Research

Publications

Below you can find a list of our published research.

6131 results

Cited 29 times since 2012 (2.3 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 15, Issue 2, 28 4 2012, Pages 290-296 Incremental prognostic value of an abnormal baseline spatial QRS-T angle in chronic dialysis patients. de Bie MK, Koopman MG, Gaasbeek A, Dekker FW, Maan AC, Swenne CA, Scherptong RW, van Dessel PF, Wilde AA, Schalij MJ, Rabelink TJ, Jukema JW

Aims: In order to improve the abysmal outcome of dialysis patients, it is critical to identify patients with a high mortality risk. The spatial QRS-T angle, which can be easily calculated from the 12 lead electrocardiogram (ECG), might be useful in the prognostication in dialysis patients. The objective of this study was to establish the prognostic value of the spatial QRS-T angle. Methods and results: All patients who initiated dialysis therapy between 2002 and 2009 in the hospitals of Leiden (... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 2, 22 4 2012, Pages 453-461 Effect of dose reduction on image quality and diagnostic performance in coronary computed tomography angiography. van der Bijl N, Joemai RM, Mertens BJ, de Roos A, Veldkamp WJ, Bax JJ, Schuijf JD, Geleijns J, Kroft LJ

To evaluate the effect of radiation dose reduction on image quality and diagnostic accuracy of coronary computed tomography (CT) angiography. Coronary CT angiography studies of 40 patients with (n = 20) and without (n = 20) significant (≥50 %) stenosis were included (26 male, 14 female, 57 ± 11 years). In addition to the original clinical reconstruction (100 % dose), simulated images were created that correspond to 50, 25 and 12.5 % of the original dose. Image quality and diagnostic performance... Abstract

Cited 14 times since 2012 (1.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 3, 22 4 2012, Pages 633-641 Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. van Schinkel LD, Auger D, van Elderen SG, Ajmone Marsan N, Delgado V, Lamb HJ, Ng AC, Smit JW, Bax JJ, Westenberg JJ, de Roos A

Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle t... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

Pediatric cardiology, Volume 34, Issue 3, 22 4 2012, Pages 630-638 Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery. Klitsie LM, Hazekamp MG, Roest AA, Van der Hulst AE, Gesink-van der Veer BJ, Kuipers IM, Blom NA, Ten Harkel AD

Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response, which can lead to myocardial damage. However, knowledge concerning the time course of ventricular performance deterioration and restoration after correction of a congenital heart defect (CHD) in pediatric patients is sparse. Therefore, the authors perioperatively quantified left ventricular (LV) and right ventricular (RV) performance using echocardiography. Their study included 141... Abstract

Cited 26 times since 2012 (2.1 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 20 3 2012, Pages 2977-2982 MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome. Kröner ES, Scholte AJ, de Koning PJ, van den Boogaard PJ, Kroft LJ, van der Geest RJ, Hilhorst-Hofstee Y, Lamb HJ, Siebelink HM, Mulder BJ, Groenink M, Radonic T, van der Wall EE, de Roos A, Reiber JH, Westenberg JJ

Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional... Abstract

Cited 19 times since 2012 (1.5 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 94, Issue 6, 13 2 2012, Pages 2077-2082 Mild residual pulmonary stenosis in tetralogy of fallot reduces risk of pulmonary valve replacement. van der Hulst AE, Hylkema MG, Vliegen HW, Delgado V, Hazekamp MG, Rijlaarsdam ME, Holman ER, Blom NA, Roest AA

Background: Current surgical strategies that aim at preventing pulmonary regurgitation in patients with corrected tetralogy of Fallot (cToF) may result in a certain grade of residual pulmonary stenosis (PS). The clinical implications of a postoperative residual PS in cToF patients remain unclear. Pulmonary valve replacement (PVR) is frequently needed during follow-up of cToF patients. The aim of the current study was to determine the role of residual PS in the need for PVR during follow-up in cT... Abstract

Cited 12 times since 2012 (1 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 171-181 Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms. Askar SF, Bingen BO, Schalij MJ, Swildens J, Atsma DE, Schutte CI, de Vries AA, Zeppenfeld K, Ypey DL, Pijnappels DA

Aims: Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models. Methods and results: Fibrosis was mi... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 161-170 Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization. Bingen BO, Askar SF, Schalij MJ, Kazbanov IV, Ypey DL, Panfilov AV, Pijnappels DA

Aims: Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysiological parameters, allowing a search for novel factors and underlying mechanisms affecting stability... Abstract

Cited 53 times since 2012 (4.2 per year) source: EuropePMC

Human molecular genetics, Volume 21, Issue 24, 8 2 2012, Pages 5329-5343 Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, WTCCC2, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck

In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that ar... Abstract

Cited 54 times since 2012 (4.3 per year) source: EuropePMC

PLoS pathogens, Volume 8, Issue 9, 6 1 2012, Pages e1002908 Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. Marcinowski L, Lidschreiber M, Windhager L, Rieder M, Bosse JB, Rädle B, Bonfert T, Györy I, de Graaf M, Prazeres da Costa O, Rosenstiel P, Friedel CC, Zimmer R, Ruzsics Z, Dölken L

During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real-time kinetics of cellular and viral transcriptional activity during lytic murine cytomegalovirus (MCMV) infection. Microarray profiling on newly transcribed RNA obtained at different times during the first six hours of MCMV infection revealed discr... Abstract

Cited 1385 times since 2012 (110.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 60, Issue 16, 5 1 2012, Pages 1581-1598 Third universal definition of myocardial infarction. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Joint ESC/ACCF/AHA/WHF Task Force for Universal Definition of Myocardial Infarction, Authors/Task Force Members Chairpersons, Thygesen K, Alpert JS, White HD, Biomarker Subcommittee, Jaffe AS, Katus HA, Apple FS, Lindahl B, Morrow DA, ECG Subcommittee, Chaitman BR, Clemmensen PM, Johanson P, Hod H, Imaging Subcommittee, Underwood R, Bax JJ, Bonow JJ, Pinto F, Gibbons RJ, Classification Subcommittee, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Intervention Subcommittee, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasche P, Ravkilde J, Trials & Registries Subcommittee, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Trials & Registries Subcommittee, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Trials & Registries Subcommittee, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Trials & Registries Subcommittee, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Me

Abstract

Cited 23 times since 2012 (1.8 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 21, Issue 4, 5 1 2012, Pages 469-470 High prevalence of occult paragangliomas in asymptomatic carriers of SDHD and SDHB gene mutations. Heesterman BL, Bayley JP, Tops CM, Hes FJ, van Brussel BT, Corssmit EP, Hamming JF, van der Mey AG, Jansen JC

Hereditary paraganglioma is a benign tumor syndrome with an age-dependent penetrance. Carriers of germline mutations in the SDHB or SDHD genes may develop parasympathetic paragangliomas in the head and neck region or sympathetic catecholamine-secreting abdominal and thoracic paragangliomas (pheochromocytomas). In this study, we aimed to establish paraganglioma risk in 101 asymptomatic germline mutation carriers and evaluate the results of our surveillance regimen. Asymptomatic carriers of an SDH... Abstract

Cited 23 times since 2012 (1.8 per year) source: EuropePMC

Rhinology, Volume 50, Issue 3, 1 1 2012, Pages 255-261 Quality of life in extended endonasal approaches for skull base tumours. Georgalas C, Badloe R, van Furth W, Reinartz S, Fokkens WJ

Objective: To assess the quality of life (QOL) impact of extended endonasal approaches and nasoseptal flap reconstruction for benign skull base tumours Methods: A random sample of 110 patients undergoing either limited endonasal transphenoidal hypophysectomy or extended endonasal approaches (trans-cribriform, trans-sellar, trans-tuberculum, trans-pterygoid) for the removal of benign skull base tumours were asked to complete Rhinosinusitis Outcome Measure (RSOM-31) questionnaire. Results: A total... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 8 Suppl Q, 1 1 2012, Pages Q21-30 Imaging and quantification of aortic regurgitation after TAVI. Ewe SH, Delgado V, Bax JJ

During the last decade, transcatheter aortic valve implantation (TAVI) techniques have evolved rapidly providing several systems that conform to a broad spectrum of aortic valve annulus sizes, developing new delivery systems that provide an alternative to patients with difficult vascular access and permitting more controlled and accurate prosthesis deployment that result in improved procedural outcomes. However, residual aortic regurgitation (AR) (paravalvular or transvalvular) remains a recurre... Abstract

Cited 12 times since 2012 (1 per year) source: EuropePMC

Current opinion in cardiology, Volume 27, Issue 5, 1 1 2012, Pages 455-464 Contemporary imaging of normal mitral valve anatomy and function. Debonnaire P, Palmen M, Marsan NA, Delgado V

Purpose of review: Mitral valve disease is highly prevalent. Accurate characterization of normal anatomy and function of the mitral valve is crucial to understand the pathophysiology of mitral valve disease. This review summarizes recent advances in noninvasive cardiac imaging to assess normal mitral valve anatomy and function and provides an overview of the clinical applications of these novel imaging techniques in the evaluation of patients with mitral valve disease. Recent findings: Echocardi... Abstract

Cited 6 times since 2012 (0.5 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 19, Issue 6, 30 5 2012, Pages 1162-1169 Right ventricular ejection fraction measured by multigated planar equilibrium radionuclide ventriculography is an independent prognostic factor in patients with ischemic heart disease. van der Maas N, Braam RL, van der Zaag-Loonen HJ, Meerman J, Cozijnsen L, Scholte AJ

Background: The number of studies on the prognostic value of the right ventricular ejection fraction (RVEF) in patients with ischemic heart disease (IHD) is limited, whereas it is widely accepted that the left ventricular ejection fraction (LVEF) is a strong prognostic factor. We assessed whether RVEF measured by multigated planar equilibrium radionuclide ventriculography (RNV) is an independent prognostic factor in patients with IHD. Methods and results: We retrospectively identified 347 consec... Abstract

Cited 17 times since 2012 (1.4 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 29 5 2012, Pages 2882-2888 Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction. Verschuren JJ, Boden H, Wessels JA, van der Hoeven BL, Trompet S, Heijmans BT, Putter H, Guchelaar HJ, Schalij MJ, Jukema JW

Background: Antiplatelet drug resistance is a well-known problem, causing recurrent cardiovascular events. Multiple genetic polymorphisms have been related to antiplatelet resistance by several large trials, however data from common clinical practice is limited. We examined the influence of previously described polymorphisms, related to aspirin and clopidogrel resistance, on treatment outcome in a real life unselected population of patients presenting with ST-segment elevation myocardial infarct... Abstract

Cited 66 times since 2012 (5.3 per year) source: EuropePMC

Oral oncology, Volume 49, Issue 1, 28 4 2012, Pages 15-19 Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients. van der Vorst JR, Schaafsma BE, Verbeek FP, Keereweer S, Jansen JC, van der Velden LA, Langeveld AP, Hutteman M, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Objectives: Elective neck dissection is frequently performed during surgery in head and neck cancer patients. The sentinel lymph node (SLN) procedure can prevent the morbidity of a neck dissection and improve lymph node staging by fine pathology. Near-infrared (NIR) fluorescence imaging is a promising technique to identify the sentinel lymph node (SLN) intraoperatively. This feasibility study explored the use of indocyanine green adsorbed to human serum albumin (ICG:HSA) for SLN mapping in head... Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

Protein expression and purification, Volume 86, Issue 1, 26 4 2012, Pages 7-11 Efficient expression and purification of tag-free Epstein-Barr virus EBNA1 protein in Escherichia coli by auto-induction. Mayer CE, Geerlof A, Schepers A

Epstein-Barr nuclear antigen 1 (EBNA1) is the essential Epstein-Barr virus (EBV) protein at the interface between the EBV genome and the host chromatin. It is EBNA1's task to guarantee replication and segregation of the multicopy closed circular viral genome in infected cells. While EBNA1's functions are relatively well understood, little is known about the molecular mechanisms of EBNA1 mediating chromatin tethering and DNA replication. To characterize those, purified EBNA1 would be a... Abstract

Cited 1442 times since 2012 (115 per year) source: EuropePMC

Circulation, Volume 126, Issue 16, 24 4 2012, Pages 2020-2035 Third universal definition of myocardial infarction. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Katus HA, Lindahl B, Morrow DA, Clemmensen PM, Johanson P, Hod H, Underwood R, Bax JJ, Bonow RO, Pinto F, Gibbons RJ, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasché P, Ravkilde J, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Mendis S

Abstract