Research

Publications

Below you can find a list of our published research.

6128 results

Cited 91 times since 2008 (5.5 per year) source: EuropePMC

European journal of immunology, Volume 38, Issue 9, 1 1 2008, Pages 2389-2400 Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B. Nagasawa M, Schmidlin H, Hazekamp MG, Schotte R, Blom B

Plasmacytoid dendritic cells (pDC) are central players in the innate and adaptive immune response against viral infections. The molecular mechanism that underlies pDC development from progenitor cells is only beginning to be elucidated. Previously, we reported that the Ets factor Spi-B and the inhibitors of DNA binding protein 2 (Id2) or Id3, which antagonize E-protein activity, are crucially involved in promoting or impairing pDC development, respectively. Here we show that the basic helix-loop... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 52, Issue 11, 1 1 2008, Pages 921-923 Aggressive therapy is not always the best therapy. Bruschke AV, Jukema JW

Abstract

Cited 25 times since 2008 (1.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 9, 1 1 2008, Pages 1214-1226 Cell therapy for ischaemic heart disease. Beeres SL, Atsma DE, van Ramshorst J, Schalij MJ, Bax JJ

Abstract

Cited 33 times since 2008 (2 per year) source: EuropePMC

The Journal of bone and joint surgery. British volume, Volume 90, Issue 9, 1 1 2008, Pages 1205-1209 Early magnetic resonance imaging compared with bone scintigraphy in suspected scaphoid fractures. Beeres FJ, Rhemrev SJ, den Hollander P, Kingma LM, Meylaerts SA, le Cessie S, Bartlema KA, Hamming JF, Hogervorst M

We evaluated 100 consecutive patients with a suspected scaphoid fracture but without evidence of a fracture on plain radiographs using MRI within 24 hours of injury, and bone scintigraphy three to five days after injury. The reference standard for a true radiologically-occult scaphoid fracture was either a diagnosis of fracture on both MRI and bone scintigraphy, or, in the case of discrepancy, clinical and/or radiological evidence of a fracture. MRI revealed 16 scaphoid and 24 other fractures. B... Abstract

Cited 14 times since 2008 (0.8 per year) source: EuropePMC

PloS one, Volume 3, Issue 8, 29 5 2008, Pages e3084 Targeted chromosomal insertion of large DNA into the human genome by a fiber-modified high-capacity adenovirus-based vector system. Gonçalves MA, Holkers M, van Nierop GP, Wieringa R, Pau MG, de Vries AA

A prominent goal in gene therapy research concerns the development of gene transfer vehicles that can integrate exogenous DNA at specific chromosomal loci to prevent insertional oncogenesis and provide for long-term transgene expression. Adenovirus (Ad) vectors arguably represent the most efficient delivery systems of episomal DNA into eukaryotic cell nuclei. The most advanced recombinant Ads lack all adenoviral genes. This renders these so-called high-capacity (hc) Ad vectors less cytotoxic/imm... Abstract

Cited 172 times since 2008 (10.4 per year) source: EuropePMC

BMJ (Clinical research ed.), Volume 337, 29 5 2008, Pages a1331 Drug eluting and bare metal stents in people with and without diabetes: collaborative network meta-analysis. Stettler C, Allemann S, Wandel S, Kastrati A, Morice MC, Schömig A, Pfisterer ME, Stone GW, Leon MB, de Lezo JS, Goy JJ, Park SJ, Sabaté M, Suttorp MJ, Kelbaek H, Spaulding C, Menichelli M, Vermeersch P, Dirksen MT, Cervinka P, De Carlo M, Erglis A, Chechi T, Ortolani P, Schalij MJ, Diem P, Meier B, Windecker S, Jüni P

Objective: To compare the effectiveness and safety of three types of stents (sirolimus eluting, paclitaxel eluting, and bare metal) in people with and without diabetes mellitus. Design: Collaborative network meta-analysis. Data sources: Electronic databases (Medline, Embase, the Cochrane Central Register of Controlled Trials), relevant websites, reference lists, conference abstracts, reviews, book chapters, and proceedings of advisory panels for the US Food and Drug Administration. Manufacturers... Abstract

Cited 20 times since 2008 (1.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 34, Issue 6, 28 4 2008, Pages 1149-1157 Early and late outcome of left ventricular reconstruction surgery in ischemic heart disease. Klein P, Bax JJ, Shaw LJ, Feringa HH, Versteegh MI, Dion RA, Klautz RJ

A systematic review of the literature was performed to determine early and late mortality associated with left ventricular (LV) reconstruction surgery and to assess the influence of different surgical techniques, concomitant surgical procedures, clinical and hemodynamic parameters on mortality. The MEDLINE database (January 1980-January 2005) was searched and from the pooled data, hospital mortality and survival were calculated. Summary estimates of relative risks (RR) were calculated for the te... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 9, 27 4 2008, Pages 1156-1158 Prognostic significance of myocardial ischemia by dobutamine stress echocardiography in patients without angina pectoris after coronary revascularization. Pedone C, Elhendy A, Biagini E, van Domburg RT, Schinkel AF, Di Pasquale G, Bax JJ, Poldermans D

The clinical utility of stress testing in patients without angina pectoris after revascularization has been questioned. Dobutamine stress echocardiography (DSE) is an established technique for detection of myocardial ischemia and cardiac risk stratification. We studied the prognostic value of DSE in 393 patients without typical angina pectoris after coronary revascularization. Ischemia was incremental to clinical data in predicting all-cause death (hazard ratio 3.5, 95% confidence interval 1.8 t... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 24, Issue 8, 12 2 2008, Pages 907-909 Coronary artery calcium screening: sufficient evidence for accurate risk assessment? van der Wall EE, Schuijf JD, Jukema JW, Bax JJ

Abstract

Cited 10 times since 2008 (0.6 per year) source: EuropePMC

Molecular and cellular biochemistry, Volume 320, Issue 1-2, 9 2 2008, Pages 75-84 Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent. Umar S, van der Valk EJ, Schalij MJ, van der Wall EE, Atsma DE, van der Laarse A

Prolonged myocardial stretch typically leads to hypertrophy of cardiomyocytes. As integrins are cellular receptors of stretch, we hypothesize that integrin stimulation induces cardiomyocyte hypertrophy. Integrins of neonatal rat cardiomyocytes (NRCMs) were stimulated with a peptide containing the Arg-Gly-Asp (RGD) sequence for 24 h. For comparison, alpha(1)-adrenergic stimulation by phenylephrine (PE) for 24 h was applied. Saline-treated NRCMs were used as control. The hypertrophic response was... Abstract

Cited 43 times since 2008 (2.6 per year) source: EuropePMC

Heart rhythm, Volume 5, Issue 9, 6 1 2008, Pages 1257-1264 Real-time three-dimensional echocardiography as a novel approach to assess left ventricular and left atrium reverse remodeling and to predict response to cardiac resynchronization therapy. Marsan NA, Bleeker GB, Ypenburg C, Van Bommel RJ, Ghio S, Van de Veire NR, Delgado V, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Background: Real-time 3-dimensional echocardiography (RT3DE) is a novel promising technique for the assessment of left ventricular (LV) dyssynchrony. Objective: This study sought to explore the value of RT3DE to assess LV and left atrium (LA) reverse remodeling and to predict response to cardiac resynchronization therapy (CRT). Methods: A total of 57 consecutive heart failure patients scheduled for CRT were included, and RT3DE was performed before and 6 months after implantation. LV dyssynchrony... Abstract

Cited 144 times since 2008 (8.7 per year) source: EuropePMC

European heart journal, Volume 29, Issue 19, 5 1 2008, Pages 2373-2381 Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis. Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Boersma E, Reiber JH, Schalij MJ, Wijns W, Bax JJ

Aims: Atherosclerotic plaque characteristics play an important role in the development of coronary events. We investigated coronary plaque characteristics on multi-slice computed tomography (MSCT) and virtual histology intravascular ultrasound (VH IVUS) in patients with acute coronary syndromes (ACS) and stable coronary artery disease (CAD). Methods and results: Fifty patients (25 with ACS, 25 with stable CAD) underwent 64-slice MSCT followed by VH IVUS in 48 (96%) patients. In ACS patients, 32%... Abstract

Cited 34 times since 2008 (2.1 per year) source: EuropePMC

Experimental and molecular pathology, Volume 85, Issue 2, 5 1 2008, Pages 90-95 Release kinetics of intact and degraded troponin I and T after irreversible cell damage. Hessel MH, Michielsen EC, Atsma DE, Schalij MJ, van der Valk EJ, Bax WH, Hermens WT, van Dieijen-Visser MP, van der Laarse A

Purpose: We characterized the release kinetics of cardiac troponin I and T in relation to lactate dehydrogenase (LDH) from cardiomyocytes before and after the transition from reversible to irreversible cell damage. Methods: Cardiomyocytes were exposed to mild metabolic inhibition (1 mmol/L sodium azide) to induce a necrotic cell death process that is characterized by a reversible (0-12 h) and irreversible phase (12-30 h). At various time intervals cells and media were collected and analyzed for... Abstract

Cited 30 times since 2008 (1.8 per year) source: EuropePMC

Journal of leukocyte biology, Volume 84, Issue 6, 4 1 2008, Pages 1379-1391 Insights into mechanisms behind arteriogenesis: what does the future hold? van Oostrom MC, van Oostrom O, Quax PH, Verhaar MC, Hoefer IE

Arteriogenesis, the enlargement of collateral vessels, seems a promising new target to improve blood flow to ischemic regions in patients suffering from cardiovascular conditions. With the growing knowledge of the mechanisms involved in arteriogenesis and the factors that influence the process, an increasing number of clinical trials are being performed to stimulate arteriogenesis, providing more insight in therapeutic opportunities for arteriogenesis. The expression of growth factors and the co... Abstract

Cited 3 times since 2008 (0.2 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 94, Issue 8, 1 1 2008, Pages 973-975 Multislice CT: is it essential before atrial fibrillation ablation? Tops LF, Schalij MJ

Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 7-8, 1 1 2008, Pages 270-271 Atrial fibrillation: an unusual cause. Siebelink HJ, Willems TP, Götte MJ

Abstract

Cited 11 times since 2008 (0.7 per year) source: EuropePMC

Current problems in cardiology, Volume 33, Issue 8, 1 1 2008, Pages 417-457 Percutaneous valve procedures: an update. Tops LF, Kapadia SR, Tuzcu EM, Vahanian A, Alfieri O, Webb JG, Bax JJ

Valvular heart disease is an important cause of morbidity and mortality. Aortic stenosis and mitral regurgitation account for the majority of patients with native valve disease. Although surgical treatment provides satisfactory outcome, a large proportion of patients do not undergo a surgical intervention, because of the high estimated operative risk and multiple comorbidities. Recently, new techniques that enable percutaneous treatment of valvular heart disease have been developed and their fea... Abstract

Cited 24 times since 2008 (1.4 per year) source: EuropePMC

Circulation research, Volume 103, Issue 4, 1 1 2008, Pages 334-336 Unraveling pleiotropic effects of statins: bit by bit, a slow case with perspective. Arslan F, Pasterkamp G, de Kleijn DP

Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 16, Issue 7-8, 1 1 2008, Pages 250-254 Pulmonary hypertension: the role of the electrocardiogram. Henkens IR, Scherptong RW, van Kralingen KW, Said SA, Vliegen HW

A 54-year-old female was referred to our centre for further evaluation of recently established severe pulmonary hypertension. Six months prior to presentation to the cardiologist of the referring centre, the patient had first experienced exertional dyspnoea. At the time of presentation to the referring cardiologist, the patient's ECG showed signs of an increased right heart load. Interestingly, this patient had undergone a thorough cardiac evaluation in the referring centre seven years befo... Abstract

Cited 109 times since 2008 (6.6 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 28, Issue 11, 31 5 2008, Pages 2016-2022 Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice. van der Hoorn JW, de Haan W, Berbée JF, Havekes LM, Jukema JW, Rensen PC, Princen HM

Objective: Niacin potently decreases plasma triglycerides and LDL-cholesterol. In addition, niacin is the most potent HDL-cholesterol-increasing drug used in the clinic. In the present study, we aimed at elucidation of the mechanism underlying its HDL-raising effect. Methods and results: In APOE*3Leiden transgenic mice expressing the human CETP transgene, niacin dose-dependently decreased plasma triglycerides (up to -77%, P Abstract