8684 results
Cited 34 times since 2014 (3.1 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 18, Issue 10, 15 3 2014, Pages 2020-2030
Complement factor C5a induces atherosclerotic plaque disruptions.
Wezel A, de Vries MR, Lagraauw HM, Foks AC, Kuiper J, Quax PH, Bot I
Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE(-/-) mice. After 24 days, when advanced plaques had developed, C5a or PBS was applied locally at the lesion site in a pluronic gel. Three days later mice were killed to examine the acute effect of C5a on late stage atherosclerosis. A signi...
Abstract
Cited 140 times since 2014 (13 per year)
source: EuropePMC
Circulation,
Volume 130, Issue 15, 14 2 2014, Pages 1225-1235
Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation.
Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL, Jukema JW, Chasman DI, Albert CM, Ebana Y, Furukawa T, Macfarlane PW, Harris TB, Darbar D, Dörr M, Holst AG, Svendsen JH, Hofman A, Uitterlinden AG, Gudnason V, Isobe M, Malik R, Dichgans M, Rosand J, Van Wagoner DR, METASTROKE Consortium, AFGen Consortium, Benjamin EJ, Milan DJ, Melander O, Heckbert SR, Ford I, Liu Y, Barnard J, Olesen MS, Stricker BH, Tanaka T, Kääb S, Ellinor PT
Background: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. Methods and results: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. F...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
European journal of psychotraumatology,
Volume 5, 14 2 2014
Do soldiers seek more mental health care after deployment? Analysis of mental health consultations in the Netherlands Armed Forces following deployment to Afghanistan.
Taal EL, Vermetten E, van Schaik DA, Leenstra T
Background: Military deployment to combat zones puts military personnel to a number of physical and mental challenges that may adversely affect mental health. Until now, few studies have been performed in Europe on mental health utilization after military deployment. Objective: We compared the incidence of mental health consultations with the Military Mental Health Service (MMHS) of military deployed to Afghanistan to that of non-deployed military personnel. Method: We assessed utilization of th...
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 8, 14 2 2014, Pages e105019
Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques.
Rutten B, Tersteeg C, Vrijenhoek JE, van Holten TC, Elsenberg EH, Mak-Nienhuis EM, de Borst GJ, Jukema JW, Pijls NH, Waltenberger J, van Zonneveld AJ, Moll FL, McClellan E, Stubbs A, Pasterkamp G, Hoefer I, de Groot PG, Roest M
Objective: Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. Methods: Platelet reactivity was determined by measuring platelet P-selectin expression after platelet stimulation with increasing concentrations of adenosine diphosphate...
Abstract
Cited 24 times since 2014 (2.2 per year)
source: EuropePMC
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Volume 104, Issue 10, 13 2 2014, Pages 680-687
Monitoring of non-communicable diseases such as hypertension in South Africa: challenges for the post-2015 global development agenda.
Day C, Groenewald P, Laubscher R, Chaudhry S, Van Schaik N, Bradshaw D
Background: Examining the non-communicable disease (NCD) profile for South Africa (SA) is crucial when developing health interventions that aim to reduce the burden of NCDs. Objective: To review NCD indicators in national data sources in order to describe the burden of NCDs in SA, using hypertension as an example. Methods: Age, gender, district of death and underlying cause of death data were obtained for 2008 and 2009 mortality unit records from Statistics SA and adjusted using STATA 11. Data f...
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 8, 12 2 2014, Pages e105052
Estimation of the use of antibiotics in the small ruminant industry in The Netherlands in 2011 and 2012.
Santman-Berends I, Luttikholt S, Van den Brom R, Van Schaik G, Gonggrijp M, Hage H, Vellema P
The aim of this study was to estimate the quantity of antibiotics and classes of antibiotics used in the small ruminant industry in the Netherlands in 2011 and 2012. Twelve large veterinary practices, located throughout the Netherlands were selected for this study. All small ruminant farms associated with these practices that had complete records on the quantity of antibiotics prescribed were included. The veterinary practices provided data on all antibiotics prescribed, and the estimated animal...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 6, 12 2 2014, Pages 1072-1074
The potential role of gated myocardial perfusion SPECT imaging in patient selection for cardiac resynchronization therapy.
Marsan NA, Bax JJ
Abstract
Cited 34 times since 2014 (3.1 per year)
source: EuropePMC
Journal of surgical oncology,
Volume 110, Issue 7, 11 2 2014, Pages 845-850
Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging.
Schaafsma BE, Verbeek FP, Elzevier HW, Tummers QR, van der Vorst JR, Frangioni JV, van de Velde CJ, Pelger RC, Vahrmeijer AL
Background and objectives: Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Methods: Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (co...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Volume 73, 10 2 2014, Pages 105-112
Evaluation of in vitro cytotoxicity and genotoxicity of copper-zinc alloy nanoparticles in human lung epithelial cells.
Kumbıçak U, Cavaş T, Cinkılıç N, Kumbıçak Z, Vatan O, Yılmaz D
In the present study, in vitro cytotoxic and genotoxic effect of copper-zinc alloy nanoparticles (Cu-Zn ANPs) on human lung epithelial cells (BEAS-2B) were investigated. XTT test and clonogenic assay were used to determine cytotoxic effects. Cell death mode and intracellular reactive oxygen species formations were analyzed using M30, M65 and ROS Elisa assays. Genotoxic effects were evaluated using micronucleus, comet and γ-H2AX foci assays. Cu-Zn ANPs were characterized by transmission electron...
Abstract
Cited 59 times since 2014 (5.5 per year)
source: EuropePMC
International journal of cancer,
Volume 136, Issue 6, 8 2 2014, Pages 1434-1444
Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation.
Groenendijk FH, Mellema WW, van der Burg E, Schut E, Hauptmann M, Horlings HM, Willems SM, van den Heuvel MM, Jonkers J, Smit EF, Bernards R
The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. We further show in a phase II clinical trial in...
Abstract
Cited 246 times since 2014 (22.7 per year)
source: EuropePMC
American heart journal,
Volume 168, Issue 5, 7 1 2014, Pages 682-689
Effect of alirocumab, a monoclonal antibody to PCSK9, on long-term cardiovascular outcomes following acute coronary syndromes: rationale and design of the ODYSSEY outcomes trial.
Schwartz GG, Bessac L, Berdan LG, Bhatt DL, Bittner V, Diaz R, Goodman SG, Hanotin C, Harrington RA, Jukema JW, Mahaffey KW, Moryusef A, Pordy R, Roe MT, Rorick T, Sasiela WJ, Shirodaria C, Szarek M, Tamby JF, Tricoci P, White H, Zeiher A, Steg PG
Background: Following acute coronary syndrome (ACS), the risk for future cardiovascular events is high and is related to levels of low-density lipoprotein cholesterol (LDL-C) even within the setting of intensive statin treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates LDL receptor expression and circulating levels of LDL-C. Antibodies to PCSK9 can produce substantial and sustained reductions of LDL-C. The ODYSSEY Outcomes trial tests the hypothesis that treatment with al...
Abstract
Cited 29 times since 2014 (2.7 per year)
source: EuropePMC
Psychotherapy and psychosomatics,
Volume 83, Issue 5, 6 1 2014, Pages 263-269
The effectiveness of the cognitive behavioral analysis system of psychotherapy for chronic depression: a randomized controlled trial.
Wiersma JE, Van Schaik DJ, Hoogendorn AW, Dekker JJ, Van HL, Schoevers RA, Blom MB, Maas K, Smit JH, McCullough JP, Beekman AT, Van Oppen P
Background: It is widely agreed that chronic depression is difficult to treat, knowledge about optimal treatment approaches is emerging. Method: A multisite randomized controlled trial was conducted comparing the cognitive behavioral analysis system of psychotherapy (CBASP), a psychotherapy model developed specifically to treat chronic depression (n = 67) with care as usual (CAU; evidence-based treatments, n = 72) over a period of 52 weeks, with 23 sessions on average, in 3 outpatient clinics in...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
American journal of physical anthropology,
Volume 155, Issue 3, 6 1 2014, Pages 430-435
Why do chimpanzee males attack the females of neighboring communities?
Pradhan GR, Pandit SA, Van schaik CP
Our closest nonhuman primate relatives, chimpanzees, engage in potentially lethal between-group conflict; this collective aggressive behavior shows parallels with human warfare. In some communities, chimpanzee males also severely attack and even kill females of the neighboring groups. This is surprising given their system of resource defense polygyny, where males are expected to acquire potential mates. We develop a simple mathematical model based on reproductive skew among primate males to solv...
Abstract
Cited 859 times since 2014 (79.3 per year)
source: EuropePMC
Lancet (London, England),
Volume 384, Issue 9959, 6 1 2014, Pages 2027-2035
Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up.
Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Zappa M, Nelen V, Kwiatkowski M, Lujan M, Määttänen L, Lilja H, Denis LJ, Recker F, Paez A, Bangma CH, Carlsson S, Puliti D, Villers A, Rebillard X, Hakama M, Stenman UH, Kujala P, Taari K, Aus G, Huber A, van der Kwast TH, van Schaik RH, de Koning HJ, Moss SM, Auvinen A, ERSPC Investigators
Background: The European Randomised study of Screening for Prostate Cancer (ERSPC) has shown significant reductions in prostate cancer mortality after 9 years and 11 years of follow-up, but screening is controversial because of adverse events such as overdiagnosis. We provide updated results of mortality from prostate cancer with follow-up to 2010, with analyses truncated at 9, 11, and 13 years. Methods: ERSPC is a multicentre, randomised trial with a predefined centralised database, analysis pl...
Abstract
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 10, 4 1 2014, Pages 855-857
Value of intraoperative electrical parameters obtained during implantation of cardiac resynchronization therapy devices for the prediction of reverse remodeling.
de Riva-Silva M, López-Gil M, Salgado-Aranda R, Fontenla-Cerezuela A, Salguero-Bodes R, Arribas-Ynsaurriaga F
Abstract
Cited 15 times since 2014 (1.4 per year)
source: EuropePMC
International journal of cardiology,
Volume 176, Issue 3, 3 1 2014, Pages 788-793
RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice.
Louwe MC, Karper JC, de Vries MR, Nossent AY, Bastiaansen AJ, van der Hoorn JW, Willems van Dijk K, Rensen PC, Steendijk P, Smit JW, Quax PH
Background: Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after myocardial infarction (MI). RP105 (CD180) is a TLR4 homolog lacking the intracellular signaling domain that competitively inhibits TLR4-signaling. Thus, we hypothesized that RP105 deficiency, by amplifying TLR4 signaling, would lead to aggravated cardiac dysfunction after MI. Methods and results: First, whole blood from RP105-/- and wild-type (WT) ma...
Abstract
Cited 34 times since 2014 (3.1 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 117, Issue 2, 2 1 2014, Pages 375-387
A multidisciplinary approach to determine factors associated with calf rearing practices and calf mortality in dairy herds.
Santman-Berends IM, Buddiger M, Smolenaars AJ, Steuten CD, Roos CA, Van Erp AJ, Van Schaik G
In the Netherlands, an increase in ear-tagged calf mortality (3 days to 1 year of age) in dairy farms was observed. The aim was to determine why calf mortality increased and how to reduce calf mortality in herds with structural high rates. A multi-disciplinary approach was chosen to study this phenomenon. First analysis of census data revealed that the majority of the calves died in the first month of life. In addition, a panel of 236 farmers indicated that the increase in calf mortality might b...
Abstract
Cited 22 times since 2014 (2 per year)
source: EuropePMC
Lung cancer (Amsterdam, Netherlands),
Volume 86, Issue 1, 2 1 2014, Pages 73-77
Retrospective evaluation of thromboembolic events in patients with non-small cell lung cancer treated with platinum-based chemotherapy.
Mellema WW, van der Hoek D, Postmus PE, Smit EF
Objectives: Thromboembolic events (TE) are common in patients with cancer and are potentially life-threatening. In lung cancer, little is known about thrombosis during chemotherapy treatment. The aim of this study was to describe the incidence of TE in patients with non-small cell lung cancer (NSCLC), occurring during treatment with platinum-based chemotherapy. Methods: We retrospectively selected patients with NSCLC treated with platinum-based chemotherapy at the VU University Medical Center Am...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 7, Issue 4, 1 1 2014, Pages 567-569
The ideal end point for ablation in postinfarction ventricular tachycardia: one may not fit all.
Zeppenfeld K
Abstract
Cited 672 times since 2014 (62 per year)
source: EuropePMC
European heart journal,
Volume 35, Issue 35, 1 1 2014, Pages 2383-2431
2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA).
Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, Hert SD, Ford I, Gonzalez-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Kjeldsen KP, Longrois D, Lüscher TF, Pierard L, Pocock S, Price S, Roffi M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C, Authors/Task Force Members
Abstract
