Research

Publications

Below you can find a list of our published research.

6131 results

Cited 1447 times since 2012 (115.4 per year) source: EuropePMC

European heart journal, Volume 33, Issue 20, 24 4 2012, Pages 2551-2567 Third universal definition of myocardial infarction. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Writing Group on the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, Thygesen K, Alpert JS, White HD, Jaffe AS, Katus HA, Apple FS, Lindahl B, Morrow DA, Chaitman BA, Clemmensen PM, Johanson P, Hod H, Underwood R, Bax JJ, Bonow RO, Pinto F, Gibbons RJ, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasché P, Ravkilde J, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Mendis S, ESC Committee for Practice Guidelines (CPG)

Abstract

Cited 29 times since 2012 (2.3 per year) source: EuropePMC

Viruses, Volume 4, Issue 8, 22 4 2012, Pages 1328-1334 Performance of VIDISCA-454 in feces-suspensions and serum. De Vries M, Oude Munnink BB, Deijs M, Canuti M, Koekkoek SM, Molenkamp R, Bakker M, Jurriaans S, Van Schaik BDC, Luyf AC, Olabarriaga SD, Van Kampen AHC, Van der Hoek L

Virus discovery combining sequence unbiased amplification with next generation sequencing is now state-of-the-art. We have previously determined that the performance of the unbiased amplification technique which is operational at our institute, VIDISCA-454, is efficient when respiratory samples are used as input. The performance of the assay is, however, not known for other clinical materials like blood or stool samples. Here, we investigated the sensitivity of VIDISCA-454 with feces-suspensions... Abstract

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

Clinical genetics, Volume 83, Issue 4, 21 3 2012, Pages 337-344 An unanticipated copy number variant of chromosome 15 disrupting SMAD3 reveals a three-generation family at serious risk for aortic dissection. Hilhorst-Hofstee Y, Scholte AJ, Rijlaarsdam ME, van Haeringen A, Kroft LJ, Reijnierse M, Ruivenkamp CA, Versteegh MI, Pals G, Breuning MH

Several genes involved in the familial appearance of thoracic aortic aneurysms and dissections (FTAAD) have been characterized recently, one of which is SMAD3. Mutations of SMAD3 cause a new syndromic form of aortic aneurysms and dissections associated with skeletal abnormalities. We discovered a small interstitial deletion of chromosome 15, leading to disruption of SMAD3, in a boy with mild mental retardation, behavioral problems and revealed features of the aneurysms-osteoarthritis syndrome (A... Abstract

Cited 19 times since 2012 (1.5 per year) source: EuropePMC

Thrombosis research, Volume 130, Issue 6, 18 3 2012, Pages 935-941 The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity. Etscheid M, Muhl L, Pons D, Jukema JW, König H, Kanse SM

Introduction: Factor VII activating protease (FSAP) is a plasma protease with FVII and pro-urokinase (pro-uPA) activating properties. A single nucleotide polymorphism (SNP) (Marburg I, MI) in the FSAP gene (HABP-2) leads to a low activity of the MI-FSAP towards pro-uPA, but supposedly not towards FVII and is described as a risk factor for athero-thrombosis and liver fibrosis. Recently we found, however, that FVII is an extremely poor substrate of FSAP and identified tissue factor pathway inhibit... Abstract

Cited 89 times since 2012 (7.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 60, Issue 10, 15 3 2012, Pages 875-881 The controversies of statin therapy: weighing the evidence. Jukema JW, Cannon CP, de Craen AJ, Westendorp RG, Trompet S

The debate whether statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are safe to use has been raging since their introduction in 1987. Statins are generally well tolerated and are believed to have minimal adverse effects. However, individual, specific rare adverse events have been reported, such as elevations of liver enzymes, muscle aches, and very rarely, rhabdomyolysis. Discontinuation and/or reduction in the dose of the statin usually leads to resolution of these sid... Abstract

Cited 11 times since 2012 (0.9 per year) source: EuropePMC

The Journal of cell biology, Volume 198, Issue 4, 13 2 2012, Pages 509-528 Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus. Papior P, Arteaga-Salas JM, Günther T, Grundhoff A, Schepers A

Whether or not metazoan replication initiates at random or specific but flexible sites is an unsolved question. The lack of sequence specificity in origin recognition complex (ORC) DNA binding complicates genome-scale chromatin immunoprecipitation (ChIP)-based studies. Epstein-Barr virus (EBV) persists as chromatinized minichromosomes that are replicated by the host replication machinery. We used EBV to investigate the link between zones of pre-replication complex (pre-RC) assembly, replication... Abstract

Cited 573 times since 2012 (45.6 per year) source: EuropePMC

Nature genetics, Volume 44, Issue 9, 12 2 2012, Pages 991-1005 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PC, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, Timpson NJ, Evans DM, Pourcain BS, Wu Y, Andrews JS, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Isaacs A, O'Connell JR, Stirrups K, Vitart V, Hayward C, Esko T, Mihailov E, Fraser RM, Fall T, Voight BF, Raychaudhuri S, Chen H, Lindgren CM, Morris AP, Rayner NW, Robertson N, Rybin D, Liu CT, Beckmann JS, Willems SM, Chines PS, Jackson AU, Kang HM, Stringham HM, Song K, Tanaka T, Peden JF, Goel A, Hicks AA, An P, Müller-Nurasyid M, Franco-Cereceda A, Folkersen L, Marullo L, Jansen H, Oldehinkel AJ, Bruinenberg M, Pankow JS, North KE, Forouhi NG, Loos RJ, Edkins S, Varga TV, Hallmans G, Oksa H, Antonella M, Nagaraja R, Trompet S, Ford I, Bakker SJ, Kong A, Kumari M, Gigante B

Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified furt... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 12 2 2012, Pages 2836-2840 Impaired cardiac reserve in asymptomatic patients with moderate pulmonary restenosis late after relief of severe pulmonary stenosis: evidence for diastolic dysfunction. Romeih S, Blom NA, Van der Plas MN, Spijkerboer AM, Roest AA, Vliegen HW, Mulder BJ, Groenink M

Background: Patients with moderate pulmonary valve restenosis late after relief of severe pulmonary stenosis (PS) may show decreased exercise tolerance. To elucidate the mechanism of decreased exercise tolerance, we evaluated cardiac response to physical and pharmacological stress in these patients and compared results with those of patients with native moderate PS. Methods: Twenty asymptomatic patients with moderate PS were divided into 2 groups: Group I (late after relief of severe PS, n=9), a... Abstract

Cited 18 times since 2012 (1.4 per year) source: Scopus

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 42, Issue 4, 10 2 2012, Pages e53-7 Primary closure using Redon drains vs vacuum-assisted closure in post-sternotomy mediastinitis. Vos RJ, Yilmaz A, Sonker U, Kelder JC, Kloppenburg GT

Objectives: Vacuum-assisted closure (VAC) is a commonly used therapy for the treatment of post-sternotomy mediastinitis. Primary closure of the sternum with high vacuum suction using Redon drains is an alternative that may reduce hospital stay. The aim of this study was to describe for the first time, the results of VAC compared with Redon drainage. Methods: We performed a retrospective analysis of 132 patients undergoing VAC (n = 89) or primary closure of the sternum with Redon drains (n = 43)... Abstract

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 9 2 2012, Pages 2841-2845 Rates and determinants of progressive aortic valve dysfunction in aortic coarctation. Luijendijk P, Stevens AW, de Bruin-Bon RH, Boekholdt SM, Vriend JW, Vliegen HW, Bouma BJ, Mulder BJ

Purpose: Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunction in CoA. Methods: 96 CoA patients prospectively underwent echocardiography twice between 2001 and 2010. AS was defined as an aortic valve gradient ≥ 20 mmHg, AR as none/minor, or... Abstract

Cited 132 times since 2012 (10.5 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 5, Issue 5, 8 2 2012, Pages 628-636 Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension. Haeck ML, Scherptong RW, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V

Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluat... Abstract

Cited 13 times since 2012 (1 per year) source: EuropePMC

PloS one, Volume 7, Issue 8, 3 1 2012, Pages e42401 Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study. Verschuren JJ, Trompet S, Postmus I, Sampietro ML, Heijmans BT, Houwing-Duistermaat JJ, Slagboom PE, Jukema JW

Background: Coronary restenosis after percutaneous coronary intervention still remains a significant problem, despite all medical advances. Unraveling the mechanisms leading to restenosis development remains challenging. Many studies have identified genetic markers associated with restenosis, but consistent replication of the reported markers is scarce. The aim of the current study was to analyze the joined effect of previously in literature reported candidate genes for restenosis in the GENetic... Abstract

Cited 12 times since 2012 (1 per year) source: EuropePMC

Optics express, Volume 20, Issue 18, 1 1 2012, Pages 20635-20646 Asymmetric light propagation in chirped photonic crystal waveguides. Kurt H, Yilmaz D, Akosman AE, Ozbay E

We report numerical and experimental investigations of asymmetric light propagation in a newly designed photonic structure that is formed by creating a chirped photonic crystal (PC) waveguide. The use of a non-symmetric distribution of unit cells of PC ensures the obtaining of asymmetric light propagation. Properly designing the spatial modulation of a PC waveguide inherently modifies the band structure. That in turn induces asymmetry for the light's followed path. The investigation of the... Abstract

Cited 68 times since 2012 (5.4 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 98, Issue 16, 1 1 2012, Pages 1229-1236 Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation. Gripari P, Ewe SH, Fusini L, Muratori M, Ng AC, Cefalù C, Delgado V, Schalij MJ, Bax JJ, Marsan NA, Tamborini G, Pepi M

Background: Post-procedural aortic regurgitation (AR) has been described in a large number of patients receiving transcatheter aortic valve implantation (TAVI). Objective: The aim of this study was to examine the intraoperative 2-dimensional (2D) and 3-dimensional (3D) echocardiographic features of the aortic valve associated with significant post-procedural paravalvular AR. Methods: A total of 135 patients (81±7 years) with severe symptomatic aortic stenosis, who underwent TAVI, were imaged wit... Abstract

Cited 20 times since 2012 (1.6 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 16, Issue 8, 1 1 2012, Pages 1866-1877 Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors. Wierda RJ, Kuipers HF, van Eggermond MC, Benard A, van Leeuwen JC, Carluccio S, Geutskens SB, Jukema JW, Marquez VE, Quax PH, van den Elsen PJ

Previously, we have shown that CCR5 transcription is regulated by CREB-1. However, the ubiquitous pattern of CREB-1 expression suggests the involvement of an additional level of transcriptional control in the cell type-specific expression of CCR5. In this study, we show that epigenetic changes (i.e. DNA methylation and histone modifications) within the context of the CCR5 P1 promoter region correlate with transcript levels of CCR5 in healthy and in malignant CD4(+) T lymphocytes as well as in C... Abstract

Cited 1733 times since 2012 (137.5 per year) source: EuropePMC

European journal of heart failure, Volume 14, Issue 8, 1 1 2012, Pages 803-869 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P, ESC Committee for Practice Guidelines

Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

The Eurasian journal of medicine, Volume 44, Issue 2, 1 1 2012, Pages 94-98 Obesity and its diagnostic methods in Turkish children. Yilmaz D, Inan G, Karakas S, Buyukozturk-Karul A, Sonmez F

Objective: The application of body mass index (BMI) for obesity classification in all population studies has been questioned by the scientific community. It has been found that the bioelectrical impedance analysis (BIA) is an accurate method for screening obesity. This study was conducted to evaluate the accuracies of BMI, skinfold thickness (SFT), leptin and BIA measurements in obesity classification and to find correlations between BIA and the other indicators for obesity. Materials and method... Abstract

Cited 16 times since 2012 (1.3 per year) source: EuropePMC

American heart journal, Volume 164, Issue 2, 1 1 2012, Pages 146-152 The rationale and design of the Shockless IMPLant Evaluation (SIMPLE) trial: a randomized, controlled trial of defibrillation testing at the time of defibrillator implantation. Healey JS, Hohnloser SH, Glikson M, Neuzner J, Viñolas X, Mabo P, Kautzner J, O'Hara G, Van Erven L, Gadler F, Appl U, Connolly SJ

Defibrillation testing (DT) has been an integral part of defibrillator (implantable cardioverter defibrillator [ICD]) implantation; however, there is little evidence that it improves outcomes. Surveys show a trend toward ICD implantation without DT, which now exceeds 30% to 60% in some regions. Because there is no evidence to support dramatic shift in practice, a randomized trial is urgently needed. The SIMPLE trial will determine if ICD implantation without any DT is noninferior to implantation... Abstract

Cited 26 times since 2012 (2.1 per year) source: EuropePMC

Developmental dynamics : an official publication of the American Association of Anatomists, Volume 241, Issue 9, 30 5 2012, Pages 1413-1422 Morphogenesis of outflow tract rotation during cardiac development: the pulmonary push concept. Scherptong RW, Jongbloed MR, Wisse LJ, Vicente-Steijn R, Bartelings MM, Poelmann RE, Schalij MJ, Gittenberger-De Groot AC

Background: Understanding of cardiac outflow tract (OFT) remodeling is essential to explain repositioning of the aorta and pulmonary orifice. In wild type embryos (E9.5-14.5), second heart field contribution (SHF) to the OFT was studied using expression patterns of Islet 1, Nkx2.5, MLC-2a, WT-1, and 3D-reconstructions. Abnormal remodeling was studied in VEGF120/120 embryos. Results: In wild type, Islet 1 and Nkx2.5 positive myocardial precursors formed an asymmetric elongated column almost exclu... Abstract

Cited 105 times since 2012 (8.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 14, Issue 1, 29 5 2012, Pages 69-76 Global longitudinal strain predicts left ventricular dysfunction after mitral valve repair. Witkowski TG, Thomas JD, Debonnaire PJ, Delgado V, Hoke U, Ewe SH, Versteegh MI, Holman ER, Schalij MJ, Bax JJ, Klautz RJ, Marsan NA

Aims: Despite a successful surgical procedure and adherence to current recommendations, postoperative left ventricular (LV) dysfunction after mitral valve repair (MVr) for organic mitral regurgitation (MR) may still occur. New approaches are therefore needed to detect subclinical preoperative LV dysfunction. LV global longitudinal strain (GLS), assessed with speckle-tracking echocardiographic analysis, has been proposed as a novel measure to better depict latent LV dysfunction. The aim of this s... Abstract