Research

Publications

Below you can find a list of our published research.

8684 results

Cited 19 times since 2014 (1.8 per year) source: EuropePMC

Nutrition, metabolism, and cardiovascular diseases : NMCD, Volume 25, Issue 1, 1 1 2014, Pages 93-99 The role of insulin resistance in the association between body fat and autonomic function. Hillebrand S, Swenne CA, Gast KB, Maan AC, le Cessie S, Jukema JW, Rosendaal FR, den Heijer M, de Mutsert R

Background and aim: Excess body fat is associated with altered autonomic function. We investigated whether this association is mediated by insulin resistance. Methods and results: Cross-sectional analysis of a subgroup of the Netherlands Epidemiology of Obesity study with measurements of autonomic function (heart rate variability calculated as mean interbeat interval, standard deviation of all normal intervals (SDNN), low frequency (LF) power and high frequency (HF) power). We measured BMI(kg/m²... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Der Urologe. Ausg. A, Volume 53, Issue 8, 1 1 2014, Pages 1136-1145 [The demographic development in Germany : challenge and chances for urology]. Schneider AW, Fichtner J

Urology is affected by the demographic development in Germany more than any other medical discipline. Despite a relatively stable total population, by the year 2040 there will be an absolute and relevant increase in urological diseases caused only by the demographic development in the population. This is particularly true for the increase in oncological treatment just in the field of the discipline of urology. Even now the current numbers for tumor development in Germany (RKI 2014) in the urolog... Abstract

Cited 35 times since 2014 (3.2 per year) source: EuropePMC

Proceedings. Biological sciences, Volume 281, Issue 1788, 1 1 2014, Pages 20140263 Language evolution: syntax before phonology? Collier K, Bickel B, van Schaik CP, Manser MB, Townsend SW

Phonology and syntax represent two layers of sound combination central to language's expressive power. Comparative animal studies represent one approach to understand the origins of these combinatorial layers. Traditionally, phonology, where meaningless sounds form words, has been considered a simpler combination than syntax, and thus should be more common in animals. A linguistically informed review of animal call sequences demonstrates that phonology in animal vocal systems is rare, where... Abstract

Cited 6 times since 2014 (0.6 per year) source: EuropePMC

Pharmacogenomics, Volume 15, Issue 11, 1 1 2014, Pages 1471-1477 No association between CYP3A4*22 and statin effectiveness in reducing the risk for myocardial infarction. Leusink M, de Keyser CE, Onland-Moret NC, Hofman A, Visser LE, Stricker BH, de Bakker PI, de Boer A, van Schaik RH, Maitland-van der Zee AH

Aim: Genetic variation has been shown to influence statin response in terms of lowering LDL cholesterol. The recently discovered CYP3A4*22 allele (defined as rs35599367) has been shown to affect statin-induced LDL cholesterol lowering. Our objective was to investigate whether this polymorphism modifies the risk reduction for myocardial infarction (MI) by statins. Patients & methods: We analyzed the interaction between the *22 minor allele and statin use in the independent Utrecht Cardiovascu... Abstract

Cited 117 times since 2014 (10.8 per year) source: EuropePMC

Circulation research, Volume 115, Issue 8, 1 1 2014, Pages 696-708 Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 increases neovascularization and blood flow recovery after ischemia. Welten SM, Bastiaansen AJ, de Jong RC, de Vries MR, Peters EA, Boonstra MC, Sheikh SP, La Monica N, Kandimalla ER, Quax PH, Nossent AY

Rationale: Effective neovascularization is crucial for recovery after cardiovascular events. Objective: Because microRNAs regulate expression of up to several hundred target genes, we set out to identify microRNAs that target genes in all pathways of the multifactorial neovascularization process. Using www.targetscan.org, we performed a reverse target prediction analysis on a set of 197 genes involved in neovascularization. We found enrichment of binding sites for 27 microRNAs in a single microR... Abstract

Cited 23 times since 2014 (2.1 per year) source: EuropePMC

Magnetic resonance in medicine, Volume 72, Issue 2, 1 1 2014, Pages 409-417 Quantitative T2 mapping of the mouse heart by segmented MLEV phase-cycled T2 preparation. Coolen BF, Simonis FF, Geelen T, Moonen RP, Arslan F, Paulis LE, Nicolay K, Strijkers GJ

Purpose: A high-quality, reproducible, multi-slice T2-mapping protocol for the mouse heart is presented. Methods: A T2-prepared sequence with composite 90° and 180° radiofrequency pulses in a segmented MLEV phase cycling scheme was developed. The T2-mapping protocol was optimized using simulations and evaluated with phantoms. Results: Repeatability for determination of myocardial T2 values was assessed in vivo in n = 5 healthy mice on 2 different days. The average baseline T2 of the left ventric... Abstract

Cited 4 times since 2014 (0.4 per year) source: Scopus

Perfusion, Volume 30, Issue 4, 1 1 2014, Pages 295-301 Sevoflurane-enriched blood cardioplegia: the intramyocardial delivery of a volatile anesthetic. van der Baan A, Kortekaas KA, van Es E, Meier S, Klautz RJ, Engbers FH

Myocardial ischemia/reperfusion injury is a major problem in cardiac surgery, characterized by an enhanced inflammatory response postoperatively. Sevoflurane has anti-inflammatory effects and may attenuate this injury. This study describes a novel approach to using sevoflurane as a local anti-inflammatory drug and not as an anesthetic. Therefore, a pediatric oxygenator with a sevoflurane vaporizer was integrated into the blood cardioplegia system of an adult bypass system. In addition, a gas ble... Abstract

Cited 2 times since 2014 (0.2 per year) source: EuropePMC

Circulation research, Volume 115, Issue 4, 1 1 2014, Pages e6-7 Cardiac anisotropy, regeneration, and rhythm. Pijnappels DA, Schalij MJ, Atsma DE, de Vries AA

Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 7-8, 1 1 2014, Pages 336-343 Cardiologist and cardiac surgeon view on decision-making in prosthetic aortic valve selection: does profession matter? Korteland NM, Kluin J, Klautz RJ, Roos-Hesselink JW, Versteegh MI, Bogers AJ, Takkenberg JJ

Aims: Assess and compare among Dutch cardiothoracic surgeons and cardiologists: opinion on (1) patient involvement, (2) conveying risk in aortic valve selection, and (3) aortic valve preferences. Methods and results: A survey among 117 cardiothoracic surgeons and cardiologists was conducted. Group responses were compared using the Mann-Whitney U test. Most respondents agreed that patients should be involved in decision-making, with surgeons leaning more toward patient involvement (always: 83 % v... Abstract

Cited 76 times since 2014 (7 per year) source: EuropePMC

Cardiovascular research, Volume 104, Issue 1, 31 5 2014, Pages 194-205 Light-induced termination of spiral wave arrhythmias by optogenetic engineering of atrial cardiomyocytes. Bingen BO, Engels MC, Schalij MJ, Jangsangthong W, Neshati Z, Feola I, Ypey DL, Askar SF, Panfilov AV, Pijnappels DA, de Vries AA

Aims: Atrial fibrillation (AF) is the most common cardiac arrhythmia and often involves reentrant electrical activation (e.g. spiral waves). Drug therapy for AF can have serious side effects including proarrhythmia, while electrical shock therapy is associated with discomfort and tissue damage. Hypothetically, forced expression and subsequent activation of light-gated cation channels in cardiomyocytes might deliver a depolarizing force sufficient for defibrillation, thereby circumventing the afo... Abstract

Cited 9 times since 2014 (0.8 per year) source: EuropePMC

Journal of dairy science, Volume 97, Issue 10, 30 5 2014, Pages 6135-6150 Can routinely recorded reproductive events be used as indicators of disease emergence in dairy cattle? An evaluation of 5 indicators during the emergence of bluetongue virus in France in 2007 and 2008. Marceau A, Madouasse A, Lehébel A, van Schaik G, Veldhuis A, Van der Stede Y, Fourichon C

In response to increasing risks of emerging infectious diseases, syndromic surveillance can be a suitable approach to detect outbreaks of such diseases across a large territory in an early phase. To implement a syndromic surveillance system, the primary challenge is to find appropriate health-related data. The objective of this study was to evaluate whether routinely collected dates of reproductive events in dairy cattle could be used to build indicators of health anomalies for syndromic surveil... Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

Pesticide biochemistry and physiology, Volume 114, 27 4 2014, Pages 1-7 Effects of fullerenol nanoparticles on acetamiprid induced cytoxicity and genotoxicity in cultured human lung fibroblasts. Çavaş T, Çinkılıç N, Vatan Ö, Yılmaz D

The aim of this study was to investigate the effects of water soluble fullerene (fullerenol) nanoparticles on the in vitro genotoxicity induced by the insecticide acetamiprid. Healthy human lung cells (IMR-90) were treated with fullerenol C60(OH)n (n: 18-22) alone and in combination with acetamiprid for 24h. The micronucleus test, comet assay and γ-H2AX foci formation assays were used as genotoxicity endpoints. Cytotoxicity was evaluated using the clonogenic assay. The maximum tested concentrati... Abstract

Cited 121 times since 2014 (11.1 per year) source: EuropePMC

European urology, Volume 66, Issue 6, 26 4 2014, Pages 1065-1077 The impact of the extent of lymphadenectomy on oncologic outcomes in patients undergoing radical cystectomy for bladder cancer: a systematic review. Bruins HM, Veskimae E, Hernandez V, Imamura M, Neuberger MM, Dahm P, Stewart F, Lam TB, N'Dow J, van der Heijden AG, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, Ribal MJ, Sherif A, Witjes JA

Context: Controversy exists regarding the therapeutic value of lymphadenectomy (LND) in patients undergoing radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). Objective: To systematically review the relevant literature assessing the impact of LND on oncologic and perioperative outcomes in patients undergoing RC for MIBC. Evidence acquisition: Medline, Medline In-Process, Embase, the Cochrane Central Register of Controlled Trials, and the Latin American and Caribbean Center on Hea... Abstract

Cited 64 times since 2014 (5.9 per year) source: EuropePMC

European heart journal, Volume 35, Issue 38, 25 4 2014, Pages 2627-2638 Open issues in transcatheter aortic valve implantation. Part 1: patient selection and treatment strategy for transcatheter aortic valve implantation. Bax JJ, Delgado V, Bapat V, Baumgartner H, Collet JP, Erbel R, Hamm C, Kappetein AP, Leipsic J, Leon MB, MacCarthy P, Piazza N, Pibarot P, Roberts WC, Rodés-Cabau J, Serruys PW, Thomas M, Vahanian A, Webb J, Zamorano JL, Windecker S

An exponential increase in the use of transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis has been witnessed over the recent years. The current article reviews different areas of uncertainty related to patient selection. The use and limitations of risk scores are addressed, followed by an extensive discussion on the value of three-dimensional imaging for prosthesis sizing and the assessment of complex valve anatomy such as degenerated bicuspid valves. The uncer... Abstract

Cited 67 times since 2014 (6.2 per year) source: EuropePMC

European heart journal, Volume 35, Issue 38, 25 4 2014, Pages 2639-2654 Open issues in transcatheter aortic valve implantation. Part 2: procedural issues and outcomes after transcatheter aortic valve implantation. Bax JJ, Delgado V, Bapat V, Baumgartner H, Collet JP, Erbel R, Hamm C, Kappetein AP, Leipsic J, Leon MB, MacCarthy P, Piazza N, Pibarot P, Roberts WC, Rodés-Cabau J, Serruys PW, Thomas M, Vahanian A, Webb J, Zamorano JL, Windecker S

This article provides an overview on procedure-related issues and uncertainties in outcomes after transcatheter aortic valve implantation (TAVI). The different access sites and how to select them in an individual patient are discussed. Also, the occurrence and potential predictors of aortic regurgitation (AR) after TAVI are addressed. The different methods to quantify AR are reviewed, and it appears that accurate and reproducible quantification is suboptimal. Complications such as prosthesis-pat... Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 25, Issue 9, 24 4 2014, Pages 1012-1020 Impact of pacing site on QRS duration and its relationship to hemodynamic response in cardiac resynchronization therapy for congestive heart failure. Derval N, Bordachar P, Lim HS, Sacher F, Ploux S, Laborderie J, Steendijk P, Deplagne A, Ritter P, Garrigue S, Denis A, Hocini M, Haissaguerre M, Clementy J, Jaïs P

Introduction: Recent studies have demonstrated that left ventricular (LV) pacing site is a critical parameter in optimizing cardiac resynchronization therapy (CRT). The present study evaluates the effect of pacing from different LV locations on QRS duration (QRSd) and their relationship to acute hemodynamic response in congestive heart failure patients. Methods and results: Thirty-five patients with nonischemic dilated cardiomyopathy and left bundle branch block referred for CRT device implantat... Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

BMC cardiovascular disorders, Volume 14, 18 3 2014, Pages 87 Scarcity of atrial fibrillation in a traditional African population: a community-based study. Koopman JJ, van Bodegom D, Westendorp RG, Jukema JW

Background: In western societies, atrial fibrillation is an increasingly common finding among the elderly. Established risk factors of atrial fibrillation include obesity, diabetes, hypertension, and cardiovascular disease. Atrial fibrillation has almost exclusively been studied in western populations where these risk factors are widely present. Therefore, we studied the epidemiology of atrial fibrillation in a traditional African community. Methods: In rural Ghana, among 924 individuals aged 50... Abstract

Clinical and experimental rheumatology, Volume 32, Issue 6 Suppl 86, 17 3 2014, Pages S-60-7 Detection of pulmonary vasculopathy by novel analysis of oxygen uptake in patients with systemic sclerosis: association with pulmonary arterial pressures. Ninaber MK, Hamersma WB, Schouffoer AA, Kovacs G, Olschewski H, Holman ER, Ajmone Marsan N, Stolk J

Objectives: During cardiopulmonary exercise testing (CPET) compromised pulmonary vasculature in patients with systemic sclerosis (SSc) may lead to increases in pulmonary arterial pressures (PAP) and decreased oxygen uptake. We hypothesised that this may lead into a disproportional heart rate (HR) increase with a corresponding V'O₂/HR breakpoint and relates to systolic PAP at rest. Methods: In a prospective design we evaluated V'O₂/HR slopes for breakpoints. To understand its physiologi... Abstract

Cited 96 times since 2014 (8.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 17, 17 3 2014, Pages 1373-1381 Prospective validation and assessment of cardiovascular and offspring risk models for pregnant women with congenital heart disease. Balci A, Sollie-Szarynska KM, van der Bijl AG, Ruys TP, Mulder BJ, Roos-Hesselink JW, van Dijk AP, Wajon EM, Vliegen HW, Drenthen W, Hillege HL, Aarnoudse JG, van Veldhuisen DJ, Pieper PG, ZAHARA-II investigators

Objectives: Adequate prepregnancy prediction of maternal cardiovascular and offspring risk is important for counselling and management of pregnancy in women with congenital heart disease (CHD). Therefore we performed a study to identify the optimal assessment strategy for estimating the risk of pregnancy in women with CHD. Methods: In this prospective study, we determined the outcomes of 213 pregnancies in 203 women with CHD. The ZAHARA I (Zwangerschap bij Aangeboren HARtAfwijkingen I) and CARPR... Abstract

Cited 14 times since 2014 (1.3 per year) source: EuropePMC

Journal of the neurological sciences, Volume 345, Issue 1-2, 16 3 2014, Pages 15-25 Muscle and nerve inflammation in intensive care unit-acquired weakness: a systematic translational review. Witteveen E, Wieske L, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Background: Intensive care unit-acquired weakness (ICU-AW) is an important complication of critical illness. The main risk factors, sepsis and the systemic inflammatory response syndrome, suggest an inflammatory pathogenesis. In this systematic translational review we summarize current knowledge on inflammation in muscle and nerve tissue in animal models of ICU-AW and in critically ill patients with ICU-AW. Methods: We conducted a systematic search in the databases of MEDLINE, EMBASE and Web of... Abstract