8684 results
Cited 74 times since 2013 (6 per year)
source: EuropePMC
Journal of internal medicine,
Volume 274, Issue 1, 11 2 2013, Pages 77-85
Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study.
Mooijaart SP, Sattar N, Trompet S, Lucke J, Stott DJ, Ford I, Jukema JW, Westendorp RG, de Craen AJ, PROSPER Study Group
Background: Inflammation is involved in the pathogenesis of cardiovascular disease and cognitive decline. Interleukin-6 (IL-6) has a role in cardiovascular disease, but the association of IL-6 concentration and the functional IL-6 -174 polymorphism with cognitive decline has not been demonstrated unequivocally. The objective of this study was to investigate the associations between both high concentration of IL-6 and the -174 promoter polymorphism, and increased cognitive decline in old age. Met...
Abstract
Cited 100 times since 2013 (8.2 per year)
source: EuropePMC
Microbial ecology,
Volume 65, Issue 4, 9 2 2013, Pages 1011-1023
A microbial signature approach to identify fecal pollution in the waters off an urbanized coast of Lake Michigan.
Newton RJ, Bootsma MJ, Morrison HG, Sogin ML, McLellan SL
Urban coasts receive watershed drainage from ecosystems that include highly developed lands with sewer and stormwater infrastructure. In these complex ecosystems, coastal waters are often contaminated with fecal pollution, where multiple delivery mechanisms that often contain multiple fecal sources make it difficult to mitigate the pollution. Here, we exploit bacterial community sequencing of the V6 and V6V4 hypervariable regions of the bacterial 16S rRNA gene to identify bacterial distributions...
Abstract
Cited 88 times since 2013 (7.2 per year)
source: EuropePMC
International journal of medical microbiology : IJMM,
Volume 303, Issue 6-7, 8 2 2013, Pages 360-379
Antibiotic resistant enterococci-tales of a drug resistance gene trafficker.
Werner G, Coque TM, Franz CM, Grohmann E, Hegstad K, Jensen L, van Schaik W, Weaver K
Enterococci have been recognized as important hospital-acquired pathogens in recent years, and isolates of E. faecalis and E. faecium are the third- to fourth-most prevalent nosocomial pathogen worldwide. Acquired resistances, especially against penicilin/ampicillin, aminoglycosides (high-level) and glycopeptides are therapeutically important and reported in increasing numbers. On the other hand, isolates of E. faecalis and E. faecium are commensals of the intestines of humans, many vertebrate a...
Abstract
Cited 16 times since 2013 (1.3 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 3, 6 1 2013, Pages e58572
Small hydrophobic protein of human metapneumovirus does not affect virus replication and host gene expression in vitro.
de Graaf M, Herfst S, Aarbiou J, Burgers PC, Zaaraoui-Boutahar F, Bijl M, van Ijcken W, Schrauwen EJ, Osterhaus AD, Luider TM, Scholte BJ, Fouchier RA, Andeweg AC
Human metapneumovirus (HMPV) encodes a small hydrophobic (SH) protein of unknown function. HMPV from which the SH open reading frame was deleted (HMPVΔSH) was viable and displayed similar replication kinetics, cytopathic effect and plaque size compared with wild type HMPV in several cell-lines. In addition, no differences were observed in infection efficiency or cell-to-cell spreading in human primary bronchial epithelial cells (HPBEC) cultured at an air-liquid interphase. Host gene expression w...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 99, Issue 8, 6 1 2013, Pages 556-561
Association between discharge heart rate and left ventricular adverse remodelling in ST segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention.
Joyce E, Hoogslag GE, Leong DP, Fox K, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Objective: Left ventricular (LV) adverse remodelling is an important determinant of mortality after ST segment elevation myocardial infarction (STEMI). Recently, discharge heart rate (DHR) has been associated with long-term outcomes after STEMI. Whether DHR is related to the development of LV remodelling after STEMI remains unknown. The present study evaluated the association between DHR after STEMI and the occurrence of LV remodelling at 6 months. DESIGN, SETTING, PATIENTS AND INTERVENTIONS: In...
Abstract
Cited 25 times since 2013 (2 per year)
source: EuropePMC
The pharmacogenomics journal,
Volume 14, Issue 1, 5 1 2013, Pages 6-13
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
Avery CL, Sitlani CM, Arking DE, Arnett DK, Bis JC, Boerwinkle E, Buckley BM, Ida Chen YD, de Craen AJ, Eijgelsheim M, Enquobahrie D, Evans DS, Ford I, Garcia ME, Gudnason V, Harris TB, Heckbert SR, Hochner H, Hofman A, Hsueh WC, Isaacs A, Jukema JW, Knekt P, Kors JA, Krijthe BP, Kristiansson K, Laaksonen M, Liu Y, Li X, Macfarlane PW, Newton-Cheh C, Nieminen MS, Oostra BA, Peloso GM, Porthan K, Rice K, Rivadeneira FF, Rotter JI, Salomaa V, Sattar N, Siscovick DS, Slagboom PE, Smith AV, Sotoodehnia N, Stott DJ, Stricker BH, Stürmer T, Trompet S, Uitterlinden AG, van Duijn C, Westendorp RG, Witteman JC, Whitsel EA, Psaty BM
Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the 'missing heritability' of complex traits. Here, we describe four independent analyses in 33 781 participants of European ancestry from 10 cohorts that were designed to identify genetic variants modifying the effects of drugs on QT interval duration (QT). Each analysis cross-sectionally examined four therapeutic classes: thiazide diuretics (prevalence of...
Abstract
Cited 140 times since 2013 (11.4 per year)
source: EuropePMC
Annals of neurology,
Volume 73, Issue 3, 4 1 2013, Pages 397-407
Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis.
Pluk H, van Hoeve BJ, van Dooren SH, Stammen-Vogelzangs J, van der Heijden A, Schelhaas HJ, Verbeek MM, Badrising UA, Arnardottir S, Gheorghe K, Lundberg IE, Boelens WC, van Engelen BG, Pruijn GJ
Objective: Sporadic inclusion body myositis (sIBM) is an inflammatory myopathy characterized by both degenerative and autoimmune features. In contrast to other inflammatory myopathies, myositis-specific autoantibodies had not been found in sIBM patients until recently. We used human skeletal muscle extracts as a source of antigens to detect autoantibodies in sIBM and to characterize the corresponding antigen. Methods: Autoantibodies to skeletal muscle antigens were detected by immunoblotting. Th...
Abstract
Cited 189 times since 2013 (15.4 per year)
source: EuropePMC
Circulation,
Volume 127, Issue 14, 4 1 2013, Pages 1466-75, 1475e1-28
MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation.
Dawson K, Wakili R, Ordög B, Clauss S, Chen Y, Iwasaki Y, Voigt N, Qi XY, Sinner MF, Dobrev D, Kääb S, Nattel S
Background: Congestive heart failure (CHF) causes atrial fibrotic remodeling, a substrate for atrial fibrillation (AF) maintenance. MicroRNA29 (miR29) targets extracellular matrix proteins. In the present study, we examined miR29b changes in patients with AF and/or CHF and in a CHF-related AF animal model and assessed its potential role in controlling atrial fibrous tissue production. Methods and results: Control dogs were compared with dogs subjected to ventricular tachypacing for 24 hours, 1 w...
Abstract
Cited 20 times since 2013 (1.6 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 3, 1 1 2013, Pages 113-117
Ebstein's anomaly may be caused by mutations in the sarcomere protein gene MYH7.
van Engelen K, Postma AV, van de Meerakker JB, Roos-Hesselink JW, Helderman-van den Enden AT, Vliegen HW, Rahman T, Baars MJ, Sels JW, Bauer U, Pickardt T, Sperling SR, Moorman AF, Keavney B, Goodship J, Klaassen S, Mulder BJ
Ebstein's anomaly is a rare congenital heart malformation characterised by adherence of the septal and posterior leaflets of the tricuspid valve to the underlying myocardium. Associated abnormalities of left ventricular morphology and function including left ventricular noncompaction (LVNC) have been observed. An association between Ebstein's anomaly with LVNC and mutations in the sarcomeric protein gene MYH7, encoding β-myosin heavy chain, has been shown by recent studies. This might...
Abstract
Cited 9 times since 2013 (0.7 per year)
source: EuropePMC
Circulation,
Volume 127, Issue 12, 1 1 2013, Pages 1340-1341
Compression of the left main coronary artery by a giant pulmonary artery aneurysm.
Jurado-Román A, Hernández-Hernández F, Ruíz-Cano MJ, Velázquez-Martín MT, Medina JM, Pérez-López I, Barrios-Garrido-Lestache E, Montero-Cabezas JM, Escribano-Subías P
Abstract
Cited 7 times since 2013 (0.6 per year)
source: EuropePMC
Annals of plastic surgery,
Volume 70, Issue 3, 1 1 2013, Pages 360-365
Intraoperative prediction of postoperative flap outcome using the near-infrared fluorophore methylene blue.
Ashitate Y, Lee BT, Laurence RG, Lunsford E, Hutteman M, Oketokoun R, Choi HS, Frangioni JV
Methylene blue (MB) is a near-infrared fluorophore that provides a stable visual map of skin perfusion after intravenous injection. We explored the capability of MB to predict submental flap postoperative outcome using a single intraoperative measurement. Submental flaps were created in N = 15 pigs and imaged using the FLARE imaging system immediately after surgery and at 72 hours. Using the first 3 pigs, optimal MB dosing was found to be 2.0 mg/kg. Training and validation sets of 6 pigs each we...
Abstract
Cited 82 times since 2013 (6.7 per year)
source: EuropePMC
The Journal of urology,
Volume 190, Issue 2, 1 1 2013, Pages 574-579
Intraoperative near infrared fluorescence guided identification of the ureters using low dose methylene blue: a first in human experience.
Verbeek FP, van der Vorst JR, Schaafsma BE, Swijnenburg RJ, Gaarenstroom KN, Elzevier HW, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Purpose: Near infrared fluorescence imaging is a promising technique that offers real-time visual information during surgery. In this study we report the first clinical results to our knowledge of ureteral imaging using near infrared fluorescence after a simple peripheral infusion of methylene blue. Furthermore, we assessed the optimal timing and dose of methylene blue. Materials and methods: A total of 12 patients who underwent lower abdominal surgery were included in this prospective feasibili...
Abstract
Cited 28 times since 2013 (2.3 per year)
source: EuropePMC
Pharmacogenetics and genomics,
Volume 23, Issue 3, 1 1 2013, Pages 148-155
Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.
Elens L, Nieuweboer AJ, Clarke SJ, Charles KA, de Graan AJ, Haufroid V, van Gelder T, Mathijssen RH, van Schaik RH
Objective: P450 oxidoreductase (POR) is essential for cytochrome P450 (CYP) activity in humans. The POR*28 allele (A503V) has been shown to impact on in-vitro CYP-mediated metabolism, including CYP3A isoenzymes. The aim of the present study was to determine the in vivo impact of the POR*28 allele on the pharmacokinetics of the classic CYP3A phenotyping probes midazolam and erythromycin. Whereas midazolam is metabolized by both CYP3A4 and CYP3A5, erythromycin is exclusively oxidized by CYP3A4. Ma...
Abstract
Cited 57 times since 2013 (4.6 per year)
source: EuropePMC
PLoS genetics,
Volume 9, Issue 2, 28 4 2013, Pages e1003301
Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.
Kiezun A, Pulit SL, Francioli LC, van Dijk F, Swertz M, Boomsma DI, van Duijn CM, Slagboom PE, van Ommen GJ, Wijmenga C, Genome of the Netherlands Consortium, de Bakker PI, Sunyaev SR
Large-scale population sequencing studies provide a complete picture of human genetic variation within the studied populations. A key challenge is to identify, among the myriad alleles, those variants that have an effect on molecular function, phenotypes, and reproductive fitness. Most non-neutral variation consists of deleterious alleles segregating at low population frequency due to incessant mutation. To date, studies characterizing selection against deleterious alleles have been based on all...
Abstract
Cited 65 times since 2013 (5.3 per year)
source: EuropePMC
The Journal of infectious diseases,
Volume 207, Issue 11, 27 4 2013, Pages 1780-1786
Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatment.
Zhang X, Top J, de Been M, Bierschenk D, Rogers M, Leendertse M, Bonten MJ, van der Poll T, Willems RJ, van Schaik W
Intestinal colonization by antibiotic-resistant Enterococcus faecium is the first step in a process that can lead to infections in hospitalized patients. By comparative genome analysis and subsequent polymerase chain reaction screening, we identified a locus that encodes a putative phosphotransferase system (PTS). The PTS locus was widespread in isolates from hospital outbreaks of infection (84.2%) and nonoutbreak clinical infections (66.0%) but absent from human commensal isolates. Deletion of...
Abstract
Cited 14 times since 2013 (1.1 per year)
source: EuropePMC
PLoS computational biology,
Volume 9, Issue 2, 21 3 2013, Pages e1002874
Cost and effects of different admission screening strategies to control the spread of methicillin-resistant Staphylococcus aureus.
Gurieva T, Bootsma MC, Bonten MJ
Nosocomial infection rates due to antibiotic-resistant bacteriae, e.g., methicillin-resistant Staphylococcus aureus (MRSA) remain high in most countries. Screening for MRSA carriage followed by barrier precautions for documented carriers (so-called screen and isolate (S&I)) has been successful in some, but not all settings. Moreover, different strategies have been proposed, but comparative studies determining their relative effects and costs are not available. We, therefore, used a mathemati...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
EJIFCC,
Volume 24, Issue 3, 21 3 2013, Pages 105-112
Clinical Application of Pharmacogenetics: Where are We Now?
van Schaik RH, IFCC Task Force on Pharmacogenetics: Prof Dr Maurizio Ferrari (IT), Prof Dr Michael Neumaier (GER), Prof Dr Munir Pirmohamed (UK), Prof Dr Henk-Jan Guchelaar (NL), Prof Dr Ron van Schaik (NL)
Pharmacogenetic (PGx) testing has the potential to improve drug therapy in an individual by informing appropriate drug dosing or drug selection in order to maximize efficacy and safety. Although multiple studies have illustrated the potential benefits of such testing when applied to specific drugs across a broad range of therapy areas, the uptake of PGx testing in routine clinical practice has been relatively limited. Implementation appears to be hampered by the absence of sufficiently strong ev...
Abstract
Cited 40 times since 2013 (3.3 per year)
source: EuropePMC
BJOG : an international journal of obstetrics and gynaecology,
Volume 120, Issue 6, 19 3 2013, Pages 758-764
Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers.
Schaafsma BE, Verbeek FP, Peters AA, van der Vorst JR, de Kroon CD, van Poelgeest MI, Trimbos JB, van de Velde CJ, Frangioni JV, Vahrmeijer AL, Gaarenstroom KN
This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received 99mTc-nanocolloid and patent blue for SLN detection. Subsequently, women randomly received ICG:HSA or ICG alone. In 24 women, 35 SLNs were intraoperatively detected. All SLNs detected were radioactive and NIR fluorescent and 27 (77%) were bl...
Abstract
Cited 27 times since 2013 (2.2 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 6, Issue 2, 18 3 2013, Pages 380-391
Engraftment patterns of human adult mesenchymal stem cells expose electrotonic and paracrine proarrhythmic mechanisms in myocardial cell cultures.
Askar SF, Ramkisoensing AA, Atsma DE, Schalij MJ, de Vries AA, Pijnappels DA
Background: After intramyocardial injection, mesenchymal stem cells (MSCs) may engraft and influence host myocardium. However, engraftment rate and pattern of distribution are difficult to control in vivo, hampering assessment of potential adverse effects. In this study, the role of the engraftment patterns of MSCs on arrhythmicity in controllable in vitro models is investigated. Methods and results: Cocultures of 4×10(5) neonatal rat cardiomyocytes and 7% or 28% adult human MSCs (hMSCs) in diff...
Abstract
Cited 129 times since 2013 (10.5 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 29, Issue 5, 16 3 2013, Pages 1177-1190
Automatic quantification and characterization of coronary atherosclerosis with computed tomography coronary angiography: cross-correlation with intravascular ultrasound virtual histology.
de Graaf MA, Broersen A, Kitslaar PH, Roos CJ, Dijkstra J, Lelieveldt BP, Jukema JW, Schalij MJ, Delgado V, Bax JJ, Reiber JH, Scholte AJ
Plaque constitution on computed tomography coronary angiography (CTA) is associated with prognosis. At present only visual assessment of plaque constitution is possible. An accurate automatic, quantitative approach for CTA plaque constitution assessment would improve reproducibility and allows higher accuracy. The present study assessed the feasibility of a fully automatic and quantitative analysis of atherosclerosis on CTA. Clinically derived CTA and intravascular ultrasound virtual histology (...
Abstract
