Research

Publications

Below you can find a list of our published research.

6131 results

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

Case reports in pediatrics, Volume 2012, 12 2 2012, Pages 314256 Left pulmonary artery thrombosis in a neonate with left lung hypoplasia. van Schendel MP, Visser DH, Rammeloo LA, Hazekamp MG, Hruda J

Thrombotic events in neonates may origin from fetal life. A 4-day-old newborn infant with a family history of heterozygous type 1 protein C deficiency was diagnosed with left lung hypoplasia and left pulmonary artery thrombosis. Its source was prenatally closed ductus arteriosus. Surgical removal of the thrombus was performed. Abstract

Cited 25 times since 2012 (2 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 14, Issue 8, 7 1 2012, Pages 774-781 Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival. Bertini M, Höke U, van Bommel RJ, Ng AC, Shanks M, Nucifora G, Auger D, Borleffs CJ, van Rijnsoever EP, van Erven L, Schalij MJ, Marsan NA, Bax JJ, Delgado V

Background: Clinical or echocardiographic mid-term responses to cardiac resynchronization therapy (CRT) may have a different influence on a long-term prognosis of heart failure patients treated with CRT. The aim of the evaluation was to establish which definition of response to CRT, clinical or echocardiographic, best predicts long-term prognosis. Methods and results: A total of 679 heart failure patients treated with CRT were included. All the patients underwent a complete history and physical... Abstract

Cited 51 times since 2012 (4.2 per year) source: EuropePMC

Clinical cancer research : an official journal of the American Association for Cancer Research, Volume 19, Issue 3, 6 1 2012, Pages 743-751 A phase II study of sorafenib in patients with platinum-pretreated, advanced (Stage IIIb or IV) non-small cell lung cancer with a KRAS mutation. Dingemans AM, Mellema WW, Groen HJ, van Wijk A, Burgers SA, Kunst PW, Thunnissen E, Heideman DA, Smit EF

Purpose: Sorafenib inhibits the Ras/Raf pathway, which is overactive in cancer patients with a KRAS mutation. We hypothesized that patients with non-small cell lung cancer (NSCLC) with KRAS mutation will benefit from treatment with sorafenib. Experimental design: In this phase II study, patients with KRAS-mutated, stage IIIb or IV NSCLC that progressed after at least one platinum-containing regimen were treated with sorafenib. Treatment consisted of sorafenib 400 mg twice daily until disease pro... Abstract

European heart journal. Cardiovascular Imaging, Volume 14, Issue 5, 5 1 2012, Pages 507 Rapid aortic aneurysm formation in Marfan patient with dissection of the entire aorta. Scholte AJ, Hilhorst-Hofstee Y, Versteegh MI, Kroft LJ

Abstract

Cited 15 times since 2012 (1.2 per year) source: EuropePMC

Diabetes care, Volume 36, Issue 4, 5 1 2012, Pages 985-991 Influence of diabetes on left ventricular systolic and diastolic function and on long-term outcome after cardiac resynchronization therapy. Höke U, Thijssen J, van Bommel RJ, van Erven L, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Objective: The influence of diabetes on cardiac resynchronization therapy (CRT) remains unclear. The aims of the current study were to 1) assess the changes in left ventricular (LV) systolic and diastolic function and 2) evaluate long-term prognosis in CRT recipients with diabetes. Research design and methods: A total of 710 CRT recipients (171 with diabetes) were included from an ongoing registry. Echocardiographic evaluation, including LV systolic and diastolic function assessment, was perform... Abstract

Cited 24 times since 2012 (2 per year) source: EuropePMC

Injury, Volume 44, Issue 4, 3 1 2012, Pages 498-503 Re-displacement of stable distal both-bone forearm fractures in children: a randomised controlled multicentre trial. Colaris JW, Allema JH, Biter LU, de Vries MR, van de Ven CP, Bloem RM, Kerver AJ, Reijman M, Verhaar JA

Introduction: Displaced metaphyseal both-bone fractures of the distal forearm are generally reduced and stabilised by an above-elbow cast (AEC) with or without additional pinning. The purpose of this study was to find out if re-displacement of a reduced stable metaphyseal both-bone fracture of the distal forearm in a child could be prevented by stabilisation with Kirschner wires. Methods: Consecutive children aged Abstract

Cited 58 times since 2012 (4.7 per year) source: EuropePMC

Nature structural & molecular biology, Volume 20, Issue 1, 2 1 2012, Pages 73-81 Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Hoefig KP, Rath N, Heinz GA, Wolf C, Dameris J, Schepers A, Kremmer E, Ansel KM, Heissmeyer V

The exoRNase Eri1 inhibits RNA interference and trims the 5.8S rRNA 3' end. It also binds to the stem-loop of histone mRNAs, but the functional importance of this interaction remains elusive. Histone mRNAs are normally degraded at the end of S phase or after pharmacological inhibition of replication. Both processes are impaired in Eri1-deficient mouse cells, which instead accumulate oligouridylated histone mRNAs. Eri1 trims the mature histone mRNAs by two unpaired nucleotides at the 3'... Abstract

Cited 7 times since 2012 (0.6 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 94, Issue 6, 1 1 2012, Pages 2122-2125 Implantation of a left ventricular assist device in patients with a complex apical anatomy. Palmen M, Verwey HF, Haeck ML, Holman ER, Schalij MJ, Klautz RJ

Implantation of a left ventricular assist device can be challenging in patients with an altered apical anatomy after cardiac surgery or as the result of the presence of a calcified apical aneurysm. In this paper we present 2 cases with a challenging apical anatomy and introduce a new surgical technique facilitating left ventricular assist device implantation in these patients. Abstract

Cited 16 times since 2012 (1.3 per year) source: EuropePMC

Expert review of cardiovascular therapy, Volume 10, Issue 12, 1 1 2012, Pages 1517-1531 Surgical versus percutaneous treatment of aortic coarctation: new standards in an era of transcatheter repair. Luijendijk P, Bouma BJ, Groenink M, Boekholdt M, Hazekamp MG, Blom NA, Koolbergen DR, de Winter RJ, Mulder BJ

Aortic coarctation is a common congenital cardiovascular defect, which can be diagnosed over a wide range of ages and with varying degrees of severity. Surgery has proven to be an effective treatment for the management of native aortic coarctation, and remains the treatment of choice in neonates. Balloon angioplasty with or without stenting has evolved rapidly over the past decade. Balloon angioplasty is the treatment of choice in children with re-coarctation, and currently available immediate r... Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 12, 1 1 2012, Pages 509-512 Two cases of aorto-right atrial tunnel: clinical presentation, imaging and percutaneous closure. de Winter RJ, Blom NA, Straver B, Bouma BJ, Backx AP, Clur SA, Kuipers IM, Hoekstra F, Boekholdt SM, Groenink M, Koolbergen DR, Hazekamp MG, Mulder BJ

Communication between the aortic sinus and a cardiac chamber is a rare anomaly that can be diagnosed in children and young adults. We describe two cases with a tunnel between the aortic sinus and right atrium, discuss diagnostic modalities, and review the literature on this anomaly. Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 30, Issue 12, 1 1 2012, Pages 2830-2834 Brief report: Misinterpretation of coculture differentiation experiments by unintended labeling of cardiomyocytes through secondary transduction: delusions and solutions. Ramkisoensing AA, De Vries AA, Schalij MJ, Atsma DE, Pijnappels DA

Cardiomyogenic differentiation of stem cells can be accomplished by coculture with cardiomyocytes (CMCs). To facilitate their identification, stem cells are often labeled through viral transduction with a fluorescent protein. A second marker to distinguish stem cell-derived CMCs from native CMCs is rarely used. This study aimed to investigate the occurrence of secondary transduction of unlabeled neonatal rat (nr) CMCs after coculture with human cells that had been transduced 0, 7, or 14 days ear... Abstract

Cited 69 times since 2012 (5.6 per year) source: EuropePMC

Radiation oncology (London, England), Volume 7, 24 4 2012, Pages 198 Management of radiation oncology patients with a pacemaker or ICD: a new comprehensive practical guideline in The Netherlands. Dutch Society of Radiotherapy and Oncology (NVRO). Hurkmans CW, Knegjens JL, Oei BS, Maas AJ, Uiterwaal GJ, van der Borden AJ, Ploegmakers MM, van Erven L, Dutch Society of Radiotherapy and Oncology (NVRO)

Current clinical guidelines for the management of radiotherapy patients having either a pacemaker or implantable cardioverter defibrillator (both CIEDs: Cardiac Implantable Electronic Devices) do not cover modern radiotherapy techniques and do not take the patient's perspective into account. Available data on the frequency and cause of CIED failure during radiation therapy are limited and do not converge. The Dutch Society of Radiotherapy and Oncology (NVRO) initiated a multidisciplinary ta... Abstract

Cited 7 times since 2012 (0.6 per year) source: EuropePMC

Cytokine, Volume 61, Issue 2, 24 4 2012, Pages 438-444 A comparative study of the immune modulating properties of antifibrinolytics in cardiac surgery. Later AF, Bruggemans EF, Romijn FP, van Pelt J, Klautz RJ

Purpose: Antifibrinolytics, used in cardiac surgery to abate postoperative blood loss, share anti-inflammatory properties by suppression of pro-inflammatory D-dimer and plasmin levels. Additional drug specific immune modulating qualities are often mentioned in the discussion on which antifibrinolytic can best be used. To determine the extent and relevance of these effects, we investigated cytokine and growth factor plasma levels in cardiac surgery patients randomized to receive either tranexamic... Abstract

Cited 21 times since 2012 (1.7 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 3, 20 3 2012, Pages 382-387 Pregnancy outcomes in women with aortic valve substitutes. Heuvelman HJ, Arabkhani B, Cornette JM, Pieper PG, Bogers AJ, Takkenberg JJ, Roos-Hesselink JW

Young women who require aortic valve replacement need information on the potential cardiac and obstetric complications of pregnancy for the different valve substitutes available. We, therefore, assessed the pregnancy outcomes in women who had received an autograft, homograft, or mechanical valve in the aortic position. Women who were pregnant after surviving aortic valve replacement at our institution from 1987 to 2011 were included. Information on cardiac status and pregnancy outcome was obtain... Abstract

Cited 518 times since 2012 (42.1 per year) source: EuropePMC

mBio, Volume 3, Issue 6, 20 3 2012, Pages e00473-12 Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. van Boheemen S, de Graaf M, Lauber C, Bestebroer TM, Raj VS, Zaki AM, Osterhaus AD, Haagmans BL, Gorbalenya AE, Snijder EJ, Fouchier RA

Unlabelled: A novel human coronavirus (HCoV-EMC/2012) was isolated from a man with acute pneumonia and renal failure in June 2012. This report describes the complete genome sequence, genome organization, and expression strategy of HCoV-EMC/2012 and its relation with known coronaviruses. The genome contains 30,119 nucleotides and contains at least 10 predicted open reading frames, 9 of which are predicted to be expressed from a nested set of seven subgenomic mRNAs. Phylogenetic analysis of the re... Abstract

Cited 36 times since 2012 (2.9 per year) source: EuropePMC

The American journal of cardiology, Volume 111, Issue 3, 15 3 2012, Pages 312-318 Influence of gender on ischemic times and outcomes after ST-elevation myocardial infarction. Velders MA, Boden H, van Boven AJ, van der Hoeven BL, Heestermans AA, Cannegieter SC, Umans VA, Jukema JW, Hofma SH, Schalij MJ

Previous studies investigating the influence of gender on ST-segment elevation myocardial infarction have reported conflicting results. The aim of this study was to assess the influence of gender on ischemic times and outcomes after ST-segment elevation myocardial infarction in patients treated with primary percutaneous coronary intervention in modern practice. The present multicenter registry included consecutive patients with ST-segment elevation myocardial infarctions treated with primary per... Abstract

Cited 37 times since 2012 (3 per year) source: EuropePMC

European heart journal, Volume 34, Issue 8, 15 3 2012, Pages 586-596 Epicardial substrate mapping for ventricular tachycardia ablation in patients with non-ischaemic cardiomyopathy: a new algorithm to differentiate between scar and viable myocardium developed by simultaneous integration of computed tomography and contrast-enhanced magnetic resonance imaging. Piers SR, van Huls van Taxis CF, Tao Q, van der Geest RJ, Askar SF, Siebelink HM, Schalij MJ, Zeppenfeld K

Aims: During epicardial electroanatomical mapping (EAM), it is difficult to differentiate between fibrosis and fat, as both exhibit attenuated bipolar voltage (BV). The purpose of this study was to assess whether unipolar voltage (UV), BV, and electrogram characteristics (EC) can distinguish fibrosis from viable myocardium and fat during epicardial EAM for ventricular tachycardia (VT) ablation in non-ischaemic cardiomyopathy (NICM). Methods and results: Ten NICM patients (7 males, 56 ± 13 years)... Abstract

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

European journal of heart failure, Volume 15, Issue 4, 9 2 2012, Pages 400-407 Heart failure determines the myocardial inflammatory response to injury. Kortekaas KA, Lindeman JH, Versteegh MI, van Beelen E, Kleemann R, Klautz RJ

Aims: Systemic complications after cardiac surgery are common in heart failure patients. However, the pathophysiological mechanisms, such as a different local inflammatory response of failing hearts, remain in question. This study examines whether failing hearts respond differently to cardioplegic arrest and reperfusion compared with non-failing hearts (controls). Methods and results: The inflammatory response was evaluated in samples collected simultaneously from the radial artery and coronary... Abstract

Cited 33 times since 2012 (2.7 per year) source: EuropePMC

Diabetes care, Volume 36, Issue 2, 8 2 2012, Pages 457-462 Right ventricular involvement in diabetic cardiomyopathy. Widya RL, van der Meer RW, Smit JW, Rijzewijk LJ, Diamant M, Bax JJ, de Roos A, Lamb HJ

Objective: To compare magnetic resonance imaging-derived right ventricular (RV) dimensions and function between men with type 2 diabetes and healthy subjects, and to relate these parameters to left ventricular (LV) dimensions and function. Research design and methods: RV and LV volumes and functions were assessed in 78 men with uncomplicated type 2 diabetes and 28 healthy men within the same range of age using magnetic resonance imaging. Steady-state free precession sequences were used to assess... Abstract

Cited 49 times since 2012 (4 per year) source: EuropePMC

Journal of hepato-biliary-pancreatic sciences, Volume 19, Issue 6, 1 1 2012, Pages 626-637 Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light. Verbeek FP, van der Vorst JR, Schaafsma BE, Hutteman M, Bonsing BA, van Leeuwen FW, Frangioni JV, van de Velde CJ, Swijnenburg RJ, Vahrmeijer AL

Background: Improved imaging methods and surgical techniques have created a new era in hepatopancreatobiliary (HPB) surgery. Despite these developments, visual inspection, palpation, and intraoperative ultrasound remain the most utilized tools during surgery today. This is problematic, though, especially in laparoscopic HPB surgery, where palpation is not possible. Optical imaging using near-infrared (NIR) fluorescence can be used for the real-time assessment of both anatomy (e.g., sensitive det... Abstract