Research

Publications

Below you can find a list of our published research.

8684 results

Cited 55 times since 2014 (5.2 per year) source: EuropePMC

Inflammatory bowel diseases, Volume 20, Issue 11, 1 1 2014, Pages 2013-2021 Carbohydrate intake in the etiology of Crohn's disease and ulcerative colitis. Chan SS, Chan SS, Luben R, van Schaik F, Oldenburg B, Bueno-de-Mesquita HB, Hallmans G, Karling P, Lindgren S, Grip O, Key T, Crowe FL, Bergmann MM, Overvad K, Palli D, Masala G, Khaw KT, Racine A, Carbonnel F, Boutron-Ruault MC, Olsen A, Tjonneland A, Kaaks R, Tumino R, Trichopoulou A, Hart AR

Background: Diet may have a role in the etiology of inflammatory bowel disease. In previous studies, the associations between increased intakes of carbohydrates, sugar, starch, and inflammatory bowel disease are inconsistent. However, few prospective studies have investigated the associations between these macronutrients and incident Crohn's disease (CD) or ulcerative colitis (UC). Methods: A total of 401,326 men and women were recruited between 1991 and 1998. At recruitment, dietary intake... Abstract

Cited 13 times since 2014 (1.2 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 11, 1 1 2014, Pages 484-490 Role of the ECG in initial acute coronary syndrome triage: primary PCI regardless presence of ST elevation or of non-ST elevation. IJkema BB, Bonnier JJ, Schoors D, Schalij MJ, Swenne CA

The major initial triaging decision in acute coronary syndrome (ACS) is whether or not percutaneous coronary intervention (PCI) is the primary treatment. Current guidelines recommend primary PCI in ST-elevation ACS (STEACS) and initial antithrombotic therapy in non-ST-elevation ACS (NSTEACS). This review probes the question whether this decision can indeed be based on the ECG. Genesis of STE/NSTE ECGs depends on the coronary anatomy, collateral circulation and site of the culprit lesion. Other c... Abstract

Cited 17 times since 2014 (1.6 per year) source: EuropePMC

British journal of clinical pharmacology, Volume 78, Issue 5, 1 1 2014, Pages 950-960 Evaluation of lecithinized human recombinant super oxide dismutase as cardioprotectant in anthracycline-treated breast cancer patients. Broeyer FJ, Osanto S, Suzuki J, de Jongh F, van Slooten H, Tanis BC, Bruning T, Bax JJ, Ritsema van Eck HJ, de Kam ML, Cohen AF, Mituzhima Y, Burggraaf J

Aim: Anthracycline-induced cardiotoxicity is (partly) mediated by free radical overload. A randomized study was performed in breast cancer patients to investigate whether free radical scavenger super oxide dismutase (SOD) protects against anthracycline-induced cardiotoxicity as measured by changes in echo, electrocardiography and an array of biomarkers. Method and results: Eighty female, chemotherapy-naïve breast cancer patients (median age 49, range 24-67 years) scheduled for four or five cours... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

Chest, Volume 146, Issue 5, 1 1 2014, Pages 1310-1318 Predicting mortality and morbidity after elective cardiac surgery using vasoactive and inflammatory biomarkers with and without the EuroSCORE model. Schoe A, Schippers EF, Ebmeyer S, Struck J, Klautz RJM, de Jonge E, van Dissel JT

Background: In cardiac surgery, preoperative mortality risk assessment tools like the EuroSCORE help to guide physicians in optimizing perioperative care of patients. We investigated the value of preoperative levels of inflammatory (procalcitonin [PCT]) and vasoactive (C-terminal pro-arginine vasopressin [CT-proAVP], midregional pro-atrial natriuretic peptide [MR-proANP], midregional proadrenomedullin [MR-proADM], and C-terminal pro-endothelin-1 [CT-proET-1]) biomarkers for risk assessment of mo... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 11, 1 1 2014, Pages 491-492 Image-guided intramyocardial cell injection: putting a puzzle piece in the right place. Ramkisoensing AA, Atsma DE

Abstract

Cited 141 times since 2014 (13.3 per year) source: EuropePMC

Vaccine, Volume 32, Issue 52, 30 5 2014, Pages 7098-7107 A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis-specific T-cell responses in human. van Dissel JT, Joosten SA, Hoff ST, Soonawala D, Prins C, Hokey DA, O'Dee DM, Graves A, Thierry-Carstensen B, Andreasen LV, Ruhwald M, de Visser AW, Agger EM, Ottenhoff TH, Kromann I, Andersen P

Here, we report on a first-in-man trial where the tuberculosis (TB) vaccine Ag85B-ESAT-6 (H1) was adjuvanted with escalating doses of a novel liposome adjuvant CAF01. On their own, protein antigens cannot sufficiently induce immune responses in humans, and require the addition of an adjuvant system to ensure appropriate delivery and concomitant immune activation. To date no approved adjuvants are available for induction of cellular immunity, which seems essential for a number of vaccines, includ... Abstract

Cited 57 times since 2014 (5.4 per year) source: EuropePMC

The American journal of cardiology, Volume 115, Issue 2, 29 5 2014, Pages 234-242 Value of the "TAVI2-SCORe" versus surgical risk scores for prediction of one year mortality in 511 patients who underwent transcatheter aortic valve implantation. Debonnaire P, Fusini L, Wolterbeek R, Kamperidis V, van Rosendael P, van der Kley F, Katsanos S, Joyce E, Tamborini G, Muratori M, Gripari P, Bax JJ, Marsan NA, Pepi M, Delgado V

A bedside-available transcatheter aortic valve implantation (TAVI)-dedicated prognostic risk score is an unmet clinical need. We aimed to develop such a risk score predicting 1-year mortality post-TAVI and to compare it with the performance of the logistic EuroSCORE (LES) I and LES-II and the Society of Thoracic Surgeons' (STS) score. Baseline variables of 511 consecutive patients who underwent TAVI that were independently associated with 1-year mortality post-TAVI were included in the &quo... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

Stroke, Volume 45, Issue 12, 28 4 2014, Pages 3508-3513 Polygenic overlap between kidney function and large artery atherosclerotic stroke. Holliday EG, Traylor M, Malik R, Bevan S, Maguire J, Koblar SA, Sturm J, Hankey GJ, Oldmeadow C, McEvoy M, Sudlow C, Rothwell PM, Coresh J, Hamet P, Tremblay J, Turner ST, de Andrade M, Rao M, Schmidt R, Crick PA, Robino A, Peralta CA, Jukema JW, Mitchell P, Rosas SE, Wang JJ, Scott RJ, Dichgans M, Mitchell BD, Kao WH, Fox CS, Levi C, Attia J, Markus HS, CKDGen Consortium and the International Stroke Genetics Consortium

Background and purpose: Epidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes. Methods: Polygenic models were derived using genome-wide association studies meta-analysis results for 3 kidney traits: estimated glomerular filtration rate us... Abstract

Cited 25 times since 2014 (2.4 per year) source: EuropePMC

PloS one, Volume 9, Issue 10, 27 4 2014, Pages e111259 Early prediction of intensive care unit-acquired weakness using easily available parameters: a prospective observational study. Wieske L, Witteveen E, Verhamme C, Dettling-Ihnenfeldt DS, van der Schaaf M, Schultz MJ, van Schaik IN, Horn J

Introduction: An early diagnosis of Intensive Care Unit-acquired weakness (ICU-AW) using muscle strength assessment is not possible in most critically ill patients. We hypothesized that development of ICU-AW can be predicted reliably two days after ICU admission, using patient characteristics, early available clinical parameters, laboratory results and use of medication as parameters. Methods: Newly admitted ICU patients mechanically ventilated ≥2 days were included in this prospective observati... Abstract

Cited 16 times since 2014 (1.5 per year) source: EuropePMC

The Journal of biological chemistry, Volume 289, Issue 51, 27 4 2014, Pages 35421-35430 Differential complement activation pathways promote C3b deposition on native and acetylated LDL thereby inducing lipoprotein binding to the complement receptor 1. Klop B, van der Pol P, van Bruggen R, Wang Y, de Vries MA, van Santen S, O'Flynn J, van de Geijn GJ, Njo TL, Janssen HW, de Man P, Jukema JW, Rabelink TJ, Rensen PC, van Kooten C, Cabezas MC

Lipoproteins can induce complement activation resulting in opsonization and binding of these complexes to complement receptors. We investigated the binding of opsonized native LDL and acetylated LDL (acLDL) to the complement receptor 1 (CR1). Binding of complement factors C3b, IgM, C1q, mannose-binding lectin (MBL), and properdin to LDL and acLDL were investigated by ELISA. Subsequent binding of opsonized LDL and acLDL to CR1 on CR1-transfected Chinese Hamster Ovarian cells (CHO-CR1) was tested... Abstract

Cited 10 times since 2014 (0.9 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 31, Issue 2, 24 4 2014, Pages 369-377 Preprocedural magnetic resonance imaging for image-guided catheter ablation of scar-related ventricular tachycardia. Tao Q, Piers SR, Lamb HJ, Zeppenfeld K, van der Geest RJ

To present and validate a highly automated MRI analysis workflow for image-guided catheter ablation of scar-related ventricular tachycardia (VT) ablation procedures. A cohort of 15 post-infarction patients underwent MRI prior to VT ablation. The MRI study included a black-blood turbo spin echo sequence for visualizing the aortic root and ostium of the left main (LM) coronary artery, and a 3D late gadolinium enhanced sequence for visualizing the LV anatomy and myocardial scar substrate. Semi-auto... Abstract

Cited 4 times since 2014 (0.4 per year) source: EuropePMC

Clinica chimica acta; international journal of clinical chemistry, Volume 439, 23 4 2014, Pages 128-136 Implementation of a companion diagnostic in the clinical laboratory: the BRAF example in melanoma. Mancini I, Pinzani P, Simi L, Brandslund I, Vermeersch P, Di Resta C, Schwab M, Marc J, van Schaik R, Pazzagli M, European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)–European Society of Pharmacogenomics and Theranostics (ESPT) joint Working Group Personalized Laboratory Medicine (WG-PLM)

A companion diagnostic test provides information that is essential for the safe and effective use of a corresponding therapeutic product as indicated in the drug instructions. The implementation of a companion diagnostic follows the rules of a molecular test for somatic mutations in a routine clinical laboratory environment and needs guidance on practical aspects, including the choice of the proper analytical method and the procedures for internal and external quality controls. Selection of the... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

Journal of immunology (Baltimore, Md. : 1950), Volume 193, Issue 10, 22 4 2014, Pages 5338-5344 Discovery of invariant T cells by next-generation sequencing of the human TCR α-chain repertoire. van Schaik B, Klarenbeek P, Doorenspleet M, van Kampen A, Moody DB, de Vries N, Van Rhijn I

During infection and autoimmune disease, activation and expansion of T cells take place. Consequently, the TCR repertoire contains information about ongoing and past diseases. Analysis and interpretation of the human TCR repertoire are hampered by its size and stochastic variation and by the diversity of Ags and Ag-presenting molecules encoded by the MHC, but are highly desirable and would greatly impact fundamental and clinical immunology. A subset of the TCR repertoire is formed by invariant T... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

International journal of surgery case reports, Volume 5, Issue 12, 22 4 2014, Pages 972-974 Cutaneous Ewing's sarcoma secondary to chemotherapy given for testis tumor: Case report. Tanık S, Zengin K, Albayrak S, Eryılmaz R, Yılmaz D, Pirinçci N

Introduction: Testicular cancer has high cure rates, especially after the adjuvant use of chemotherapy. Secondary tumors may develop months and years after the primary tumor. We aimed to report a case of cutaneous Ewing's sarcoma at the site of surgery 3 years after BEP chemotherapy. Presentation of case: 21 year old male underwent radical orchiectomy in 2008. After one year surgical site complaints brought him to same hospital. A limited surgical resection was made. As his complaints conti... Abstract

Cited 67 times since 2014 (6.3 per year) source: EuropePMC

Journal of psychosomatic research, Volume 78, Issue 2, 22 4 2014, Pages 123-129 Depression, anxiety and 6-year risk of cardiovascular disease. Seldenrijk A, Vogelzangs N, Batelaan NM, Wieman I, van Schaik DJ, Penninx BJ

Objective: Depression and anxiety are considered etiological factors in cardiovascular disease (CVD), though their relative contribution and differentiation by clinical characteristics have not been studied intensively. We examined 6-year associations between depressive and anxiety disorders, clinical characteristics and newly-developed CVD. Methods: DSM-IV diagnoses were established in 2510 CVD-free participants of the Netherlands Study of Depression and Anxiety. Data on subtype, severity, and... Abstract

Cited 24 times since 2014 (2.3 per year) source: EuropePMC

Journal of virology, Volume 89, Issue 1, 22 4 2014, Pages 568-580 Clonal evolution of CD8+ T cell responses against latent viruses: relationship among phenotype, localization, and function. Remmerswaal EB, Klarenbeek PL, Alves NL, Doorenspleet ME, van Schaik BD, Esveldt RE, Idu MM, van Leeuwen EM, van der Bom-Baylon N, van Kampen AH, Koch SD, Pircher H, Bemelman FJ, Ten Brinke A, Baas F, Ten Berge IJ, van Lier RA, de Vries N

Unlabelled: Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice, interleukin-7 receptor α (IL-7Rα)-expressing cells contain the precursors for long-lived antigen-experienced CD8(+) T cells, but it is unclear if similar mechanisms operate to maintain these pools in humans. Here, we studied whether IL-7Rα-expressing cells obtained from peripheral blood (PB) or lymph nodes (LNs) sustain the circulati... Abstract

Cited 62 times since 2014 (5.8 per year) source: EuropePMC

Parkinsonism & related disorders, Volume 21, Issue 1, 22 4 2014, Pages 1-11 Predictors of the psychosocial impact of being a carer of people living with Parkinson's disease: a systematic review. Greenwell K, Gray WK, van Wersch A, van Schaik P, Walker R

Introduction: Caring for a person with Parkinson's disease (PwP) can have a variety of negative consequences that may challenge their ability to continue their caring role. It is still unknown why some individuals adapt better than others in response to such burdens. This review is the first to synthesize and evaluate the evidence on the predictive factors of psychosocial outcomes in PwP carers. Methods: Studies which identified predictors of psychosocial outcomes for unpaid carers were inc... Abstract

Cited 15 times since 2014 (1.4 per year) source: EuropePMC

European journal of cardiovascular nursing, Volume 15, Issue 1, 20 3 2014, Pages 72-81 Clinical and psychological characteristics predict future healthcare use in adults with congenital heart disease. Schoormans D, Sprangers MA, van Melle JP, Pieper PG, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ

Background: To deliver adequate care to patients with congenital heart disease (CHD), it is important to know which patients use what type of care. This knowledge is valuable, as modification of these factors may be used as means to regulate healthcare use. Our objective was to examine the predictive value of psychological characteristics for future healthcare use, independent of clinical characteristics. Methods: In total 845 adult CHD-patients participated in a longitudinal questionnaire study... Abstract

Cited 8 times since 2014 (0.8 per year) source: EuropePMC

Journal of cardiac surgery, Volume 30, Issue 1, 17 3 2014, Pages 13-19 Aortic valve repair versus replacement for aortic regurgitation: effects on left ventricular remodeling. Regeer MV, Versteegh MI, Klautz RJ, Stijnen T, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Background: Left ventricular (LV) reverse remodeling after aortic valve replacement (AVR) for aortic regurgitation (AR) is associated with superior prognosis. The outcomes of valve-sparing aortic root replacement techniques on LV performance have not been compared with LV reverse remodeling in AVR. The present evaluation compared the extent of long-term LV reverse remodeling in patients with aortic root pathology and/or AR who underwent aortic valve repair (AVr) with patients who underwent AVR.... Abstract

Cited 39 times since 2014 (3.7 per year) source: EuropePMC

Surgical endoscopy, Volume 29, Issue 8, 16 3 2014, Pages 2235-2243 Increasing efficiency of surgical training: effects of spacing practice on skill acquisition and retention in laparoscopy training. Spruit EN, Band GP, Hamming JF

Objectives: The goal of this study was to investigate the effects of spaced versus massed practice on skill acquisition and retention in the context of laparoscopic motor skill training. Background: Reaching proficiency in performing laparoscopic surgery involves extensive training to acquire the required motor skills. Conventionally, training of such skills occurs during a full day training event utilizing surgical simulators that train specific motor skills pertinent to laparoscopic surgery. A... Abstract