Research

Publications

Below you can find a list of our published research.

6131 results

Cited 6 times since 2011 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 19, Issue 12, 1 1 2011, Pages 509-513 Advanced therapy for pulmonary arterial hypertension due to congenital heart disease: a clinical perspective in a new therapeutic era. Schuuring MJ, Boekholdt SM, Windhausen A, Bouma BJ, Groenink M, Keijzers M, De Winter RJ, Koolbergen DR, Blom NA, Mulder BJ

Abstract

Cited 60 times since 2011 (4.5 per year) source: EuropePMC

Arthritis and rheumatism, Volume 63, Issue 12, 1 1 2011, Pages 3969-3978 Left ventricular dysfunction assessed by speckle-tracking strain analysis in patients with systemic sclerosis: relationship to functional capacity and ventricular arrhythmias. Yiu KH, Schouffoer AA, Marsan NA, Ninaber MK, Stolk J, Vlieland TV, Scherptong RW, Delgado V, Holman ER, Tse HF, Huizinga TW, Bax JJ, Schuerwegh AJ

Objective: Systemic sclerosis (SSc) is a connective tissue disease characterized by vascular inflammation and fibrosis. Visceral involvement, including cardiac manifestations, can lead to severe clinical complications, such as congestive heart failure, arrhythmias, and sudden death. Conventional echocardiography parameters have limited sensitivity to detect subtle myocardial dysfunction in patients with SSc. The aim of this study was to assess, using novel speckle-tracking strain analysis, the p... Abstract

Cited 22 times since 2011 (1.7 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 15, Issue 12, 1 1 2011, Pages 2675-2683 Epithelial-to-mesenchymal transformation alters electrical conductivity of human epicardial cells. Bax NA, Pijnappels DA, van Oorschot AA, Winter EM, de Vries AA, van Tuyn J, Braun J, Maas S, Schalij MJ, Atsma DE, Goumans MJ, Gittenberger-de Groot AC

The myocardium of the developing heart tube is covered by epicardium. These epicardial cells undergo a process of epithelial-to-mesenchymal transformation (EMT) and develop into epicardium-derived cells (EPDCs). The ingrowing EPDCs differentiate into several celltypes of which the cardiac fibroblasts form the main group. Disturbance of EMT of the epicardium leads to serious hypoplasia of the myocardium, abnormal coronary artery differentiation and Purkinje fibre paucity. Interestingly, the elect... Abstract

Cited 83 times since 2011 (6.3 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 5, Issue 1, 1 1 2011, Pages 51-59 Association between diffuse myocardial fibrosis by cardiac magnetic resonance contrast-enhanced T₁ mapping and subclinical myocardial dysfunction in diabetic patients: a pilot study. Ng AC, Auger D, Delgado V, van Elderen SG, Bertini M, Siebelink HM, van der Geest RJ, Bonetti C, van der Velde ET, de Roos A, Smit JW, Leung DY, Bax JJ, Lamb HJ

Background: Diabetic patients have increased interstitial myocardial fibrosis on histological examination. Magnetic resonance imaging (MRI) T(1) mapping is a previously validated imaging technique that can quantify the burden of global and regional interstitial fibrosis. However, the association between MRI T(1) mapping and subtle left ventricular (LV) dysfunction in diabetic patients is unknown. Methods and results: Fifty diabetic patients with normal LV ejection fraction (EF) and no underlying... Abstract

Cited 7 times since 2011 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 421-429 Ventricular dyssynchrony assessed by gated myocardial perfusion SPECT using a geometrical approach: a feasibility study. van der Veen BJ, Al Younis I, Ajmone-Marsan N, Westenberg JJ, Bax JJ, Stokkel MP, de Roos A

Purpose: Left ventricular dyssynchrony may predict response to cardiac resynchronization therapy and may well predict adverse cardiac events. Recently, a geometrical approach for dyssynchrony analysis of myocardial perfusion scintigraphy (MPS) was introduced. In this study the feasibility of this geometrical method to detect dyssynchrony was assessed in a population with a normal MPS and in patients with documented ventricular dyssynchrony. Methods: For the normal population 80 patients (40 men... Abstract

Cited 6 times since 2011 (0.5 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 39, Issue 3, 24 4 2011, Pages 416-420 Microvascular dysfunction in nonfailing arrhythmogenic right ventricular cardiomyopathy. Paul M, Rahbar K, Gerss J, Kies P, Schober O, Schäfers K, Breithardt G, Schulze-Bahr E, Wichter T, Schäfers M

Purpose: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a nonischaemic cardiomyopathy and leading cause of sudden death in the young. It has been shown that microvascular dysfunction reflected by an impaired myocardial blood flow (MBF) response to stress is present in patients with other forms of nonischaemic cardiomyopathy, e.g. dilated cardiomyopathy, and that the reduced MBF may be related to a poor prognosis. Therefore, we quantified MBF, coronary flow reserve and coronary vascula... Abstract

Cited 2 times since 2011 (0.2 per year) source: EuropePMC

European heart journal, Volume 33, Issue 5, 21 3 2011, Pages 567-569 Prediction of individual response to heart failure therapy. Bax JJ, Delgado V

Abstract

Cited 64 times since 2011 (4.8 per year) source: EuropePMC

BMC musculoskeletal disorders, Volume 12, 21 3 2011, Pages 262 Outcome in hip fracture patients related to anemia at admission and allogeneic blood transfusion: an analysis of 1262 surgically treated patients. Vochteloo AJ, Borger van der Burg BL, Mertens B, Niggebrugge AH, de Vries MR, Tuinebreijer WE, Bloem RM, Nelissen RG, Pilot P

Background: Anemia is more often seen in older patients. As the mean age of hip fracture patients is rising, anemia is common in this population. Allogeneic blood transfusion (ABT) and anemia have been pointed out as possible risk factors for poorer outcome in hip fracture patients. Methods: In the timeframe 2005-2010, 1262 admissions for surgical treatment of a hip fracture in patients aged 65 years and older were recorded. Registration was prospective from 2008 on. Anemic and non-anemic patien... Abstract

Cited 29 times since 2011 (2.2 per year) source: EuropePMC

In vitro cellular & developmental biology. Animal, Volume 48, Issue 1, 20 3 2011, Pages 21-29 Endothelial colony-forming cells show a mature transcriptional response to shear stress. Egorova AD, DeRuiter MC, de Boer HC, van de Pas S, Gittenberger-de Groot AC, van Zonneveld AJ, Poelmann RE, Hierck BP

Endothelial progenitor cells (EPC) play a central role in endothelial maintenance and repair. Endothelial colony-forming cells (ECFC) form a subpopulation of EPC. ECFC are readily attainable, can be easily isolated, possess a high proliferation potential, and are therefore a promising source of endothelial cells (EC) for future cardiovascular therapeutic applications. The extent to which these cells respond to shear stress as adult vascular EC remains to be elucidated. Here, we study the transcr... Abstract

Cited 46 times since 2011 (3.5 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 5, Issue 1, 17 3 2011, Pages 101-110 Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks? Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, van Erven L, van Dijk AP, Wilde AA, Pieper PG, Sieswerda GT, Mulder BJ

Background: The value of implantable cardioverter defibrillators (ICDs) in adults with congenital heart disease (CHD) is unknown. We investigated the long-term outcome after ICD implantation and developed a simple risk stratification score for ICD therapy. Methods and results: A total of 136 adults with CHD and ICD (mean age±SD, 41±13 years; 67% male) were identified from 10 tertiary referral centers in the Netherlands and Belgium. The indication for ICD implantation was primary prevention in 50... Abstract

Cited 48 times since 2011 (3.6 per year) source: EuropePMC

International journal of epidemiology, Volume 41, Issue 1, 17 3 2011, Pages 106-115 Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction. Talens RP, Jukema JW, Trompet S, Kremer D, Westendorp RG, Lumey LH, Sattar N, Putter H, Slagboom PE, Heijmans BT, PROSPER Group

Background: Human epidemiological studies suggest that small size at birth and food deprivation during gestation confer an excess risk of coronary heart diseases (CHD) in adulthood, frequently in a sex-specific manner. Prior epigenetic studies indicate that such prenatal conditions are marked by persistent and sometimes sex-specific changes in DNA methylation. Here, we have investigated the association between DNA methylation and myocardial infarction (MI) at six loci sensitive to prenatal nutri... Abstract

Cited 31 times since 2011 (2.3 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 14, Issue 1, 16 3 2011, Pages 17-21 Vacuum-assisted closure of post-sternotomy mediastinitis as compared to open packing. Vos RJ, Yilmaz A, Sonker U, Kelder JC, Kloppenburg GT

Post-sternotomy mediastinitis is a rare but serious complication of cardiac surgery leading to prolonged hospital stay and higher mortality. In the last decades several treatment modalities have been described, of which vacuum-assisted closure (VAC) shows the most promising results. The aim of this study is to describe clinical outcomes of VAC as compared to open packing and to predict risk factors for mortality. We performed a retrospective analysis of 113 patients with mediastinitis undergoing... Abstract

Cited 38 times since 2011 (2.9 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 4, 15 3 2011, Pages 513-519 Implantable cardioverter-defibrillator longevity under clinical circumstances: an analysis according to device type, generation, and manufacturer. Thijssen J, Borleffs CJ, van Rees JB, Man S, de Bie MK, Venlet J, van der Velde ET, van Erven L, Schalij MJ

Background: One of the major drawbacks of implantable cardioverter-defibrillator (ICD) treatment is the limited device service life. Thus far, data concerning ICD longevity under clinical circumstances are scarce. In this study, the ICD service life was assessed in a large cohort of ICD recipients. Objective: To assess the battery longevity of ICDs under clinical circumstances. Methods: All patients receiving an ICD in the Leiden University Medical Center were included in the analysis. During pr... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Contemporary clinical trials, Volume 33, Issue 2, 13 2 2011, Pages 410-416 Rationale and design of a trial on the effect of high dose statins on cardiovascular risk in adults after successful coarctation repair. Luijendijk P, Bouma BJ, Vriend JW, Groenink M, Vliegen HW, de Groot E, Pieper PG, van Dijk AP, Sieswerda GT, Veen G, Zwinderman AH, Mulder BJ

Background: HMG-coA-reductase-inhibitors (statins) have been proven to reduce atherosclerosis progression as observed by carotid intima-media thickness in patients with known coronary heart disease, independent of lipid lowering. Cardiovascular complications are common in patients after successful coarctation repair. The effect of statins on cardiovascular risk in adults after successful coarctation repair has not yet been established. Methods: We designed a multicentre, prospective, randomised,... Abstract

Cited 441 times since 2011 (33.1 per year) source: EuropePMC

The New England journal of medicine, Volume 366, Issue 1, 13 2 2011, Pages 20-33 Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. Tricoci P, Huang Z, Held C, Moliterno DJ, Armstrong PW, Van de Werf F, White HD, Aylward PE, Wallentin L, Chen E, Lokhnygina Y, Pei J, Leonardi S, Rorick TL, Kilian AM, Jennings LH, Ambrosio G, Bode C, Cequier A, Cornel JH, Diaz R, Erkan A, Huber K, Hudson MP, Jiang L, Jukema JW, Lewis BS, Lincoff AM, Montalescot G, Nicolau JC, Ogawa H, Pfisterer M, Prieto JC, Ruzyllo W, Sinnaeve PR, Storey RF, Valgimigli M, Whellan DJ, Widimsky P, Strony J, Harrington RA, Mahaffey KW, TRACER Investigators

Background: Vorapaxar is a new oral protease-activated-receptor 1 (PAR-1) antagonist that inhibits thrombin-induced platelet activation. Methods: In this multinational, double-blind, randomized trial, we compared vorapaxar with placebo in 12,944 patients who had acute coronary syndromes without ST-segment elevation. The primary end point was a composite of death from cardiovascular causes, myocardial infarction, stroke, recurrent ischemia with rehospitalization, or urgent coronary revascularizat... Abstract

Cited 13 times since 2011 (1 per year) source: EuropePMC

Nucleic acids research, Volume 40, Issue 5, 12 2 2011, Pages 1984-1999 Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells. Holkers M, de Vries AA, Gonçalves MA

DNA repeats constitute potential sites for the nucleation of secondary structures such as hairpins and cruciforms. Studies performed mostly in bacteria and yeast showed that these noncanonical DNA structures are breakage-prone, making them candidate targets for cellular DNA repair pathways. Possible culprits for fragility at repetitive DNA sequences include replication and transcription as well as the action of structure-specific nucleases. Despite their patent biological relevance, the paramete... Abstract

Cited 10 times since 2011 (0.8 per year) source: EuropePMC

Journal of electrocardiology, Volume 45, Issue 2, 9 2 2011, Pages 154-160 Role of the vectorcardiogram-derived spatial QRS-T angle in diagnosing left ventricular hypertrophy. Man S, Rahmattulla C, Maan AC, Holman E, Bax JJ, van der Wall EE, Schalij MJ, Swenne CA

Introduction: Current criteria for electrocardiographic (ECG) diagnosis of left ventricular hypertrophy (LVH) have a low diagnostic accuracy. Addition of demographic, anthropomorphic, and additional ECG variables may improve accuracy. As hypertrophy affects action potential morphology and intraventricular conduction, QRS prolongation and T-wave morphology may occur and become manifest in the vectorcardiographic variables spatial QRS-T angle (SA) and spatial ventricular gradient. In this study, w... Abstract

Cited 4 times since 2011 (0.3 per year) source: EuropePMC

Journal of interventional cardiology, Volume 25, Issue 1, 8 2 2011, Pages 1-9 Aspiration thrombectomy during primary percutaneous coronary intervention as adjunctive therapy to early (in-ambulance) abciximab administration in patients with acute ST elevation myocardial infarction: an analysis from Leiden MISSION! acute myocardial infarction treatment optimization program. Ahmed TA, Atary JZ, Wolterbeek R, Hasan-Ali H, Abdel-Kader SS, Schalij MJ, Jukema JW

Background: The benefits of early abciximab administration and thrombus aspiration in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) have previously been elaborated. However, whether there is an adjunctive effect of thrombus aspiration among STEMI patients, with angiographic evidence of thrombus, receiving early prehospital abciximab remains unclear. Methods: In the context of a fixed protocol for PPCI, 158 consecutive patients w... Abstract

Cited 40 times since 2011 (3 per year) source: EuropePMC

Heart rhythm, Volume 9, Issue 4, 3 1 2011, Pages 494-498 Cardiac device infections are associated with a significant mortality risk. de Bie MK, van Rees JB, Thijssen J, Borleffs CJ, Trines SA, Cannegieter SC, Schalij MJ, van Erven L

Background: Cardiac device infections (CDIs) are a serious complication associated with the implantation of cardiac rhythm devices. However, the effect of CDI on the subsequent risk of mortality is unknown. Objective: To assess the prognostic importance of CDI in recipients of implantable cardioverter-defibrillator and cardiac resynchronization therapy - defibrillator. Methods: All patients who received their initial implantable cardioverter-defibrillator/cardiac resynchronization therapy - defi... Abstract

Cited 49 times since 2011 (3.7 per year) source: EuropePMC

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Volume 21, Issue 8, 1 1 2011, Pages 1472-1478 Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients. van der Vorst JR, Hutteman M, Gaarenstroom KN, Peters AA, Mieog JS, Schaafsma BE, Kuppen PJ, Frangioni JV, van de Velde CJ, Vahrmeijer AL

Objective: In early cervical cancer, a total pelvic lymphadenectomy is the standard of care, even though most patients have negative nodes and thus undergo lymphadenectomy unnecessarily. Although the value of sentinel lymph node (SLN) mapping in early-stage cervical cancer has not yet been established, near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. Near-infrared fluorescence imaging is based on invisible NIR light and can provide high sensitivity, hi... Abstract