Research

Publications

Below you can find a list of our published research.

6125 results

Cited 34 times since 1994 (1.1 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 107, Issue 6, 1 1 1994, Pages 1416-1422 Inhibition of the fetal stress response improves cardiac output and gas exchange after fetal cardiac bypass. Fenton KN, Heinemann MK, Hickey PR, Klautz RJ, Liddicoat JR, Hanley FL

Cardiac bypass in late-gestation fetal lambs causes severe placental vasoconstriction, which leads to fetal death from hypoxemia and respiratory acidosis. This response can be blocked by the administration of indomethacin; however, a fatal metabolic acidosis then gradually develops in the fetus. Because the fetus is known to mount an intensive catecholamine response to stress, and because the fetal myocardium is particularly sensitive to increased afterload, we hypothesized that elevated afterlo... Abstract

Cited 11 times since 1994 (0.4 per year) source: EuropePMC

Journal of molecular and cellular cardiology, Volume 26, Issue 5, 1 1 1994, Pages 639-648 The effect of sarcolemmal cholesterol content on the tolerance to anoxia in cardiomyocyte cultures. Bastiaanse EM, van der Valk-Kokshoorn LJ, Egas-Kenniphaas JM, Atsma DE, van der Laarse A

To determine whether the sarcolemmal-free cholesterol content influences the tolerance to anoxia in cultured neonatal rat cardiomyocytes, we modulated the free cholesterol content of the cultures, and determined the time course of anoxia-induced cell death. Incubation for 5 h with liposomes having a free cholesterol to phospholipid molar ratio of 2, 0.5 and 0, resulted in a change of cellular free cholesterol content by +54.7 +/- 5.8% (P < 0.001), by -5.2 +/- 6.3% (n.s.), and by -22.1 +/- 4.9... Abstract

Cited 14 times since 1994 (0.5 per year) source: EuropePMC

Journal of vascular research, Volume 31, Issue 3, 1 1 1994, Pages 153-162 In the normal rabbit femoral artery increasing arterial wall injury does not lead to increased intimal hyperplasia. van Erven L, Post MJ, Velema E, Borst C

Angioplasty inflicts damage to the arterial wall. We studied whether augmented medial smooth muscle cell necrosis leads to augmented intimal hyperplasia and thus aggravates restenosis. Sixty-three normal femoral arteries of New Zealand White rabbits were overstretched with an angioplasty balloon during either maximal vasoconstriction with phenylephrine (32 arteries) or maximal vasodilation with nitroprusside (31 arteries). After 3 days' survival, medial necrosis was determined as percentage... Abstract

Cited 87 times since 1994 (2.8 per year) source: EuropePMC

The American journal of physiology, Volume 266, Issue 4 Pt 2, 1 1 1994, Pages H1565-71 Heart rate and heart rate variability as indexes of sympathovagal balance. Bootsma M, Swenne CA, Van Bolhuis HH, Chang PC, Cats VM, Bruschke AV

According to the Rosenblueth-Simeone model, the heart rate (HR) is proportional to the sympathovagal balance. The individual proportionality constant is the intrinsic heart rate, which can only be determined invasively. The normalized low-frequency heart rate variability power (LF) has been raised as a calibrated noninvasive alternative. To concrete this assumption, we studied the individual LF-HR relation during incremental head-up tilt (0, 10, 20, 30, 40, 45, 50, 55, 60, 65, 70, 75, and 80 deg... Abstract

Cited 17 times since 1994 (0.5 per year) source: EuropePMC

Pharmacological research, Volume 29, Issue 3, 1 1 1994, Pages 261-272 Endothelial dysfunction and dyslipidemia: possible effects of lipid lowering and lipid modifying therapy. van Boven AJ, Jukema JW, Paoletti R

Hypercholesterolemic and atherosclerotic coronary endothelial dysfunction consist of a progressive, not irreversible, impairment in reactions to various endothelium dependent relaxing substances in both the epicardial coronary artery and in the resistance vessel. Paradoxical vasoconstriction, dynamic stenoses and dysregulation of the coronary blood flow make this endothelial dysfunction contribute to the pathogenesis of myocardial ischemia. The selectivity of the impairment makes the concept of... Abstract

Cited 10 times since 1994 (0.3 per year) source: EuropePMC

FEBS letters, Volume 343, Issue 2, 1 1 1994, Pages 151-154 Simvastatin-sodium delays cell death of anoxic cardiomyocytes by inhibition of the Na+/Ca2+ exchanger. Bastiaanse EM, Atsma DE, Kuijpers MM, Van der Laarse A

When incubated under anoxic conditions, cultured neonatal cardiomyocytes undergo cell necrosis. Simvastatin-sodium, the bioactive metabolite of simvastatin (a potent serum cholesterol-lowering drug), delayed the anoxia-induced myocyte necrosis in a dose-dependent manner. This beneficial effect of simvastatin-sodium could not be attributed to its cholesterol-lowering properties. We found that simvastatin-sodium, at concentrations of 20 and 50 microM, attenuated the rise in intracellular Ca2+ conc... Abstract

Cited 75 times since 1994 (2.4 per year) source: EuropePMC

Pediatric research, Volume 35, Issue 3, 1 1 1994, Pages 329-333 Relationship between brain blood flow and carotid arterial flow in the sheep fetus. van Bel F, Roman C, Klautz RJ, Teitel DF, Rudolph AM

The present study investigates whether changes in total brain blood flow can be reliably estimated by changes in carotid arterial blood flow in fetal and perinatal lambs. We therefore compared carotid arterial blood flow, measured with implanted transit-time ultrasound transducers, with brain blood flow, measured by radioactive microspheres in fetal lambs during normal oxygenation and during pulmonary ventilation with oxygen, with PO2 ranging from levels normal for the healthy fetus to levels no... Abstract

Cited 1 times since 1994 (0 per year) source: EuropePMC

The Netherlands journal of medicine, Volume 44, Issue 2, 1 1 1994, Pages 60-64 Q-fever in a patient with a ventriculo-peritoneal drain. Case report and short review of the literature. Lohuis PJ, Ligtenberg PC, Diepersloot RJ, de Graaf M

Although Q-fever is still a relatively rare disease in the Netherlands, its incidence seems to be increasing. In this article we describe the case-history of a 65-year-old woman with a Pudenz-drain, who acquired Q-fever pneumonia while manuring her garden. The course of the disease was deviant, which most likely was caused by colonization of the ventriculo-peritoneal drain with Coxiella burnetii. Q-fever usually presents as a self-limiting illness. In the case of chronic Q-fever, complications s... Abstract

Cited 17 times since 1994 (0.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 23, Issue 2, 1 1 1994, Pages 514-524 Nonlinearity of the left ventricular end-systolic wall stress-velocity of fiber shortening relation in young pigs: a potential pitfall in its use as a single-beat index of contractility. Banerjee A, Brook MM, Klautz RJ, Teitel DF

Objectives: We sought to evaluate in the young heart the primary assumptions on which the current use of the mean "velocity of fiber shortening corrected for heart rate" as a noninvasive index of contractility are based. Background: End-systolic wall stress-velocity of fiber shortening relation has been applied as a single-beat, load-independent index of contractility in children. This use is based on poorly validated assumptions of linearity, parallel shifts with changing contractile... Abstract

Cited 80 times since 1994 (2.6 per year) source: EuropePMC

The American journal of pathology, Volume 144, Issue 1, 1 1 1994, Pages 70-81 Plasminogen activators, their inhibitors, and urokinase receptor emerge in late stages of melanocytic tumor progression. de Vries TJ, Quax PH, Denijn M, Verrijp KN, Verheijen JH, Verspaget HW, Weidle UH, Ruiter DJ, van Muijen GN

Degradation of the extracellular matrix and other tissue barriers by proteases like plasminogen activators (PAs) is a prerequisite for neoplastic growth and metastasis. Recently, we reported that highly metastatic behavior of human melanoma cells in nude mice correlates with urokinase-type PA (u-PA) expression and activity and with PA inhibitor type 1 and 2 (PAI-1, PAI-2) expression. Here we report on the occurrence of components of the PA system in the various stages of human melanoma tumor pro... Abstract

Cited 1 times since 1994 (0 per year) source: EuropePMC

Annales de biologie clinique, Volume 52, Issue 11, 1 1 1994, Pages 775-782 Studies on functional and structural role of urokinase receptor and other components of the plasminogen activation system in malignancy. Weidle UH, Wöllisch E, Rønne E, Ploug M, Behrendt N, de Vries TJ, Quax PH, Verheijen JH, van Muijen GN, Ruiter DJ

Using immunohistochemistry and in-situ hybridization, we studied the expression of the components of the plasminogen activation system during progression to malignant melanoma with fresh melanocytic lesions. Expression of these components is confined to late stages of melanoma. t-PA expression is limited to rare cases of metastatic melanoma. The other components are frequently expressed concomitantly in the same tumour. Urokinase (u-PA) is expressed in stromal cells and only in tumour cells at i... Abstract

Cited 5 times since 1994 (0.2 per year) source: EuropePMC

Magnetic resonance imaging, Volume 12, Issue 3, 1 1 1994, Pages 531-534 Cardiovascular MR imaging: pressure-gating using the arterial pressure signal from a conventional ferromagnetic micromanometer-tip catheter. Pattynama PM, van der Velde ET, Steendijk P, Lamb HJ, Baan J, de Roos A

We used the arterial pressure wave as a reliable trigger to synchronize MR imaging to the cardiac cycle. Pressure readings and MR images remained undistorted using a conventional ferromagnetic micromanometer-tip catheter. As a safe alternative to triggering to ventricular pressure, this approach allows varying the time relation between the trigger and the cardiac cycle while maintaining the advantages of pressure-gating. Abstract

Cited 1 times since 1994 (0 per year) source: EuropePMC

European heart journal, Volume 15, Issue 1, 1 1 1994, Pages 83-88 Acute effects of balloon valvuloplasty and pacing on left ventricular performance in children with moderate pulmonary valve stenosis, analysed by systolic and diastolic pressure-volume relationships. Witsenburg M, van der Velde ET, Klautz RJ, Hess J, Baan J

Right ventricular overload of volume and/or pressure type may affect left ventricular systolic and diastolic function. This has been shown in animal studies and has been suggested in non-invasive studies in man. Altered geometry of the left ventricle, myocardial hypertrophy and changes in contractile state may be responsible for the change in function. Balloon valvuloplasty is an effective treatment for isolated valvular pulmonary stenosis in children, and results in an immediate decrease of rig... Abstract

Cited 21 times since 1994 (0.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 23, Issue 1, 1 1 1994, Pages 82-91 Systemic and cardiac neuroendocrine activation and severity of myocardial ischemia in humans. Remme WJ, Kruyssen DA, Look MP, Bootsma M, de Leeuw PW

Objectives: The purpose of this study was to assess the effect of different degrees of ischemia on circulating and cardiac neurohormones and vasotone. Background: Neuroendocrine activation and subsequent systemic vasoconstriction may complicate ischemia. Whether this relates to severity of ischemia and subsequent cardiac dysfunction, and whether neurohormonal balance in the ischemic area changes, is unknown. Methods: Fifty-six normotensive patients with coronary artery disease were evaluated dur... Abstract

Cited 8 times since 1993 (0.3 per year) source: EuropePMC

Pflugers Archiv : European journal of physiology, Volume 425, Issue 5-6, 1 1 1993, Pages 426-433 Cardiac sympathetic denervation does not change the load dependence of the left ventricular end-systolic pressure/volume relationship in dogs. Schipper IB, Steendijk P, Klautz RJ, van der Velde ET, Baan J

It has been shown that in the intact canine heart the left-ventricular end-systolic pressure/volume relation (ESPVR) depends on loading conditions: an increase in arterial vascular resistance causes a leftwards shift and a steeper slope of the ESPVR, suggesting an increased inotropic state. Our purpose was to investigate the possible contribution of the sympathetic nervous system to this load sensitivity of the ESPVR, using intact, but denervated, hearts with normal coronary perfusion and afterl... Abstract

Cited 57 times since 1993 (1.8 per year) source: EuropePMC

IEEE transactions on bio-medical engineering, Volume 40, Issue 11, 1 1 1993, Pages 1138-1148 The four-electrode resistivity technique in anisotropic media: theoretical analysis and application on myocardial tissue in vivo. Steendijk P, Mur G, Van Der Velde ET, Baan J

Several aspects of the four-electrode resistivity technique were studied with special emphasis on the theoretical determination of penetration depth and sample volume in anisotropic media such as (cardiac) muscle. Moreover, the presence of a thin disturbing layer on top of the medium under study was analyzed. A four-electrode sensor was developed for the measurement of local myocardial resistivity in two orthogonal directions. The sensor was applied to the epicardium of anesthetized open chest d... Abstract

Cited 9 times since 1993 (0.3 per year) source: EuropePMC

Scandinavian journal of gastroenterology, Volume 28, Issue 11, 1 1 1993, Pages 929-933 Detection and management of common bile duct stones in the era of laparoscopic cholecystectomy. van der Hul RL, Plaisier PW, Hamming JF, Bruining HA, van Blankenstein M

Abstract

Cited 15 times since 1993 (0.5 per year) source: EuropePMC

Nuclear medicine and biology, Volume 20, Issue 7, 1 1 1993, Pages 825-833 The labeling of proteins and LDL with 99mTc: a new direct method employing KBH4 and stannous chloride. Pauwels EK, Welling MM, Feitsma RI, Atsma DE, Nieuwenhuizen W

A new direct labeling technique for proteins with technetium-99m (99mTc) has been developed and makes use of borohydride and stannous chloride. The method is simple and reproducible and gives a high labeling efficiency and high retention of biological activity for proteins, including polyclonal immunoglobulin (Ig), antifibrin monoclonal antibody, tissue type plasminogen activator, fibrinogen and low density lipoprotein (LDL). This method can be used in kit-format and takes about 20 min preparati... Abstract

Cited 92 times since 1993 (2.9 per year) source: EuropePMC

The EMBO journal, Volume 12, Issue 10, 1 1 1993, Pages 3921-3929 A transcription factor with homology to the AP-1 family links RNA transcription and DNA replication in the lytic cycle of Epstein-Barr virus. Schepers A, Pich D, Hammerschmidt W

oriLyt, the lytic origin of DNA replication of Epstein-Barr virus (EBV), ensures viral DNA amplification during the productive or lytic phase of the virus' life cycle. To understand the contribution of cis- and transacting elements involved in DNA replication of oriLyt, a detailed mutational analysis was undertaken which defined BZLF1, a viral transcriptional activator, as an essential replication factor. The BZLF1 protein belongs to the extended fos/jun family of transcription factors and... Abstract

Cited 3 times since 1993 (0.1 per year) source: EuropePMC

Catheterization and cardiovascular diagnosis, Volume 29, Issue 4, 1 1 1993, Pages 283-284 Nineteen years survival after occlusion of the left main coronary artery by virtue of an anomalous septal branch. Vliegen HW, Cats VM

This case presents a patient who survived 19 years with an occluded left main coronary artery as a result of collateral flow to the anterior wall from an anomalous septal branch arising from the right coronary artery. The case illustrates that minor variations in coronary anatomy may have important effects on the prognosis of a patient. Abstract