6125 results
Pulmonary pharmacology & therapeutics,
Volume 19, Issue 6, 18 3 2005, Pages 397-403
Clinically masked increases in bronchial inflammation in guideline-treated persistent asthma.
Koopmans JG, Lutter R, Jansen HM, van der Zee JS
Background: Current guidelines generally recommend a combination of inhaled corticosteroids and a Beta2-agonist for persistent asthma. The adjustment of anti-inflammatory therapy in persistent asthma is advised to be guided mainly by the presence of symptoms. Objective: To investigate whether clinically masked increases in bronchial inflammation occur in guideline-treated, persistent asthma following allergen exposure. Methods: After a 4-week steroid-run-in period (fluticasone 250 microg twice d...
Abstract
Cited 19 times since 2005 (1 per year)
source: EuropePMC
Basic research in cardiology,
Volume 101, Issue 1, 11 2 2005, Pages 36-42
Suppression of physiological cardiomyocyte proliferation in the rat pup after neonatal glucocorticosteroid treatment.
de Vries WB, Bal MP, Homoet-van der Kraak P, Kamphuis PJ, van der Leij FR, Baan J, Steendijk P, de Weger RA, van Bel F, van Oosterhout MF
Background: Glucocorticosteroids (mostly dexamethasone) are widely used to prevent chronic lung disease in premature infants. Neonatal rats treated with dexamethasone have been shown to have reduced cardiac mass and cardiomyocyte hypertrophy, suggesting a lower number of cardiomyocytes at adult age, and a severely reduced life expectancy. In the present study we tested the hypothesis that a lower number of cardiomyocytes in later life is caused by a reduced cardiomyocyte proliferation and/or by...
Abstract
Cited 5 times since 2005 (0.3 per year)
source: EuropePMC
Heart, lung & circulation,
Volume 14 Suppl 2, 7 1 2005, Pages S8-13
Assessment of myocardial viability in ischemic cardiomyopathy.
Bax JJ
The number of patients with ischemic cardiomyopathy has increased extensively over recent years. Therapies include medical treatment, cardiac transplantation, cardiac resynchronization therapy and surgery. In the diagnostic and prognostic work-up, the assessment of myocardial viability has become more important over time. In particular, patients with viable myocardium can improve in LV function after revascularization; this will not occur in patients without viable tissue. In view of the high ri...
Abstract
Cited 73 times since 2005 (3.8 per year)
source: EuropePMC
Circulation,
Volume 112, Issue 20, 7 1 2005, Pages 3058-3065
Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
Packard CJ, Ford I, Robertson M, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, PROSPER Study Group
Background: Statins are important in vascular disease prevention in the elderly. However, the best method of selecting older patients for treatment is uncertain. We assessed the role of plasma lipoproteins as predictors of risk and of treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Method and results: The association of LDLc and HDLc with risk was examined in the 5804 70- to 82-year-old subjects of PROSPER. Baseline LDLc showed no relation to risk of t...
Abstract
Cited 15 times since 2005 (0.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 97, Issue 1, 4 1 2005, Pages 1-6
Prognostic implications of a normal stress technetium-99m-tetrofosmin myocardial perfusion study in patients with a healed myocardial infarct and/or previous coronary revascularization.
Schinkel AF, Elhendy A, Bax JJ, van Domburg RT, Huurman A, Valkema R, Biagini E, Rizzello V, Feringa HH, Krenning EP, Simoons ML, Poldermans D
Previous studies have shown a good outcome for patients who present with normal findings on stress myocardial perfusion imaging. Currently, the prognostic implications of a normal study in patients who have a history of coronary artery disease (CAD) are not clear. This study investigated the long-term prognosis after a normal finding on stress technetium-99m (Tc-99m)-tetrofosmin single-photon emission computed tomography in patients with a history of CAD. The study included 147 consecutive patie...
Abstract
Cited 5 times since 2005 (0.3 per year)
source: EuropePMC
Acta physiologica Scandinavica,
Volume 185, Issue 3, 1 1 2005, Pages 181-191
Left ventricular pressure-volume relationships during normal growth and development in the adult rat--studies in 8- and 50-week-old male Wistar rats.
Bal MP, de Vries WB, van der Leij FR, van Oosterhout MF, Baan J, van der Wall EE, van Bel F, Steendijk P
Aims: Left ventricular (LV) pressure-volume relations provide relatively load-independent indexes of systolic and diastolic LV function, but few data are available on pressure-volume relations during growth and development in the normal adult heart. Furthermore, to quantify intrinsic ventricular function the indexes should be normalized for heart weight. However, in many studies the indexes are reported in absolute terms, or body weight-correction is used as a surrogate for heart weight-correcti...
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 13, Issue Suppl 2, 1 1 2005, Pages 12-13
Acute coronary syndrome without ST elevation: what is new?: Stockholm, 4 September 2005.
Beeres SL
Abstract
Cited 14 times since 2005 (0.7 per year)
source: EuropePMC
European journal of nuclear medicine and molecular imaging,
Volume 32, Issue 11, 1 1 2005, Pages 1337-1347
Multislice CT coronary angiography: how to do it and what is the current clinical performance?
Cademartiri F, Schuijf JD, Mollet NR, Malagutti P, Runza G, Bax JJ, de Feyter PJ
The introduction of multislice computed tomography (MSCT) has allowed non-invasive coronary angiography. Although widely applied, extensive information on technical details of the technique is lacking. This survey offers detailed information on patient preparation, data acquisition, reconstruction and interpretation. In addition, a summary of the available studies using MSCT for non-invasive angiography is provided. Based on pooled analysis of direct comparisons between MSCT and invasive angiogr...
Abstract
Future cardiology,
Volume 1, Issue 6, 1 1 2005, Pages 701-704
Prevention of perioperative cardiovascular complications in non-cardiac surgery: the future role of statins.
Schouten O, Bax JJ, Poldermans D
Abstract
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 13, Issue Suppl 2, 1 1 2005, Pages 16-17
Insights into the management of atrial fibrillation in clinical practice in Europe: results of the Euro Heart Survey on atrial fibrillation: Stockholm, 5 September 2005.
Tops LF
Abstract
Cited 37 times since 2005 (1.9 per year)
source: EuropePMC
Current medical research and opinion,
Volume 21, Issue 11, 1 1 2005, Pages 1865-1874
LDL-C/HDL-C ratio in subjects with cardiovascular disease and a low HDL-C: results of the RADAR (Rosuvastatin and Atorvastatin in different Dosages And Reverse cholesterol transport) study.
Jukema JW, Liem AH, Dunselman PH, van der Sloot JA, Lok DJ, Zwinderman AH
Background: The ratio of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol (LDL-C/HDL-C) is a reliable predictor of cardiovascular risk. Low HDL-C levels in patients with coronary artery disease are associated with a high risk for cardiovascular events. Objectives: This study compared the effects of rosuvastatin and atorvastatin on the LDL-C/HDL-C. Methods: Patients aged 40-80 years with established cardiovascular disease and HDL-C < 1.0 mmol/L (< 40 mg/dL) enter...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 149, Issue 48, 1 1 2005, Pages 2655-2658
[The practice guideline 'Heart failure' (first revision) from the Dutch College of General Practitioners; a response from the perspective of cardiology].
Ypenburg C, Schalij MJ, van der Wall EE
The Dutch College of General Practitioners' practice guideline 'Heart failure' provides a clear insight into the history, diagnosis and treatment of patients with chronic heart failure. The revised guideline does however warrant some minor comments. It suggests that an elevated BNP value contributes towards the diagnosis of heart failure, however taking into account the high negative predictive value, BNP should, for the time being at least, only act as an 'instrument of excl...
Abstract
Cited 40 times since 2005 (2.1 per year)
source: EuropePMC
Stem cells (Dayton, Ohio),
Volume 23, Issue 10, 1 1 2005, Pages 1598-1607
Endowing human adenovirus serotype 5 vectors with fiber domains of species B greatly enhances gene transfer into human mesenchymal stem cells.
Knaän-Shanzer S, van de Watering MJ, van der Velde I, Gonçalves MA, Valerio D, de Vries AA
Bone marrow-derived human mesenchymal stem cells (hMSCs) lack the Coxsackie-adenovirus (Ad) receptor and thus are poorly transduced by vectors based on human Ad serotype 5 (Ad5). We investigated whether this problem could be overcome by using tropism-modified Ad5 vectors carrying fiber shaft domains and knobs of different human species B Ads (Ad5FBs). To allow quantitative analyses, these vectors coded for the enhanced green fluorescent protein (eGFP). Transgene expression analysis showed superi...
Abstract
Cited 23 times since 2005 (1.2 per year)
source: EuropePMC
Pediatric cardiology,
Volume 26, Issue 6, 1 1 2005, Pages 756-761
High mortality rate after extubation failure after pediatric cardiac surgery.
Harkel AD, van der Vorst MM, Hazekamp MG, Ottenkamp J
The objective of this study was to evaluate the different causes of extubation failure and the consequent mortality rates in a pediatric population after cardiac surgery. We studied 184 consecutive patients with a median age of 9 months (range, 0-165). In 158 patients, extubation was successful (group A). Nine patients were reintubated for upper airway obstruction and finally extubated successfully (group B). Seventeen patients were reintubated for cardiorespiratory failure, finally leading to d...
Abstract
Cited 94 times since 2005 (4.9 per year)
source: EuropePMC
Atherosclerosis,
Volume 187, Issue 2, 28 4 2005, Pages 415-422
C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003.
Boekholdt SM, Hack CE, Sandhu MS, Luben R, Bingham SA, Wareham NJ, Peters RJ, Jukema JW, Day NE, Kastelein JJ, Khaw KT
Introduction: Measurement of C-reactive protein (CRP) levels has been proposed as a useful marker to improve the prediction of future coronary artery disease (CAD) risk, but this notion has been challenged recently. Methods and results: We performed a prospective case-control study among apparently healthy men and women. The odds ratio (OR) for future CAD incidence was 2.49 (95% CI=2.02-3.08, p for linearity
Abstract
Cited 8 times since 2005 (0.4 per year)
source: EuropePMC
Radiology,
Volume 237, Issue 3, 26 4 2005, Pages 861-867
Intraatrial repair of transposition of the great arteries: use of MR imaging after exercise to evaluate regional systemic right ventricular function.
Tops LF, Roest AA, Lamb HJ, Vliegen HW, Helbing WA, van der Wall EE, de Roos A
Purpose: To prospectively assess regional systemic right ventricular (RV) function at rest and in response to exercise by using magnetic resonance (MR) imaging in patients who have undergone surgical correction at the atrial level for transposition of the great arteries (TGA). Materials and methods: Informed consent was obtained, and the medical review board approved this study. In 25 adult patients (mean age, 25.8 years +/- 4.7 [standard deviation]; 13 men) who had undergone correction for TGA...
Abstract
Cited 66 times since 2005 (3.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 46, Issue 10, 21 3 2005, Pages 1943-1952
Human adult bone marrow mesenchymal stem cells repair experimental conduction block in rat cardiomyocyte cultures.
Beeres SL, Atsma DE, van der Laarse A, Pijnappels DA, van Tuyn J, Fibbe WE, de Vries AA, Ypey DL, van der Wall EE, Schalij MJ
Objectives: We evaluated whether human adult bone marrow-derived mesenchymal stem cells (hMSCs) could repair an experimentally induced conduction block in cardiomyocyte cultures. Background: Autologous stem cell therapy is a novel treatment option for patients with heart disease. However, detailed electrophysiological characterization of hMSCs is still lacking. Methods: Neonatal rat cardiomyocytes were seeded on multi-electrode arrays. After 48 h, abrasion of a 200- to 450-microm-wide channel ca...
Abstract
Cited 57 times since 2005 (2.9 per year)
source: EuropePMC
European journal of heart failure,
Volume 8, Issue 2, 7 1 2005, Pages 115-121
Diltiazem treatment prevents diastolic heart failure in mice with familial hypertrophic cardiomyopathy.
Westermann D, Knollmann BC, Steendijk P, Rutschow S, Riad A, Pauschinger M, Potter JD, Schultheiss HP, Tschöpe C
Background: The cardiac troponin T I79N mutation, linked to familial hypertrophic cardiomyopathy, carries a high risk of sudden cardiac death even in the absence of significant cardiac hypertrophy. The pathology underlying this mechanism has not yet been identified. Aims: To study the underlying mechanism of this phenomenon we characterized the left ventricular (LV) performance of transgenic mice carrying the human troponin T mutation I79N under basal and isoproterenol-induced stress conditions....
Abstract
Cited 5 times since 2005 (0.3 per year)
source: EuropePMC
European heart journal,
Volume 26, Issue 22, 4 1 2005, Pages 2358-2360
Should the ACC/AHA guidelines be changed in patients undergoing vascular surgery?
Hoeks SE, Bax JJ, Poldermans D
Abstract
Cited 21 times since 2005 (1.1 per year)
source: EuropePMC
The Journal of allergy and clinical immunology,
Volume 116, Issue 5, 3 1 2005, Pages 1007-1013
Adding salmeterol to an inhaled corticosteroid reduces allergen-induced serum IL-5 and peripheral blood eosinophils.
Koopmans JG, Lutter R, Jansen HM, van der Zee JS
Background: Adding a long-acting beta(2)-agonist to inhaled corticosteroids results in better symptomatic asthma control than increasing the dose of inhaled corticosteroids. Objective: Investigating whether adding the long-acting beta(2)-agonist salmeterol to the inhaled corticosteroid fluticasone propionate has an effect on allergen-induced allergic inflammation in asthma. Methods: Bronchial allergen challenges were performed in 26 patients with allergic asthma, pretreating them with a single d...
Abstract
