Research

Publications

Below you can find a list of our published research.

6125 results

Cited 153 times since 2005 (7.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 45, Issue 5, 1 1 2005, Pages 749-753 Noninvasive visualization of the cardiac venous system using multislice computed tomography. Jongbloed MR, Lamb HJ, Bax JJ, Schuijf JD, de Roos A, van der Wall EE, Schalij MJ

Objectives: We sought to evaluate the value of multislice computed tomography (MSCT) to depict the cardiac venous anatomy. Background: During cardiac resynchronisation therapy (CRT), left ventricular (LV) pacing is established by a pacemaker lead in a tributary of the coronary sinus (CS). Knowledge of the CS anatomy and variations may facilitate the implantation of LV leads. Methods: The MSCT scans of 38 patients (34 men; age 60 +/- 12 years) were studied. Anatomical variants were divided in thr... Abstract

Cited 4 times since 2005 (0.2 per year) source: EuropePMC

Critical care medicine, Volume 33, Issue 3, 1 1 2005, Pages 688-690 Sepsis and intracellular calcium homeostasis, a sparkling story. Steendijk P

Abstract

Cited 102 times since 2005 (5.1 per year) source: EuropePMC

International journal of cardiology, Volume 99, Issue 1, 1 1 2005, Pages 9-17 Drug-eluting stents: results, promises and problems. van der Hoeven BL, Pires NM, Warda HM, Oemrawsingh PV, van Vlijmen BJ, Quax PH, Schalij MJ, van der Wall EE, Jukema JW

In-stent restenosis is the major drawback of percutaneous coronary interventions, occurring in 10-40% of the patients. Recently, new stents have emerged which are loaded with anti-inflammatory, anti-migratory, anti-proliferative or pro-healing drugs. These drugs are supposed to inhibit inflammation and neointimal growth and subsequently in-stent restenosis. In this review article the results of human clinical studies investigating drug-eluting stents are discussed from a clinical point of view,... Abstract

Cited 5 times since 2005 (0.2 per year) source: EuropePMC

Current cardiology reports, Volume 7, Issue 2, 1 1 2005, Pages 124-129 Assessment of myocardial viability by nuclear imaging techniques. Bax JJ, Poldermans D, Elhendy A, Boersma E, van der Wall EE

The assessment of myocardial viability has become important in the diagnostic and prognostic work up of patients with ischemic cardiomyopathy. Patients with viable myocardium may benefit from revascularization in terms of improvement of function, symptoms, and prognosis. In contrast, patients without viable myocardium do not benefit and should be treated conservatively. Various nuclear imaging techniques are available. Abstract

Cited 53 times since 2005 (2.6 per year) source: EuropePMC

The American journal of cardiology, Volume 95, Issue 5, 1 1 2005, Pages 658-660 Safety of perioperative statin use in high-risk patients undergoing major vascular surgery. Schouten O, Kertai MD, Bax JJ, Durazzo AE, Biagini E, Boersma E, van Waning VH, Lameris TW, van Sambeek MR, Poldermans D

No clinical data are available on the influence of perioperative statin use on postoperative myopathy in patients undergoing major noncardiac surgery except for some case reports. Therefore, the aim of this study was to clarify the potential risk of myopathy in statin users who underwent major noncardiac surgery. Abstract

Cited 26 times since 2005 (1.3 per year) source: EuropePMC

Journal of virology, Volume 79, Issue 5, 1 1 2005, Pages 3146-3162 Transfer of the full-length dystrophin-coding sequence into muscle cells by a dual high-capacity hybrid viral vector with site-specific integration ability. Gonçalves MA, van Nierop GP, Tijssen MR, Lefesvre P, Knaän-Shanzer S, van der Velde I, van Bekkum DW, Valerio D, de Vries AA

Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, making it a potential target for gene therapy. There is, however, a scarcity of vectors that can accommodate the 14-kb DMD cDNA and permanently genetically correct muscle tissue in vivo or proliferating myogenic progenitors in vitro for use in autologous transplantation. Here, a dual high-capacity adenovirus-adeno-associated virus (hcAd/AAV) vector with two full-length human dystrophin-coding sequences flanked by AAV integ... Abstract

Cited 9 times since 2005 (0.4 per year) source: EuropePMC

European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, Volume 6, Issue 5, 24 4 2005, Pages 382-384 Tissue Doppler imaging to assess left ventricular dyssynchrony and resynchronization therapy. Bleeker GB, Bax JJ, Schalij MJ, van der Wall EE

We describe the use of tissue Doppler imaging to assess left ventricular dyssynchrony and subsequent resynchronization in a patient with end-stage heart failure undergoing cardiac resynchronization therapy. Abstract

Cited 27 times since 2005 (1.3 per year) source: EuropePMC

European radiology, Volume 15, Issue 4, 22 4 2005, Pages 702-707 Right ventricular function late after total repair of tetralogy of Fallot. van Straten A, Vliegen HW, Hazekamp MG, de Roos A

Over the past decades, life expectancy in patients with congenital heart disease has increased dramatically. However, serious complications may develop late after total repair in infancy. These complications are usually the result of longstanding pulmonary regurgitation, which leads to dilatation of the right ventricle and an increased risk for severe arrhythmias. Therefore lifelong follow-up in these patients is required. Cardiac magnetic resonance imaging is the current imaging tool of choice... Abstract

Cited 55 times since 2005 (2.7 per year) source: EuropePMC

European heart journal, Volume 26, Issue 9, 16 3 2005, Pages 928-932 Reduction of QRS duration after pulmonary valve replacement in adult Fallot patients is related to reduction of right ventricular volume. van Huysduynen BH, van Straten A, Swenne CA, Maan AC, van Eck HJ, Schalij MJ, van der Wall EE, de Roos A, Hazekamp MG, Vliegen HW

Aims: Late after total correction, Fallot patients with a long QRS duration are prone to serious arrhythmias and sudden cardiac death. Pulmonary regurgitation is a common cause of right ventricular (RV) failure and QRS lengthening. We studied the effects of pulmonary valve replacement (PVR) on QRS duration and RV volume. Methods and results: Twenty-six consecutive Fallot patients were evaluated both pre-operatively and 6-12 months post-operatively by cardiac magnetic resonance (CMR). In this stu... Abstract

Cited 71 times since 2005 (3.5 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 25, Issue 4, 3 1 2005, Pages 839-846 Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. Boekholdt SM, Keller TT, Wareham NJ, Luben R, Bingham SA, Day NE, Sandhu MS, Jukema JW, Kastelein JJ, Hack CE, Khaw KT

Objectives: To study the prospective relationship between serum levels of type II secretory phospholipase A2 (sPLA2) and the risk of future coronary artery disease (CAD) in apparently healthy men and women. Methods and results: We conducted a prospective nested case-control study among apparently healthy men and women aged 45 to 79 years. Cases (n=1105) were people in whom fatal or nonfatal CAD developed during follow-up. Controls (n=2209) were matched by age, sex, and enrollment time. sPLA2 lev... Abstract

Cited 40 times since 2005 (2 per year) source: EuropePMC

The American journal of cardiology, Volume 95, Issue 4, 1 1 2005, Pages 457-461 Cardiac multidetector-row computed tomography in patients with unstable angina. Dirksen MS, Jukema JW, Bax JJ, Lamb HJ, Boersma E, Tuinenburg JC, Geleijns J, van der Wall EE, de Roos A

Ideally, information on coronary artery stenosis and left ventricular (LV) function is obtained in patients who have unstable angina to allow optimal risk stratification. The value of multidetector-row computed tomography (MDCT) was evaluated for a simultaneous assessment of coronary artery disease and global/regional LV function using a single acquisition. Twenty-five patients who had unstable angina underwent a single multidetector-row computed tomographic acquisition using a 4-slice multidete... Abstract

Cited 9 times since 2005 (0.4 per year) source: EuropePMC

American journal of medical genetics. Part A, Volume 133A, Issue 1, 1 1 2005, Pages 101-102 A novel mutation in the DIA1 gene in a patient with methemoglobinemia type II. Yilmaz D, Cogulu O, Ozkinay F, Kavakli K, Roos D

Abstract

Cited 4 times since 2005 (0.2 per year) source: EuropePMC

Pediatrics international : official journal of the Japan Pediatric Society, Volume 47, Issue 1, 1 1 2005, Pages 43-48 Evaluation of anticoagulant system in Turkish children with Perthes disease. Yilmaz D, Karapinar L, Karapinar B, Ozturk H, Kavakli K

Background: Perthes Disease (PD) is generally a self-limiting disease of childhood but it causes severe pain and may lead to deformity of the femoral head. Intravascular thrombosis seems to form the main mechanism in the pathogenesis of the disease. The aim of this study was to determine hereditary thrombotic risk factors in Turkish children with PD. Methods: In 46 Perthes patients (35 male, 11 female), family history of thrombotic events was investigated, Protein C (PC), free-Protein S (f-PS),... Abstract

Cited 44 times since 2005 (2.2 per year) source: EuropePMC

Pediatrics international : official journal of the Japan Pediatric Society, Volume 47, Issue 1, 1 1 2005, Pages 84-89 Psychosocial implications of Thalassemia Major. Aydinok Y, Erermis S, Bukusoglu N, Yilmaz D, Solak U

Background: Many causes including the chronicity of disease, burden of treatment modalities, morbidities, and the expectation of early death resulting from the disease complications, may lead to psychosocial burden in Thalassemia Major (TM) patients. Methods: A total of 38 patients with TM and their mothers were recruited to evaluate the psychosocial burden as well as to disclose whether the psychological status of the patients contribute to the compliance with the therapy or to the contrary. De... Abstract

Cited 8 times since 2005 (0.4 per year) source: EuropePMC

American heart journal, Volume 149, Issue 2, 1 1 2005, Pages 200-208 Magnetic resonance imaging of coronary arteries, the ischemic cascade, and myocardial infarction. Kaandorp TA, Lamb HJ, Bax JJ, van der Wall EE, de Roos A

Abstract

Cited 72 times since 2005 (3.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 45, Issue 3, 1 1 2005, Pages 343-350 Multislice computed tomography versus intracardiac echocardiography to evaluate the pulmonary veins before radiofrequency catheter ablation of atrial fibrillation: a head-to-head comparison. Jongbloed MR, Bax JJ, Lamb HJ, Dirksen MS, Zeppenfeld K, van der Wall EE, de Roos A, Schalij MJ

Objectives: The purpose of this study was to perform a head-to-head comparison between multislice computed tomography (MSCT) and intracardiac echocardiography (ICE). Background: Different imaging techniques have been used to visualize the pulmonary veins (PV) before radiofrequency ablation of atrial fibrillation. Methods: The PV and their atrial insertion were evaluated in 42 patients (35 men, 49 +/- 9 years) admitted for ablation of PV ostia. Ostia were measured in two directions (anterior-post... Abstract

Cited 77 times since 2005 (3.8 per year) source: EuropePMC

Radiology, Volume 234, Issue 3, 21 3 2005, Pages 702-709 Atrial fibrillation: multi-detector row CT of pulmonary vein anatomy prior to radiofrequency catheter ablation--initial experience. Jongbloed MR, Dirksen MS, Bax JJ, Boersma E, Geleijns K, Lamb HJ, van der Wall EE, de Roos A, Schalij MJ

Purpose: To evaluate multi-detector row computed tomographic (CT) depiction of pulmonary veins to provide a road map for radiofrequency catheter ablation. Materials and methods: For patients, institutional review board (IRB) approval was not required, and consent was obtained for treatment. Control subjects were part of an IRB-approved research protocol at the institution, in which they had consented to participate. Multi-detector row CT was performed in 23 patients (17 men, six women; mean age,... Abstract

Cited 207 times since 2005 (10.3 per year) source: EuropePMC

Circulation, Volume 111, Issue 3, 17 3 2005, Pages 278-287 Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Boekholdt SM, Sacks FM, Jukema JW, Shepherd J, Freeman DJ, McMahon AD, Cambien F, Nicaud V, de Grooth GJ, Talmud PJ, Humphries SE, Miller GJ, Eiriksdottir G, Gudnason V, Kauma H, Kakko S, Savolainen MJ, Arca M, Montali A, Liu S, Lanz HJ, Zwinderman AH, Kuivenhoven JA, Kastelein JJ

Background: Several studies have reported that the cholesteryl ester transfer protein (CETP) TaqIB gene polymorphism is associated with HDL cholesterol (HDL-C) levels and the risk of coronary artery disease (CAD), but the results are inconsistent. In addition, an interaction has been implicated between this genetic variant and pravastatin treatment, but this has not been confirmed. Methods and results: A meta-analysis was performed on individual patient data from 7 large, population-based studie... Abstract

Cited 4 times since 2005 (0.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 27, Issue 4, 6 1 2005, Pages 599-605 Left ventricular function and chronotropic responses after normothermic cardiopulmonary bypass with intermittent antegrade warm blood cardioplegia in patients undergoing coronary artery bypass grafting. Tulner SA, Klautz RJ, Engbers FH, Bax JJ, Baan J, van der Wall EE, Dion RA, Steendijk P

Objective: Recent studies indicate that normothermic cardiopulmonary bypass (CPB) with intermittent antegrade warm blood cardioplegia (IAWBC) may have metabolic and clinical advantages, but limited data exist on its effects on myocardial function. Therefore, we investigated the acute effects of this approach on systolic and diastolic left ventricular function and on chronotropic responses. Methods: In 10 patients undergoing isolated CABG we obtained on-line left ventricular pressure-volume loops... Abstract

Cited 14 times since 2005 (0.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 91, Issue 1, 1 1 2005, Pages 111-117 Clinical assessment of myocardial hibernation. Schinkel AF, Bax JJ, Poldermans D

Abstract