6131 results
Cited 94 times since 2011 (6.8 per year)
source: EuropePMC
Journal of the American Academy of Dermatology,
Volume 65, Issue 2, 20 3 2011, Pages 320-327
Adverse effects of propranolol when used in the treatment of hemangiomas: a case series of 28 infants.
de Graaf M, Breur JMPJ, Raphaël MF, Vos M, Breugem CC, Pasmans SGMA
Background: Infantile hemangioma (IH) is a frequently encountered tumor with a potentially complicated course. Recently, propranolol was discovered to be an effective treatment option. Objective: To describe the effects and side effects of propranolol treatment in 28 children with (complicated) IH. Methods: A protocol for treatment of IH with propranolol was designed and implemented. Propranolol was administered to 28 children (21 girls and 7 boys, mean age at onset of treatment: 8.8 months). Re...
Abstract
Cited 41 times since 2011 (3 per year)
source: EuropePMC
Developmental dynamics : an official publication of the American Association of Anatomists,
Volume 240, Issue 7, 20 3 2011, Pages 1670-1680
Tgfβ/Alk5 signaling is required for shear stress induced klf2 expression in embryonic endothelial cells.
Egorova AD, Van der Heiden K, Van de Pas S, Vennemann P, Poelma C, DeRuiter MC, Goumans MJ, Gittenberger-de Groot AC, ten Dijke P, Poelmann RE, Hierck BP
Endothelial cells (EC) translate biomechanical forces into functional and phenotypic responses that play important roles in cardiac development. Specifically, EC in areas of high shear stress, i.e., in the cardiac outflow tract and atrioventricular canal, are characterized by high expression of Krüppel-like factor 2 (Klf2) and by transforming growth factor-beta (Tgfβ)-driven endothelial-to-mesenchymal transition. Extraembryonic venous obstruction (venous clip model) results in congenital heart m...
Abstract
The international journal of cardiovascular imaging,
Volume 28, Issue 3, 19 3 2011, Pages 563-565
Does heart rate influence CMR image quality of the coronary vessel wall?
van der Wall EE, Kröner EJ, Siebelink HM, Scholte AJ, Schalij MJ
Abstract
Cited 9 times since 2011 (0.7 per year)
source: EuropePMC
PloS one,
Volume 6, Issue 5, 16 3 2011, Pages e18609
The dyad symmetry element of Epstein-Barr virus is a dominant but dispensable replication origin.
Ott E, Norio P, Ritzi M, Schildkraut C, Schepers A
OriP, the latent origin of Epstein-Barr virus (EBV), consists of two essential elements: the dyad symmetry (DS) and the family of repeats (FR). The function of these elements has been predominantly analyzed in plasmids transfected into transformed cells. Here, we examined the molecular functions of DS in its native genomic context and at an ectopic position in the mini-EBV episome. Mini-EBV plasmids contain 41% of the EBV genome including all information required for the proliferation of human B...
Abstract
Cited 4 times since 2011 (0.3 per year)
source: EuropePMC
Current medical research and opinion,
Volume 27, Issue 7, 12 2 2011, Pages 1347-1357
How to reduce the incidence of contrast induced acute kidney injury after cardiac invasive procedures, a review and practical recommendations.
de Bie MK, van Rees JB, Herzog CA, Rabelink TJ, Schalij MJ, Jukema JW
Background: Contrast induced acute kidney injury is an important complication after cardiac (invasive) procedures and is associated with substantial morbidity and mortality. The aim of the current article is to provide a comprehensive overview of the current knowledge regarding contrast induced acute kidney injury. Methods: Current literature was reviewed and relevant articles were selected. Articles were identified through MEDLINE and Pubmed selecting articles, limited between 1980 and 2010. Re...
Abstract
Cited 2 times since 2011 (0.1 per year)
source: EuropePMC
The Cochrane database of systematic reviews,
Issue 5, 11 2 2011, Pages CD008128
Treatment of valvular heart disease during pregnancy for improving maternal and neonatal outcome.
Henriquez DD, Roos-Hesselink JW, Schalij MJ, Klautz RJ, Helmerhorst FM, de Groot CJ
Background: Valvular heart disease constitutes the majority of all causes of heart disease in pregnancy. In the presence of valvular heart disease, the necessary haemodynamic changes of pregnancy might cause heart failure, leading to severe maternal and fetal morbidity and even mortality. Treatment of valvular heart disease is indicated when patients experience a deterioration of symptoms and in case of a severe valvular lesion. Whether medical therapy or interventional therapy is the optimal tr...
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 4, Issue 4, 11 2 2011, Pages 486-493
ECG identification of scar-related ventricular tachycardia with a left bundle-branch block configuration.
Wijnmaalen AP, Stevenson WG, Schalij MJ, Field ME, Stephenson K, Tedrow UB, Koplan BA, Putter H, Epstein LM, Zeppenfeld K
Background: A left bundle-branch block (LBBB)-like pattern with a dominant S-wave in V(1) is common in idiopathic ventricular arrhythmias (VA). Discrimination between idiopathic and scar-related LBBB pattern VA has important clinical implications. We hypothesized that the VA QRS morphology is influenced by the presence of ventricular scar, allowing ECG discrimination of VA arising from structurally normal versus scarred myocardium. Methods and results: Twelve-lead ECGs of 297 LBBB pattern monomo...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
American heart journal,
Volume 161, Issue 6, 11 2 2011, Pages 1060-1066
Site of latest activation in patients eligible for cardiac resynchronization therapy: patterns of dyssynchrony among different QRS configurations and impact of heart failure etiology.
van Bommel RJ, Ypenburg C, Mollema SA, Borleffs CJ, Delgado V, Bertini M, Marsan NA, van der Wall EE, Schalij MJ, Bax JJ
Introduction: Cardiac resynchronization therapy (CRT) has emerged as a treatment option for patients with end-stage heart failure and a QRS duration ≥120 ms. Nonetheless, many patients with a prolonged QRS do not demonstrate left ventricular (LV) mechanical dyssynchrony, and discrepancies between electrical and mechanical dyssynchrony have been observed. In addition, several studies demonstrated that superior benefits after CRT could be achieved when the LV pacing lead was positioned at the most...
Abstract
Cited 28 times since 2011 (2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 108, Issue 3, 6 1 2011, Pages 435-439
Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood.
Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ
Chronic hypertension is a major concern in adults who have undergone resection of coarctation of the aorta (CoA) in childhood. In otherwise healthy subjects, exercise-induced hypertension is prognostic for chronic hypertension; however, the prognostic value in patients with CoA remains unknown. The aim of the present study was to evaluate the predictive value of exercise-induced hypertension for chronic hypertension in these patients. In the present prospective follow-up study, 74 patients with...
Abstract
Cited 16 times since 2011 (1.2 per year)
source: EuropePMC
Congenital heart disease,
Volume 6, Issue 3, 5 1 2011, Pages 219-227
The perspective of patients with congenital heart disease: does health care meet their needs?
Schoormans D, Sprangers MA, Pieper PG, van Melle JP, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ
Objective: A first step in the delivery of tailored care is answering the following question: does health care meet the needs of patients? Therefore patients' perspective on health care use and their needs was examined. The design used was cross-sectional questionnaire study. Patients: A total of 1109 adult congenital heart defect (CHD) patients attending one of eight Dutch hospitals were randomly selected from a national database (10% of all registered patients). Main outcome measures: Pat...
Abstract
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 18, Issue 3, 1 1 2011, Pages 393-395
Cardiac risk assessment in asymptomatic diabetes: combining [corrected] different imaging modalities and surrogate markers?
Scholte AJ
Abstract
Cited 12 times since 2011 (0.9 per year)
source: EuropePMC
Mycoses,
Volume 54, Issue 3, 1 1 2011, Pages 234-242
A rescue therapy with a combination of caspofungin and liposomal amphotericin B or voriconazole in children with haematological malignancy and refractory invasive fungal infections.
Yilmaz D, Balkan C, Ay Y, Akin M, Karapinar B, Kavakli K
Combination treatment of paediatric invasive fungal infections (IFIs) has rarely been reported. A total of 17 children with 19 IFI episodes were enrolled in the study. The median age of the patients was 5.3 (range 0.5-17) years. IFI was classified as proven in 4, probable in 12 and possible in 3 episodes. These patients received empiric antifungal treatment, which consisted of liposomal amphotericin B (LAmB) monotherapy for a median duration of 12 days (range 3-69 days). All patients were refrac...
Abstract
Cited 10 times since 2011 (0.7 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 13 Suppl 2, 1 1 2011, Pages ii32-8
Cardiac resynchronization therapy: a cost or an investment?
Boriani G, Mantovani LG, Biffi M, Schalij MJ, Martignani C, Leclercq C, Bax JJ, Auricchio A
Cost-effectiveness estimates can help optimize use of available financial resources and this is especially relevant for implementation of cardiac resynchronization therapy (CRT), given the high upfront costs and the timescale of expected benefits. All available cost-effectiveness estimates for devices with (CRT-P) or without (CRT-D) a defibrillator are based on results of randomized trials of selected patients, with a relatively brief follow-up. Extrapolation suggests that the cost effectiveness...
Abstract
Cited 28 times since 2011 (2 per year)
source: EuropePMC
The American journal of cardiology,
Volume 108, Issue 1, 27 4 2011, Pages 63-68
Comparison of long-term survival of men versus women with heart failure treated with cardiac resynchronization therapy.
Mooyaart EA, Marsan NA, van Bommel RJ, Thijssen J, Borleffs CJ, Delgado V, van der Wall EE, Schalij MJ, Bax JJ
Cardiac resynchronization therapy (CRT) is an established treatment of patients with heart failure. Several baseline characteristics can influence the CRT outcomes, and little is known about the effect of gender. The aim of the present study was to elucidate the gender-related differences in long-term survival after CRT. A total of 578 consecutive patients with heart failure underwent CRT. At baseline and 6 months after CRT, the clinical and echocardiographic parameters were obtained. All-cause...
Abstract
Cited 228 times since 2011 (16.4 per year)
source: EuropePMC
Journal of translational medicine,
Volume 9, 25 4 2011, Pages 47
Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs.
Chen TS, Arslan F, Yin Y, Tan SS, Lai RC, Choo AB, Padmanabhan J, Lee CN, de Kleijn DP, Lim SK
Background: Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale production of these exosomes would require replenishment of hESC-MSC through derivation from hESCs and incur recurring costs for testing and validation of each new batch. Our aim was therefore to investigate if MYC immortalization of hESC-MSC...
Abstract
Cited 5 times since 2011 (0.4 per year)
source: EuropePMC
Transfusion medicine (Oxford, England),
Volume 21, Issue 4, 24 4 2011, Pages 236-246
The effect of RBC transfusions on cytokine gene expression after cardiac surgery in patients developing post-operative multiple organ failure.
Sitniakowsky LS, Later AF, van de Watering LM, Bogaerts M, Brand A, Klautz RJ, Smit NP, van Hilten JA
Aim: To determine the effect of red blood cell (RBC) transfusions during cardiac surgery on cytokine gene expression (GE) in relation to multiple organ failure (MOF) development after systemic inflammatory response syndrome (SIRS). Background: RBC transfusion in cardiac surgery patients is dose-dependently associated with post-operative MOF, possibly acting as a second hit after cardiopulmonary bypass. Methods: For this observational study, 29 patients divided into four groups of cardiac surgery...
Abstract
Cited 45 times since 2011 (3.2 per year)
source: EuropePMC
Basic research in cardiology,
Volume 106, Issue 5, 24 4 2011, Pages 829-847
In vitro epithelial-to-mesenchymal transformation in human adult epicardial cells is regulated by TGFβ-signaling and WT1.
Bax NA, van Oorschot AA, Maas S, Braun J, van Tuyn J, de Vries AA, Groot AC, Goumans MJ
Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibroblasts, which contribute to cardiac repair. To understand what drives epicardial EMT, we used an in vitro model for human adult epicardial cells. These cells have an epithelium-like...
Abstract
Cited 9 times since 2011 (0.6 per year)
source: EuropePMC
Emergency medicine journal : EMJ,
Volume 29, Issue 4, 21 3 2011, Pages 301-305
The utility of EEG in the emergency department.
Yigit O, Eray O, Mihci E, Yilmaz D, Arslan S, Eray B
Background and aim: Seizure-related visits are common in the emergency department (ED) but the clinical situations for ordering emergency electroencephalography (EEG) are unclear. The aim of this study is to identify which clinical conditions meet with the pathological EEG and whether patient management is changed by abnormal results. Methods: A retrospective chart review study of all patients visiting the ED with a seizure or symptoms mimicking a seizure was performed. Patients who recorded an...
Abstract
Cited 2 times since 2011 (0.1 per year)
source: EuropePMC
Applied nursing research : ANR,
Volume 25, Issue 3, 20 3 2011, Pages 158-163
Examining barriers to emergency contraception use.
Kisa S, Zeyneloğlu S, Yilmaz D, Verim E
Using a cross-sectional survey research design, this study examined barriers to emergency contraception (EC) use among a sample of 318 Turkish women. Only 34% of the respondents reported being aware of EC methods, and about 20% had actually used EC. More than 90% of the participant women considered use of EC methods as a sin. The results of the study showed that the major barriers to EC use are lack of awareness and common misconceptions about EC methods. This study highlights the need of educat...
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Neuromodulation : journal of the International Neuromodulation Society,
Volume 14, Issue 3, 19 3 2011, Pages 258-65; discussion 265
Subcutaneous electrical nerve stimulation: a feasible and new method for the treatment of patients with refractory angina.
Buiten MS, DeJongste MJ, Beese U, Kliphuis C, Durenkamp A, Staal MJ
Introduction: Patients suffering from chronic angina pectoris, insufficiently controllable with medication and revascularization, are an increasing medical and psychosocial problem. Although spinal cord stimulation (SCS) is proven to employ, safe, long-term anti-angina, and anti-ischemic effects for these patients, the use of SCS in this group remains limited. The reason for this restricted use is largely unknown. However, among other reasons, it may be related to the difficulties in positioni...
Abstract
