstract